Peptide Synthesizer overview
Peptide synthesizer product family
Vapourtec offer a range of world class fast flow solid phase peptide synthesizer systems from 0.05 mmol to 20 mmol
- Provides the clear benefits of single pass continuous flow peptide synthesis
- Higher quality crude peptides than other technologies
- A process that is well suited to synthesis of long peptides, 70-mer and beyond
- Continuous in-line analytics including resin solvation data and UV absorption data
- Fast cycle times even with large scale synthesis
- Lower consumption of reagents and wash solvents compared with other technologies
- Reaction protocols developed at lab scale are transferred up to 20 mmol scale without redevelopment
- All the above benefits are enabled by Vapourtec’s patented reactor (VBFR) technology
- The reassurance of a peptide synthesizer based on a flow chemistry system chosen by all major pharma companies and mentioned in 1003 peer reviewed publications
Peptide-Builder
More on the Peptide-Builder
The Peptide-Builder is designed for peptide chemists who want to make high quality peptides quickly and easily at laboratory scale. Peptides are synthesized sequentially fully automated either one at a time or queued up to 16, for example overnight.
- Product under development, launch scheduled for Q3 2024
- Synthesis scale 0.05 mmol to 0.20 mmol
- Uses Vapourtec’s patented reactor technology for continuous flow single pass SPPS
- Fmoc solid phase peptide chemistry with DIC and oxyma activation
- Fully automated up to 16 peptides
- Fast cycle times
- Continuous in-line analytics including resin solvation data and UV absorption data
- Automated addition of side chain(s) as required
Peptide-Explorer
More on the Peptide-Explorer
The Peptide-Explorer is designed for scientists who need to explore and optimise peptide chemistry and ultimately scale-up. The product is a high spec flow chemistry system adapted for continuous flow peptide synthesis and has comprehensive flexibility and analytical capability with proven reliability over 15 years of operation.
- Synthesis scale 0.05 – 1.00 mmol
- Ideal for research
- State of the art peptide synthesis software including sequence generator with automated addition of side chain(s)
- Uses Vapourtec’s patented reactor technology for continuous flow single pass SPPS
- Fmoc solid phase peptide chemistry with DIC and oxyma activation
- Minimises solvent and reagent use compared with competing products
- Continuous in-line analytics including resin solvation data and UV absorption data
- Fast cycle times even at larger scale
- This is a highly flexible product capable of peptide synthesis and continuous flow organic small molecule synthesis including photochemistry and electrochemistry
Peptide-Scaleup
More on the Peptide-Scaleup
The Peptide-Scaleup is designed for the peptide chemist aiming to scaleup their peptides where synthesis time is critical. The Peptide-Scaleup is an advanced alternative to traditional room temperature batch scaleup peptide synthesizers. Typically a 30-mer peptide can be synthesized at 4 mmol scale in just 14 hours.
- Synthesis scale 0.5 mmol to 5.0 mmol
- Highest quality crude peptides at large scale, minimises demands on purification
- Heated reactors (VBFR) ensures fast cycle times even at largest scale
- State of the art peptide synthesis software including sequence generator with automated addition of side chain(s)
- Uses Vapourtec’s patented reactor technology (VBFR) for continuous flow single pass SPPS
- Fmoc solid phase peptide chemistry with DIC and oxyma activation
- Minimises solvent and reagent usage compared with competing products
- Continuous in-line analytics including resin solvation data and UV absorption data
- A synthesis optimised on the Peptide-Explorer can be transferred to the Peptide-Pilot without further development
Peptide-Pilot
More on the Peptide-Pilot
The Peptide-Pilot is a unique peptide synthesizer designed to reduce the drug development cycle time by reducing the time required to produce significant quantities of a target peptide. Synthesis times are reduced from weeks to less than a day when compared with the normal room temperature batch methods. Crude purity is excellent even when non-natural amino acids are required.
- Product under development, launch date Q4, 2023
- Synthesis scale 2.0 mmol to 30.0 mmol
- Highest quality crude peptides at large scale
- Heated reactors (VBFR) ensures fast cycle times even at largest scale
- Typical reaction time for a 30-mer peptide at 20 mmol scale is 20 hours
- Uses Vapourtec’s patented reactor technology (VBFR) for continuous flow single pass SPPS
- State of the art peptide synthesis software including sequence generator with automated addition of side chain(s) and real time analysis of synthesis quality
- Fmoc solid phase peptide chemistry with DIC and oxyma activation
- Minimises solvent and reagent usage. Solvent usage typically less than 180 ml per mmol / cycle even when using PEG resins
- Continuous in-line analytics including resin solvation data and UV absorption data
- A synthesis optimised on the Peptide-Explorer can be transferred to the Peptide-Pilot without further development
Peptide synthesis publications
See publication
Real-time monitoring of solid-phase peptide synthesis using a variable bed flow reactor†
Eric T. Sletten a, Manuel Nuño b, Duncan Guthrie b and Peter H. Seeberger *ac
aDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany.