Publications citing Vapourtec

    To date, the Vapourtec R-Series and E-Series systems have featured in 219 or more peer reviewed publications.

    Use the filter tools to see the sort of things that are possible, but note that most published papers will require a journal subscription.

    Vapourtec Flow Chemistry Publications August 2016

    A laboratory-scale continuous flow chlorine generator for organic synthesis

    Franz J. Straussa, David Cantillo*ab, Javier Guerrac, C. Oliver Kappe*ab

    • * Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, Graz, Austria
    • a Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria
    • b Crystal Pharma, Gadea Pharmaceutical Group, A Division of AMRI, Parque Tecnológico de Boecillo, Valladolid, Spain
    View abstract

    Continuous processing and efficient in situ reaction monitoring of a hypervalent iodine (III) mediated cyclopropanation using benchtop NMR spectroscopy

    Batool Ahmed-Omer, Eric Sliwinski, John Paul Cerroti, Steven V Ley

    View abstract

    Aryl amination using ligand-free Ni(II) salts and photoredox catalysis

    Emily B. Corcoran1, Michael T. Pirnot2, Shishi Lin3, Spencer D. Dreher3, Daniel A. DiRocco3, Ian W. Davies3, Stephen L. Buchwald2,*, David W. C. MacMillan1,*

    • 1 Merck Center for Catalysis at Princeton University, Princeton, NJ 08544, USA
    • 2 Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    • 3 Department of Process Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
    View abstract

    Catalytic Chan–Lam coupling using a ‘tube-in-tube’ reactor to deliver molecular oxygen as an oxidant

    Carl J. Mallia1, Paul M. Burton2, Alexander M. R. Smith2, Gary C. Walter2, Ian R. Baxendale1

    • 1 Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, United Kingdom
    • 2 Syngenta CP R&D Chemistry, Jealott’s Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, United Kingdom
    View abstract

    An approach to the synthesis of 4-aryl and 5-aryl substituted thiazole-2(3H)-thiones employing flow processing

    Monaem Baltia, Shelli A. Millerb, Mohamed Lotfi Efrita, Nicholas E. Leadbeater*b

    • * Corresponding authors
    • a Université Tunis El Manar, Laboratory of Organic Synthesis and Heterocyclic Chemistry, Faculty of Science of Tunis, Department of Chemistry, 1060 Tunis, Tunisia
    • b Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, USA
    View abstract

    Flow carbonylation of sterically hindered ortho-subsituted iodoarenes

    Carl J. Mallia1, Gary C. Walter2, Ian R. Baxendale1

    • 1 Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, United Kingdom
    • 2 Syngenta CP R&D Chemistry, Jealott’s Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, United Kingdom
    View abstract

    Exploring flow procedures for diazonium formation

    Te Hu, Ian R. Baxendale and Marcus Baumann*

    • * Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK
    View abstract

    Catalytic macrocyclization strategies using continuous flow: formal total synthesis of ivorenolide A

    Mylène de Léséleuc, Eric Godin, Shawn Parisien-Collette, Alexandre Levesque, and Shawn K. Collins*

    • * University of Montréal, Department of Chemistry, Montréal, Canada
    View abstract

    Delivering enhanced efficiency in the synthesis of α-diazosulfoxides by exploiting the process control enabled in flow

    Patrick G. McCaw1, Benjamin J. Deadman1, Anita R. Maguire1,2, Stuart G. Collins1

    • 1 Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork, Ireland
    • 2 Department of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork, Ireland
    View abstract

    The generation of a library of bromodomain-containing protein modulators expedited by continuous flow synthesis

    Paolo Filipponi and Ian R. Baxendale*

    • * Department of Chemistry, University of Durham South Road, Durham, DH1 3LE, United Kingdom
    View abstract

    An efficient etherification of Ginkgol biloba extracts with fewer side effects in a micro-flow system

    Yin-Lin Qina, Wei Hea, Mei Sub, Zheng Fangc, Ping-Kai Ouyanga, Kai Guoa,d

    • a College of Biotechnology and Pharmaceutical Engineering, Nanjing Technology University, Nanjing 210009, China
    • b Jiangsu Carephar Pharmaceutical Co., Ltd., Nanjing 210014, China
    • c School of Pharmaceutical, Nanjing Technology University, Nanjing 210009, China
    • d State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Technology University, Nanjing 211816, China
    View abstract

    Continuous-flow synthesis and derivatization of aziridines through palladium-catalyzed C(sp3)−H activation

    Jacek Zakrzewski1, Adam P. Smalley2, Dr. Mikhail A. Kabeshov2, Prof. Matthew J. Gaunt2, Prof. Alexei A. Lapkin1

    • 1 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
    • 2 Chemistry Department, University of Cambridge, Cambridge, UK
    View abstract

    Metal-free borylation of electron-rich aryl(pseudo)halides under continuous-flow photolytic conditions

    Kai Chena, Man Sing Cheungb, Zhenyang Lin*b, Pengfei Li*a

    • a Center for Organic Chemistry, Frontier Institute of Science and Technology (FIST) and Frontier Institute of Chemistry, Xi'an Jiaotong University, 99 Yanxiang Road, Xi'an, China
    • b Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, China
    View abstract

    Difluorocarbene addition to alkenes and alkynes in continuous flow

    Pauline Rullière, Patrick Cyr, André B. Charette*

    • Université de Montréal, Centre in Green Chemistry and Catalysis, Department of Chemistry, Faculty of Arts and Science, P.O. Box 6128, Station Downtown, Québec, Canada H3C 3J7
    View abstract

    A simple setup for transfer hydrogenations in flow chemistry

    Matthew Hutchings, Thomas Wirth*

    • School of Chemistry, Cardiff University, Cardiff CF10 3AT, UK
    View abstract

    A scalable and operationally simple radical trifluoromethylation

    Joel W. Beatty1, James J. Douglas1,2, Kevin P. Cole2, Corey R. J. Stephenson1

    • 1 Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    • 2 Small Molecule Design and Development, Lilly Research Laboratoires, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    View abstract

    Photoactive and metal-free polyamide-based polymers for water and wastewater treatment under visible light irradiation

    Junjie Shena, Roman Steinbacha, John Tobina, Mayumi Mouro Nakataa, Matthew Bowerb, Martin McCoustraa, Helen Bridlea, Valeria Arrighia, Filipe Vilelaa

    • a School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, United Kingdom
    • b Drinking Water Quality Regulator for Scotland, Edinburgh, EH6 6WW, United Kingdom
    View abstract

    Biodiesel synthesis using integrated acid and base catalysis in continuous flow

    Mousa Asadi, Joel F. Hooper, David W. Lupton

    • School of Chemistry, Monash University, Clayton 3800, Victoria, Australia
    View abstract

    Fine chemical syntheses under flow using SiliaCat catalysts

    Rosaria Ciriminna a, Valerica Pandarus b, François Béland *b, Mario Pagliaro *a

    • * Corresponding authors a Istituto per lo Studio dei Materiali Nanostrutturati, CNR, via U. La Malfa 153, 90146 Palermo, Italy
    • b SiliCycle, 2500, Parc-Technologique Blvd, Québec, G1P 4S6 Canada
    View abstract

    Continuous-flow synthesis of 2H-azirines and their diastereoselective transformation to aziridines

    Marcus Baumann *, Ian R. Baxendale

    • Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK
    View abstract

    Continuous flow magnesiation or zincation of acrylonitriles, acrylates, and nitroolefins. Application to the synthesis of butenolides

    Maximilian A. Ganiek, Matthias R. Becker, Marthe Ketels, Paul Knochel *

    • Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich, Germany
    View abstract

    Continuous flow photo-initiated RAFT polymerisation using a tubular photochemical reactor

    James Gardiner a, Christian H. Hornung a, John Tsanaktsidis a, Duncan Guthrie b

    • a CSIRO Manufacturing, Bag 10, Clayton South, Victoria 3169, Australia
    • b Vapourtec Ltd, Park Farm Business Centre, Bury St Edmunds IP28 6TS, United Kingdom
    View abstract

