Peptide Synthesizer overview

    • Peptide-Pilot - continuous-flow-solid-phase-peptide-synthesizer
    • Vapourtec solid-phase-peptide-system
    • Vapourtec_peptide_sythesizer_peptide-scaleup_reactor
    • Peptide-Builder automated peptide synthesizer
    • Vapourtec_peptide_sythesizer_peptide
    • Vapourtec_peptide_sythesizer_peptide-scaleup_system
    • Vapourtec_peptide_scaleup_reagent_delivery
    • Peptide synthesizer user interface software peptide sequence generator
    • Peptide_sequence_progress
    • Peptide synthesizer user interface software live Fmoc AUC analysis

    Peptide synthesizer product family

    Vapourtec offer a range of world class peptide synthesizer systems offering fast flow solid phase peptide synthesis from 0.05 mmol to 30 mmol

    • Provides the clear benefits of single pass continuous flow peptide synthesis
    • Higher quality crude peptides than other peptide synthesizer
    • A process that is well suited to synthesis of long peptides, 70-mer and beyond
    • Continuous in-line analytics including resin solvation data and UV absorption data
    • Fast cycle times even with large scale synthesis
    • Lower consumption of reagents and wash solvents compared with other peptide synthesizer
    • Reaction protocols developed at lab scale are transferred up to 30 mmol scale without redevelopment
    • All the above benefits are enabled by Vapourtec’s patented reactor (VBFR) technology
    • The reassurance of a peptide synthesizer based on a flow chemistry system chosen by all major pharma companies and mentioned in 1003 peer reviewed publications

    The Peptide-Builder is designed for peptide chemists who want to make high quality peptides quickly and easily at laboratory scale. Peptides are synthesized sequentially fully automated either one at a time or queued up to 16, for example overnight.

     

     

     

     

     

    • Product under development, launch scheduled for Q3 2024
    • Synthesis scale 0.05 mmol to 0.20 mmol
    • Uses Vapourtec’s patented reactor technology for continuous flow single pass SPPS
    • Fmoc solid phase peptide chemistry with DIC and oxyma activation
    • Fully automated up to 16 peptides
    • Fast cycle times
    • Continuous in-line analytics including resin solvation data and UV absorption data
    • Automated addition of side chain(s) as required

    Vapourtec Peptide-ExplorerLT

    The Peptide-ExplorerLT is a fast-flow peptide synthesiser designed for peptide chemists who want a flexible yet compact synthesiser for making and optimising linear peptides at scale between 0.05 mmol and 1 mmol.

     

     

     

     

    • Compact footprint
    • Low price point
    • Synthesis scale 0.05 – 1.00 mmol
    • Ideal for research
    • State of the art peptide synthesis software including sequence generator and real-time presentation of in-line analytic data
    • Uses Vapourtec’s patented reactor technology for continuous flow single pass SPPS
    • Fmoc solid phase peptide chemistry with DIC and oxyma activation
    • Minimises solvent and reagent use compared with competing products
    • Continuous in-line analytics including resin solvation data and UV absorption data
    • Fast cycle times even at larger scale

     


    Vapourtec solid-phase-peptide-system

    The Peptide-Explorer is designed for scientists who need to explore and optimise peptide chemistry and ultimately scale-up. The product is a high spec flow chemistry system adapted for continuous flow peptide synthesis and has comprehensive flexibility and analytical capability with proven reliability over 15 years of operation.

     

     

    • Synthesis scale 0.05 – 1.00 mmol
    • Ideal for research
    • State of the art peptide synthesis software including sequence generator with automated addition of side chain(s)
    • Uses Vapourtec’s patented reactor technology for continuous flow single pass SPPS
    • Fmoc solid phase peptide chemistry with DIC and oxyma activation
    • Minimises solvent and reagent use compared with competing products
    • Continuous in-line analytics including resin solvation data and UV absorption data
    • Fast cycle times even at larger scale
    • This is a highly flexible product capable of peptide synthesis and continuous flow organic small molecule synthesis including photochemistry and electrochemistry

    Vapourtec_peptide_sythesizer_peptide-scaleup_system

    The Peptide-Scaleup is designed for the peptide chemist aiming to scaleup their peptides where synthesis time is critical. The Peptide-Scaleup is an advanced alternative to traditional room temperature batch scaleup peptide synthesizers. Typically a 30-mer peptide can be synthesized at 4 mmol scale in just 16 hours.

     

     

    • Synthesis scale 0.5 mmol to 5.0 mmol
    • Highest quality crude peptides at large scale, minimises demands on purification
    • Heated reactors (VBFR) ensures fast cycle times even at largest scale
    • State of the art peptide synthesis software including sequence generator with automated addition of side chain(s)
    • Uses Vapourtec’s patented reactor technology (VBFR) for continuous flow single pass SPPS
    • Fmoc solid phase peptide chemistry with DIC and oxyma activation
    • Minimises solvent and reagent usage compared with competing products
    • Continuous in-line analytics including resin solvation data and UV absorption data
    • A synthesis optimised on the Peptide-Explorer can be transferred to the PS-30 pilot scale peptide synthesizer without further development

    Peptide-Pilot - continuous-flow-solid-phase-peptide-synthesizer

    The PS-30 pilot scale peptide synthesizer is a unique peptide synthesizer designed to reduce the drug development cycle time by reducing the time required to produce significant quantities of a target peptide.  Synthesis times are reduced from weeks to less than a day when compared with the normal room temperature batch methods.  Crude purity is excellent even when non-natural amino acids are required.

     

     

     

    • Product available to order now
    • Synthesis scale 2.0 mmol to 30.0 mmol
    • Highest quality crude peptides at large scale
    • Heated reactors (VBFR) ensures fast cycle times even at largest scale
    • Typical reaction time for a 30-mer peptide at 30 mmol scale is 15 hours
    • Uses Vapourtec’s patented reactor technology (VBFR) for continuous flow single pass SPPS
    • State of the art peptide synthesis software including sequence generator with automated addition of side chain(s) and real time analysis of synthesis quality
    • Fmoc solid phase peptide chemistry with DIC and oxyma activation
    • Minimises solvent and reagent usage.  Solvent usage typically less than 140 ml per mmol / cycle even when using PEG resins
    • Continuous in-line analytics including resin solvation data and UV absorption data
    • A synthesis optimised on the Peptide-Explorer can be transferred to the PS-30 pilot scale peptide synthesizer without further development

    Vapourtec_peptide_scaleup_reagent_delivery

    Real-time monitoring of solid-phase peptide synthesis using a variable bed flow reactor†

    Eric T. Sletten  a, Manuel Nuño  b, Duncan Guthrie b and Peter H. Seeberger  *ac
    aDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany.

     

     

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