Examples of published literature for General synthesis

Conjugated polymers via direct arylation polymerization in continuous flow: minimizing the cost and batch-to-batch variations for high-throughput energy conversion

Nemal S. Gobalasingham1, Jon E. Carlé2, Frederik C. Krebs2, Barry C. Thompson1, Eva Bundgaard2, Martin Helgesen*,2

  • 1 Department of Chemistry and Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, California, 90089-1661
  • 2 DTU Energy, Technical University of Denmark, Roskilde, DK-4000, Denmark
View abstract

Recent advances of microfluidics technologies in the field of medicinal chemistry

László Ürge*, Jesus Alcazar, Lena Huck, György Dormán

  • * DBH Group, Budapest, Hungary
  • Janssen Research and Development, Toledo, Spain
  • Innostudio Inc., Budapest, Hungary
View abstract

Sustainable flow synthesis of a versatile cyclopentenone building block

Marcus Baumann, Ian R. Baxendale, Paolo Filipponi, Te Hu

  • Department of Chemistry, University of Durham, South Road, DH1 3LE Durham, U.K
  • Novartis Pharma AG, Fabrikstrasse 14, 4002 Basel, Switzerland
View abstract

Auto-Tandem Catalysis: Pd(II)-Catalysed Dehydrogenation/Oxidative Heck of Cyclopentane-1,3-diones

Claire J C Lamb, Bryan G Nderitu, Gemma McMurdo, John MTobin, Filipe Vilela, and Ai-Lan Lee

  • Institute of Chemical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, United Kingdom
View abstract

Targeting a mirabegron precursor by BH3-mediated continuous flow reduction process

Sonia De Angelisa, Claudia Carluccia, Modesto de Candiaa, Gabriele Rebuzzinib, Paolo Celestinib, Massimiliano Riscazzib, Renzo Luisia, Leonardo Degennaroa

  • a FLAME-Lab − Flow Chemistry and Microreactor Technology Laboratory, Department of Pharmacy — Drug Sciences, University of Bari “A. Moro” Via E. Orabona 4, Bari 70125, Italy
  • b COSMA S.p.A, Via Colleoni 15/17, Ciserano, BG 24040, Italy
View abstract

In Situ Preparation and Consumption of O-Mesitylsulfonylhydroxylamine (MSH) in Continuous Flow for the Amination of Pyridines

Cara E. Brocklehurst*, Guido Koch, Stephanie Rothe-Pöllet, Luigi La Vecchia

  • Synthesis and Technologies, Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Klybeckstrasse 141, 4057 Basel, Switzerland
View abstract

Highly efficient oxidation of amines to aldehydes with flow-based biocatalysis

Dr. Martina L. Contente1,2, Federica Dall'Oglio3, Dr. Lucia Tamborini3, Prof. Francesco Molinari4, Prof. Francesca Paradisi1,2

  • 1 School of Chemistry, University of Nottingham, Nottingham, UK
  • 2 UCD School of Chemistry, University College Dublin, Dublin, Ireland
  • 3 Department of Pharmaceutical Sciences, DISFARM, University of Milan, Milan, Italy
  • 4 Department of Food, Environmental and Nutritional Science, DeFENS, University of Milan, Milan, Italy
View abstract

A novel micro-flow system under microwave irradiation for continuous synthesis of 1, 4-dihydropyridines in the absence of solvents via Hantzsch reaction

Wei Hea,b, Zheng Fangb, Kai Zhangb, Tao Tua, Niuniu Lvb, Chuanhong Qiub, Kai Guob,c

  • a Department of Chemistry, Fudan University, No. 220 Handan Road, Shanghai, 200433, PR China
  • b College of Biotechnology and Pharmaceutical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China
  • c State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China
View abstract

Methanolysis of epoxidized soybean oil in continuous flow conditions

Vincenzo Pantonea, Amelita Grazia Laurensab, Cosimo Annesec, Francesco Fracassib, Caterina Fuscob, Angelo Naccib,c, Antonella Russoa, Lucia D’Accoltib,c