    Continuous-flow photochemistry: a need for chemical engineering

    Karine Loubière a,b, Michael Oelgemöller c, Tristan Aillet a,b, Odile Dechy-Cabaret a,d, Laurent Prat a,b

    • a CNRS, Laboratoire de Génie Chimique (LGC UMR 5503), 4 allée Emile Monso, BP 84234, 31432 Toulouse, France
    • b Université de Toulouse, INPT, ENSIACET, F-31432 Toulouse, France
    • c James Cook University, College of Science, Technology and Engineering, Townsville, Queensland 4811, Australia
    • d CNRS, Laboratoire de Chimie de Coordination (LCC UPR 8241), 205 route de Narbonne, BP 44099, F-31077 Toulouse, France
    View abstract

    Efficient metal-free photochemical borylation of aryl halides under batch and continuous-flow conditions†

    Kai Chen, Shuai Zhang, Pei He, Pengfei Li *

    • Center for Organic Chemistry, Frontier Institute of Science and Technology (FIST), Xi'an Jiaotong University, 99 Yanxiang Road, Xi'an, Shaanxi 710054, China
    View abstract

    Continuous flow photochemistry as an enabling synthetic technology: synthesis of substituted-6(5H)-phenanthridinones for use as poly(ADP-ribose) polymerase inhibitors

    Y. Fang a, G. K. Tranmer *a,b

    • * Corresponding authors a College of Pharmacy, Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
    • b Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, Canada
    View abstract

    Controlled generation and use of CO in flow†‡

    Steffen V. F. Hansen a,b, Zoe E. Wilson a, Trond Ulven *b, Steven V. Ley *a

    • a Department of Chemistry, University of Cambridge Lensfield Road, Cambridge, CB2 1EW, UK
    • b Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
    View abstract

    The solid copper-mediated C-N cross-coupling of phenylboronic acids under continuous flow conditions

    Jennifer Bao a, Geoffrey K. Tranmer a,b

    • a College of Pharmacy, Faculty of Health Science, University of Manitoba, Winnipeg, MB R3E 0T5, Canada
    • b Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
    View abstract

    Visible-light photoredox catalysis using a macromolecular ruthenium complex: reactivity and recovery by size-exclusion nanofiltration in continuous flow†

    Javier Guerra ab, David Cantillo a, C. Oliver Kappe *a, Antonio Macchiarulo a, Antimo Gioiello *a

    • a Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz, Austria
    • b Crystal Pharma, Gadea Pharmaceutical Group, a division of AMRI, Parque Tecnológico de Boecillo, Valladolid, 47151, Spain
    View abstract

    Integrating multicomponent flow synthesis and computational approaches for the generation of a tetrahydroquinoline compound based library

    Bruno Cerra a, Serena Mostarda a, Chiara Custodi a, Antonio Macchiarulo a, Antimo Gioiello *a

    • * Corresponding authors
    • a Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, I-06122 Perugia, Italy
    View abstract

    The expanding utility of continuous flow hydrogenation

    Peter J. Cossar a, Lacey Hizartzidis a, Michela I. Simone a, Adam McCluskey *a, Christopher P. Gordon *b

    • * Corresponding authors
    • a Centre for Chemical Biology, Chemistry Building, School of Environmental and Life Science, The University of Newcastle, University Drive, Callaghan, Australia
    • b Nanoscale Organisation and Dynamics Group, School of Science and Health, University of Western Sydney, Locked Bag, Penrith, Australia
    View abstract

    Highly efficient and safe procedure for the synthesis of aryl 1,2,3-triazoles from aromatic amine in a continuous flow reactor

    Federica Stazi a, Damiano Cancogni a, Lucilla Turco b, Pieter Westerduin a, Sergio Bacchi a

    • a GlaxoSmithKline Spa, Chemical Development Department, Synthetic Chemistry, Via Fleming 4, 37135 Verona, Italy
    • b GlaxoSmithKline Spa, Analytical Chemistry, Via Fleming 4, 37135 Verona, Italy
    View abstract

    Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor

    Keiji Nakayama,a, Duncan L. Browne,b, Ian R. Baxendale,b,1, Steven V. Ley,*a

    • a Process Technology Research Laboratories, Pharmaceutical Technology Division, Daiichi Sankyo, Shinomiya, Hiratsuka, Kanagawa, 254-0014, Japan
    • b Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
    View abstract

    The Changing Face of Organic Synthesis

    Ley, Steven V., Baxendale, Ian R.

    • CHIMIA International Journal for Chemistry, Volume 62, Number 3, March 2008, pp. 162-168(7)
    View abstract

    Continuous Heterogeneously Catalyzed Oxidation of Benzyl Alcohol in a Ceramic Membrane Packed- Bed Reactor

    Achilleas Constantinou†¶, Gaowei Wu, Albert Corredera, Peter Ellis, Donald Bethell§, Graham J. Hutchings, Simon Kuhn, Asterios Gavriilidis*†

    • Department of Chemical Engineering, University College London, Torrington Place, London, WC1E 7JE, United Kingdom
    • Division of Chemical and Petroleum Engineering, School of Engineering, London South Bank University, London, SE1 0AA, United Kingdom
    • Johnson Matthey, Blounts Court Road, Reading, RG4 9NH, United Kingdom
    • § Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, United Kingdom
    • School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, United Kingdom
    • Department of Chemical Engineering, KU Leuven, W. de Croylaan 46, 3001 Leuven, Belgium
    View abstract

    Continuous flow Buchwald–Hartwig amination of a pharmaceutical intermediate†

    Polina Yaseneva a, Paul Hodgson a, Jacek Zakrzewski a, Sebastian Falß b, Rebecca E. Meadows c, Alexei A. Lapkin * a

    •   a Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK. E-mail: aal35@cam.ac.uk Fax: +44 (0)1223 334796
    • INVITE GmbH, Chempark Leverkusen, 51373 Leverkusen, Germany
    • Pharmaceutical Development, AstraZeneca, Silk Road Business Park, Macclesfield SK10 2NA, UK
    View abstract

    Thermolysis of 1,3-dioxin-4-ones: fast generation of kinetic data using in-line analysis under flow

    Thomas Duranda, Cyril Henrya, David Boliena, David C. Harrowvena, Sally Bloodwortha, Xavier Franckb, Richard J. Whitby* a

    • a Chemistry, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, UK
    • b Normandie Université, COBRA, UMR 6014 & FR 3038, Université de Rouen, INSA Rouen, CNRS, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex, France
    View abstract

    Continuous photochemistry: the flow synthesis of ibuprofen via a photo-Favorskii rearrangement

    M. Baumanna, Ian R. Baxendale* a

    • a Department of Chemistry, University of Durham, South Road, Durham, UK
    View abstract

    Automated glycan assembly of xyloglucan oligosaccharides

    Pietro Dallabernardinaa b, Frank Schuhmachera b, Peter H. Seebergera b, Fabian Pfrengle* a b

    • a Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany
    • b Freie Universität Berlin, Institute of Chemistry and Biochemistry, Arnimallee 22, 14195 Berlin, Germany
    View abstract

    Dynamic flow synthesis of porous organic cages

    Michael E. Briggsa, Anna G. Slatera, Neil Lunta, Shan Jianga, Marc A. Littlea, Rebecca L. Greenawaya, Tom Hasella, Claudio Battilocchiob, Steven V. Leyb, Andrew I. Cooper* a

    • a Department of Chemistry and Centre for Materials Discovery, University of Liverpool, Crown Street, Liverpool, UK
    • b Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
    View abstract

    An integrated flow and microwave approach to a broad spectrum protein kinase inhibitor

    Cecilia Russella, Andrew J. S. Lina, Peter Hainsb, Michela I. Simonea, Phillip J. Robinsonb, Adam McCluskey* a

    • A Centre for Chemical Biology, Chemistry, School of Environmental and Life Science, The University of Newcastle, University Drive, Callaghan, Australia
    • B Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, Australia
    View abstract

