General synthesis

A practical flow synthesis of 1,2,3-triazoles

Dawid Drelinkiewicz^a, Richard J. Whitby^a

• ^aSchool of Chemistry, Faculty of Engineering and Physical Sciences, The University of Southampton, Southampton, UK

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Scalable synthesis of favipiravir via conventional and continuous flow chemistry

Thanat Tiyasakulchai^a, Netnapa Charoensetakul^a, Thitiphong Khamkhenshorngphanuch^b, Chawanee Thongpanchanga^a, Onsiri Srikun^c, Yongyuth Yuthavong^a, Nitipol Srimongkolpithak^a

• ^aNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand
• ^bDepartment of General Education, Faculty of Science and Health Technology, Navamindradhiraj University, Bangkok, Thailand
• ^cGovernment Pharmaceutical Organization (GPO), Bangkok, Thailand

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Synthesis of CTA and DNAN using flow chemistry

Ankit Kumar Mittal^a, Gaurav Prakash^a, Pramod Pathak^a, Debabrata Maiti^a

• ^aIndian Institute of Technology Bombay, Department of Chemistry, Mumbai, INDIA

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Microfluidic Asymmetrical Synthesis and Chiral Analysis

Konstantin A.Kochetkov^a, Nataliya A.Bystrova^a, Pavel A.Pavlov^b, Maxim S.Oshchepkov^b, Aleksandr S.Oshchepkov^c

• ^aNesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Moscow 119991, Russia
• ^bMendeleev University of Chemical Technology of Russia, Miusskaya pl. 9, Moscow 125047, Russia
• ^cMax Planck Institute for the Science of Light, Department of Physics, D-91058 Erlangen, Germany

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Synthesis and chemical reactions of thieno[3,2-c]quinolines from arylamine derivatives, part (V): a review

Ameen A. Abu-Hashem^{a, b}, A. B. A. El-Gazzar^a, Ahmed A. M. Abdelgawad^{b, c}, Moustafa A. Gouda^{d, e}

• ^aPhotochemistry Department (Heterocyclic Unit), National Research Centre, Dokki, Giza, Egypt
• ^bChemistry Department, Faculty of Science, Jazan University, Jazan, Saudi Arabia
• ^cMedicinal and Aromatic Plants Department, Desert Research Center, Cairo, Egypt
• ^dDepartment of Chemistry, Faculty of Science and Arts, Taibah University, Ulla, Medina, Saudi Arabia
• ^eDepartment of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt

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Scalable Synthesis of Norbornadienes via in situ Cracking of Dicyclopentadiene using Continuous Flow Chemistry

Jessica Orrego-Hernández^a, Helen Hölzel^a, Maria Quant^a, Zhihang Wang^a, Kasper Moth-Poulsen^a

• ^aChalmers University of Technology: Chalmers tekniska hogskola, Chemistry, Sweden

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Delineating a green, catalyst free synthesis of a popular nutraceutical methylsulfonylmethane (MSM) in continuous flow

Chinmay A. Shukla^a, Bantu Udaykumar^a, Y. Saisivanarayana^a, Arsh Ismaili^a, T Haripriya^a, Manish M. Shinde^b, Srinivasan Neti^c, Maheshkumar Uppada^a, Vishnuvardhana Eda^c, Saikat Sen^c, Srinivas Oruganti^a,b,c

• ^a10X Chemical Process Automation Laboratory, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India
• ^bFlow Chemistry Technology Hub, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India
• ^cCentre for Process Research and Innovation, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India

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Efficient Chemo-Enzymatic Flow Synthesis of High Value Amides and Esters

Francesca Annunziata¹, Martina Letizia Contente², Daniele Betti¹, Cecilia Pinna¹, Francesco Molinari³, Lucia Tamborini^1*, Andrea Pinto³

• ¹Department of Pharmaceutical Sciences (DISFARM), University of Milan, via Mangiagalli 25, 20133 Milan, Italy
• ²School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK
• ³ Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, Italy

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Automation of Synthesis in Medicinal Chemistry: Progress and Challenges

Elizabeth Farrant*

• New Path Molecular Research Ltd, Building 580, Babraham Research Campus, Cambridge CB22 3AT, UK.

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Streamlined Synthesis of Fluoroquinolones

Gupton, Frank B. (Midlothian, VA, US) Tosso, Perrer N. (Glen Allen, VA, US)

• VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, VA, US)

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Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry en Route to the Synthesis of Remdesivir

Tiago Vieira^1*, Andrew C. Stevens^1*, Andrei Chtchemelinine², Detian Gao¹, Pavel Badalov¹, Lars Heumann²

• ¹Gilead Alberta ULC, 1021 Hayter Road, Edmonton, Alberta T6S 1A1, Canada
• ²Gilead Sciences, Inc. 333 Lakeside Drive, Foster City, California 94404, United States

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A Continuous Flow Sulfuryl Chloride Based Reaction – Synthesis of a Key Intermediate in a New Route Toward Emtricitabine and Lamivudine

Juliana M. de Souza, Mateo Berton, David R. Snead*, D. Tyler McQuade

• Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, 23284-3068, USA.

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Automated radial synthesis of organic molecules

Sourav Chatterjee¹, Mara Guidi^{1, 2}, Peter H. Seeberger^{1, 2}, Kerry Gilmore¹

• ¹Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany
• ²Freie Universität Berlin, Institute of Chemistry and Biochemistry, Berlin, Germany

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Preparation of 5-Hydroxymethylfurfural from High Fructose Corn Syrup Using Organic Weak Acid in Situ as Catalyst

Changqu Lin, Hongli Wu, Junyi Wang, Jinsha Huang, Fei Cao*, Wei Zhuang*, Yanyu Lu, Jiao Chen, Honghua Jia, Pingkai Ouyang

• College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, P. R. China

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Amino Alcohol Acrylonitriles as Activators of the Aryl hydrocarbon Receptor Pathway, An Unexpected MTT Phenotypic Screening Outcome

Jennifer Baker ¹, Cecilia C Russel ¹, Jayne Gilbert ², Jennette Sakoff ², Adam McCluskey ¹

• ¹ The University of Newcastle, Chemistry, University Drive, Callaghan, 2308 Newcastle, AUSTRALIA
• ² Calvary Mater Hospital, Medical Oncology, Eidith Street, Waratah, 2298 Newcastle, AUSTRALIA

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Continuous flow aminolysis under high temperature and pressure

Bryan Li¹, Scott Bader^{1, 2}, Steve M. Guinness¹, Sally Gut Ruggeri¹, Cheryl M. Hayward¹, Steve Hoagland¹, John Lucas^{1, 3}, Ruizhi Li¹, David Limburg¹, J. Christopher McWilliams¹, Jeffrey Raggo¹, John Van Alsten^{1, 4}

• ¹Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT, 06340, USA
• ²Celgene Corporation, 556 Morris Ave, Summit, NJ, USA
• ³Rhodes Technologies, 498 Washington Street, Coventry, RI, USA
• ⁴Nitto Denko Avecia Inc, 155 Fortune Blvd., Milford, MA, USA