  • a Greenswitch s.r.l., Ferrandina MT, Italy
  • b Dipartimento di Chimica, Università di Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy
  • c ICCOM-CNR, SS Bari, Via E. Orabona 4, 70126 Bari, Italy
View abstract

Continuous preparation and use of dibromoformaldoxime as a reactive intermediate for the synthesis of 3- bromoisoxazolines

View abstract

Flow assisted synthesis: a key fragment of SR 142948A

Matthew Oliver Kitching, Olivia E Dixon, Marcus Baumann, Ian Richard Baxendale

  • University of Durham, Chemistry, Durham, UK
View abstract

A continuous flow method for the desulfurization of substituted thioimidazoles applied to the synthesis of new etomidate derivatives

Marcus Baumann, Ian R Baxendale

  • Durham University, Department of Chemistry, Durham, UK
View abstract

Phase separation macrocyclization in a complex pharmaceutical setting: application toward the synthesis of vaniprevir

Eric Godin, Anne-Catherine Bédard, Michael Raymond, Shawn K. Collins*

  • Département de Chimie, Centre for Green Chemistry and Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, H3C 3J7 Canada
View abstract

Co-production of HMF and gluconic acid from sucrose by chemo-enzymatic method

Hongli Wu, Ting Huang, Fei Cao, Qiaogen Zou, Ping Wei, Pingkai Ouyang

  • College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816 PR China
View abstract

Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic

Chinmay A. Shukla1,2, Amol A. Kulkarni1,2

  • 1 Academy of Scientific and Innovative Research (AcSIR), CSIR-National Chemical Laboratory (NCL) Campus, Pune 411008, India
  • 2 Chem. Eng. & Proc. Dev. Div., CSIR-National Chemical Laboratory, Dr. Homi Bhaba Road, Pashan, Pune 411008, India
View abstract

Utilizing on‐and off‐line monitoring tools to follow a kinetic resolution step during flow synthesis

Kathleen A. Farley, Usa Reilly, Dennis P. Anderson, Brian P. Boscoe, Mark W. Bundesmann, David A. Foley, Manjinder S. Lall, Chao Li, Matthew R. Reese, Jiangli Yan

  • Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT, United States
View abstract

Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes

Swapna S. Mohapatraa,b, Zoe E. Wilsona, Sujit Royb, Steven V. Leya

  • a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
  • b Organometallics & Catalysis Laboratory, School of Basic Sciences, Indian Institute of Technology, Bhubaneswar 751013, India
View abstract

Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction

Ananda Herath, Nicholas D. P. Cosford

  • Cancer Metabolism & Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
View abstract

A Continuous Flow Synthesis and Derivatization of 1,2,4-Thiadiazoles

Marcus Baumann, Ian R. Baxendale

  • Department of Chemistry, University of Durham, South Road, DH1 3LE Durham, United Kingdom.
View abstract

Self-Optimisation and Model-Based Design of Experiments for Developing a C–H Activation Flow Process

Alexander Echtermeyer1,2, Yehia Amar2, Jacek Zakrzewski2, Alexei Lapkin2

  • 1 Aachener Verfahrenstechnik – Process Systems Engineering, RWTH Aachen University, Aachen, Germany
  • 2 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom
View abstract

Multi-Step Continuous-Flow Synthesis

Joshua Britton*a, Colin L. Raston*a

  • * Corresponding authors
  • a School of Chemical and Physical Sciences, Flinders University, Bedford Park, Australia
View abstract

Diels–Alder reactions of myrcene using intensified continuous-flow reactors

Christian H. Hornung, Miguel Á. Álvarez-Diéguez, Thomas M. Kohl and John Tsanaktsidis

  • CSIRO Manufacturing, Bag 10, Clayton South, Victoria 3169, Australia
View abstract

Halogenation of organic compounds using continuous flow and microreactor technology

David Cantilloab, C. Oliver Kappe*ab

  • a Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, Graz, Austria
  • b Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria
View abstract