    A Flow-based Synthesis of Telmisartan

    Alex Martin, Ali Siamaki, Katherine Belecki, B. Gupton

    • Department of Chemistry and Department of Chemical and Life Science Engineering Virginia Commonwealth University 601 W. Main St. Richmond Virginia 23284 United States
    View abstract

    The Preparation of Ethyl Levulinate Facilitated by Flow Processing: The Catalyzed and Uncatalyzed Esterification of Levulinic Acid

    Meghan P. Negus1, Andrew C. Mansfield2, Nicholas E. Leadbeater1

    • 1 Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269, United States
    • 2 Vapourtec Ltd., Park Farm Business Centre, Bury St. Edmunds IP28 6TS, United Kingdom
    • 3 Department of Community Medicine and Health Care, University of Connecticut Health Center, The Exchange, 263 Farmington Ave, Farmington, CT 06030, United States
    View abstract

    Photodecarboxylations in an advanced meso-scale continuous flow photoreactor

    Sam Josland1, Saira Mumtaz2, Michael Oelgemöller2 *

    • 1 University of Southampton, Department of Chemistry, University Road, Southampton, SO17 1BJ, United Kingdom
    • 2 James Cook University, College of Science, Technology and Engineering, Townsville, QLD 4811, Australia
    View abstract

    Efficient Continuous-Flow Synthesis of Macrocyclic Triazoles

    Anne-Catherine Bédard, Jeffrey Santandrea, Shawn K. Collins

    • Department of Chemistry and Centre for Green Chemistry and Catalysis, University of Montreal
    View abstract

    Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing

    Thomas M. Kohl *, Christian H. Hornung, John Tsanaktsidis

    • CSIRO Manufacturing Flagship, Bag 10, Clayton South, Victoria 3169, Australia
    View abstract

    A Short Multi-step Flow Synthesis of a Potential Spirocyclic Fragrance Component

    Ian R. Baxendale*

    • Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK
    View abstract

    Flow Synthesis of 2-Methylpyridines via α-Methylation

    Camille Manansala1, Geoffrey K. Tranmer1 2 *

    • 1 College of Pharmacy, Faculty of Health Science, University of Manitoba, Winnipeg, MB R3E 0T6, Canada
    • 2 Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
    View abstract

    The development of a short route to the API ropinirole hydrochloride

    Zeshan Yousufa, Andrew K. Richardsb, Andrew N. Dwyerc, Bruno Linclaua, David C. Harrowven* a

    • a Chemistry, University of Southampton, Highfield, Southampton, UK
    • b GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, UK
    • c Formally at GlaxoSmithKline Innovation and Sustainable Manufacturing COE, Worthing, UK
    View abstract

    Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform

    Bimbisar Desai, Karen Dixon, Elizabeth Farrant, Qixing Feng, Karl R. Gibson, Willem P. van Hoorn, James Mills, Trevor Morgan, David M. Parry, Manoj K. Ramjee, Christopher Nicholas Selway, Gary J. Tarver, Gavin Whitlock, Adrian G. Wright

    • Cyclofluidic Ltd.
    View abstract

    Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

    Ashley R. Longstreet1, Suzanne M. Opalka1, Brian S. Campbell1, B. Frank Gupton2, Tyler McQuade1

    • 1 Department of Chemistry and Biochemistry, Florida State University, United States
    • 1 Department of Chemistry, Virginia Commonwealth University, United States
    View abstract

    Efficient synthesis of panaxadiol derivatives using continuous-flow microreactor and evaluation of anti-tumor activity

    Yan Wua,1, Wei-Qi Chenb,1, Yu-Qing Zhaoc, Hu-Ri Piaoa

    • aKey Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy, China
    • bDepartment of Chemistry, Fudan University, Shanghai, China
    • cSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
    View abstract

    Continuous Reductions and Reductive Aminations Using Solid Sodium borohydride

    Kerry Gilmore, Stella Vukelic, D. Tyler McQuade†§, Beate Koksch, Peter H. Seeberger*†‡

    • Max Planck Institute of Colloids and Interfaces, Germany
    • Institute of Chemistry and Biochemistry, Freie Universität Berlin, Germany
    • § Department of Chemistry and Biochemistry, Florida State University, United States
    View abstract

    Photodecarboxylative Benzylations of N-Methoxyphthalimide under Batch and Continuous-Flow Conditions

    Hossein Mohammadkhani Pordanjani A B, Christian Faderl A C, Jun Wang A, Cherie A. Motti D, Peter C. Junk A, Michael Oelgemöller A E

    • A James Cook University, College of Science, Technology and Engineering, Townsville, Qld 4811, Australia.
    • B Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 6517838683, Iran.
    • C Institut für Organische Chemie, Universität Regensburg, Universitätsstr. 31, D-93053 Regensburg, Germany.
    • D Australian Institute of Marine Science (AIMS), Biomolecular Analysis Facility, Townsville, Qld 4810, Australia.
    • E Corresponding author. Email: michael.oelgemoeller@jcu.edu.au
    View abstract

    Chemical Assembly Systems: Layered Control for Divergent, Continuous, Multistep Syntheses of Active Pharmaceutical Ingredients

    Dr. Diego Ghislieri, Dr. Kerry Gilmore, Prof. Dr. Peter H. Seeberger*

    • Department of Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Universität Berlin, Germany
    View abstract

    Light-Induced C-H Arylation of (Hetero)arenes by In Situ Generated Diazo Anhydrides

    Dr. David Cantillo1, Dr. Carlos Mateos2, Dr. Juan A. Rincon2, Dr. Oscar de Frutos2 *, Prof. Dr. C. Oliver Kappe1 *

    • 1 Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010 Graz (Austria)
    • 2 Centro de Investigación Lilly S. A. Avda. de la Industria 30, 28108 Alcobendas-Madrid (Spain)
    View abstract

    Two-Stage Flow Synthesis of Coumarin via O-Acetylation of Salicylaldehyde

    Xin Li1, Anbang Chen1, Yangzhi Zhou1, Lingling Huang2, Zheng Fang2, Haifeng Gan1, Kai Guo1

    • 1 College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
    • 2 School of Pharmaceutical Sciences, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
    • 3 State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
    View abstract

    Flow Alkylation of Thiols, Phenols, and Amines Using a Heterogenous Base in a Packed-Bed Reactor

    Alastair Baker1, Michael Graz2, Robert Saunders2, Gareth J. S. Evans2, Ilaria Pitotti1 Thomas Wirth1

    • 1 School of Chemistry, Cardiff University, Park Place, Main Building, Cardiff CF10 3AT, UK
    • 2 Neem Biotech, Willowbrook Technical Units, Llandogo Road, St. Mellons, Cardiff CF3 0EF, UK
    View abstract

    An efficient continuous flow process for the synthesis of a non-conventional mixture of fructooligosaccharides

    Paolo Zambellia, Lucia Tamborinib, Samuele Cazzamallib, Andrea Pintob, Stefania Ariolia, Silvia Balzarettia, Francisco J. Plouc, Lucia Fernandez-Arrojoc, Francesco Molinaria, Paola Contib, Diego Romanoa

    • a Department of Food Environmental and Nutritional Science (DeFENS), University of Milan, Via Mangiagalli, 20133 Milan, Italy
    • b Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
    • c Instituto de Catálisis y Petroleoquímica, CSIC, 28049 Madrid, Spain
    View abstract

    A practical deca-gram scale ring expansion of (R)-(−)-carvone to (R)-(+)-3-methyl-6-isopropenyl- cyclohept-3-enone-1

    Leandro de C. Alvesa, André L. Desideráa, Kleber T. de Oliveiraa, Sean Newtonb, Steven V. Ley* b, Timothy J. Brocksom* a

    • a Departamento de Química, Universidade Federal de São Carlos, P.O. Box 676, São Carlos – SP, Brazil
    • b Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
    View abstract

    Factors Influencing the Regioselectivity of the Oxidation of Asymmetric Secondary Amines with Singlet Oxygen

    Dr. Dmitry B. Ushakov 1 †, Matthew B. Plutschack 1 †, Dr. Kerry Gilmore 1 *, Prof. Dr. Peter H. Seeberger 1

