General synthesis
Examples of published literature for General synthesis
A practical flow synthesis of 1,2,3-triazoles
Dawid Drelinkiewicza, Richard J. Whitbya
View abstract
- aSchool of Chemistry, Faculty of Engineering and Physical Sciences, The University of Southampton, Southampton, UK
Scalable synthesis of favipiravir via conventional and continuous flow chemistry
Thanat Tiyasakulchaia, Netnapa Charoensetakula, Thitiphong Khamkhenshorngphanuchb, Chawanee Thongpanchangaa, Onsiri Srikunc, Yongyuth Yuthavonga, Nitipol Srimongkolpithaka
View abstract
- aNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand
- bDepartment of General Education, Faculty of Science and Health Technology, Navamindradhiraj University, Bangkok, Thailand
- cGovernment Pharmaceutical Organization (GPO), Bangkok, Thailand
Synthesis of CTA and DNAN using flow chemistry
Ankit Kumar Mittala, Gaurav Prakasha, Pramod Pathaka, Debabrata Maitia
View abstract
- aIndian Institute of Technology Bombay, Department of Chemistry, Mumbai, INDIA
Microfluidic Asymmetrical Synthesis and Chiral Analysis
Konstantin A.Kochetkova, Nataliya A.Bystrovaa, Pavel A.Pavlovb, Maxim S.Oshchepkovb, Aleksandr S.Oshchepkovc
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- aNesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Moscow 119991, Russia
- bMendeleev University of Chemical Technology of Russia, Miusskaya pl. 9, Moscow 125047, Russia
- cMax Planck Institute for the Science of Light, Department of Physics, D-91058 Erlangen, Germany
Synthesis and chemical reactions of thieno[3,2-c]quinolines from arylamine derivatives, part (V): a review
Ameen A. Abu-Hashema, b, A. B. A. El-Gazzara, Ahmed A. M. Abdelgawadb, c, Moustafa A. Goudad, e
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- aPhotochemistry Department (Heterocyclic Unit), National Research Centre, Dokki, Giza, Egypt
- bChemistry Department, Faculty of Science, Jazan University, Jazan, Saudi Arabia
- cMedicinal and Aromatic Plants Department, Desert Research Center, Cairo, Egypt
- dDepartment of Chemistry, Faculty of Science and Arts, Taibah University, Ulla, Medina, Saudi Arabia
- eDepartment of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt
Scalable Synthesis of Norbornadienes via in situ Cracking of Dicyclopentadiene using Continuous Flow Chemistry
Jessica Orrego-Hernándeza, Helen Hölzela, Maria Quanta, Zhihang Wanga, Kasper Moth-Poulsena
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- aChalmers University of Technology: Chalmers tekniska hogskola, Chemistry, Sweden
Delineating a green, catalyst free synthesis of a popular nutraceutical methylsulfonylmethane (MSM) in continuous flow
Chinmay A. Shuklaa, Bantu Udaykumara, Y. Saisivanarayanaa, Arsh Ismailia, T Haripriyaa, Manish M. Shindeb, Srinivasan Netic, Maheshkumar Uppadaa, Vishnuvardhana Edac, Saikat Senc, Srinivas Orugantia,b,c
View abstract
- a10X Chemical Process Automation Laboratory, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India
- bFlow Chemistry Technology Hub, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India
- cCentre for Process Research and Innovation, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India
Efficient Chemo-Enzymatic Flow Synthesis of High Value Amides and Esters
Francesca Annunziata1, Martina Letizia Contente2, Daniele Betti1, Cecilia Pinna1, Francesco Molinari3, Lucia Tamborini1*, Andrea Pinto3
View abstract
- 1Department of Pharmaceutical Sciences (DISFARM), University of Milan, via Mangiagalli 25, 20133 Milan, Italy
- 2School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK
- 3 Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, Italy
Automation of Synthesis in Medicinal Chemistry: Progress and Challenges
Elizabeth Farrant*
View abstract
- New Path Molecular Research Ltd, Building 580, Babraham Research Campus, Cambridge CB22 3AT, UK.
Streamlined Synthesis of Fluoroquinolones
Gupton, Frank B. (Midlothian, VA, US) Tosso, Perrer N. (Glen Allen, VA, US)
View abstract
- VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, VA, US)
Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry en Route to the Synthesis of Remdesivir
Tiago Vieira1*, Andrew C. Stevens1*, Andrei Chtchemelinine2, Detian Gao1, Pavel Badalov1, Lars Heumann2
View abstract
- 1Gilead Alberta ULC, 1021 Hayter Road, Edmonton, Alberta T6S 1A1, Canada
- 2Gilead Sciences, Inc. 333 Lakeside Drive, Foster City, California 94404, United States
A Continuous Flow Sulfuryl Chloride Based Reaction – Synthesis of a Key Intermediate in a New Route Toward Emtricitabine and Lamivudine
Juliana M. de Souza, Mateo Berton, David R. Snead*, D. Tyler McQuade
View abstract
- Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, 23284-3068, USA.