Design and Development of Pd-catalyzed Aerobic N-Demethylation Strategies for the Synthesis of Noroxymorphone in Continuous Flow Mode

Bernhard Gutmanna,b, David Cantilloa,b, Ulrich Weiglc, D Phillip Coxd, C. Oliver Kappea,b

  • a,b Institute of Chemistry, University of Graz, Nawi Graz, Heinrichstrasse 28, 8010 Graz, Austria and Research Center Pharmaceutical Engineering (RCPE), Inffeldgasse 13, 8010 Graz, Austria
  • c Cilag AG, Hochstrasse 201, 8200 Schaffhausen, Switzerland
  • d Noramco Inc., 503 Carr Road, Suite 200, Wilmington, DE 19809, USA
View abstract

A benchtop NMR spectrometer as a tool for monitoring mesoscale continuous-flow organic synthesis: equipment interface and assessment in four organic transformations

Cynthia M. Archambaulta, Nicholas E. Leadbeater*a

  • * Corresponding author
  • a Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, USA
View abstract

Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform

D. E. Fitzpatricka, S. V. Ley*a

  • * Corresponding author
  • a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
View abstract

A facile hybrid ‘flow and batch’ access to substituted 3,4-dihydro-2H-benzo[b][1,4]oxazinones

Andrew J. S. Lina, Cecilia C. Russella, Jennifer R. Bakera, Shelby L. Fraileyab, Jennette A. Sakoffc, Adam McCluskey*a

  • * Corresponding authors
  • a Chemistry, Centre for Chemical Biology, School of Environmental & Life Sciences, University of Newcastle, University Drive, Callaghan, Australia
  • b Chemical Engineering, Trine University, Angola, 46703 USA
  • c Department of Medical Oncology, Calvary Mater Newcastle Hospital, Waratah, Australia
View abstract

Continuous processing and efficient in situ reaction monitoring of a hypervalent iodine (III) mediated cyclopropanation using benchtop NMR spectroscopy

Batool Ahmed-Omer, Eric Sliwinski, John Paul Cerroti, Steven V Ley

View abstract

An approach to the synthesis of 4-aryl and 5-aryl substituted thiazole-2(3H)-thiones employing flow processing

Monaem Baltia, Shelli A. Millerb, Mohamed Lotfi Efrita, Nicholas E. Leadbeater*b

  • * Corresponding authors
  • a Université Tunis El Manar, Laboratory of Organic Synthesis and Heterocyclic Chemistry, Faculty of Science of Tunis, Department of Chemistry, 1060 Tunis, Tunisia
  • b Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, USA
View abstract

Exploring flow procedures for diazonium formation

Te Hu, Ian R. Baxendale and Marcus Baumann*

  • * Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK
View abstract

Delivering enhanced efficiency in the synthesis of α-diazosulfoxides by exploiting the process control enabled in flow

Patrick G. McCaw1, Benjamin J. Deadman1, Anita R. Maguire1,2, Stuart G. Collins1

  • 1 Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork, Ireland
  • 2 Department of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork, Ireland
View abstract

The generation of a library of bromodomain-containing protein modulators expedited by continuous flow synthesis

Paolo Filipponi and Ian R. Baxendale*

  • * Department of Chemistry, University of Durham South Road, Durham, DH1 3LE, United Kingdom
View abstract

An efficient etherification of Ginkgol biloba extracts with fewer side effects in a micro-flow system

Yin-Lin Qina, Wei Hea, Mei Sub, Zheng Fangc, Ping-Kai Ouyanga, Kai Guoa,d

  • a College of Biotechnology and Pharmaceutical Engineering, Nanjing Technology University, Nanjing 210009, China
  • b Jiangsu Carephar Pharmaceutical Co., Ltd., Nanjing 210014, China
  • c School of Pharmaceutical, Nanjing Technology University, Nanjing 210009, China
  • d State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Technology University, Nanjing 211816, China
View abstract