    • 1 Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany)
    View abstract

    Electroactive and Photoactive Poly[Isoindigo-alt-EDOT] Synthesized Using Direct (Hetero)Arylation Polymerization in Batch and in Continuous Flow

    François Grenier , Badrou Réda Aïch † ‡, Yu-Ying Lai §, Maxime Guérette , Andrew B. Holmes §, Ye Tao , Wallace W. H. Wong * §, Mario Leclerc * †

    • Département de Chimie, Université Laval, Québec City, Qc G1V 0A6, Canada
    • Information and Communications Technologies Portfolio, National Research Council of Canada, Ottawa, ON K1A 0R6, Canada
    • § School of Chemistry, Bio21 Institute, the University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia
    View abstract

    A Concise Flow Synthesis of Efavirenz†

    Dr. Camille A. Correia1, Dr. Kerry Gilmore1, Prof. Dr. D. Tyler McQuade3, Prof. Dr. Peter H. Seeberger1 2 *

    • 1 Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany)
    • 2 Institute for Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195 Berlin (Germany)
    • 3 Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306 (USA)
    View abstract

    Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines

    Marcus Baumann 1, Antonio M. Rodriguez Garcia 1 2, Ian R. Baxendale * 1

    • 1 Department of Chemistry, Durham University, South Road, Durham, UK
    • 2 Universidad de Castilla-La Mancha, Departamento de Química Orgánica, Facultad de Ciencias y Tecnologías Químicas, Avd. Camilo José Cela, 10, 13071 Ciudad Real, Spain
    View abstract

    Development of a flow method for the hydroboration/oxidation of olefins

    José A. Souto* 1 2, Robert A. Stockman3, Steven V. Ley1

    • 1 Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    • 2 Departamento de Química Orgánica, Universidade de Vigo, Vigo, Spain
    • 3 School of Chemistry, University of Nottingham, Nottingham, UK
    View abstract

    Making Ends Meet: Flow Synthesis as the Answer to Reproducible High-Performance Conjugated Polymers on the Scale that Roll-to-Roll Processing Demands

    Martin Helgesen, Jon E. Carlé, Gisele A. dos Reis Benatto, Roar R. Søndergaard, Mikkel Jørgensen, Eva Bundgaard, Frederik C. Krebs

    • Department of Energy Conversion and Storage, Technical University of Denmark, Roskilde, Denmark
    View abstract

    Reevaluation of the 2-nitrobenzyl protecting group for nitrogen containing compounds: an application of flow photochemistry

    Chloe I. Wendell, Michael J. Boyd

    • Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA, United States
    View abstract

    Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent

    Catherine J. Smith, Christopher D. Smith, Nikzad Nikbin, Steven V. Ley, Ian R. Baxendale

    • Innovative Technology Centre, Cambridge, UK
    View abstract

    Generation and Trapping of Ketenes in Flow

    Cyril Henry1, David Bolien1, Bogdan Ibanescu1, Sally Bloodworth1, David C. Harrowven1, Xunli Zhang2, Andy Craven3, Helen F. Sneddon3, Richard J. Whitby1 *

    • 1 Chemistry, University of Southampton, Southampton, HANTS, SO17 1BJ, UK,
    • 2 Bioengineering Group, Faculty of Engineering and the Environment, University of Southampton, Southampton, HANTS, SO17 1BJ, UK
    • 3 GlaxoSmithKline R&D Ltd., Medicines Research Centre, Gunnels Wood Road, Stevenage, HERTS, SG1 2NY, UK
    View abstract

    A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions

    Maria Victoria Rojo* 1, Lucie Guetzoyan1, Ian. R. Baxendale1 2

    • 1 Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
    • 2 Department of Chemistry, University of Durham, South Road, Durham, UK
    View abstract

    C(sp³)–H functionalisation of N-aryl tetrahydroisoquinolines via an iron-catalysed aerobic nitro-Mannich reaction and continuous flow processing

    Martin Brzozowski, Jose A. Forni, G. Paul Savage and Anastasios Polyzos*

    • CSIRO Manufacturing Flagship, Bayview Avenue, Clayton, Australia
    View abstract

    Facilitating Biomimetic Syntheses of Borrerine Derived Alkaloids by Means of Flow-Chemical Methods

    Sonja B. KamptmannA, Steven V. Ley

    • A Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    View abstract

    The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

    Steffen Glöckner, Duc N. Tran, Richard J. Ingham, Sabine Fenner, Zoe E. Wilson, Claudio Battilocchio, Steven V. Ley*

    • Department of Chemistry, University of Cambridge, Cambridge, UK
    View abstract

    Development of a Grignard-Type Reaction for Manufacturing in a Continuous-Flow Reactor

    Fabrice G. J. Odille†§, Anna Stenemyr†§, Fritiof Pontén*‡

    • Pharmaceutical Development R&D, Chemical Science, AstraZeneca, SE-151 85 Södertälje, Sweden
    • Innovative Medicines, Cardiovascular and Metabolic Diseases, Medicinal Chemistry, AstraZeneca R&D, Sweden
    • § SP Process Development, Forskargatan, Sweden
    View abstract

    Regioselective Synthesis of 3-Aminoimidazo[1,2-a]-pyrimidines under Continuous Flow Conditions

    Ashlie J. E. Butler, Mark J. Thompson, Patrick J. Maydom, James A. Newby, Kai Guo, Harry Adams, Beining Chen*

    • Department of Chemistry, University of Sheffield, Sheffield, U.K.
    View abstract

    Microwave irradiation and flow chemistry for a straightforward synthesis of piano-stool iron complexes

    Anastassiya Pagnoux-Ozherelyevaa, David Bolienb, Sylvain Gaillarda, Flavie Peudrua, Jean-François Lohiera, Richard J. Whitbyb, Jean-Luc Renauda

    • aNormandie University, University of Caen Basse Normandie, Laboratoire de Chimie Moléculaire et Thioorganique, CNRS, Caen, France
    • bChemistry, University of Southampton, Southampton, UK
    View abstract

    Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs–Knorr reaction optimization

    Serena Mostardaa, Paolo Filipponia, Roccaldo Sardellaa, Francesco Venturonia, Benedetto Natalinia, Roberto Pellicciariab, Antimo Gioiello*a

    • aLaboratory of Medicinal and Advanced Synthetic Chemistry (Lab MASC), Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy
    • bTES Pharma S.r.l., Corciano, Italy
    View abstract

    A General Continuous Flow Method for Palladium Catalysed Carbonylation Reactions Using Single and Multiple Tube-in-Tube Gas-Liquid Microreactors

    Ulrike Gross1, Peter Koos1, Matthew O'Brien1,2,*, Anastasios Polyzos1,3, Steven V. Ley1

    • 1Whiffen Laboratory, Department of Chemistry, University of Cambridge, Cambridge, UK
    • 2School of Physical and Geographical Sciences, Keele University, Staffordshire, UK
    • 3CSIRO, Materials Science and Engineering, Clayton South, Australia
    View abstract

    Consecutive Oxygen-based Oxidations Convert Amines to a-Cyanoepoxides

    Dmitry B. Ushakova, Kerry Gilmore*a, Peter H. Seeberger*a,b

    • aMax Planck Institute of Colloids and Interfaces, Potsdam, Germany
    • bInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany
    View abstract

    Synthesis of a Carprofen Analogue Using a Continuous Flow UV-Reactor

    Antoine Caron, Augusto C. Hernandez-Perez, Shawn K. Collins*

    • Department of Chemistry and Centre for Green Chemistr
    • Catalysis, Université de Montréal, Québec, Canada.
    View abstract

    Flow Chemistry Meets Advanced Functional Materials

    Dr. Rebecca M. Myers, Daniel E. Fitzpatrick, Dr. Richard M. Turner, Prof. Steven V. Ley*

    • Department of Chemistry, University of Cambridge, Cambridge, UK
    View abstract