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Continuous Flow Photochemistry for the Preparation of Bioactive Molecules

Mara Di Filippo, Cormac Bracken, Marcus Baumann*

• School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland

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Development of a Continuous Flow Photoisomerization Reaction Converting Isoxazoles into Diverse Oxazole Products

Cormac Bracken, Marcus Baumann*

• School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland

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Continuous-Flow Biocatalytic Process for the Synthesis of the Best Stereoisomers of the Commercial Fragrances Leather Cyclohexanol (4-Isopropylcyclohexanol) and Woody Acetate (4-(Tert-Butyl)Cyclohexyl Acetate)

Francesca Tentori ^1,†, Elisabetta Brenna ^1,2,*, Michele Crotti ¹, Giuseppe Pedrocchi-Fantoni ², Maria Chiara Ghezzi ¹, and Davide Tessaro ¹

• ¹ Dipartimento di Chimica, Materiali ed Ingegneria Chimica “Giulio Natta”, Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy
• ² Istituto di Scienze e Tecnologie Chimiche – CNR, Via Mancinelli 7, 20131 Milano, Italy

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Continuous Flow Synthesis of Methyl Oximino Acetoacetate: Accessing Greener Purification Methods with Inline Liquid-Liquid Extraction and Membrane Separation Technology

René Lebl^{1, 2}, Trevor Murray³, Andrea Adamo³, David Cantillo^{1, 2}, C. Oliver Kappe^{1, 2}

• ¹Center for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria
• ²Institute of Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria
• ³Zaiput Flow Technologies, 300 2nd Avenue, Waltham, Massachusetts 02451, United States

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Cellulose fast pyrolysis for platform chemicals: assessment of potential targets and suitable reactor technology

Anurag Parihar, Sankar Bhattacharya

• Department of Chemical Engineering, Monash University, Clayton, VIC, Australia

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A new formulation for symbolic regression to identify physico-chemical laws from experimental data

Pascal Neumann^ab, Liwei Cao ^bc, Danilo Russo^b, Vassilios S. Vassiliadis^b, Alexei A.Lapkin^bc

• ^a Aachener Verfahrenstchnik – Process Systems Engineering, RWTH Aachen University, Aachen, Germany
• ^b Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK
• ^c Cambridge Centre for Advanced Research and Education in Singapore, CARES Ltd., 1 CREATE Way, CREATE Tower #05-05, 138602 Singapore, Singapore

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In situ non-invasive Raman spectroscopic characterisation of succinic acid polymorphism during segmented flow crystallisation

Anuradha R. Pallipurath^a, Pierre-Baptiste Flandrin^a, Lois E. Wayment^{a, b, c}, Chick C. Wilson^{a, b}, Karen Robertson^a

• ^aDepartment of Chemistry, University of Bath, Claverton Down, BA2 7AY, UK
• ^bCMAC Future Manufacturing Hub, University of Bath, Claverton Down, Bath BA2 7AY, UK
• ^c.Diamond Light Source, Harwell Campus, Didcot, Oxfordshire OX11 0DE, UK

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Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction

Sonia De Angelis^{1, 2}, Paolo Celestini³, Rosa Purgatorio¹, Leonardo Degennaro^{1, 2}, Gabriele Rebuzzini³, Renzo Luisi^{1, 2}, Claudia Carlucci^{1, 2}

• ¹Department of Pharmacy - Drug Sciences, University of Bari "A. Moro" Via E. Orabona 4, Bari, Italy
• ²Flow Chemistry and Microreactor Technology FLAME-Lab, Bari, Italy
• ³COSMA S.p.A, Ciserano Italy

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Batch Versus Flow Lithiation‐Substitution of 1,3,4‐Oxadiazoles: Exploitation of Unstable Intermediates Using Flow Chemistry

Jeff Y. F. Wong, John M. Tobin, Filipe Vilela, Graeme Barker

• Institute of Chemical Sciences, Heriot-Watt University, Edinburgh EH11 4AS, Scotland, UK

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Heumann Indole Flow Chemistry Process

Cynthia Crifar, Fenja Leena Dücker, Sacha Nguyen Thanh, Vanessa Kairouz, William D. Lubell

• Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montreal, Quebec H3C 3J7, Canada

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Microfluidic process intensification for synthesis and formulation in the pharmaceutical industry

Aliaa I. Shallan^a,b,*, Craig Priest^a,c

• ^aFuture Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia
• ^bFaculty of Pharmacy, Helwan University, Cairo, 11795, Egypt
• ^cSchool of Engineering, University of South Australia, Mawson Lakes, SA, 5095, Australia

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Synthetic Route Design of AZD4635, an A2AR Antagonist

Mairi M. Littleson ^*†, Andrew D. Campbell ^†, Adam Clarke ^†, Mark Dow ^†, Gareth Ensor ^†, Matthew C. Evans ^†, Adam Herring ^†,Bethany A. Jackson ^†, Lucinda V. Jackson ^†, Staffan Karlsson ^‡, David J. Klauber ^†, Danny H. Legg ^§, Kevin W. Leslie ^†, Štefan Moravcí̌k ^‡, Chris D. Parsons ^§, Thomas O. Ronson ^†, Rebecca E. Meadows ^†

• ^† Chemical Development, Pharmaceutical Technology and Development, AstraZeneca, Macclesfield Campus, SK10 2NA, Macclesfield, U.K.
• ^‡ Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, SE-431 83 Mölndal, Sweden
• ^§ Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Macclesfield Campus, SK10 2NA, Macclesfield, U.K.

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Transaminase‐catalyzed continuous synthesis of biogenic aldehydes

Martina L. Contente ^a, Francesca Paradisi ^*a,b

• ^a School of Chemistry, University of Nottingham, University Park, Nottingham, NG7, 2RD, United Kingdom
• ^b Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern

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Flow Hydrodediazoniation of Aromatic Heterocycles

Liesa Röder¹, Alexander J. Nicholls², Ian R. Baxendale²

• ¹ Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany
• ² Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK

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Experimental Methods in Chemical Engineering: Micro‐Reactors

Arturo Macchi ^a, Patrick Plouffe ^a, Gregory S. Patience ^b, Dominique M. Roberge ^c

• ^a Centre for Catalysis Research and Innovation, Department of Chemical and Biological Engineering, University of Ottawa, Ottawa, ON, K1N 6N5 Canada
• ^b Department of Chemical Engineering ‐ Ecole Polytechnique de Montreal, QC, H3C 3A7 Canada
• ^c Chemical Manufacturing Technologies, Lonza AG, CH‐, 3930 Visp, Switzerland

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Peroxidation of 2-oxindole and barbituric acid derivatives under batch and continuous flow using an eco-friendly ethyl acetate solvent

Moreshwar B. Chaudhari ^a, Nirmala Mohanta ^a, Akanksha M. Pandey ^a, Madhusoodhanan Vandana ^b, Krishanpal Karmodiya ^b, Boopathy Gnanaprakasam*^a

• ^a Department of Chemistry, Indian Institute of Science Education and Research (IISER) Pune, Dr. Homi Bhabha Road, Pune 411008, India
• ^b Department of Biology, Indian Institute of Science Education and Research (IISER) Pune, Dr. Homi Bhabha Road, Pune 411008, India

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Continuous manufacturing – the Green Chemistry promise?