Automated radial synthesis of organic molecules
Sourav Chatterjee1, Mara Guidi1, 2, Peter H. Seeberger1, 2, Kerry Gilmore1
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- 1Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany
- 2Freie Universität Berlin, Institute of Chemistry and Biochemistry, Berlin, Germany
Preparation of 5-Hydroxymethylfurfural from High Fructose Corn Syrup Using Organic Weak Acid in Situ as Catalyst
Changqu Lin, Hongli Wu, Junyi Wang, Jinsha Huang, Fei Cao*, Wei Zhuang*, Yanyu Lu, Jiao Chen, Honghua Jia, Pingkai Ouyang
View abstract
- College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, P. R. China
Amino Alcohol Acrylonitriles as Activators of the Aryl hydrocarbon Receptor Pathway, An Unexpected MTT Phenotypic Screening Outcome
Jennifer Baker 1, Cecilia C Russel 1, Jayne Gilbert 2, Jennette Sakoff 2, Adam McCluskey 1
View abstract
- 1 The University of Newcastle, Chemistry, University Drive, Callaghan, 2308 Newcastle, AUSTRALIA
- 2 Calvary Mater Hospital, Medical Oncology, Eidith Street, Waratah, 2298 Newcastle, AUSTRALIA
Continuous flow aminolysis under high temperature and pressure
Bryan Li1, Scott Bader1, 2, Steve M. Guinness1, Sally Gut Ruggeri1, Cheryl M. Hayward1, Steve Hoagland1, John Lucas1, 3, Ruizhi Li1, David Limburg1, J. Christopher McWilliams1, Jeffrey Raggo1, John Van Alsten1, 4
View abstract
- 1Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT, 06340, USA
- 2Celgene Corporation, 556 Morris Ave, Summit, NJ, USA
- 3Rhodes Technologies, 498 Washington Street, Coventry, RI, USA
- 4Nitto Denko Avecia Inc, 155 Fortune Blvd., Milford, MA, USA
Continuous Flow Photochemistry for the Preparation of Bioactive Molecules
Mara Di Filippo, Cormac Bracken, Marcus Baumann*
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- School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland
Development of a Continuous Flow Photoisomerization Reaction Converting Isoxazoles into Diverse Oxazole Products
Cormac Bracken, Marcus Baumann*
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- School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland
Continuous-Flow Biocatalytic Process for the Synthesis of the Best Stereoisomers of the Commercial Fragrances Leather Cyclohexanol (4-Isopropylcyclohexanol) and Woody Acetate (4-(Tert-Butyl)Cyclohexyl Acetate)
Francesca Tentori 1,†, Elisabetta Brenna 1,2,*, Michele Crotti 1, Giuseppe Pedrocchi-Fantoni 2, Maria Chiara Ghezzi 1, and Davide Tessaro 1
View abstract
- 1 Dipartimento di Chimica, Materiali ed Ingegneria Chimica “Giulio Natta”, Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy
- 2 Istituto di Scienze e Tecnologie Chimiche – CNR, Via Mancinelli 7, 20131 Milano, Italy
Continuous Flow Synthesis of Methyl Oximino Acetoacetate: Accessing Greener Purification Methods with Inline Liquid-Liquid Extraction and Membrane Separation Technology
René Lebl1, 2, Trevor Murray3, Andrea Adamo3, David Cantillo1, 2, C. Oliver Kappe1, 2
View abstract
- 1Center for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria
- 2Institute of Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria
- 3Zaiput Flow Technologies, 300 2nd Avenue, Waltham, Massachusetts 02451, United States
Cellulose fast pyrolysis for platform chemicals: assessment of potential targets and suitable reactor technology
Anurag Parihar, Sankar Bhattacharya
View abstract
- Department of Chemical Engineering, Monash University, Clayton, VIC, Australia
A new formulation for symbolic regression to identify physico-chemical laws from experimental data
Pascal Neumannab, Liwei Cao bc, Danilo Russob, Vassilios S. Vassiliadisb, Alexei A.Lapkinbc
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- a Aachener Verfahrenstchnik – Process Systems Engineering, RWTH Aachen University, Aachen, Germany
- b Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK
- c Cambridge Centre for Advanced Research and Education in Singapore, CARES Ltd., 1 CREATE Way, CREATE Tower #05-05, 138602 Singapore, Singapore
In situ non-invasive Raman spectroscopic characterisation of succinic acid polymorphism during segmented flow crystallisation
Anuradha R. Pallipuratha, Pierre-Baptiste Flandrina, Lois E. Waymenta, b, c, Chick C. Wilsona, b, Karen Robertsona
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- aDepartment of Chemistry, University of Bath, Claverton Down, BA2 7AY, UK
- bCMAC Future Manufacturing Hub, University of Bath, Claverton Down, Bath BA2 7AY, UK
- c.Diamond Light Source, Harwell Campus, Didcot, Oxfordshire OX11 0DE, UK
Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction
Sonia De Angelis1, 2, Paolo Celestini3, Rosa Purgatorio1, Leonardo Degennaro1, 2, Gabriele Rebuzzini3, Renzo Luisi1, 2, Claudia Carlucci1, 2
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- 1Department of Pharmacy - Drug Sciences, University of Bari "A. Moro" Via E. Orabona 4, Bari, Italy
- 2Flow Chemistry and Microreactor Technology FLAME-Lab, Bari, Italy
- 3COSMA S.p.A, Ciserano Italy
Batch Versus Flow Lithiation‐Substitution of 1,3,4‐Oxadiazoles: Exploitation of Unstable Intermediates Using Flow Chemistry
Jeff Y. F. Wong, John M. Tobin, Filipe Vilela, Graeme Barker
View abstract
- Institute of Chemical Sciences, Heriot-Watt University, Edinburgh EH11 4AS, Scotland, UK
Heumann Indole Flow Chemistry Process
Cynthia Crifar, Fenja Leena Dücker, Sacha Nguyen Thanh, Vanessa Kairouz, William D. Lubell
View abstract
- Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montreal, Quebec H3C 3J7, Canada
Microfluidic process intensification for synthesis and formulation in the pharmaceutical industry
Aliaa I. Shallana,b,*, Craig Priesta,c
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- aFuture Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia
- bFaculty of Pharmacy, Helwan University, Cairo, 11795, Egypt
- cSchool of Engineering, University of South Australia, Mawson Lakes, SA, 5095, Australia
Synthetic Route Design of AZD4635, an A2AR Antagonist
Mairi M. Littleson *†, Andrew D. Campbell †, Adam Clarke †, Mark Dow †, Gareth Ensor †, Matthew C. Evans †, Adam Herring †,Bethany A. Jackson †, Lucinda V. Jackson †, Staffan Karlsson ‡, David J. Klauber †, Danny H. Legg §, Kevin W. Leslie †, Štefan Moravcí̌k ‡, Chris D. Parsons §, Thomas O. Ronson †, Rebecca E. Meadows †
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- † Chemical Development, Pharmaceutical Technology and Development, AstraZeneca, Macclesfield Campus, SK10 2NA, Macclesfield, U.K.
- ‡ Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, SE-431 83 Mölndal, Sweden
- § Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Macclesfield Campus, SK10 2NA, Macclesfield, U.K.
Transaminase‐catalyzed continuous synthesis of biogenic aldehydes
Martina L. Contente a, Francesca Paradisi *a,b
View abstract
- a School of Chemistry, University of Nottingham, University Park, Nottingham, NG7, 2RD, United Kingdom
- b Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern
Flow Hydrodediazoniation of Aromatic Heterocycles
Liesa Röder1, Alexander J. Nicholls2, Ian R. Baxendale2
View abstract
- 1 Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany
- 2 Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK
Experimental Methods in Chemical Engineering: Micro‐Reactors
Arturo Macchi a, Patrick Plouffe a, Gregory S. Patience b, Dominique M. Roberge c
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- a Centre for Catalysis Research and Innovation, Department of Chemical and Biological Engineering, University of Ottawa, Ottawa, ON, K1N 6N5 Canada
- b Department of Chemical Engineering ‐ Ecole Polytechnique de Montreal, QC, H3C 3A7 Canada
- c Chemical Manufacturing Technologies, Lonza AG, CH‐, 3930 Visp, Switzerland
Peroxidation of 2-oxindole and barbituric acid derivatives under batch and continuous flow using an eco-friendly ethyl acetate solvent
Moreshwar B. Chaudhari a, Nirmala Mohanta a, Akanksha M. Pandey a, Madhusoodhanan Vandana b, Krishanpal Karmodiya b, Boopathy Gnanaprakasam*a
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- a Department of Chemistry, Indian Institute of Science Education and Research (IISER) Pune, Dr. Homi Bhabha Road, Pune 411008, India
- b Department of Biology, Indian Institute of Science Education and Research (IISER) Pune, Dr. Homi Bhabha Road, Pune 411008, India
Continuous manufacturing – the Green Chemistry promise?