    Continuous Synthesis of Artemisinin-Derived Medicines

    Kerry Gilmorea, Daniel Kopetzkia, Ju Weon Leeb, Zoltan Horvathb, D. Tyler McQuadea, Andreas Seidel-Morgensternb,c, Peter H. Seebergera,d

    • aMax-Planck-Institute of Colloids and Interfaces, Department of Biomolecular Systems, Germany
    • bMax-Planck-Institute for Dynamics of Complex Technical Systems, Germany
    • cOtto-von-Guericke-University, Chair for Chemical Process Technology, Germany
    • dFreie Universität Berlin, Institute of Chemistry and Biochemistry, Berlin, Germany
    View abstract

    A Continuous-Flow Approach to 3,3,3-Trifluoromethylpropenes: Bringing Together Grignard Addition, Peterson Elimination, Inline Extraction, and Solvent Switching

    Trevor A. Hamlin, Gillian M. L. Lazarus, Christopher B. Kelly, Nicholas E. Leadbeater*†‡

    • Department of Chemistry, University of Connecticut, United States
    • Department of Community Medicine & Health Care, University of Connecticut Health Center, United States
    View abstract

    Heterogenization of Pd–NHC complexes onto a silica support and their application in Suzuki–Miyaura coupling under batch and continuous flow conditions

    Alberto Martíneza, Jamin L. Krinskya, Itziar Peñafiela, Sergio Castillónb, Konstantin Loponovc, Alexei Lapkinc, Cyril Godard*a, Carmen Claver*a

    • aDepartment of Physical and Inorganic Chemistry, Universitat Rovira i Virgili, Tarragona, Spain
    • bDepartment of Analytical and Organic Chemistry, Universitat Rovira i Virgili, Tarragona, Spain
    • cDepartment of Chemical Engineering and Biotechnology, University of Cambridge, , Cambridge, UK
    View abstract

    Glycosylation with N-acetyl glycosamine donors using catalytic iron(III) triflate: from microwave batch chemistry to a scalable continuous-flow process

    Amandine Xolina, Arnaud Stévenina, Mathieu Pucheaultb, Stéphanie Norsikiana, François-Didier Boyer*ac, Jean-Marie Beau*ad

    • aCentre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France
    • bInstitut des Sciences Moléculaires, CNRS-Université de Bordeaux, Talence, France
    • cInstitut Jean-Pierre Bourgin, UMR1318 INRA-AgroParisTech, Versailles, France
    • dUniversité Paris-Sud and CNRS, Laboratoire de Synthèse de Biomolécules, Institut de Chimie Moléculaire et des Matériaux, Orsay, France
    View abstract

    Multistep Flow Synthesis of 5-Amino-2-aryl-2H-[1,2,3]-triazole-4-carbonitriles

    YDr. Jérôme Jacq, Dr. Patrick Pasau*

    • UCB Biopharma, Avenue de l'Industrie, 1420 Braine l'Alleud (Belgium)
    View abstract

    Versatile, High Quality and Scalable Continuous Flow Production of Metal-Organic Frameworks

    Marta Rubio-Martinez, Michael P. Batten, Anastasios Polyzos, Keri-Constanti Carey, James I. Mardel, Kok-Seng Lim, Matthew R. Hill

    • CSIRO Materials Science and Engineering, Australia
    View abstract

    Continuous Flow Magnesiation of Functionalized Heterocycles and Acrylates with TMPMgCl·LiCl

    Dr. Trine P. Petersen, Matthias R. Becker, Prof. Dr. Paul Knochel*

    • Ludwig-Maximilians-Universität München, Department Chemie, München, Germany
    View abstract

    Continuous Synthesis of Organozinc Halides Coupled to Negishi Reactions

    Nerea Alonso2,3, L. Zane Miller1, Juan de M. Muñoz2, Jesus Alcázar2,*, D. Tyler McQuade1,*

    • 1Department of Chemistry and Biochemistry, Florida State University, USA
    • 2Janssen Research and Development, Janssen-Cilag, Toledo, Spain
    • 3Facultad de Química, Universidad de Castilla-La Mancha, Spain
    View abstract

    Continuous Flow Synthesis of Thieno[2,3-c]isoquinolin-5(4H)-one Scaffold: A Valuable Source of PARP-1 Inhibitors

    Paolo Filipponi, Carmine Ostacolo, Ettore Novellino, Roberto Pellicciari†§, Antimo Gioiello*†

    • Dipartimento di Scienze Farmaceutiche, Università di Perugia, Via del Liceo 1, I-06123 Perugia, Italy
    • Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Napoli, Italy §TES Pharma S.r.l., Corciano (Perugia), Italy
    View abstract

    First Example of a Continuous-Flow Carbonylation Reaction Using Aryl Formates as CO Precursors

    Nerea Alonso1,3, Juan de Muñoz1, Brecht Egle2, Johannes L. Vrijdag2, Wim M. De Borggraeve2, Antonio de la Hoz3, Angel Díaz-Ortiz3, Jesús Alcázar1

    • 1Janssen Research and Development, Janssen-Cilag Department of Medicinal Chemistry S.A., Toledo, Spain
    • 2Molecular Design and Synthesis University of Leuven, Department of Chemistry, Heverlee Belgium
    • 3Universidad de Castilla-La Mancha Facultad de Ciencias y Tecnologías Químicas Real, Spain
    View abstract

    Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

    Richard J. Ingham1, Claudio Battilocchio1, Joel M. Hawkins2, Steven V. Ley1

    • 1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK
    • 2 Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA
    View abstract

    Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure–Activity Relationship Data of ?-Secretase (BACE1) Inhibitors

    Dr. Michael Werner1,*, Christoph Kuratli1, Dr. Rainer E. Martin1,*, Dr. Remo Hochstrasser1, David Wechsler1, Dr. Thilo Enderle1, Dr. Alexander I. Alanine1, Prof. Dr. Horst Vogel2

    • 1 Medicinal Chemistry, Small Molecule Research, Pharma Research & Early Development (pRED), F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel (Switzerland)
    • 2 Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology of Lausanne (EPFL), Station 6, 1015 Lausanne (Switzerland)
    View abstract

    Sequential flow process for the controlled polymerisation and thermolysis of RAFT-synthesised polymers

    CH Hornung, A Postma, S Saubern, J Chiefari

    • CSIRO Materials Science and Engineering, Victoria, Australia
    View abstract

    Robust and reusable supported palladium catalysts for cross-coupling reactions in flow

    William R. Reynoldsab, Pawel Plucinskibc, Christopher G. Frost*ab

    •   * Corresponding authors
    • a Centre for Sustainable Chemical Technologies, University of Bath, Claverton Down, Bath, UK
    • b Department of Chemistry, University of Bath, Claverton Down, Bath, UK
    • c Department of Chemical Engineering, University of Bath, Claverton Down, Bath, UK
    View abstract

    Continuous-Flow Oxidative Cyanation of Primary and Secondary Amines Using Singlet Oxygen

    Dmitry B. Ushakov, Kerry Gilmore, Daniel Kopetzki, D. Tyler McQuade, Peter H. Seeberger

    • 1Department für Biomolekulare Systeme, Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Potsdam, Germany
    • 2Institut für Chemie und Biochemie, Freie Universität Berlin, Berlin, Germany
    • 3Department of Chemistry and Biochemistry, Florida State University, Tallahassee, USA
    View abstract

    Flow synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe

    Matthew B. Plutschack1,2, D. Tyler McQuade1,2, Giulio Valenti2, Peter H. Seeberger2, 1Department of Chemistry and Biochemistry, Florida State University, USA, 2Max Planck Institute of Colloids and Interfaces, Germany

    View abstract

    The Fit For Purpose Development of S1P1 Receptor Agonist GSK2263167 Using a Robinson Annulation and Saegusa Oxidation to Access an Advanced Phenol Intermediate

    Robert M. Harris, Benjamin I. Andrews, Stacy Clark, Jason W. B. Cooke, John C. S. Gray, Stephanie Q. Q. Ng

    • Chemical Development, GlaxoSmithKline Research and Development Ltd., UK
    View abstract

