With over a decade of working in the flow chemistry industry, Vapourtec has accumulated a wealth of experience. To enable our customers to access this, we are launching an 8-part series of videos that show a broad range of reactions being performed using our products in our own laboratory. Each video in the series aims to provide a reference of the operational procedures and system configurations that can be used to achieve efficient, reproducible and safe chemistry using our products.
Suzuki coupling using a packed-bed catalyst
Vapourtec R-Series has been used to achieve rapid reaction times and high conversion of a Suzuki coupling, using a commercially available supported palladium catalyst. With a reaction time of just 1 min 15 seconds, it was possible to achieve yields of over 80%, at greater than 95% purity following a simple chromatographic separation.
Selective hydrogenation using a slurry of Pd/C and hydrogen gas
At Vapourtec we have made use of our patented V-3 peristaltic pumps, and new pressure regulation mode to perform a continuous flow hydrogenation with a heterogeneous catalyst pumping as a slurry.