Continuous-flow synthesis and derivatization of aziridines through palladium-catalyzed C(sp3)−H activation

Jacek Zakrzewski1, Adam P. Smalley2, Dr. Mikhail A. Kabeshov2, Prof. Matthew J. Gaunt2, Prof. Alexei A. Lapkin1

  • 1 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
  • 2 Chemistry Department, University of Cambridge, Cambridge, UK
View abstract

Difluorocarbene addition to alkenes and alkynes in continuous flow

Pauline Rullière, Patrick Cyr, André B. Charette*

  • Université de Montréal, Centre in Green Chemistry and Catalysis, Department of Chemistry, Faculty of Arts and Science, P.O. Box 6128, Station Downtown, Québec, Canada H3C 3J7
View abstract

Biodiesel synthesis using integrated acid and base catalysis in continuous flow

Mousa Asadi, Joel F. Hooper, David W. Lupton

  • School of Chemistry, Monash University, Clayton 3800, Victoria, Australia
View abstract

Continuous-flow synthesis of 2H-azirines and their diastereoselective transformation to aziridines

Marcus Baumann *, Ian R. Baxendale

  • Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK
View abstract

Continuous flow magnesiation or zincation of acrylonitriles, acrylates, and nitroolefins. Application to the synthesis of butenolides

Maximilian A. Ganiek, Matthias R. Becker, Marthe Ketels, Paul Knochel *

  • Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich, Germany
View abstract

The solid copper-mediated C-N cross-coupling of phenylboronic acids under continuous flow conditions

Jennifer Bao a, Geoffrey K. Tranmer a,b

  • a College of Pharmacy, Faculty of Health Science, University of Manitoba, Winnipeg, MB R3E 0T5, Canada
  • b Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
View abstract

Integrating multicomponent flow synthesis and computational approaches for the generation of a tetrahydroquinoline compound based library

Bruno Cerra a, Serena Mostarda a, Chiara Custodi a, Antonio Macchiarulo a, Antimo Gioiello *a

  • * Corresponding authors
  • a Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, I-06122 Perugia, Italy
View abstract

Highly efficient and safe procedure for the synthesis of aryl 1,2,3-triazoles from aromatic amine in a continuous flow reactor

Federica Stazi a, Damiano Cancogni a, Lucilla Turco b, Pieter Westerduin a, Sergio Bacchi a

  • a GlaxoSmithKline Spa, Chemical Development Department, Synthetic Chemistry, Via Fleming 4, 37135 Verona, Italy
  • b GlaxoSmithKline Spa, Analytical Chemistry, Via Fleming 4, 37135 Verona, Italy
View abstract

Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor

Keiji Nakayama,a, Duncan L. Browne,b, Ian R. Baxendale,b,1, Steven V. Ley,*a

  • a Process Technology Research Laboratories, Pharmaceutical Technology Division, Daiichi Sankyo, Shinomiya, Hiratsuka, Kanagawa, 254-0014, Japan
  • b Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
View abstract

The Changing Face of Organic Synthesis

Ley, Steven V., Baxendale, Ian R.

  • CHIMIA International Journal for Chemistry, Volume 62, Number 3, March 2008, pp. 162-168(7)
View abstract

Efficient synthesis of panaxadiol derivatives using continuous-flow microreactor and evaluation of anti-tumor activity

Yan Wua,1, Wei-Qi Chenb,1, Yu-Qing Zhaoc, Hu-Ri Piaoa

  • aKey Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy, China
  • bDepartment of Chemistry, Fudan University, Shanghai, China
  • cSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
View abstract

Two-Stage Flow Synthesis of Coumarin via O-Acetylation of Salicylaldehyde

Xin Li1, Anbang Chen1, Yangzhi Zhou1, Lingling Huang2, Zheng Fang2, Haifeng Gan1, Kai Guo1

  • 1 College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
  • 2 School of Pharmaceutical Sciences, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
  • 3 State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
View abstract