    Flow-Based, Cerium Oxide Enhanced, Low-Level Palladium Sonogashira and Heck Coupling Reactions by Perovskite Catalysts

    Claudio Battilocchio1, Benjamin N. Bhawal1, Rajeev Chorghade1, Benjamin J. Deadman1, Joel M. Hawkins2, Steven V. Ley1

    • 1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, UK
    • 2 Pfizer Worldwide Research & Development, Groton, USA
    View abstract

    Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions

    Trevor A. Hamlin, Nicholas E. Leadbeater

    • Department of Chemistry, University of Connecticut, USA
    View abstract

    Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z)-Tamoxifen

    Philip R D Murray, Duncan L Browne, Julio C Pastre, Chris Butters, Duncan Guthrie, Steven V Ley

    • Department of Chemistry, University of Cambridge, UK Instituto de Química, University of Campinas, Brazil Vapourtec Ltd, UK
    View abstract

    Biotransformation with whole microbial systems in a continuous flow reactor: resolution of (RS)-flurbiprofen using Aspergillus oryzae by direct esterification with ethanol in organic solvent

    Lucia Tamborinia, Diego Romanob, Andrea Pintoa, Martina Contentea, Maria C. Iannuzzia, Paola Contia, Francesco Molinarib

    • a Dipartimento di Scienze Farmaceutiche, Universitá degli Studi di Milano, Italy
    • b Dipartimento di Scienze per gli Alimenti, la Nutrizione e l'Ambiente (DEFENS), Universitá degli Studi di Milano, Italy
    View abstract

    Porous, functional, poly(styrene-co-divinylbenzene) monoliths by RAFT polymerization

    Kristine J. Barlow (née Tan), Xiaojuan Hao, Timothy C. Hughes, Oliver E. Hutt, Anastasios Polyzos, Kathleen A. Turner, Graeme Moad

    • Commonwealth Scientific and Industrial Research Organisation (CSIRO), Materials Science & Engineering, Australia
    View abstract

    The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow

    Kimberley A. Roper1, Malcolm B. Berry2, Steven V. Ley1

    • 1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, Cambridge, U.K.
    • 2 GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
    View abstract

    Continuous Flow Synthesis of Coumarin

    Anbang Chen1, Xin Li1, Yangzhi Zhou1, Lingling Huang2, Zheng Fang2, Haifeng Gan1, Kai Guo1

    • 1 College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology 2 School of Pharmceutical Sciences, Nanjing University of Technology
    View abstract

    Synthesis of All Four Stereoisomers of 3-(tert-Butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid

    Bettina Bakonyi, Markus Furegati*‡, Christian Kramer§, Luigi La Vecchia, Flavio Ossola

    • Doetsch Grether AG, Falkensteinerstrasse 37, 4132 Muttenz, Switzerland
    • Preparations Laboratories, Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Klybeckstrasse 141, 4057 Basel,Switzerland
    • § Institute of General, Inorganic and Theoretical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria
    View abstract

    The rapid generation of isothiocyanates in flow

    Marcus Baumann, Ian R. Baxendale

    • Department of Chemistry, University of Durham, U.K.
    View abstract

    Continuous synthesis of pyridocarbazoles and initial photophysical and bioprobe characterization

    D. Tyler McQuade*ab, Alexander G. O'Briena, Markus Dörrc, Rajathees Rajaratnamc, Ursula Eisoldd, Bopanna Monnandaa, Tomoya Nobutaa, Hans-Gerd Löhmannsröbend, Eric Meggersc, Peter H. Seebergerae

    • a Department for Biomolecular Systems, Max Planck Institute for Colloids and Interfaces
    • b Department of bChemistry and Biochemistry, Florida State University
    • c Fachbereich Chemie, Philipps-Universität Marburg
    • d Potsdam Institut für Chemie
    • e Freie Universität Berlin
    View abstract

    Microwave heating and conventionally-heated continuous-flow processing as tools for performing cleaner palladium-catalyzed decarboxylative couplings using oxygen as the oxidant – a proof of principle study

    Nicholas E. Leadbeater1, DiAndra M. Rudzinski1

    • 1 Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269, USA
    View abstract

    Hypervalent iodine/TEMPO-mediated oxidation in flow systems: a fast and efficient protocol for alcohol oxidation

    Nida Ambreen, Ravi Kumar, Thomas Wirth

    • Innovative Technology Centre, Cardiff University, School of Chemistry, Park Place, Cardiff, UK
    View abstract

    First Example of Alkyl-Aryl Negishi Cross-Coupling in Flow: Mild, Efficient and Clean Introduction of Functionalized Alkyl Groups

    Brecht Egle2, Juan de Muñoz1, Nerea Alonso1, Wim M. De Borggraeve2, Antonio de la Hoz3, Angel Díaz-Ortiz3, Jesús Alcázar1

    • 1Janssen Research and Development Department of Medicinal Chemistry Janssen-Cilag, Toledo Spain
    • 2Department of Chemistry, Molecular Design and Synthesis University of Leuven, Heverlee Belgium
    • 3Universidad de Castilla-La Mancha Facultad de Ciencias y Tecnologías Químicas, Spain
    View abstract

    Controlled synthesis of poly(3-hexylthiophene) in continuous flow

    Helga Seyler, Jegadesan Subbiah, David J. Jones, Andrew B. Holmes, Wallace W. H. Wong*

    • School of Chemistry, Bio21 Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia
    • *Corresponding author
    View abstract

    Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhibitors: Application to Drug Discovery

    Werngard Czechtizky, Jurgen Dedio, Bimbisar Desai, Karen Dixon, Elizabeth Farrant, Qixing Feng Trevor Morgen, David M Parry, Manoj K. Ramjee, Christopher N. Selway, Thorsten Schmidt, Gary J. Tarver, Adrian G. Wright

    • Sanofi-Aventis, Frankfurt, Germany. Cyclofluidic Ltd., U.K.
    View abstract

    Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis

    D. Tyler McQuade1 3, Peter H. Seeberger1 2

    • 1 Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces
    • 2 Institute for Chemistry and Biochemistry, Freie Universität Berlin,
    • 3 Department of Chemistry and Biochemistry, Florida State University
    View abstract

    Continuous flow macrocyclization at high concentrations: synthesis of macrocyclic lipids

    Anne-Catherine Bédard, Sophie Régnie, Shawn K. Collins

    • Département de Chimie, Centre for Green Chemistry, Catalysis, Université de Montréal, Montréal, Canada
    View abstract

    Continuous Synthesis and Use of N-Heterocyclic Carbene Copper(I) Complexes from Insoluble Cu2O

    Suzanne M. Opalka1, Jin Kyoon Park3, Ashley R. Longstreet2, D. Tyler McQuade2

    • 1Department of Chemistry and Biochemistry, Florida State University, USA
    • 2Department of Chemistry and Chemical Biology, Cornell University, USA
    • 3Department of Chemistry and Chemical Institute for Functional Materials, Pusan National University, Korea
    View abstract

    Ozonolysis of some complex organic substrates in flow

    M. D. Roydhouse1, W. B. Motherwell1, A. Constantinou2, A. Gavriilidis2, R. Wheeler3, K. Down3, I. Campbell3

    • 1Dept of Chemistry, University College London, UK
    • 2Dept of Chemical Engineering, University College London, UK
    • 3GSK, Stevenage, UK
    View abstract

    Synthesis of Carbohydrate-Functionalised Sequence-Defined Oligo(amidoamine)s by Photochemical ThiolEne Coupling in a Continuous Flow Reactor

    Felix Wojcik1,2, Alexander G. O'Brien1,2, Sebastian Götze1,2, Peter H. Seeberger1,2, Laura Hartmann1,2

    • 1Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam (Germany)
    • 2Institute for Chemistry and Biochemistry, Freie Universität Berlin, Berlin (Germany)
    View abstract

    Continuous-flow generation of diazoesters and their direct use in S-H and P-H insertion reactions: synthesis of a-sulfanyl, a-sulfonyl and a-phosphono carboxylates

    Hannah E. Bartrum1, David C. Blakemore2, Christopher J. Moody1, Christopher J. Hayes1