Luke Rogers and Klavs F. Jensen

• Department of Chemical Engineering, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139-4307, USA

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Reversible chemoselective transetherification of vinylogous esters using Fe-catalyst under additive free conditions

Nenavath Parvathalu, Sandip G. Agalave, Nirmala Mohanta and Boopathy Gnanaprakasam

• Department of Chemistry, Indian Institute of Science Education and Research, Pune-411008, India

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Investigation of a Weak Temperature–Rate Relationship in the Carbamoylation of a Barbituric Acid Pharmaceutical Intermediate

Alexander G. O’Brien ^*†, Yangmu Chloe Liu ^*†, Mark J. Hughes ^‡, John Jin Lim ^†, Neil S. Hodnett ^‡, Nicholas Falco^†

• ^† GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States
• ^‡ GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom

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Overcoming Water Insolubility in Flow: Enantioselective Hydrolysis of Naproxen Ester

David Roura Padrosa¹, Valerio De Vitis², Martina Letizia Contente^1*, Francesco Molinari², Francesca Paradisi^1*

• ¹ School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK
• ² Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli studi di Milano, Via Mongiagalli 25, 20133 Milan, Italy;

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Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry

Andrew R Bogdan, Amanda W Dombrowski

• Discovery Chemistry and Technologies, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States

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Continuous flow processing as a tool for the generation of terpene-derived monomer libraries

Renan Galaverna^a, Lucas P. Fernandes^a, Duncan L. Browne^b, Julio C. Pastre^a

• ^a Institute of Chemistry, University of Campinas – UNICAMP, Campinas, Brazil
• ^b School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK

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Deprotection of N-Boc Groups Under Continuous Flow High Temperature Conditions

Bryan Li, Ruizhi Li, Peter Dorff, James Christopher McWilliams, Robert M Guinn, Steven M. Guinness, Lu Han, Ke Wang, Shu Yu

• Medicinal Science, Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States

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Integrating reactive distillation with continuous flow processing

Marcus Baumann

• School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland

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Enabling tools for continuous-flow biphasic liquid–liquid reaction

Nopphon Weeranoppanant ^a

• ^a Department of Chemical Engineering, Faculty of Engineering, Burapha University, 169 Longhard Bangsaen, Saensook, Muang, Thailand

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Continuous Flow Chlorination of Alkenyl Iodides Promoted by Copper Tubing

Antoine Nitelet^a, Vanessa Kairouz^b, Hélène Lebel^b, André B. Charette^b, Gwilherm Evano^a

• ^a  Laboratoire de Chimie Organique, Service de Chimie et Physico, Chimie Organiques, Université libre de Bruxelles (ULB), Avenue F. D. Roosevelt 50, CP160/06, 1050 Brussels, Belgium
• ^b  Centre in Green Chemistry and Catalysis, Faculty of Arts and Sciences, Department of Chemistry, Université de Montréal, P.O. Box 6128, Station Downtown, Montréal, Québec, H3C 3J7, Canada

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Continuous flow palladium-catalyzed trifluoromethylthiolation of C-H bonds

Alexanne Bouchard ¹, Vanessa Kairouz ¹, Maxime Manneveau ², Heng-Ying Xiong ², Tatiana Besset ²

• ¹ Department of Chemistry and Continuous Flow Synthesis Laboratory, Université de Montréal, Montréal, Canada
• ² INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), Normandie Université, Rouen, France

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Using Carbon Dioxide as a Building Block in Continuous Flow Synthesis

Hyowon Seo, Long V. Nguyen, Timothy F. Jamison

• Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts

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Chemoselective Synthesis of Amines from Ammonium Hydroxide and Hydroxylamine in Continuous Flow

Clément Audubert, Alexanne Bouchard, Gary Mathieu, Hélène Lebel

• Department of Chemistry and Centre in Green Chemistry and Catalysis (CGCC), Université de Montréal, P.O. Box 6128, Station Downtown, Montréal, QC H3C 3J7, Canada

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Mg-Catalyzed OPPenauer Oxidation—Application to the Flow Synthesis of a Natural Pheromone

Virginie Liautard, Mélodie Birepinte, Camille Bettoli, Mathieu Pucheault

• Institut des Sciences Moléculaires (ISM), UMR 5255 CNRS—Université de Bordeaux, 351 Cours de la Libération, 33405 Talence CEDEX, France

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Dehydration of an Insoluble Urea Byproduct Enables the Condensation of DCC and Malonic Acid in Flow

Alexander G. O’Brien, Eric M. Ricci, Michel Journet

• GlaxoSmithKline, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States

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A Convergent Continuous Multistep Process for the Preparation of C4-Oxime-Substituted Thiazoles

Edouard Godineau ^*†, Claudio Battilocchio ^†‡, Matthias Lehmann ^†, Steven V. Ley ^†, Ricardo Labes ^‡, Letitia Birnoschi ^‡, Srinivas Subramanian ^§, C.S Prasanna ^§ , Amol Gorde ^§, Mahesh Kalbagh ^§, Vivek Khade ^§, Anton Scherrer ^†, Anthony C. O’Sullivan ^†

• ^† Syngenta Crop Protection, Process Research, Schaffhauserstrasse 101, CH-4332, Switzerland
• ^‡ Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, UK
• ^§ Syngenta Research and Technology Centre, Santa Monica Works, Corlim, Goa India, 403110

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Additive Free Fe-Catalyzed Conversion of Nitro to Aldehyde under Continuous Flow Module

Sandip G. Agalave, Moreshwar B. Chaudhari, Girish Singh Bisht, Boopathy Gnanaprakasam*

• Department of Chemistry, Indian Institute of Science Education and Research Pune-411008, India

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Catalytic Static Mixers for the Continuous Flow Hydrogenation of a Key Intermediate of Linezolid (Zyvox)

James Gardiner ^a*, Xuan Nguyen ^a, Charlotte Genet ^a, Mike D. Horne ^b, Christian Hornung ^a, John Tsanaktsidis ^a

• ^a CSIRO Manufacturing Flagship, Bayview Avenue, Clayton, Australia
• ^b CSIRO Mineral Resources, Bayview Avenue, Clayton, VIC 3169, Australia

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Regioselective Chlorination of Quinoline Derivatives via Fluorine Mediation in a Microfluidic Reactor

Hao Qi, Xin Li, Zhuang Liu, Shan‐Shan Miao, Prof. Zheng Fang, Lin Chen, Zheng Fang, Prof. Kai Guo

• College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, China

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Continuous flow synthesis of a carbon-based molecular cage macrocycle via a three-fold homocoupling reaction

