Sustainable flow synthesis of a versatile cyclopentenone building block

• Marcus Baumann^†
• Ian R. Baxendale^†
• Paolo Filipponi^‡
• Te Hu^†

• ^† Department of Chemistry, University of Durham, South Road, DH1 3LE Durham, U.K
• ^‡ Novartis Pharma AG, Fabrikstrasse 14, 4002 Basel, Switzerland

A flow based multistep processing sequence to reliably provide the delivery of a highly functional cyclopentenone is described. The exemplification of employing solid dosing of reagents and in-line aqueous extraction has enabled an integrated workflow in a highly automated reactor setup.

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