A practical deca-gram scale ring expansion of (R)-(−)-carvone to (R)-(+)-3-methyl-6-isopropenyl- cyclohept-3-enone-1

Leandro de C. Alvesa, André L. Desideráa, Kleber T. de Oliveiraa, Sean Newtonb, Steven V. Ley* b, Timothy J. Brocksom* a

  • a Departamento de Química, Universidade Federal de São Carlos, P.O. Box 676, São Carlos – SP, Brazil
  • b Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
View abstract

Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines

Marcus Baumann 1, Antonio M. Rodriguez Garcia 1 2, Ian R. Baxendale * 1

  • 1 Department of Chemistry, Durham University, South Road, Durham, UK
  • 2 Universidad de Castilla-La Mancha, Departamento de Química Orgánica, Facultad de Ciencias y Tecnologías Químicas, Avd. Camilo José Cela, 10, 13071 Ciudad Real, Spain
View abstract

Development of a flow method for the hydroboration/oxidation of olefins

José A. Souto* 1 2, Robert A. Stockman3, Steven V. Ley1

  • 1 Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
  • 2 Departamento de Química Orgánica, Universidade de Vigo, Vigo, Spain
  • 3 School of Chemistry, University of Nottingham, Nottingham, UK
View abstract

Flow synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe

Matthew B. Plutschack1,2, D. Tyler McQuade1,2, Giulio Valenti2, Peter H. Seeberger2, 1Department of Chemistry and Biochemistry, Florida State University, USA, 2Max Planck Institute of Colloids and Interfaces, Germany

View abstract

The Fit For Purpose Development of S1P1 Receptor Agonist GSK2263167 Using a Robinson Annulation and Saegusa Oxidation to Access an Advanced Phenol Intermediate

Robert M. Harris, Benjamin I. Andrews, Stacy Clark, Jason W. B. Cooke, John C. S. Gray, Stephanie Q. Q. Ng

  • Chemical Development, GlaxoSmithKline Research and Development Ltd., UK
View abstract

Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions

Trevor A. Hamlin, Nicholas E. Leadbeater

  • Department of Chemistry, University of Connecticut, USA
View abstract

Synthesis of All Four Stereoisomers of 3-(tert-Butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid

Bettina Bakonyi, Markus Furegati*‡, Christian Kramer§, Luigi La Vecchia, Flavio Ossola

  • Doetsch Grether AG, Falkensteinerstrasse 37, 4132 Muttenz, Switzerland
  • Preparations Laboratories, Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Klybeckstrasse 141, 4057 Basel,Switzerland
  • § Institute of General, Inorganic and Theoretical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria
View abstract

Hypervalent iodine/TEMPO-mediated oxidation in flow systems: a fast and efficient protocol for alcohol oxidation

Nida Ambreen, Ravi Kumar, Thomas Wirth

  • Innovative Technology Centre, Cardiff University, School of Chemistry, Park Place, Cardiff, UK
View abstract

Continuous-flow generation of diazoesters and their direct use in S-H and P-H insertion reactions: synthesis of a-sulfanyl, a-sulfonyl and a-phosphono carboxylates

Hannah E. Bartrum1, David C. Blakemore2, Christopher J. Moody1, Christopher J. Hayes1

  • 1School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
  • 2Pfizer Neusentis, The Portway Building, Granta Park, Cambridge, CB21 6GS, UK
View abstract

Continuous Flow Synthesis of Organic Electronic Materials : Case Studies in Methodology Translation and Scale-up

Helga Seyler1, Stefan Haid2, Tae-Hyuk Kwon1, David J. Jones1, Peter Bäuerle2, Andrew B. Holmes1, Wallace W. H. Wong1*

  • 1Bio21 Institute, University of Melbourne, Australia.
  • 2Institute of Organic Chemistry II and Advanced Materials, University of Ulm, Germany.
View abstract

Sustainable and efficient methodology for CLA synthesis and identification

Andres Moreno, Maria Moreno, Maria Victoria Gómez, Cristina Cebrian, Pilar Prieto, Antonio de la Hoz