Melanie Kitchin^ab, Kristina Konstas^a, Christopher J. Sumby^b, Milena L. Czyz^a, Peter Valente^b, Matthew R. Hill^*ab, Anastasios Polyzos^*ac, Christian J. Doonan^*ab

• ^* Corresponding authors
• ^a CSIRO Manufacturing Flagship, Bayview Avenue, Clayton, Australia
• ^b Centre for Advanced Nanomaterials and the School of Physical Sciences, The University of Adelaide, Adelaide, Australia

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Flow-based biocatalysis: Application to peracetylated arabinofuranosyl-1,5-arabinofuranose synthesis

Teodora Bavaro^a, Andrea Pinto^b, Federica Dall’Oglio^c, María J. Hernáiz^d, Carlo F. Morelli^e, Paolo Zambelli^b, Carlo De Micheli^c, Paola Conti^c, Lucia Tamborini^c, Marco Terreni^a

• ^a Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy
• ^b Department of Food Environmental and Nutritional Science (DeFENS), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
• ^c Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
• ^d Department of Pharmaceutical and Organic Chemistry, Faculty of Pharmacy, Complutense University of Madrid, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain
• ^e Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milan, Italy

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Reductive aminations using a 3D printed supported metal(0) catalyst system

Charlotte Genet¹, Xuan Nguyen¹, Bita Bayatsarmadi², Mike D. Horne², James Gardiner¹, Christian H. Hornung¹

• ¹ CSIRO Manufacturing, Clayton, South Australia
• ² CSIRO Minerals Resources, Clayton, South Australia

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Flow Synthesis of Coumalic Acid and its Derivatization

Laura K. Smith and Ian R. Baxendale

• Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK.

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Self-sustaining closed-loop multienzyme-mediated conversion of amines into alcohols in continuous reactions

Martina L. Contente, Francesca Paradisi

• School of Chemistry, University of Nottingham, Nottingham, United Kingdom

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Dichlorophenylacrylonitriles as AhR Ligands displaying selective breast cancer cytotoxicity in vitro

Jennifer R Baker¹, Jayne Gilbert², Stefan Paula³, Xiao Zhu³, Jennette A Sakoff², Adam McCluskey¹

• ¹ The University of Newcastle, Chemistry, Newcastle, Australia
• ² Calvary Mater Hospital, Medical Oncology, Newcastle, Australia
• ³ Purdue University, Chemistry, West Lafayette, United States

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Flow Chemistry Approaches Applied to the Synthesis of Saturated Heterocycles

Marcus Baumann, Ian R. Baxendale

• Department of Chemistry, University of Durham, Durham, UK

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An efficient benzoxaborole one‐pot synthesis by SiliaCat DPP‐Pd heterogeneous catalysis using diboronic acid

Kana kunihiro¹, Laurence Dumais², Guillaume Lafitte², Emeric Varvier², Loïc Tomas², Craig Harris²

• ¹ Ecole Nationale Supérieure des Ingenieurs en Arts Chimiques et Technologiques, France
• ² Nestlé Skin Health, Galderma R&D, France

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Total Synthesis of Neomarchantin A: Key Bond Constructions Performed Using Continuous Flow Methods

Émilie Morin, Michaël Raymond, Amaury Dubart, and Shawn K. Collins

• Department of Chemistry and Centre for Green Chemistry and Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, Canada H3C 3J7

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In situ epoxide generation by dimethyldioxirane oxidation and the use of epichlorohydrin in the flow synthesis of a library of β-amino alcohols

Peter J. Cossar, Jennifer R. Baker, Nicholas Cain, Adam McCluskey

• Chemistry, The University of Newcastle, University Drive Callaghan, New South Wales 2308, Australia

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Photochemical Synthesis of Heterocycles: Merging Flow Processing and Metal-Catalyzed Visible Light Photoredox Transformations

T Glasnov

• Institute of Chemistry, University of Graz, Graz, Austria

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Flow Chemistry as a Drug Discovery Tool: A Medicinal Chemistry Perspective

Andrew R. Bogdan¹, Michael G. Organ²

• ¹ Discovery Chemistry and Technology, AbbVie Inc., North Chicago, USA
• ² Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada

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Functionalization of Heteroarenes Under Continuous Flow

Joachim Demaerel, Vidmantas Bieliũnas, Wim M. De Borggraeve

• Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Leuven, Belgium

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On-demand synthesis of organozinc halides under continuous flow conditions

Mateo Berton, Lena Huck, Jesús Alcázar

• Lead Discovery, Janssen Research and Development, Janssen-Cilag, S.A., Toledo, Spain

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Iron-Catalyzed Batch/Continuous Flow C-H Functionalization Module for the Synthesis of Anticancer Peroxides

Moreshwar Bhagwan Chaudhari, Suresh Moorthy, Sohan Patil, Girish Singh Bisht, Haneef Mohamed, Sudipta Basu, and Boopathy Gnanaprakasam

• Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India

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Selective N-monomethylation of primary anilines with dimethyl carbonate in continuous flow

Hyowon Seo, Anne-Catherine Bédard, Willie P. Chen, Robert W. Hicklin, Alexander Alabugin, Timothy F. Jamison

• Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139, USA

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A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic

Marcus Baumann, Ian R. Baxendale and Fabien Deplante

• Department of Chemistry, University of Durham, South Road, Durham, Durham, DH1 3LE, UK

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Conjugated polymers via direct arylation polymerization in continuous flow: minimizing the cost and batch-to-batch variations for high-throughput energy conversion

Nemal S. Gobalasingham¹, Jon E. Carlé², Frederik C. Krebs², Barry C. Thompson¹, Eva Bundgaard², Martin Helgesen^*,2

• ¹ Department of Chemistry and Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, California, 90089-1661
• ² DTU Energy, Technical University of Denmark, Roskilde, DK-4000, Denmark

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Recent advances of microfluidics technologies in the field of medicinal chemistry

László Ürge^*, Jesus Alcazar^†, Lena Huck^†, György Dormán^‡

• ^* DBH Group, Budapest, Hungary
• ^† Janssen Research and Development, Toledo, Spain
• ^‡ Innostudio Inc., Budapest, Hungary

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Sustainable flow synthesis of a versatile cyclopentenone building block

Marcus Baumann^†, Ian R. Baxendale^†, Paolo Filipponi^‡, Te Hu^†

• ^† Department of Chemistry, University of Durham, South Road, DH1 3LE Durham, U.K
• ^‡ Novartis Pharma AG, Fabrikstrasse 14, 4002 Basel, Switzerland

View abstract

Auto-Tandem Catalysis: Pd(II)-Catalysed Dehydrogenation/Oxidative Heck of Cyclopentane-1,3-diones

Claire J C Lamb, Bryan G Nderitu, Gemma McMurdo, John MTobin, Filipe Vilela, and Ai-Lan Lee

• Institute of Chemical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, United Kingdom

View abstract

Targeting a mirabegron precursor by BH3-mediated continuous flow reduction process

Sonia De Angelis^a, Claudia Carlucci^a, Modesto de Candia^a, Gabriele Rebuzzini^b, Paolo Celestini^b, Massimiliano Riscazzi^b, Renzo Luisi^a, Leonardo Degennaro^a