Luke Rogers and Klavs F. Jensen
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- Department of Chemical Engineering, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139-4307, USA
Reversible chemoselective transetherification of vinylogous esters using Fe-catalyst under additive free conditions
Nenavath Parvathalu, Sandip G. Agalave, Nirmala Mohanta and Boopathy Gnanaprakasam
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- Department of Chemistry, Indian Institute of Science Education and Research, Pune-411008, India
Investigation of a Weak Temperature–Rate Relationship in the Carbamoylation of a Barbituric Acid Pharmaceutical Intermediate
Alexander G. O’Brien *†, Yangmu Chloe Liu *†, Mark J. Hughes ‡, John Jin Lim †, Neil S. Hodnett ‡, Nicholas Falco†
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- † GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States
- ‡ GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom
Overcoming Water Insolubility in Flow: Enantioselective Hydrolysis of Naproxen Ester
David Roura Padrosa1, Valerio De Vitis2, Martina Letizia Contente1*, Francesco Molinari2, Francesca Paradisi1*
View abstract
- 1 School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK
- 2 Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli studi di Milano, Via Mongiagalli 25, 20133 Milan, Italy;
Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry
Andrew R Bogdan, Amanda W Dombrowski
View abstract
- Discovery Chemistry and Technologies, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States
Continuous flow processing as a tool for the generation of terpene-derived monomer libraries
Renan Galavernaa, Lucas P. Fernandesa, Duncan L. Browneb, Julio C. Pastrea
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- a Institute of Chemistry, University of Campinas – UNICAMP, Campinas, Brazil
- b School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK
Deprotection of N-Boc Groups Under Continuous Flow High Temperature Conditions
Bryan Li, Ruizhi Li, Peter Dorff, James Christopher McWilliams, Robert M Guinn, Steven M. Guinness, Lu Han, Ke Wang, Shu Yu
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- Medicinal Science, Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States
Integrating reactive distillation with continuous flow processing
Marcus Baumann
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- School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland
Enabling tools for continuous-flow biphasic liquid–liquid reaction
Nopphon Weeranoppanant a
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- a Department of Chemical Engineering, Faculty of Engineering, Burapha University, 169 Longhard Bangsaen, Saensook, Muang, Thailand
Continuous Flow Chlorination of Alkenyl Iodides Promoted by Copper Tubing
Antoine Niteleta, Vanessa Kairouzb, Hélène Lebelb, André B. Charetteb, Gwilherm Evanoa
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- a Laboratoire de Chimie Organique, Service de Chimie et Physico, Chimie Organiques, Université libre de Bruxelles (ULB), Avenue F. D. Roosevelt 50, CP160/06, 1050 Brussels, Belgium
- b Centre in Green Chemistry and Catalysis, Faculty of Arts and Sciences, Department of Chemistry, Université de Montréal, P.O. Box 6128, Station Downtown, Montréal, Québec, H3C 3J7, Canada
Continuous flow palladium-catalyzed trifluoromethylthiolation of C-H bonds
Alexanne Bouchard 1, Vanessa Kairouz 1, Maxime Manneveau 2, Heng-Ying Xiong 2, Tatiana Besset 2
View abstract
- 1 Department of Chemistry and Continuous Flow Synthesis Laboratory, Université de Montréal, Montréal, Canada
- 2 INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), Normandie Université, Rouen, France
Using Carbon Dioxide as a Building Block in Continuous Flow Synthesis
Hyowon Seo, Long V. Nguyen, Timothy F. Jamison
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- Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts
Chemoselective Synthesis of Amines from Ammonium Hydroxide and Hydroxylamine in Continuous Flow
Clément Audubert, Alexanne Bouchard, Gary Mathieu, Hélène Lebel
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- Department of Chemistry and Centre in Green Chemistry and Catalysis (CGCC), Université de Montréal, P.O. Box 6128, Station Downtown, Montréal, QC H3C 3J7, Canada
Mg-Catalyzed OPPenauer Oxidation—Application to the Flow Synthesis of a Natural Pheromone
Virginie Liautard, Mélodie Birepinte, Camille Bettoli, Mathieu Pucheault
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- Institut des Sciences Moléculaires (ISM), UMR 5255 CNRS—Université de Bordeaux, 351 Cours de la Libération, 33405 Talence CEDEX, France
Dehydration of an Insoluble Urea Byproduct Enables the Condensation of DCC and Malonic Acid in Flow
Alexander G. O’Brien, Eric M. Ricci, Michel Journet
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- GlaxoSmithKline, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States
A Convergent Continuous Multistep Process for the Preparation of C4-Oxime-Substituted Thiazoles
Edouard Godineau *†, Claudio Battilocchio †‡, Matthias Lehmann †, Steven V. Ley †, Ricardo Labes ‡, Letitia Birnoschi ‡, Srinivas Subramanian §, C.S Prasanna § , Amol Gorde §, Mahesh Kalbagh §, Vivek Khade §, Anton Scherrer †, Anthony C. O’Sullivan †
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- † Syngenta Crop Protection, Process Research, Schaffhauserstrasse 101, CH-4332, Switzerland
- ‡ Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, UK
- § Syngenta Research and Technology Centre, Santa Monica Works, Corlim, Goa India, 403110
Additive Free Fe-Catalyzed Conversion of Nitro to Aldehyde under Continuous Flow Module
Sandip G. Agalave, Moreshwar B. Chaudhari, Girish Singh Bisht, Boopathy Gnanaprakasam*
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- Department of Chemistry, Indian Institute of Science Education and Research Pune-411008, India
Catalytic Static Mixers for the Continuous Flow Hydrogenation of a Key Intermediate of Linezolid (Zyvox)
James Gardiner a*, Xuan Nguyen a, Charlotte Genet a, Mike D. Horne b, Christian Hornung a, John Tsanaktsidis a
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- a CSIRO Manufacturing Flagship, Bayview Avenue, Clayton, Australia
- b CSIRO Mineral Resources, Bayview Avenue, Clayton, VIC 3169, Australia
Regioselective Chlorination of Quinoline Derivatives via Fluorine Mediation in a Microfluidic Reactor
Hao Qi, Xin Li, Zhuang Liu, Shan‐Shan Miao, Prof. Zheng Fang, Lin Chen, Zheng Fang, Prof. Kai Guo
View abstract
- College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, China
Continuous flow synthesis of a carbon-based molecular cage macrocycle via a three-fold homocoupling reaction
Melanie Kitchinab, Kristina Konstasa, Christopher J. Sumbyb, Milena L. Czyza, Peter Valenteb, Matthew R. Hill*ab, Anastasios Polyzos*ac, Christian J. Doonan*ab
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- * Corresponding authors
- a CSIRO Manufacturing Flagship, Bayview Avenue, Clayton, Australia
- b Centre for Advanced Nanomaterials and the School of Physical Sciences, The University of Adelaide, Adelaide, Australia
Flow-based biocatalysis: Application to peracetylated arabinofuranosyl-1,5-arabinofuranose synthesis
Teodora Bavaroa, Andrea Pintob, Federica Dall’Oglioc, María J. Hernáizd, Carlo F. Morellie, Paolo Zambellib, Carlo De Michelic, Paola Contic, Lucia Tamborinic, Marco Terrenia
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- a Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy
- b Department of Food Environmental and Nutritional Science (DeFENS), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
- c Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
- d Department of Pharmaceutical and Organic Chemistry, Faculty of Pharmacy, Complutense University of Madrid, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain
- e Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milan, Italy
Reductive aminations using a 3D printed supported metal(0) catalyst system
Charlotte Genet1, Xuan Nguyen1, Bita Bayatsarmadi2, Mike D. Horne2, James Gardiner1, Christian H. Hornung1
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- 1 CSIRO Manufacturing, Clayton, South Australia
- 2 CSIRO Minerals Resources, Clayton, South Australia
Flow Synthesis of Coumalic Acid and its Derivatization
Laura K. Smith and Ian R. Baxendale
View abstract
- Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK.
