With over a decade of working in the flow chemistry industry, Vapourtec has accumulated a wealth of experience. To enable our customers to access this, we are launching an 8-part series of videos that show a broad range of reactions being performed using our products in our own laboratory. Each video in the series aims to provide a reference of the operational procedures and system configurations that can be used to achieve efficient, reproducible and safe chemistry using our products.
Suzuki coupling using a packed-bed catalyst
Vapourtec R-Series has been used to achieve rapid reaction times and high conversion of a Suzuki coupling, using a commercially available supported palladium catalyst. With a reaction time of just 1 min 15 seconds, it was possible to achieve yields of over 80%, at greater than 95% purity following a simple chromatographic separation.
Selective hydrogenation using a slurry of Pd/C and hydrogen gas
At Vapourtec we have made use of our patented V-3 peristaltic pumps, and new pressure regulation mode to perform a continuous flow hydrogenation with a heterogeneous catalyst pumping as a slurry.
Vapourtec Flow Chemistry Nano-particle synthesis
In this video, Ryan demonstrates the synthesis of nanoparticles of a spin-crossover coordination polymer using a procedure developed by the group of Prof. Chick Wilson at the University of Bath.
Vapourtec Nucleophilic Aromatic Substitution at High Temperature
In this video, Ryan uses the Vapourtec high temperature reactor to carry out a nucleophilic aromatic substitution.
Vapourtec Flow Chemistry Biphasic Reactions – Stevens Oxidation
In this video, Ryan performs the biphasic oxidation of an aldehyde using methanol and sodium hypochlorite in the Vapourtec reactor for rapid mixing.