• ^a FLAME-Lab − Flow Chemistry and Microreactor Technology Laboratory, Department of Pharmacy — Drug Sciences, University of Bari “A. Moro” Via E. Orabona 4, Bari 70125, Italy
• ^b COSMA S.p.A, Via Colleoni 15/17, Ciserano, BG 24040, Italy

View abstract

In Situ Preparation and Consumption of O-Mesitylsulfonylhydroxylamine (MSH) in Continuous Flow for the Amination of Pyridines

Cara E. Brocklehurst*, Guido Koch, Stephanie Rothe-Pöllet, Luigi La Vecchia

• Synthesis and Technologies, Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Klybeckstrasse 141, 4057 Basel, Switzerland

View abstract

Highly efficient oxidation of amines to aldehydes with flow-based biocatalysis

Dr. Martina L. Contente^1,2, Federica Dall'Oglio³, Dr. Lucia Tamborini³, Prof. Francesco Molinari⁴, Prof. Francesca Paradisi^1,2

• ¹ School of Chemistry, University of Nottingham, Nottingham, UK
• ² UCD School of Chemistry, University College Dublin, Dublin, Ireland
• ³ Department of Pharmaceutical Sciences, DISFARM, University of Milan, Milan, Italy
• ⁴ Department of Food, Environmental and Nutritional Science, DeFENS, University of Milan, Milan, Italy

View abstract

A novel micro-flow system under microwave irradiation for continuous synthesis of 1, 4-dihydropyridines in the absence of solvents via Hantzsch reaction

Wei He^a,b, Zheng Fang^b, Kai Zhang^b, Tao Tu^a, Niuniu Lv^b, Chuanhong Qiu^b, Kai Guo^b,c

• ^a Department of Chemistry, Fudan University, No. 220 Handan Road, Shanghai, 200433, PR China
• ^b College of Biotechnology and Pharmaceutical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China
• ^c State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China

View abstract

Methanolysis of epoxidized soybean oil in continuous flow conditions

Vincenzo Pantone^a, Amelita Grazia Laurensa^b, Cosimo Annese^c, Francesco Fracassi^b, Caterina Fusco^b, Angelo Nacci^b,c, Antonella Russo^a, Lucia D’Accolti^b,c

• ^a Greenswitch s.r.l., Ferrandina MT, Italy
• ^b Dipartimento di Chimica, Università di Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy
• ^c ICCOM-CNR, SS Bari, Via E. Orabona 4, 70126 Bari, Italy

View abstract

Continuous preparation and use of dibromoformaldoxime as a reactive intermediate for the synthesis of 3- bromoisoxazolines

Claudio Battilocchio^a*, Francesco Bosica^a, Sam M. Rowe^a, Bruna L. Abreu^a, Edouard Godineau^b*, Matthias Lehmann^b, Steven V. Ley^a

• ^a Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
• ^b Syngenta Crop Protection AG, Crop Protection Research, Schaffhauserstrasse 101, CH-4332 Stein, Switzerland

View abstract

Flow assisted synthesis: a key fragment of SR 142948A

Matthew Oliver Kitching, Olivia E Dixon, Marcus Baumann, Ian Richard Baxendale

• University of Durham, Chemistry, Durham, UK

View abstract

A convenient, mild and green synthesis of NH-sulfoximines in flow reactors

Leonardo Degennaro¹, Arianna Tota¹, Sonia De Angelis¹, Michael Andresini¹, Cosimo Cardellicchio², Maria Annunziata Capozzi¹, Giuseppe Romanazzi³, Renzo Luisi¹

• ¹ University of Bari, Department of Pharmacy - Drug Sciences, Bari, Italy
• ² CNR ICCOM, Department of Chemistry, Bari, Italy
• ³ Politecnico di Bari, DICATECh, Bari, Italy

View abstract

A continuous flow method for the desulfurization of substituted thioimidazoles applied to the synthesis of new etomidate derivatives

Marcus Baumann, Ian R Baxendale

• Durham University, Department of Chemistry, Durham, UK

View abstract

Phase separation macrocyclization in a complex pharmaceutical setting: application toward the synthesis of vaniprevir

Eric Godin, Anne-Catherine Bédard, Michael Raymond, Shawn K. Collins*

• Département de Chimie, Centre for Green Chemistry and Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, H3C 3J7 Canada

View abstract

Co-production of HMF and gluconic acid from sucrose by chemo-enzymatic method

Hongli Wu, Ting Huang, Fei Cao, Qiaogen Zou, Ping Wei, Pingkai Ouyang

• College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816 PR China

View abstract

Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic

Chinmay A. Shukla^1,2, Amol A. Kulkarni^1,2

• ¹ Academy of Scientific and Innovative Research (AcSIR), CSIR-National Chemical Laboratory (NCL) Campus, Pune 411008, India
• ² Chem. Eng. & Proc. Dev. Div., CSIR-National Chemical Laboratory, Dr. Homi Bhaba Road, Pashan, Pune 411008, India

View abstract

Utilizing on‐and off‐line monitoring tools to follow a kinetic resolution step during flow synthesis

Kathleen A. Farley, Usa Reilly, Dennis P. Anderson, Brian P. Boscoe, Mark W. Bundesmann, David A. Foley, Manjinder S. Lall, Chao Li, Matthew R. Reese, Jiangli Yan

• Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT, United States

View abstract

Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes

Swapna S. Mohapatra^a,b, Zoe E. Wilson^a, Sujit Roy^b, Steven V. Ley^a

• ^a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
• ^b Organometallics & Catalysis Laboratory, School of Basic Sciences, Indian Institute of Technology, Bhubaneswar 751013, India

View abstract

Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction

Ananda Herath, Nicholas D. P. Cosford

• Cancer Metabolism & Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA

View abstract

A Continuous Flow Synthesis and Derivatization of 1,2,4-Thiadiazoles

Marcus Baumann, Ian R. Baxendale

• Department of Chemistry, University of Durham, South Road, DH1 3LE Durham, United Kingdom.