Self-sustaining closed-loop multienzyme-mediated conversion of amines into alcohols in continuous reactions
Martina L. Contente, Francesca Paradisi
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- School of Chemistry, University of Nottingham, Nottingham, United Kingdom
Dichlorophenylacrylonitriles as AhR Ligands displaying selective breast cancer cytotoxicity in vitro
Jennifer R Baker1, Jayne Gilbert2, Stefan Paula3, Xiao Zhu3, Jennette A Sakoff2, Adam McCluskey1
View abstract
- 1 The University of Newcastle, Chemistry, Newcastle, Australia
- 2 Calvary Mater Hospital, Medical Oncology, Newcastle, Australia
- 3 Purdue University, Chemistry, West Lafayette, United States
Flow Chemistry Approaches Applied to the Synthesis of Saturated Heterocycles
Marcus Baumann, Ian R. Baxendale
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- Department of Chemistry, University of Durham, Durham, UK
An efficient benzoxaborole one‐pot synthesis by SiliaCat DPP‐Pd heterogeneous catalysis using diboronic acid
Kana kunihiro1, Laurence Dumais2, Guillaume Lafitte2, Emeric Varvier2, Loïc Tomas2, Craig Harris2
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- 1 Ecole Nationale Supérieure des Ingenieurs en Arts Chimiques et Technologiques, France
- 2 Nestlé Skin Health, Galderma R&D, France
Total Synthesis of Neomarchantin A: Key Bond Constructions Performed Using Continuous Flow Methods
Émilie Morin, Michaël Raymond, Amaury Dubart, and Shawn K. Collins
View abstract
- Department of Chemistry and Centre for Green Chemistry and Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, Canada H3C 3J7
In situ epoxide generation by dimethyldioxirane oxidation and the use of epichlorohydrin in the flow synthesis of a library of β-amino alcohols
Peter J. Cossar, Jennifer R. Baker, Nicholas Cain, Adam McCluskey
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- Chemistry, The University of Newcastle, University Drive Callaghan, New South Wales 2308, Australia
Photochemical Synthesis of Heterocycles: Merging Flow Processing and Metal-Catalyzed Visible Light Photoredox Transformations
T Glasnov
View abstract
- Institute of Chemistry, University of Graz, Graz, Austria
Flow Chemistry as a Drug Discovery Tool: A Medicinal Chemistry Perspective
Andrew R. Bogdan1, Michael G. Organ2
View abstract
- 1 Discovery Chemistry and Technology, AbbVie Inc., North Chicago, USA
- 2 Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada
Functionalization of Heteroarenes Under Continuous Flow
Joachim Demaerel, Vidmantas Bieliũnas, Wim M. De Borggraeve
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- Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Leuven, Belgium
On-demand synthesis of organozinc halides under continuous flow conditions
Mateo Berton, Lena Huck, Jesús Alcázar
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- Lead Discovery, Janssen Research and Development, Janssen-Cilag, S.A., Toledo, Spain
Iron-Catalyzed Batch/Continuous Flow C-H Functionalization Module for the Synthesis of Anticancer Peroxides
Moreshwar Bhagwan Chaudhari, Suresh Moorthy, Sohan Patil, Girish Singh Bisht, Haneef Mohamed, Sudipta Basu, and Boopathy Gnanaprakasam
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- Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India
Selective N-monomethylation of primary anilines with dimethyl carbonate in continuous flow
Hyowon Seo, Anne-Catherine Bédard, Willie P. Chen, Robert W. Hicklin, Alexander Alabugin, Timothy F. Jamison
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- Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139, USA
A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic
Marcus Baumann, Ian R. Baxendale and Fabien Deplante
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- Department of Chemistry, University of Durham, South Road, Durham, Durham, DH1 3LE, UK
Conjugated polymers via direct arylation polymerization in continuous flow: minimizing the cost and batch-to-batch variations for high-throughput energy conversion
Nemal S. Gobalasingham1, Jon E. Carlé2, Frederik C. Krebs2, Barry C. Thompson1, Eva Bundgaard2, Martin Helgesen*,2
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- 1 Department of Chemistry and Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, California, 90089-1661
- 2 DTU Energy, Technical University of Denmark, Roskilde, DK-4000, Denmark
Recent advances of microfluidics technologies in the field of medicinal chemistry
László Ürge*, Jesus Alcazar†, Lena Huck†, György Dormán‡
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- * DBH Group, Budapest, Hungary
- † Janssen Research and Development, Toledo, Spain
- ‡ Innostudio Inc., Budapest, Hungary
Sustainable flow synthesis of a versatile cyclopentenone building block
Marcus Baumann†, Ian R. Baxendale†, Paolo Filipponi‡, Te Hu†
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- † Department of Chemistry, University of Durham, South Road, DH1 3LE Durham, U.K
- ‡ Novartis Pharma AG, Fabrikstrasse 14, 4002 Basel, Switzerland
Auto-Tandem Catalysis: Pd(II)-Catalysed Dehydrogenation/Oxidative Heck of Cyclopentane-1,3-diones
Claire J C Lamb, Bryan G Nderitu, Gemma McMurdo, John MTobin, Filipe Vilela, and Ai-Lan Lee
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- Institute of Chemical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, United Kingdom
Targeting a mirabegron precursor by BH3-mediated continuous flow reduction process
Sonia De Angelisa, Claudia Carluccia, Modesto de Candiaa, Gabriele Rebuzzinib, Paolo Celestinib, Massimiliano Riscazzib, Renzo Luisia, Leonardo Degennaroa
View abstract
- a FLAME-Lab − Flow Chemistry and Microreactor Technology Laboratory, Department of Pharmacy — Drug Sciences, University of Bari “A. Moro” Via E. Orabona 4, Bari 70125, Italy
- b COSMA S.p.A, Via Colleoni 15/17, Ciserano, BG 24040, Italy
In Situ Preparation and Consumption of O-Mesitylsulfonylhydroxylamine (MSH) in Continuous Flow for the Amination of Pyridines
Cara E. Brocklehurst*, Guido Koch, Stephanie Rothe-Pöllet, Luigi La Vecchia