    • 1School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
    • 2Pfizer Neusentis, The Portway Building, Granta Park, Cambridge, CB21 6GS, UK
    View abstract

    Synthesis of RAFT Block Copolymers in a Multi-Stage Continuous Flow Process Inside a Tubular Reactor

    Christian H. Hornung, Xuan Nguyen, Stella Kyi, John Chiefari, Simon Saubern

    • CSIRO Materials Science & Engineering, Victoria, Australia.
    View abstract

    An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

    Mark D Hopkin, Ian Baxendale, Steven.V.Ley

    • Dept of Chemistry, University of Cambridge, UK
    View abstract

    A Multi-Step Continuous Flow Process for the N-Demethylation of Alkaloids

    Yuji Nakano1, G. Paul Savage1, Simon Saubern1, Peter J. Scammells2, Anastasios Polyzos1

    • 1 CSIRO Materials Science and Engineering, Victoria, Australia.
    • 2 Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria, Australia.
    View abstract

    A Two-Stage Continuous-Flow Synthesis of Spirooxazine Photochromic Dyes

    Mark York123, Adriana Edenharter1

    • 1CSIRO Materials Science and Engineering, Clayton, Vic. 3169, Australia.
    • 2Cooperative Research Centre for Polymers, Notting Hill, Vic. 3168, Australia.
    • 3Advanced Polymerik Pty Ltd, Notting Hill, Vic. 3168, Australia.
    View abstract

    Continuous Flow Synthesis of Organic Electronic Materials : Case Studies in Methodology Translation and Scale-up

    Helga Seyler1, Stefan Haid2, Tae-Hyuk Kwon1, David J. Jones1, Peter Bäuerle2, Andrew B. Holmes1, Wallace W. H. Wong1*

    • 1Bio21 Institute, University of Melbourne, Australia.
    • 2Institute of Organic Chemistry II and Advanced Materials, University of Ulm, Germany.
    View abstract

    Preparation of Arene Chromium Tricarbonyl Complexes Using Continuous-Flow Processing: (n6-C6H5CH3)Cr(CO)3 as an example

    Christopher (Xiang) Lee1, Elizabeth A. Pedrick1, Nicholas E. Leadbeater1

    • 1Department of Chemistry, University of Connecticut, USA
    • 2Department of Community Medicine and Health Care, University of Connecticut Health Center, USA
    View abstract

    Visible Light-Initiated Preparation of Functionalized Polystyrene Monoliths for Flow Chemistry

    Farhan R. Bou-Hamdan1, Kathleen Krüger1, Klaus Tauer1, Tyler McQuade1,3 , Peter H. Seeberger 1,2

    • 1Max Planck Institute of Colloids and Interfaces Potsdam, Germany.
    • 2Institute of Chemistry and Biochemistry, Freie Universität Berlin , Germany.
    • 3Department of Chemistry and Biochemistry, Florida State University, USA.
    View abstract

    Integrated Continuous Processing and Flow Characterization of RAFT Polymerization in Tubular Flow Reactors

    Christian H. Hornung, Xuan Nguyen, Geoff Dumsday, Simon Saubern*

    • CSIRO Materials Science and Engineering, Victoria. Australia
    View abstract

    Synthesis of an H3 Antagonist via Sequential One-Pot Additions of a Magnesium Ate Complex and an Amine to a 1,4-Ketoester followed by Carbonyl-Directed Fluoride Addition

    Joel M. Hawkins, Pascal Dubé, Mark T. Maloney, Lulin Wei. Marcus Ewing, Stephen M. Chesnut, Joshua R. Denette, Brett M. Lillie, Rajappa Vaidyanathan

    • Pharmaceutical Sciences, Pfizer Inc., Groton, USA
    View abstract

    A “Catch-React-Release” Method for the Flow Synthesis of 2-Aminopyrimidines and Preparation of the Imatinib Base

    Richard J. Ingham, Elena Riva, Nikzad Nikbin, Ian R. Baxendale, Steven V. Ley*

    • Innovative Technology Centre, University of Cambridge, U.K.
    View abstract

    Sustainable and efficient methodology for CLA synthesis and identification

    Andres Moreno, Maria Moreno, Maria Victoria Gómez, Cristina Cebrian, Pilar Prieto, Antonio de la Hoz

    • Departamento de Química Inorgánica, , Universidad de Castilla-La Mancha, Ciudad Real, Spain.
    View abstract

    A Continuous Flow Process for the Radical Induced End Group Removal of RAFT Polymers

    Christian H. Hornung, Almar Postma, Simon Saubern, John Chiefari

    • CSIRO Materials Science & Engineering, Victoria Australia
    View abstract

    Continuous Synthesis and Purification by Direct Coupling of a Flow Reactor with Simulated Moving-Bed Chromatography

    Alexander G. O’Brien1, Zoltán Horváth3, François Lévesque1, Ju Weon Lee3, Andreas Seidel-Morgenstern3, Peter H. Seeberger1,2

    • 1Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Potsdam, Germany
    • 2Freie Universität Berlin, Germany
    • 3Max-Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany
    View abstract

    Asymmetric Homogeneous Hydrogenation in Flow using a Tube-in-Tube Reactor

    Sean Newton1, Steven V. Ley1, Eva Casas Arcé2, Damian M. Grainger2

    • 1Department of Chemistry, University of Cambridge, U.K.
    • 2Johnson Matthey Catalysis and Chiral Technology, Cambridge, U.K.
    View abstract

    Continuous Flow Synthesis of Secondary Amides by Tandem Azidation- Amidation of Anilines

    Christian Spiteri, John E. Moses*

    • School of Chemistry, University of Nottingham, UK
    View abstract

    Continuous Flow Hydrogenation Using an On-Demand Gas Delivery Reactor

    Michael A. Mercadante, Christopher B. Kelly, Christopher (Xiang) Lee, Nicholas E. Leadbeater*

    • Department of Chemistry, University of Connecticut, USA
    View abstract

    Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts

    Francesco Venturoni, Antimo Gioiello, Roccaldo Sardella, Benedetto Natalini, Roberto Pellicciari

    • Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy
    View abstract

    Phase-Transfer Catalysis under Continuous Flow Conditions: An Alternative Approach to the Biphasic Liquid/Liquid O-Alkylation of Phenols

    Daniele De Zani2, Matteo Colombo1

    • 1NiKem Research 20021 via Zambeletti 25 Milan Baranzate Italy
    • 2Erregierre, San Paolo D'Argon Bergamo Italy
    View abstract

    An efficient method for the lipase-catalysed resolution and in-line purification of racemic flurbiprofen in a continuous-flow reactor

    Lucia Tamborini1, Diego Romano2, Andrea Pinto1, Arianna Bertolani1,2, Francesco Molinari2, Paola Conti1

    • 1Dipartimento di Scienze Farmaceutiche ‘Pietro Pratesi’, Universitá degli Studi di Milano, Italy
    • 2Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, Universitá degli Studi di Milano, Italy
    View abstract

    Development of a Continuous Flow Scale-Up Approach of Reflux Inhibitor AZD6906

    Tomas Gustafsson, Henrik Sörensen, Fritiof Pontén*

    • Medicinal Chemistry, AstraZeneca R&D Mölndal, Sweden
    View abstract

    Soluble Polymer-Supported Flow Synthesis: A Green Process for the Preparation of Heterocycles

    Nicolò Prosa, Raphaël Turgis, Riccardo Piccardi, Marie-Christine Scherrmann

    • Institut de Chimie Moléculaire et des Matériaux d'Orsay, Université Paris-Sud, France
    View abstract

    Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands

    Claudio Battilocchio1,3, Marcus Baumann1, Ian R. Baxendale1, Mariangela Biava3, Matthew O. Kitching1, Steven V. Ley1, Rainer E. Martin*2, Stephan A. Ohnmacht2, Nicholas D. C. Tappin1