View abstract

Self-Optimisation and Model-Based Design of Experiments for Developing a C–H Activation Flow Process

Alexander Echtermeyer^1,2, Yehia Amar², Jacek Zakrzewski², Alexei Lapkin²

• ¹ Aachener Verfahrenstechnik – Process Systems Engineering, RWTH Aachen University, Aachen, Germany
• ² Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom

View abstract

Diels–Alder reactions of myrcene using intensified continuous-flow reactors

Christian H. Hornung, Miguel Á. Álvarez-Diéguez, Thomas M. Kohl and John Tsanaktsidis

• CSIRO Manufacturing, Bag 10, Clayton South, Victoria 3169, Australia

View abstract

Halogenation of organic compounds using continuous flow and microreactor technology

David Cantillo^ab, C. Oliver Kappe^*ab

• ^a Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, Graz, Austria
• ^b Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria

View abstract

Design and Development of Pd-catalyzed Aerobic N-Demethylation Strategies for the Synthesis of Noroxymorphone in Continuous Flow Mode

Bernhard Gutmann^a,b, David Cantillo^a,b, Ulrich Weigl^c, D Phillip Cox^d, C. Oliver Kappe^a,b

• ^a,b Institute of Chemistry, University of Graz, Nawi Graz, Heinrichstrasse 28, 8010 Graz, Austria and Research Center Pharmaceutical Engineering (RCPE), Inffeldgasse 13, 8010 Graz, Austria
• ^c Cilag AG, Hochstrasse 201, 8200 Schaffhausen, Switzerland
• ^d Noramco Inc., 503 Carr Road, Suite 200, Wilmington, DE 19809, USA

View abstract

A benchtop NMR spectrometer as a tool for monitoring mesoscale continuous-flow organic synthesis: equipment interface and assessment in four organic transformations

Cynthia M. Archambault^a, Nicholas E. Leadbeater^*a

• ^* Corresponding author
• ^a Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, USA

View abstract

Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform

D. E. Fitzpatrick^a, S. V. Ley^*a

• ^* Corresponding author
• ^a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK

View abstract

A facile hybrid ‘flow and batch’ access to substituted 3,4-dihydro-2H-benzo[b][1,4]oxazinones

Andrew J. S. Lin^a, Cecilia C. Russell^a, Jennifer R. Baker^a, Shelby L. Frailey^ab, Jennette A. Sakoff^c, Adam McCluskey^*a

• ^* Corresponding authors
• ^a Chemistry, Centre for Chemical Biology, School of Environmental & Life Sciences, University of Newcastle, University Drive, Callaghan, Australia
• ^b Chemical Engineering, Trine University, Angola, 46703 USA
• ^c Department of Medical Oncology, Calvary Mater Newcastle Hospital, Waratah, Australia

View abstract

An approach to the synthesis of 4-aryl and 5-aryl substituted thiazole-2(3H)-thiones employing flow processing

Monaem Balti^a, Shelli A. Miller^b, Mohamed Lotfi Efrit^a, Nicholas E. Leadbeater^*b

• ^* Corresponding authors
• ^a Université Tunis El Manar, Laboratory of Organic Synthesis and Heterocyclic Chemistry, Faculty of Science of Tunis, Department of Chemistry, 1060 Tunis, Tunisia
• ^b Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, USA

View abstract

Exploring flow procedures for diazonium formation

Te Hu, Ian R. Baxendale and Marcus Baumann

• Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK

View abstract

Delivering enhanced efficiency in the synthesis of α-diazosulfoxides by exploiting the process control enabled in flow

Patrick G. McCaw¹, Benjamin J. Deadman¹, Anita R. Maguire^1,2, Stuart G. Collins¹

• ¹ Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork, Ireland
• ² Department of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork, Ireland

View abstract

The generation of a library of bromodomain-containing protein modulators expedited by continuous flow synthesis

Paolo Filipponi and Ian R. Baxendale^*

• ^* Department of Chemistry, University of Durham South Road, Durham, DH1 3LE, United Kingdom

View abstract

An efficient etherification of Ginkgol biloba extracts with fewer side effects in a micro-flow system

Yin-Lin Qin^a, Wei He^a, Mei Su^b, Zheng Fang^c, Ping-Kai Ouyang^a, Kai Guo^a,d

• ^a College of Biotechnology and Pharmaceutical Engineering, Nanjing Technology University, Nanjing 210009, China
• ^b Jiangsu Carephar Pharmaceutical Co., Ltd., Nanjing 210014, China
• ^c School of Pharmaceutical, Nanjing Technology University, Nanjing 210009, China
• ^d State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Technology University, Nanjing 211816, China

View abstract

Continuous-flow synthesis and derivatization of aziridines through palladium-catalyzed C(sp3)−H activation

Jacek Zakrzewski¹, Adam P. Smalley², Dr. Mikhail A. Kabeshov², Prof. Matthew J. Gaunt², Prof. Alexei A. Lapkin¹

• ¹ Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
• ² Chemistry Department, University of Cambridge, Cambridge, UK

View abstract

Difluorocarbene addition to alkenes and alkynes in continuous flow

Pauline Rullière, Patrick Cyr, André B. Charette*

• Université de Montréal, Centre in Green Chemistry and Catalysis, Department of Chemistry, Faculty of Arts and Science, P.O. Box 6128, Station Downtown, Québec, Canada H3C 3J7

View abstract

Biodiesel synthesis using integrated acid and base catalysis in continuous flow

Mousa Asadi^a, Joel F. Hooper^a, David W. Lupton^a

• ^aSchool of Chemistry, Monash University, Clayton 3800, Victoria, Australia

View abstract

Continuous-flow synthesis of 2H-azirines and their diastereoselective transformation to aziridines

Marcus Baumann ^*, Ian R. Baxendale

• Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK

View abstract

Continuous flow magnesiation or zincation of acrylonitriles, acrylates, and nitroolefins. Application to the synthesis of butenolides

Maximilian A. Ganiek, Matthias R. Becker, Marthe Ketels, Paul Knochel ^*

• Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich, Germany

View abstract

The solid copper-mediated C-N cross-coupling of phenylboronic acids under continuous flow conditions

Jennifer Bao ^a, Geoffrey K. Tranmer ^a,b

• ^a College of Pharmacy, Faculty of Health Science, University of Manitoba, Winnipeg, MB R3E 0T5, Canada
• ^b Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada

View abstract

Integrating multicomponent flow synthesis and computational approaches for the generation of a tetrahydroquinoline compound based library

Bruno Cerra ^a, Serena Mostarda ^a, Chiara Custodi ^a, Antonio Macchiarulo ^a, Antimo Gioiello ^*a

• ^a Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, I-06122 Perugia, Italy

View abstract

Highly efficient and safe procedure for the synthesis of aryl 1,2,3-triazoles from aromatic amine in a continuous flow reactor

Federica Stazi ^a, Damiano Cancogni ^a, Lucilla Turco ^b, Pieter Westerduin ^a, Sergio Bacchi ^a

• ^a GlaxoSmithKline Spa, Chemical Development Department, Synthetic Chemistry, Via Fleming 4, 37135 Verona, Italy
• ^b GlaxoSmithKline Spa, Analytical Chemistry, Via Fleming 4, 37135 Verona, Italy

View abstract

Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor

Keiji Nakayama,^a, Duncan L. Browne,^b, Ian R. Baxendale,^b,1, Steven V. Ley,^*a

• ^a Process Technology Research Laboratories, Pharmaceutical Technology Division, Daiichi Sankyo, Shinomiya, Hiratsuka, Kanagawa, 254-0014, Japan
• ^b Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK

View abstract

The Changing Face of Organic Synthesis

Ley, Steven V., Baxendale, Ian R.