View abstract
- Synthesis and Technologies, Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Klybeckstrasse 141, 4057 Basel, Switzerland
Highly efficient oxidation of amines to aldehydes with flow-based biocatalysis
Dr. Martina L. Contente1,2, Federica Dall'Oglio3, Dr. Lucia Tamborini3, Prof. Francesco Molinari4, Prof. Francesca Paradisi1,2
View abstract
- 1 School of Chemistry, University of Nottingham, Nottingham, UK
- 2 UCD School of Chemistry, University College Dublin, Dublin, Ireland
- 3 Department of Pharmaceutical Sciences, DISFARM, University of Milan, Milan, Italy
- 4 Department of Food, Environmental and Nutritional Science, DeFENS, University of Milan, Milan, Italy
A novel micro-flow system under microwave irradiation for continuous synthesis of 1, 4-dihydropyridines in the absence of solvents via Hantzsch reaction
Wei Hea,b, Zheng Fangb, Kai Zhangb, Tao Tua, Niuniu Lvb, Chuanhong Qiub, Kai Guob,c
View abstract
- a Department of Chemistry, Fudan University, No. 220 Handan Road, Shanghai, 200433, PR China
- b College of Biotechnology and Pharmaceutical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China
- c State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China
Methanolysis of epoxidized soybean oil in continuous flow conditions
Vincenzo Pantonea, Amelita Grazia Laurensab, Cosimo Annesec, Francesco Fracassib, Caterina Fuscob, Angelo Naccib,c, Antonella Russoa, Lucia D’Accoltib,c
View abstract
- a Greenswitch s.r.l., Ferrandina MT, Italy
- b Dipartimento di Chimica, Università di Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy
- c ICCOM-CNR, SS Bari, Via E. Orabona 4, 70126 Bari, Italy
Continuous preparation and use of dibromoformaldoxime as a reactive intermediate for the synthesis of 3- bromoisoxazolines
Claudio Battilocchioa*, Francesco Bosicaa, Sam M. Rowea, Bruna L. Abreua, Edouard Godineaub*, Matthias Lehmannb, Steven V. Leya
View abstract
- a Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
- b Syngenta Crop Protection AG, Crop Protection Research, Schaffhauserstrasse 101, CH-4332 Stein, Switzerland
Flow assisted synthesis: a key fragment of SR 142948A
Matthew Oliver Kitching, Olivia E Dixon, Marcus Baumann, Ian Richard Baxendale
View abstract
- University of Durham, Chemistry, Durham, UK
A convenient, mild and green synthesis of NH-sulfoximines in flow reactors
Leonardo Degennaro1, Arianna Tota1, Sonia De Angelis1, Michael Andresini1, Cosimo Cardellicchio2, Maria Annunziata Capozzi1, Giuseppe Romanazzi3, Renzo Luisi1
View abstract
- 1 University of Bari, Department of Pharmacy - Drug Sciences, Bari, Italy
- 2 CNR ICCOM, Department of Chemistry, Bari, Italy
- 3 Politecnico di Bari, DICATECh, Bari, Italy
A continuous flow method for the desulfurization of substituted thioimidazoles applied to the synthesis of new etomidate derivatives
Marcus Baumann, Ian R Baxendale
View abstract
- Durham University, Department of Chemistry, Durham, UK
Phase separation macrocyclization in a complex pharmaceutical setting: application toward the synthesis of vaniprevir
Eric Godin, Anne-Catherine Bédard, Michael Raymond, Shawn K. Collins*
View abstract
- Département de Chimie, Centre for Green Chemistry and Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, H3C 3J7 Canada
Co-production of HMF and gluconic acid from sucrose by chemo-enzymatic method
Hongli Wu, Ting Huang, Fei Cao, Qiaogen Zou, Ping Wei, Pingkai Ouyang
View abstract
- College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816 PR China
Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic
Chinmay A. Shukla1,2, Amol A. Kulkarni1,2
View abstract
- 1 Academy of Scientific and Innovative Research (AcSIR), CSIR-National Chemical Laboratory (NCL) Campus, Pune 411008, India
- 2 Chem. Eng. & Proc. Dev. Div., CSIR-National Chemical Laboratory, Dr. Homi Bhaba Road, Pashan, Pune 411008, India
Utilizing on‐and off‐line monitoring tools to follow a kinetic resolution step during flow synthesis
Kathleen A. Farley, Usa Reilly, Dennis P. Anderson, Brian P. Boscoe, Mark W. Bundesmann, David A. Foley, Manjinder S. Lall, Chao Li, Matthew R. Reese, Jiangli Yan
View abstract
- Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT, United States
Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes
Swapna S. Mohapatraa,b, Zoe E. Wilsona, Sujit Royb, Steven V. Leya
View abstract
- a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
- b Organometallics & Catalysis Laboratory, School of Basic Sciences, Indian Institute of Technology, Bhubaneswar 751013, India
Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction
Ananda Herath, Nicholas D. P. Cosford
View abstract
- Cancer Metabolism & Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
A Continuous Flow Synthesis and Derivatization of 1,2,4-Thiadiazoles
Marcus Baumann, Ian R. Baxendale
View abstract
- Department of Chemistry, University of Durham, South Road, DH1 3LE Durham, United Kingdom.
Self-Optimisation and Model-Based Design of Experiments for Developing a C–H Activation Flow Process
Alexander Echtermeyer1,2, Yehia Amar2, Jacek Zakrzewski2, Alexei Lapkin2
View abstract
- 1 Aachener Verfahrenstechnik – Process Systems Engineering, RWTH Aachen University, Aachen, Germany
- 2 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom
Diels–Alder reactions of myrcene using intensified continuous-flow reactors
Christian H. Hornung, Miguel Á. Álvarez-Diéguez, Thomas M. Kohl and John Tsanaktsidis
View abstract
- CSIRO Manufacturing, Bag 10, Clayton South, Victoria 3169, Australia
Halogenation of organic compounds using continuous flow and microreactor technology
David Cantilloab, C. Oliver Kappe*ab
View abstract
- a Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, Graz, Austria
- b Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria
Design and Development of Pd-catalyzed Aerobic N-Demethylation Strategies for the Synthesis of Noroxymorphone in Continuous Flow Mode
Bernhard Gutmanna,b, David Cantilloa,b, Ulrich Weiglc, D Phillip Coxd, C. Oliver Kappea,b
View abstract