  • Departamento de Química Inorgánica, , Universidad de Castilla-La Mancha, Ciudad Real, Spain.
View abstract

Continuous Flow Synthesis of Secondary Amides by Tandem Azidation- Amidation of Anilines

Christian Spiteri, John E. Moses*

  • School of Chemistry, University of Nottingham, UK
View abstract

Phase-Transfer Catalysis under Continuous Flow Conditions: An Alternative Approach to the Biphasic Liquid/Liquid O-Alkylation of Phenols

Daniele De Zani2, Matteo Colombo1

  • 1NiKem Research 20021 via Zambeletti 25 Milan Baranzate Italy
  • 2Erregierre, San Paolo D'Argon Bergamo Italy
View abstract

New Insights into Cyclobutenone Rearrangements: A Total Synthesis of the Natural ROS-Generating Anti-Cancer Agent Cribrostatin 6†

Mubina Mohamed1, Théo P. Gonçalves1, Prof. Richard J. Whitby1, Dr. Helen F. Sneddon2, Prof. David C. Harrowven1

  • 1 Chemistry, University of Southampton, UK
  • 2 GlaxoSmithKline Medicines Research Centre, UK
View abstract

New Insights into Cyclobutenone Rearrangements: A Total Synthesis of the Natural ROS-Generating Anti-Cancer Agent Cribrostatin (ROS=reactive-oxygen species)

Mubina Mohamed1, Théo P. Gonçalves1, Richard J. Whitby1, Helen F. Sneddon2, David C. Harrowven1

  • 1Dept of Chemistry, University of Southampton, UK
  • 2GSK Medicines Research Centre, Stevenage, UK
View abstract

A continuous-flow synthesis of annulated and polysubstituted furans from the reaction of ketones and a-haloketones

Mark York

  • CSIRO Materials Science and Engineering, Australia
  • Cooperative Research Centre for Polymers, Notting Hill, Australia
View abstract

Nitrile Oxide 1,3-Dipolar Cycloaddition by Dehydration of Nitromethane Derivatives Under Continuous Flow Conditions

Malte Brasholz, Simon Saubern*, G. Paul Savage

  • CSIRO Materials Science and Engineering, Victoria, Australia.
View abstract

Nitration Chemistry in Continuous Flow using Fuming Nitric Acid in a Commercially Available Flow Reactor

Cara E. Brocklehurst, Hansjoerg Lehmann, Luigi La Vecchia

  • Global Discovery Chemistry, Novartis, Basel, Switzerland
View abstract

Highly efficient dehydration of carbohydrates to 5-(chloromethyl)furfural (CMF), 5-(hydroxymethyl)furfural (HMF) and levulinic acid by biphasic continuous flow processing

Malte Brasholz, Karin von Känel, Christian H. Hornung, Simon Saubern, John Tsanaktsidis

  • CSIRO Materials Science & Engineering, Victoria , Australia
View abstract

A General, One-Step Synthesis of Substituted Indazoles using a Flow Reactor

Rob C. Wheeler, Emma Baxter, Ian B. Campbell, Simon J. F. Macdonald

  • GlaxoSmithKline, Stevenage, UK
View abstract

Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates

Alexander G. O'Brien, François Lévesque, Peter H. Seeberger

  • Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
View abstract

Synthesis of 3-Aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole Derivatives: A Comparison between Conventional, Microwave-Assisted and Flow-Based Methodologies

Sabrina Castellano1, Lucia Tamborini2, Monica Viviano1, Andrea Pinto2, Gianluca Sbardella1, Paola Conti2

  • 1Dipartimento di Scienze Farmaceutiche, Universit degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Italy
  • 2Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universit degli Studi di Milano , Italy
View abstract

A Gram-Scale Batch and Flow Total Synthesis of Perhydrohistrionicotoxin

Dr. Malte Brasholz1, Dr. James M. Macdonald1, Dr. Simon Saubern1, Dr. John H. Ryan1, Prof. Dr. Andrew B. Holmes1,2