• CHIMIA International Journal for Chemistry, Volume 62, Number 3, March 2008, pp. 162-168(7)

View abstract

Dynamic flow synthesis of porous organic cages

Michael E. Briggs^a, Anna G. Slater^a, Neil Lunt^a, Shan Jiang^a, Marc A. Little^a, Rebecca L. Greenaway^a, Tom Hasell^a, Claudio Battilocchio^b, Steven V. Ley^b, Andrew I. Cooper^{* a}

• ^a Department of Chemistry and Centre for Materials Discovery, University of Liverpool, Crown Street, Liverpool, UK
• ^b Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK

View abstract

An integrated flow and microwave approach to a broad spectrum protein kinase inhibitor

Cecilia Russell^a, Andrew J. S. Lin^a, Peter Hains^b, Michela I. Simone^a, Phillip J. Robinson^b, Adam McCluskey^{* a}

• ^A Centre for Chemical Biology, Chemistry, School of Environmental and Life Science, The University of Newcastle, University Drive, Callaghan, Australia
• ^B Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, Australia

View abstract

Efficient synthesis of panaxadiol derivatives using continuous-flow microreactor and evaluation of anti-tumor activity

Yan Wu^a,1, Wei-Qi Chen^b,1, Yu-Qing Zhao^c, Hu-Ri Piao^a

• ^aKey Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy, China
• ^bDepartment of Chemistry, Fudan University, Shanghai, China
• ^cSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China

View abstract

Two-Stage Flow Synthesis of Coumarin via O-Acetylation of Salicylaldehyde

Xin Li¹, Anbang Chen¹, Yangzhi Zhou¹, Lingling Huang², Zheng Fang², Haifeng Gan¹, Kai Guo¹

• ¹ College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
• ² School of Pharmaceutical Sciences, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
• ³ State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China

View abstract

A practical deca-gram scale ring expansion of (R)-(−)-carvone to (R)-(+)-3-methyl-6-isopropenyl- cyclohept-3-enone-1

Leandro de C. Alves^a, André L. Desiderá^a, Kleber T. de Oliveira^a, Sean Newton^b, Steven V. Ley^{* b}, Timothy J. Brocksom^{* a}

• ^a Departamento de Química, Universidade Federal de São Carlos, P.O. Box 676, São Carlos – SP, Brazil
• ^b Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK

View abstract

Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines

Marcus Baumann ¹, Antonio M. Rodriguez Garcia ^{1 2}, Ian R. Baxendale ^{* 1}

• ¹ Department of Chemistry, Durham University, South Road, Durham, UK
• ² Universidad de Castilla-La Mancha, Departamento de Química Orgánica, Facultad de Ciencias y Tecnologías Químicas, Avd. Camilo José Cela, 10, 13071 Ciudad Real, Spain

View abstract

Development of a flow method for the hydroboration/oxidation of olefins

José A. Souto^{* 1 2}, Robert A. Stockman³, Steven V. Ley¹

• ¹ Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
• ² Departamento de Química Orgánica, Universidade de Vigo, Vigo, Spain
• ³ School of Chemistry, University of Nottingham, Nottingham, UK

View abstract

First Example of a Continuous-Flow Carbonylation Reaction Using Aryl Formates as CO Precursors

Nerea Alonso^1,3, Juan de Muñoz¹, Brecht Egle², Johannes L. Vrijdag², Wim M. De Borggraeve², Antonio de la Hoz³, Angel Díaz-Ortiz³, Jesús Alcázar¹

• ¹Janssen Research and Development, Janssen-Cilag Department of Medicinal Chemistry S.A., Toledo, Spain
• ²Molecular Design and Synthesis University of Leuven, Department of Chemistry, Heverlee Belgium
• ³Universidad de Castilla-La Mancha Facultad de Ciencias y Tecnologías Químicas Real, Spain

View abstract

Flow synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe

Matthew B. Plutschack^1,2, D. Tyler McQuade^1,2, Giulio Valenti², Peter H. Seeberger²

•   ¹Department of Chemistry and Biochemistry, Florida State University, USA
• ²Max Planck Institute of Colloids and Interfaces, Germany

View abstract

The Fit For Purpose Development of S1P1 Receptor Agonist GSK2263167 Using a Robinson Annulation and Saegusa Oxidation to Access an Advanced Phenol Intermediate

Robert M. Harris, Benjamin I. Andrews, Stacy Clark, Jason W. B. Cooke, John C. S. Gray, Stephanie Q. Q. Ng

• Chemical Development, GlaxoSmithKline Research and Development Ltd., UK

View abstract

Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions

Trevor A. Hamlin, Nicholas E. Leadbeater

• Department of Chemistry, University of Connecticut, USA

View abstract

Continuous Flow Synthesis of Coumarin

Anbang Chen¹, Xin Li¹, Yangzhi Zhou¹, Lingling Huang², Zheng Fang², Haifeng Gan¹, Kai Guo¹

• ¹ College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology ² School of Pharmceutical Sciences, Nanjing University of Technology

View abstract

Synthesis of All Four Stereoisomers of 3-(tert-Butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid

Bettina Bakonyi^†, Markus Furegati^*‡, Christian Kramer^§, Luigi La Vecchia^‡, Flavio Ossola^‡

• ^† Doetsch Grether AG, Falkensteinerstrasse 37, 4132 Muttenz, Switzerland
• ^‡ Preparations Laboratories, Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Klybeckstrasse 141, 4057 Basel,Switzerland
• ^§ Institute of General, Inorganic and Theoretical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria

View abstract

Hypervalent iodine/TEMPO-mediated oxidation in flow systems: a fast and efficient protocol for alcohol oxidation

Nida Ambreen, Ravi Kumar, Thomas Wirth

• Innovative Technology Centre, Cardiff University, School of Chemistry, Park Place, Cardiff, UK

View abstract

Continuous-flow generation of diazoesters and their direct use in S-H and P-H insertion reactions: synthesis of a-sulfanyl, a-sulfonyl and a-phosphono carboxylates

Hannah E. Bartrum¹, David C. Blakemore², Christopher J. Moody¹, Christopher J. Hayes¹

• ¹School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
• ²Pfizer Neusentis, The Portway Building, Granta Park, Cambridge, CB21 6GS, UK

View abstract

Continuous Flow Synthesis of Organic Electronic Materials : Case Studies in Methodology Translation and Scale-up

Helga Seyler¹, Stefan Haid², Tae-Hyuk Kwon¹, David J. Jones¹, Peter Bäuerle², Andrew B. Holmes¹, Wallace W. H. Wong^1*

• ¹Bio21 Institute, University of Melbourne, Australia.
• ²Institute of Organic Chemistry II and Advanced Materials, University of Ulm, Germany.

View abstract

Sustainable and efficient methodology for CLA synthesis and identification

Andres Moreno, Maria Moreno, Maria Victoria Gómez, Cristina Cebrian, Pilar Prieto, Antonio de la Hoz

• Departamento de Química Inorgánica, , Universidad de Castilla-La Mancha, Ciudad Real, Spain.