- a,b Institute of Chemistry, University of Graz, Nawi Graz, Heinrichstrasse 28, 8010 Graz, Austria and Research Center Pharmaceutical Engineering (RCPE), Inffeldgasse 13, 8010 Graz, Austria
- c Cilag AG, Hochstrasse 201, 8200 Schaffhausen, Switzerland
- d Noramco Inc., 503 Carr Road, Suite 200, Wilmington, DE 19809, USA
A benchtop NMR spectrometer as a tool for monitoring mesoscale continuous-flow organic synthesis: equipment interface and assessment in four organic transformations
Cynthia M. Archambaulta, Nicholas E. Leadbeater*a
View abstract
- * Corresponding author
- a Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, USA
Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform
D. E. Fitzpatricka, S. V. Ley*a
View abstract
- * Corresponding author
- a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
A facile hybrid ‘flow and batch’ access to substituted 3,4-dihydro-2H-benzo[b][1,4]oxazinones
Andrew J. S. Lina, Cecilia C. Russella, Jennifer R. Bakera, Shelby L. Fraileyab, Jennette A. Sakoffc, Adam McCluskey*a
View abstract
- * Corresponding authors
- a Chemistry, Centre for Chemical Biology, School of Environmental & Life Sciences, University of Newcastle, University Drive, Callaghan, Australia
- b Chemical Engineering, Trine University, Angola, 46703 USA
- c Department of Medical Oncology, Calvary Mater Newcastle Hospital, Waratah, Australia
An approach to the synthesis of 4-aryl and 5-aryl substituted thiazole-2(3H)-thiones employing flow processing
Monaem Baltia, Shelli A. Millerb, Mohamed Lotfi Efrita, Nicholas E. Leadbeater*b
View abstract
- * Corresponding authors
- a Université Tunis El Manar, Laboratory of Organic Synthesis and Heterocyclic Chemistry, Faculty of Science of Tunis, Department of Chemistry, 1060 Tunis, Tunisia
- b Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, USA
Exploring flow procedures for diazonium formation
Te Hu, Ian R. Baxendale and Marcus Baumann
View abstract
- Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK
Delivering enhanced efficiency in the synthesis of α-diazosulfoxides by exploiting the process control enabled in flow
Patrick G. McCaw1, Benjamin J. Deadman1, Anita R. Maguire1,2, Stuart G. Collins1
View abstract
- 1 Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork, Ireland
- 2 Department of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork, Ireland
The generation of a library of bromodomain-containing protein modulators expedited by continuous flow synthesis
Paolo Filipponi and Ian R. Baxendale*
View abstract
- * Department of Chemistry, University of Durham South Road, Durham, DH1 3LE, United Kingdom
An efficient etherification of Ginkgol biloba extracts with fewer side effects in a micro-flow system
Yin-Lin Qina, Wei Hea, Mei Sub, Zheng Fangc, Ping-Kai Ouyanga, Kai Guoa,d
View abstract
- a College of Biotechnology and Pharmaceutical Engineering, Nanjing Technology University, Nanjing 210009, China
- b Jiangsu Carephar Pharmaceutical Co., Ltd., Nanjing 210014, China
- c School of Pharmaceutical, Nanjing Technology University, Nanjing 210009, China
- d State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Technology University, Nanjing 211816, China
Continuous-flow synthesis and derivatization of aziridines through palladium-catalyzed C(sp3)−H activation
Jacek Zakrzewski1, Adam P. Smalley2, Dr. Mikhail A. Kabeshov2, Prof. Matthew J. Gaunt2, Prof. Alexei A. Lapkin1
View abstract
- 1 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
- 2 Chemistry Department, University of Cambridge, Cambridge, UK
Difluorocarbene addition to alkenes and alkynes in continuous flow
Pauline Rullière, Patrick Cyr, André B. Charette*
View abstract
- Université de Montréal, Centre in Green Chemistry and Catalysis, Department of Chemistry, Faculty of Arts and Science, P.O. Box 6128, Station Downtown, Québec, Canada H3C 3J7
Biodiesel synthesis using integrated acid and base catalysis in continuous flow
Mousa Asadia, Joel F. Hoopera, David W. Luptona
View abstract
- aSchool of Chemistry, Monash University, Clayton 3800, Victoria, Australia
Continuous-flow synthesis of 2H-azirines and their diastereoselective transformation to aziridines
Marcus Baumann *, Ian R. Baxendale
View abstract
- Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK
Continuous flow magnesiation or zincation of acrylonitriles, acrylates, and nitroolefins. Application to the synthesis of butenolides
Maximilian A. Ganiek, Matthias R. Becker, Marthe Ketels, Paul Knochel *
View abstract
- Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich, Germany
The solid copper-mediated C-N cross-coupling of phenylboronic acids under continuous flow conditions
Jennifer Bao a, Geoffrey K. Tranmer a,b
View abstract
- a College of Pharmacy, Faculty of Health Science, University of Manitoba, Winnipeg, MB R3E 0T5, Canada
- b Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
Integrating multicomponent flow synthesis and computational approaches for the generation of a tetrahydroquinoline compound based library
Bruno Cerra a, Serena Mostarda a, Chiara Custodi a, Antonio Macchiarulo a, Antimo Gioiello *a
View abstract
- a Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, I-06122 Perugia, Italy
Highly efficient and safe procedure for the synthesis of aryl 1,2,3-triazoles from aromatic amine in a continuous flow reactor
Federica Stazi a, Damiano Cancogni a, Lucilla Turco b, Pieter Westerduin a, Sergio Bacchi a
View abstract
- a GlaxoSmithKline Spa, Chemical Development Department, Synthetic Chemistry, Via Fleming 4, 37135 Verona, Italy
- b GlaxoSmithKline Spa, Analytical Chemistry, Via Fleming 4, 37135 Verona, Italy
Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor
Keiji Nakayama,a, Duncan L. Browne,b, Ian R. Baxendale,b,1, Steven V. Ley,*a
View abstract
- a Process Technology Research Laboratories, Pharmaceutical Technology Division, Daiichi Sankyo, Shinomiya, Hiratsuka, Kanagawa, 254-0014, Japan
- b Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
The Changing Face of Organic Synthesis
Ley, Steven V., Baxendale, Ian R.