  • 1CSIRO Molecular and Health Technologies, Victoria, Australia
  • 2School of Chemistry, Bio 21 Institute, University of Melbourne, Victoria, Australia
View abstract

KMnO4-Mediated Oxidation as a Continuous Flow Process

Jorg Sedelmeier, Steven V. Ley, Ian R. Baxendale, Marcus Baumann

  • Innovative Technology Centre, University of Cambridge
View abstract

Effect of phase transfer chemistry, segmented fluid flow, and sonication on the synthesis of cinnamic esters

Mauro Riccaboni, Elena La Porta, Andrea Martorana, Roberta Attanasio

  • Department of Medicinal Chemistry, NiKem Research Srl, Milan, Italy
View abstract

A flow-based synthesis of Imatinib: the API of Gleevec

Mark D. Hopkin, Ian R. Baxendale, Steven V. Ley

  • Innovative Technology Centre, Department of Chemistry, University of Cambridge
View abstract

A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT1B> Antagonist

Zizheng Qian, Ian R. Baxendale, Steven V. Ley

  • Innovative Technology Centre, Department of Chemistry, University of Cambridge
View abstract

A safe and reliable procedure for the iododeamination of aromatic and heteroaromatic amines in a continuous flow reactor

Laia Malet-Sanz, Julia Madrzak, Rhian S. Holvey, Toby Underwood

  • Research Chemistry, Pfizer Global Research and Development, Sandwich, UK
View abstract

Development of fluorination methods using continuous-flow microreactors

Marcus Baumann, Ian R. Baxendale, Laetitia J. Martin, Steven V. Ley

  • Innovative Technology Centre, Cambridge, UK
View abstract

A Microcapillary Flow Disc Reactor for Organic Synthesis

Christian H. Hornung1, Malcolm R. Mackley2, Ian R. Baxendale1, Steven V. Ley1

  • 1Department of Chemistry, University of Cambridge
  • 2Department of Chemical Engineering, University of Cambridge
View abstract

Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles

Marcus Baumann, Ian R. Baxendale, Steven V. Ley, Christoper D. Smith, Geoffrey K. Tranmer

  • Innovative Technology Center, University of Cambridge
View abstract

Application Notes regarding General synthesis

Application Note 53 – Sodium Hydride as a Slurry in Continuous Flow

Sodium-hydride-Reaction

As part of our ongoing series of application notes on pumping slurries of reagents we have turned our attention to sodium hydride, one of the most versatile heterogeneous strong bases.

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Application Note 52 – Rapid Mixing Reactor for Amide Formation under Biphasic Flow Reaction Conditions

Biphasic-Schotten-Baummann-conditions

In this application, Dr Claudio Battilocchio of the Ley group, University of Cambridge, has used Vapourtec’s 20 ml Rapid Mixing Reactors to perform an amide synthesis under biphasic flow reaction conditions.

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Application Note 50 – Rapid Mixing Reactor for Biphasic Reaction Scale-up

BleachOxReaction.jpg

In this application note the Vapourtec High Flow pump module and an R-series equipped with a Vapourtec large diameter Reactor for Rapid Mixing has been used to perform a scale-up of biphasic Stevens oxidation. The Reactor for Rapid Mixing enabled yields of greater than 99% to be reached with a 58 second residence time at just 50 °C, achieving a throughput of 4.5 kg/day.

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Application Note 45 – Selective oxidation using 50% aqueous hydrogen peroxide

Application-note-45-oxidation-using-hydrogen-peroxide

This new application note demonstrates the oxidation of thioanisole using hydrogen peroxide in continuous flow. It highlights the use of 50 wt% aqueous hydrogen peroxide which can be pumped neat with Vapourtec systems. Both cooled and heated conditions are explored for this exothermic reaction.  The reaction temperature was controlled using a Vapourtec cooling module for the sub-ambient conditions.  To explore the highest possible throughput, mildly heated conditions were also explored.

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