View abstract

Continuous Flow Synthesis of Secondary Amides by Tandem Azidation- Amidation of Anilines

Christian Spiteri, John E. Moses^*

• School of Chemistry, University of Nottingham, UK

View abstract

Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts

Francesco Venturoni, Antimo Gioiello, Roccaldo Sardella, Benedetto Natalini, Roberto Pellicciari

• Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy

View abstract

Phase-Transfer Catalysis under Continuous Flow Conditions: An Alternative Approach to the Biphasic Liquid/Liquid O-Alkylation of Phenols

Daniele De Zani², Matteo Colombo¹

• ¹NiKem Research 20021 via Zambeletti 25 Milan Baranzate Italy
• ²Erregierre, San Paolo D'Argon Bergamo Italy

View abstract

Application of Flow Chemistry to the Selective Reduction of Esters to Aldehydes

Juan de M. Muñoz¹, Jesús Alcázar¹, Antonio de la Hoz², Angel Díaz-Ortiz²

• ¹Janssen, Toledo, Spain
• ²Facultad de Ciencias Químicas, Universidad de Castilla-La Mancha, Spain

View abstract

Continuous Preparation of Arylmagnesium Reagents in Flow with Inline IR Monitoring

Tobias Brodmann¹, Peter Koos¹, Albrecht Metzger¹, Paul Knochel^*2, Steven V. Ley^*1

• ¹Department of Chemistry, University of Cambridge, U.K.
• ²Department of Chemistry, Ludwig Maximilians-Universität München, Germany

View abstract

New Insights into Cyclobutenone Rearrangements: A Total Synthesis of the Natural ROS-Generating Anti-Cancer Agent Cribrostatin 6

Mubina Mohamed¹, Théo P. Gonçalves¹, Prof. Richard J. Whitby¹, Dr. Helen F. Sneddon², Prof. David C. Harrowven¹

• ¹ Chemistry, University of Southampton, UK
• ² GlaxoSmithKline Medicines Research Centre, UK

View abstract

New Insights into Cyclobutenone Rearrangements: A Total Synthesis of the Natural ROS-Generating Anti-Cancer Agent Cribrostatin (ROS=reactive-oxygen species)

Mubina Mohamed¹, Théo P. Gonçalves¹, Richard J. Whitby¹, Helen F. Sneddon², David C. Harrowven¹

• ¹Dept of Chemistry, University of Southampton, UK
• ²GSK Medicines Research Centre, Stevenage, UK

View abstract

A continuous-flow synthesis of annulated and polysubstituted furans from the reaction of ketones and a-haloketones

Mark York

• CSIRO Materials Science and Engineering, Australia
• Cooperative Research Centre for Polymers, Notting Hill, Australia

View abstract

Nitrile Oxide 1,3-Dipolar Cycloaddition by Dehydration of Nitromethane Derivatives Under Continuous Flow Conditions

Malte Brasholz, Simon Saubern^*, G. Paul Savage

• CSIRO Materials Science and Engineering, Victoria, Australia.

View abstract

Nitration Chemistry in Continuous Flow using Fuming Nitric Acid in a Commercially Available Flow Reactor

Cara E. Brocklehurst, Hansjoerg Lehmann, Luigi La Vecchia

• Global Discovery Chemistry, Novartis, Basel, Switzerland

View abstract

Highly efficient dehydration of carbohydrates to 5-(chloromethyl)furfural (CMF), 5-(hydroxymethyl)furfural (HMF) and levulinic acid by biphasic continuous flow processing

Malte Brasholz, Karin von Känel, Christian H. Hornung, Simon Saubern, John Tsanaktsidis

• CSIRO Materials Science & Engineering, Victoria , Australia

View abstract

A General, One-Step Synthesis of Substituted Indazoles using a Flow Reactor

Rob C. Wheeler, Emma Baxter, Ian B. Campbell, Simon J. F. Macdonald

• GlaxoSmithKline, Stevenage, UK

View abstract

Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates

Alexander G. O'Brien, François Lévesque, Peter H. Seeberger

• Max Planck Institute of Colloids and Interfaces, Potsdam, Germany

View abstract

Synthesis of 3-Aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole Derivatives: A Comparison between Conventional, Microwave-Assisted and Flow-Based Methodologies

Sabrina Castellano¹, Lucia Tamborini², Monica Viviano¹, Andrea Pinto², Gianluca Sbardella¹, Paola Conti²

• ¹Dipartimento di Scienze Farmaceutiche, Universit degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Italy
• ²Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universit degli Studi di Milano , Italy

View abstract

A Gram-Scale Batch and Flow Total Synthesis of Perhydrohistrionicotoxin

Dr. Malte Brasholz¹, Dr. James M. Macdonald¹, Dr. Simon Saubern¹, Dr. John H. Ryan¹, Prof. Dr. Andrew B. Holmes^1,2

• ¹CSIRO Molecular and Health Technologies, Victoria, Australia
• ²School of Chemistry, Bio 21 Institute, University of Melbourne, Victoria, Australia

View abstract

KMnO4-Mediated Oxidation as a Continuous Flow Process

Jorg Sedelmeier, Steven V. Ley, Ian R. Baxendale, Marcus Baumann

• Innovative Technology Centre, University of Cambridge

View abstract

Effect of phase transfer chemistry, segmented fluid flow, and sonication on the synthesis of cinnamic esters

Mauro Riccaboni, Elena La Porta, Andrea Martorana, Roberta Attanasio

• Department of Medicinal Chemistry, NiKem Research Srl, Milan, Italy

View abstract

A flow-based synthesis of Imatinib: the API of Gleevec

Mark D. Hopkin, Ian R. Baxendale, Steven V. Ley

• Innovative Technology Centre, Department of Chemistry, University of Cambridge

View abstract

A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT1B> Antagonist

Zizheng Qian, Ian R. Baxendale, Steven V. Ley

• Innovative Technology Centre, Department of Chemistry, University of Cambridge

View abstract

A safe and reliable procedure for the iododeamination of aromatic and heteroaromatic amines in a continuous flow reactor

Laia Malet-Sanz, Julia Madrzak, Rhian S. Holvey, Toby Underwood

• Research Chemistry, Pfizer Global Research and Development, Sandwich, UK

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Development of fluorination methods using continuous-flow microreactors

Marcus Baumann, Ian R. Baxendale, Laetitia J. Martin, Steven V. Ley

• Innovative Technology Centre, Cambridge, UK

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A modular flow reactor for performing Curtius rearrangements as a continuous flow process

Marcus Baumann¹, Ian R. Baxendale¹, Steven V. Ley¹, Nikzad Nikbin¹, Christopher D. Smith¹, Jason P. Tierney²

• ¹Innovative Technology Centre, Department of Chemistry, University of Cambridge
• ²Neurology Lead Discovery Chemistry, GlaxoSmithKline R and D, Harlow, UK

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Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions

Marcus Baumann, Ian R. Baxendale, Steven V. Ley, Nikzad Nikbin, Christopher D. Smith

• Innovative Technology Centre, Cambridge, UK

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Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles

Marcus Baumann, Ian R. Baxendale, Steven V. Ley, Christoper D. Smith, Geoffrey K. Tranmer

• Innovative Technology Center, University of Cambridge

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