View abstract
- CHIMIA International Journal for Chemistry, Volume 62, Number 3, March 2008, pp. 162-168(7)
Dynamic flow synthesis of porous organic cages
Michael E. Briggsa, Anna G. Slatera, Neil Lunta, Shan Jianga, Marc A. Littlea, Rebecca L. Greenawaya, Tom Hasella, Claudio Battilocchiob, Steven V. Leyb, Andrew I. Cooper* a
View abstract
- a Department of Chemistry and Centre for Materials Discovery, University of Liverpool, Crown Street, Liverpool, UK
- b Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
An integrated flow and microwave approach to a broad spectrum protein kinase inhibitor
Cecilia Russella, Andrew J. S. Lina, Peter Hainsb, Michela I. Simonea, Phillip J. Robinsonb, Adam McCluskey* a
View abstract
- A Centre for Chemical Biology, Chemistry, School of Environmental and Life Science, The University of Newcastle, University Drive, Callaghan, Australia
- B Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, Australia
Efficient synthesis of panaxadiol derivatives using continuous-flow microreactor and evaluation of anti-tumor activity
Yan Wua,1, Wei-Qi Chenb,1, Yu-Qing Zhaoc, Hu-Ri Piaoa
View abstract
- aKey Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy, China
- bDepartment of Chemistry, Fudan University, Shanghai, China
- cSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
Two-Stage Flow Synthesis of Coumarin via O-Acetylation of Salicylaldehyde
Xin Li1, Anbang Chen1, Yangzhi Zhou1, Lingling Huang2, Zheng Fang2, Haifeng Gan1, Kai Guo1
View abstract
- 1 College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
- 2 School of Pharmaceutical Sciences, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
- 3 State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
A practical deca-gram scale ring expansion of (R)-(−)-carvone to (R)-(+)-3-methyl-6-isopropenyl- cyclohept-3-enone-1
Leandro de C. Alvesa, André L. Desideráa, Kleber T. de Oliveiraa, Sean Newtonb, Steven V. Ley* b, Timothy J. Brocksom* a
View abstract
- a Departamento de Química, Universidade Federal de São Carlos, P.O. Box 676, São Carlos – SP, Brazil
- b Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines
Marcus Baumann 1, Antonio M. Rodriguez Garcia 1 2, Ian R. Baxendale * 1
View abstract
- 1 Department of Chemistry, Durham University, South Road, Durham, UK
- 2 Universidad de Castilla-La Mancha, Departamento de Química Orgánica, Facultad de Ciencias y Tecnologías Químicas, Avd. Camilo José Cela, 10, 13071 Ciudad Real, Spain
Development of a flow method for the hydroboration/oxidation of olefins
José A. Souto* 1 2, Robert A. Stockman3, Steven V. Ley1
View abstract
- 1 Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
- 2 Departamento de Química Orgánica, Universidade de Vigo, Vigo, Spain
- 3 School of Chemistry, University of Nottingham, Nottingham, UK
First Example of a Continuous-Flow Carbonylation Reaction Using Aryl Formates as CO Precursors
Nerea Alonso1,3, Juan de Muñoz1, Brecht Egle2, Johannes L. Vrijdag2, Wim M. De Borggraeve2, Antonio de la Hoz3, Angel Díaz-Ortiz3, Jesús Alcázar1
View abstract
- 1Janssen Research and Development, Janssen-Cilag Department of Medicinal Chemistry S.A., Toledo, Spain
- 2Molecular Design and Synthesis University of Leuven, Department of Chemistry, Heverlee Belgium
- 3Universidad de Castilla-La Mancha Facultad de Ciencias y Tecnologías Químicas Real, Spain
Flow synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe
Matthew B. Plutschack1,2, D. Tyler McQuade1,2, Giulio Valenti2, Peter H. Seeberger2
View abstract
- 1Department of Chemistry and Biochemistry, Florida State University, USA
- 2Max Planck Institute of Colloids and Interfaces, Germany
The Fit For Purpose Development of S1P1 Receptor Agonist GSK2263167 Using a Robinson Annulation and Saegusa Oxidation to Access an Advanced Phenol Intermediate
Robert M. Harris, Benjamin I. Andrews, Stacy Clark, Jason W. B. Cooke, John C. S. Gray, Stephanie Q. Q. Ng
View abstract
- Chemical Development, GlaxoSmithKline Research and Development Ltd., UK
Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions
Trevor A. Hamlin, Nicholas E. Leadbeater
View abstract
- Department of Chemistry, University of Connecticut, USA
Continuous Flow Synthesis of Coumarin
Anbang Chen1, Xin Li1, Yangzhi Zhou1, Lingling Huang2, Zheng Fang2, Haifeng Gan1, Kai Guo1
View abstract
- 1 College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology 2 School of Pharmceutical Sciences, Nanjing University of Technology
Synthesis of All Four Stereoisomers of 3-(tert-Butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid
Bettina Bakonyi†, Markus Furegati*‡, Christian Kramer§, Luigi La Vecchia‡, Flavio Ossola‡
View abstract
- † Doetsch Grether AG, Falkensteinerstrasse 37, 4132 Muttenz, Switzerland
- ‡ Preparations Laboratories, Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Klybeckstrasse 141, 4057 Basel,Switzerland
- § Institute of General, Inorganic and Theoretical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria
Hypervalent iodine/TEMPO-mediated oxidation in flow systems: a fast and efficient protocol for alcohol oxidation
Nida Ambreen, Ravi Kumar, Thomas Wirth
View abstract
- Innovative Technology Centre, Cardiff University, School of Chemistry, Park Place, Cardiff, UK
Continuous-flow generation of diazoesters and their direct use in S-H and P-H insertion reactions: synthesis of a-sulfanyl, a-sulfonyl and a-phosphono carboxylates
Hannah E. Bartrum1, David C. Blakemore2, Christopher J. Moody1, Christopher J. Hayes1
View abstract
- 1School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
- 2Pfizer Neusentis, The Portway Building, Granta Park, Cambridge, CB21 6GS, UK
Continuous Flow Synthesis of Organic Electronic Materials : Case Studies in Methodology Translation and Scale-up
Helga Seyler1, Stefan Haid2, Tae-Hyuk Kwon1, David J. Jones1, Peter Bäuerle2, Andrew B. Holmes1, Wallace W. H. Wong1*
View abstract
- 1Bio21 Institute, University of Melbourne, Australia.
- 2Institute of Organic Chemistry II and Advanced Materials, University of Ulm, Germany.
Sustainable and efficient methodology for CLA synthesis and identification
Andres Moreno, Maria Moreno, Maria Victoria Gómez, Cristina Cebrian, Pilar Prieto, Antonio de la Hoz
View abstract
- Departamento de Química Inorgánica, , Universidad de Castilla-La Mancha, Ciudad Real, Spain.
Continuous Flow Synthesis of Secondary Amides by Tandem Azidation- Amidation of Anilines
Christian Spiteri, John E. Moses*
View abstract
- School of Chemistry, University of Nottingham, UK
Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts
Francesco Venturoni, Antimo Gioiello, Roccaldo Sardella, Benedetto Natalini, Roberto Pellicciari
View abstract
- Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy
Phase-Transfer Catalysis under Continuous Flow Conditions: An Alternative Approach to the Biphasic Liquid/Liquid O-Alkylation of Phenols
Daniele De Zani2, Matteo Colombo1
View abstract
- 1NiKem Research 20021 via Zambeletti 25 Milan Baranzate Italy
- 2Erregierre, San Paolo D'Argon Bergamo Italy
Application of Flow Chemistry to the Selective Reduction of Esters to Aldehydes
Juan de M. Muñoz1, Jesús Alcázar1, Antonio de la Hoz2, Angel Díaz-Ortiz2
View abstract
- 1Janssen, Toledo, Spain
- 2Facultad de Ciencias Químicas, Universidad de Castilla-La Mancha, Spain
Continuous Preparation of Arylmagnesium Reagents in Flow with Inline IR Monitoring
Tobias Brodmann1, Peter Koos1, Albrecht Metzger1, Paul Knochel*2, Steven V. Ley*1
View abstract
- 1Department of Chemistry, University of Cambridge, U.K.
- 2Department of Chemistry, Ludwig Maximilians-Universität München, Germany
New Insights into Cyclobutenone Rearrangements: A Total Synthesis of the Natural ROS-Generating Anti-Cancer Agent Cribrostatin 6
Mubina Mohamed1, Théo P. Gonçalves1, Prof. Richard J. Whitby1, Dr. Helen F. Sneddon2, Prof. David C. Harrowven1
View abstract
- 1 Chemistry, University of Southampton, UK
- 2 GlaxoSmithKline Medicines Research Centre, UK
New Insights into Cyclobutenone Rearrangements: A Total Synthesis of the Natural ROS-Generating Anti-Cancer Agent Cribrostatin (ROS=reactive-oxygen species)
Mubina Mohamed1, Théo P. Gonçalves1, Richard J. Whitby1, Helen F. Sneddon2, David C. Harrowven1
View abstract
- 1Dept of Chemistry, University of Southampton, UK
- 2GSK Medicines Research Centre, Stevenage, UK
A continuous-flow synthesis of annulated and polysubstituted furans from the reaction of ketones and a-haloketones
Mark York
View abstract
- CSIRO Materials Science and Engineering, Australia
- Cooperative Research Centre for Polymers, Notting Hill, Australia
Nitrile Oxide 1,3-Dipolar Cycloaddition by Dehydration of Nitromethane Derivatives Under Continuous Flow Conditions
Malte Brasholz, Simon Saubern*, G. Paul Savage
View abstract
- CSIRO Materials Science and Engineering, Victoria, Australia.
Nitration Chemistry in Continuous Flow using Fuming Nitric Acid in a Commercially Available Flow Reactor
Cara E. Brocklehurst, Hansjoerg Lehmann, Luigi La Vecchia
View abstract
- Global Discovery Chemistry, Novartis, Basel, Switzerland
Highly efficient dehydration of carbohydrates to 5-(chloromethyl)furfural (CMF), 5-(hydroxymethyl)furfural (HMF) and levulinic acid by biphasic continuous flow processing
Malte Brasholz, Karin von Känel, Christian H. Hornung, Simon Saubern, John Tsanaktsidis
View abstract
- CSIRO Materials Science & Engineering, Victoria , Australia
A General, One-Step Synthesis of Substituted Indazoles using a Flow Reactor
Rob C. Wheeler, Emma Baxter, Ian B. Campbell, Simon J. F. Macdonald
View abstract
- GlaxoSmithKline, Stevenage, UK
Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates
Alexander G. O'Brien, François Lévesque, Peter H. Seeberger
View abstract
- Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
Synthesis of 3-Aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole Derivatives: A Comparison between Conventional, Microwave-Assisted and Flow-Based Methodologies
Sabrina Castellano1, Lucia Tamborini2, Monica Viviano1, Andrea Pinto2, Gianluca Sbardella1, Paola Conti2
View abstract
- 1Dipartimento di Scienze Farmaceutiche, Universit degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Italy
- 2Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universit degli Studi di Milano , Italy
A Gram-Scale Batch and Flow Total Synthesis of Perhydrohistrionicotoxin
Dr. Malte Brasholz1, Dr. James M. Macdonald1, Dr. Simon Saubern1, Dr. John H. Ryan1, Prof. Dr. Andrew B. Holmes1,2
View abstract
- 1CSIRO Molecular and Health Technologies, Victoria, Australia
- 2School of Chemistry, Bio 21 Institute, University of Melbourne, Victoria, Australia
KMnO4-Mediated Oxidation as a Continuous Flow Process
Jorg Sedelmeier, Steven V. Ley, Ian R. Baxendale, Marcus Baumann
View abstract
- Innovative Technology Centre, University of Cambridge
Effect of phase transfer chemistry, segmented fluid flow, and sonication on the synthesis of cinnamic esters
Mauro Riccaboni, Elena La Porta, Andrea Martorana, Roberta Attanasio
View abstract
- Department of Medicinal Chemistry, NiKem Research Srl, Milan, Italy
A flow-based synthesis of Imatinib: the API of Gleevec
Mark D. Hopkin, Ian R. Baxendale, Steven V. Ley
View abstract
- Innovative Technology Centre, Department of Chemistry, University of Cambridge
A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT1B> Antagonist
Zizheng Qian, Ian R. Baxendale, Steven V. Ley
View abstract
- Innovative Technology Centre, Department of Chemistry, University of Cambridge
A safe and reliable procedure for the iododeamination of aromatic and heteroaromatic amines in a continuous flow reactor
Laia Malet-Sanz, Julia Madrzak, Rhian S. Holvey, Toby Underwood
View abstract
- Research Chemistry, Pfizer Global Research and Development, Sandwich, UK
Development of fluorination methods using continuous-flow microreactors
Marcus Baumann, Ian R. Baxendale, Laetitia J. Martin, Steven V. Ley
View abstract
- Innovative Technology Centre, Cambridge, UK
A modular flow reactor for performing Curtius rearrangements as a continuous flow process
Marcus Baumann1, Ian R. Baxendale1, Steven V. Ley1, Nikzad Nikbin1, Christopher D. Smith1, Jason P. Tierney2
View abstract
- 1Innovative Technology Centre, Department of Chemistry, University of Cambridge
- 2Neurology Lead Discovery Chemistry, GlaxoSmithKline R and D, Harlow, UK
Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions
Marcus Baumann, Ian R. Baxendale, Steven V. Ley, Nikzad Nikbin, Christopher D. Smith
View abstract
- Innovative Technology Centre, Cambridge, UK
Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles
Marcus Baumann, Ian R. Baxendale, Steven V. Ley, Christoper D. Smith, Geoffrey K. Tranmer
View abstract
- Innovative Technology Center, University of Cambridge
Application Notes regarding General synthesis
Application Note 58 – Visible light singlet oxygen

In this application, the conversion of α-terpinene to ascaridole was used to indirectly detect the formation of singlet oxygen in continuous flow. The production of singlet oxygen in continuous flow was optimised using the two methods, and the heterogeneous photocatalyst stability was investigated. Once optimised, the singlet oxygen was used for the aerobic oxidation of boronic acids to phenols, and to degrade two environmental pollutants: bis-phenol A and cimetidine.
This application note describes:
- Production of singlet oxygen in continuous flow
- The use of the UV-150 photochemical reactor for heterogeneous dispersions
- Use of heterogeneous photocatalysts as slurries and packed beds in continuous flow
- Easy handling of a complex flow stream of solid, liquid and gas
Application Note 57 – Automated library synthesis

Equipping a Vapourtec R-Series with a liquid handler creates a powerful, automated synthesis platform that has been used to carry out reaction screening of nucleophilic aromatic substitution partners, including volatile amines.
This application note describes:
– Automated reaction screening using automated reagent loading and collection
– Safe out-of-hours operation permitted by Flow Commander™
– The use of highly volatile amines and ammonia at 160 °C through the use of high pressures difficult to achieve in batch
Application Note 53 – Sodium Hydride as a Slurry in Continuous Flow

As part of our ongoing series of application notes on pumping slurries of reagents we have turned our attention to sodium hydride, one of the most versatile heterogeneous strong bases.
Read moreApplication Note 52 – Rapid Mixing Reactor for Amide Formation under Biphasic Flow Reaction Conditions

In this application, Dr Claudio Battilocchio of the Ley group, University of Cambridge, has used Vapourtec’s 20 ml Rapid Mixing Reactors to perform an amide synthesis under biphasic flow reaction conditions.
Read moreApplication Note 50 – Rapid Mixing Reactor for Biphasic Reaction Scale-up

In this application note the Vapourtec High Flow pump module and an R-series equipped with a Vapourtec large diameter Reactor for Rapid Mixing has been used to perform a scale-up of biphasic Stevens oxidation. The Reactor for Rapid Mixing enabled yields of greater than 99% to be reached with a 58 second residence time at just 50 °C, achieving a throughput of 4.5 kg/day.
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