    • 1Department of Chemistry, University of Cambridge, UK
    • 2F. Hoffmann-La Roche Ltd., Pharmaceuticals Division, Basel, Switzerland
    • 3Department of Pharmaceutical Chemistry and Technology, Sapienza University of Rome, Italy
    View abstract

    Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

    François Lévesque1, Peter H. Seeberger1,2

    • 1Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Germany
    • 2Institute for Chemistry and Biochemistry, Freie Universität Berlin, Germany
    View abstract

    The Continuous-Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas Permeable Membrane Reactor

    Anastasios Polyzos, Matthew O’Brien, Trine P. Petersen, Ian R. Baxendale, Steven V. Ley

    • Innovative Technology Centre, Department of Chemistry, University of Cambridge
    View abstract

    Continuous proline catalysis via leaching of solid proline

    Suzanne M. Opalka1, Ashley R. Longstreet2, D. Tyler McQuade2

    • 1Department of Chemistry and Chemical Biology, Cornell University, USA
    • 2Department of Chemistry and Biochemistry, Florida State University,USA
    View abstract

    The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

    Kimberley A. Roper1, Heiko Lange1, Anastasios Polyzos1, Malcolm B. Berry2, Ian R. Baxendale1, Steven V. Ley1

    • 1Innovative Technology Centre, University of Cambridge
    • 2GlaxoSmithKline, Stevenage, UK
    View abstract

    Application of Flow Chemistry to the Selective Reduction of Esters to Aldehydes

    Juan de M. Muñoz1, Jesús Alcázar1, Antonio de la Hoz2, Angel Díaz-Ortiz2

    • 1Janssen, Toledo, Spain
    • 2Facultad de Ciencias Químicas, Universidad de Castilla-La Mancha, Spain
    View abstract

    Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels-Alder Reaction under Superheated Continuous Flow Conditions

    Rainer E. Martin1, Falk Morawitz1, Christoph Kuratli1, André M. Alker2, Alexander I. Alanine1

    • 1Chemistry Technology and Innovation, F. Hoffmann-La Roche Ltd, Basel, Switzerland
    • 2Biostructure Section, F. Hoffmann-La Roche Ltd,Basel, Switzerland
    View abstract

    Continuous Preparation of Arylmagnesium Reagents in Flow with Inline IR Monitoring

    Tobias Brodmann1, Peter Koos1, Albrecht Metzger1, Paul Knochel*2, Steven V. Ley*1

    • 1Department of Chemistry, University of Cambridge, U.K.
    • 2Department of Chemistry, Ludwig Maximilians-Universität München, Germany
    View abstract

    Lead Diversification 2: Application to P38, gMTP and lead compounds

    M. Abid Masood1, Marc Bazin2, Mark E. Bunnage1, Andrew Calabrese3, Mark Cox1, Sally-Ann Fancy1, Elizabeth Farrant1, David W. Pearce1, Manuel Perez1, Laure Hitzel1, Torren Peakman1

    • 1Worldwide Medicinal Chemistry, Pfizer, UK
    • 2Hepatochem, Cambridge, MA, USA
    • 3Celgene San Diego, USA
    View abstract

    New Insights into Cyclobutenone Rearrangements: A Total Synthesis of the Natural ROS-Generating Anti-Cancer Agent Cribrostatin 6†

    Mubina Mohamed1, Théo P. Gonçalves1, Prof. Richard J. Whitby1, Dr. Helen F. Sneddon2, Prof. David C. Harrowven1

    • 1 Chemistry, University of Southampton, UK
    • 2 GlaxoSmithKline Medicines Research Centre, UK
    View abstract

    New Insights into Cyclobutenone Rearrangements: A Total Synthesis of the Natural ROS-Generating Anti-Cancer Agent Cribrostatin (ROS=reactive-oxygen species)

    Mubina Mohamed1, Théo P. Gonçalves1, Richard J. Whitby1, Helen F. Sneddon2, David C. Harrowven1

    • 1Dept of Chemistry, University of Southampton, UK
    • 2GSK Medicines Research Centre, Stevenage, UK
    View abstract

    A continuous-flow synthesis of annulated and polysubstituted furans from the reaction of ketones and a-haloketones

    Mark York

    • CSIRO Materials Science and Engineering, Australia
    • Cooperative Research Centre for Polymers, Notting Hill, Australia
    View abstract

    The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact

    Trine P. Petersen1,2,3, Anastasios Polyzos1,4, Matthew O’Brien1, Trond Ulven2, Ian R. Baxendale1, Steven V. Ley1

    • 1Whiffen Laboratory, University of Cambridge, UK
    • 2Department of Physics and Chemistry, University of Southern Denmark
    • 3Discovery Chemistry and DMPK, H. Lundbeck A/S,Denmark
    • 4CSIRO, Materials Science and Engineering, Australia
    View abstract

    Continuous flow synthesis of conjugated polymers

    Helga Seyler, David J. Jones, Andrew B. Holmes, Wallace W. H. Wong

    • Bio21 Institute, University of Melbourne, Australia
    View abstract

    Suzuki-Miyaura Cross-Coupling of Heteroaryl Halides and Arylboronic Acids in Continuous Flow

    Timothy Noël, Andrew J. Musacchio

    • Department of Chemistry, MIT, USA
    View abstract

    Nitrile Oxide 1,3-Dipolar Cycloaddition by Dehydration of Nitromethane Derivatives Under Continuous Flow Conditions

    Malte Brasholz, Simon Saubern*, G. Paul Savage

    • CSIRO Materials Science and Engineering, Victoria, Australia.
    View abstract

    Continuous-flow, palladium-catalysed alkoxycarbonylation reactions using a prototype reactor in which it is possible to load gas and heat simultaneously

    Michael A. Mercadante, Nicholas E. Leadbeater

    • Department of Chemistry, University of Connecticut, USA
    View abstract

    Continuous flow photolysis of aryl azides: Preparation of 3H-azepinones

    Farhan R. Bou-Hamdan, François Lévesque, Alexander G. O'Brien, Peter H. Seeberger

    • Max Planck Institute of Colloids and Interfaces, Berlin, Germany
    View abstract

    Teflon AF-2400 mediated gas–liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

    Peter Koos, Ulrike Gross, Anastasios Polyzos, Matthew O'Brien, Ian Baxendale, Steven V. Ley

    • Innovative Technology Centre, University of Cambridge, UK
    View abstract

    Rapid Access to α-Alkoxy and α-Amino Acid Derivatives through Safe Continuous-Flow Generation of Diazoesters

    Hannah E. Bartrum1, David C. Blakemore2, Christopher J. Moody1, Christopher J. Hayes1, 1School of Chemistry, University of Nottingham, UK, 2Pfizer Global Research and Development, Sandwich, UK

    View abstract

    Ozonolysis in Flow Using Capillary Reactors

    M. D. Roydhouse1, A. Ghaini2, A. Constantinou, A. Cantu-Perez2, W. B. Motherwell1, A. Gavriilidis2

    • 1 Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ
    • 2 Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE
    View abstract

    An Integrated Flow and Batch-Based Approach for the Synthesis of O-Methyl Siphonazole

    Marcus Baumann, Ian R. Baxendale, Malte Brasholz, John J. Hayward, Steven V. Ley, Nikzad Nikbin

    • Innovative Technology Centre, Cambridge, UK
    View abstract

    Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods

    Marcus Baumann1, Ian R. Baxendale1, Steven V. Ley1, Christoph Kuratli2, Rainer E. Martin2, Josef Schneider2

    • 1Innovative Technology Centre, University of Cambridge, U.K.
    • 2F. Hoffmann-La Roche Ltd., Basel, Switzerland
    View abstract

    Nitration Chemistry in Continuous Flow using Fuming Nitric Acid in a Commercially Available Flow Reactor

    Cara E. Brocklehurst, Hansjoerg Lehmann, Luigi La Vecchia

    • Global Discovery Chemistry, Novartis, Basel, Switzerland
    View abstract

    Synthesis of (+)-Dumetorine and Congeners by Using Flow Chemistry Technologies

    Elena Riva2, Anna Rencurosi1, Stefania Gagliardi1, Daniele Passarella2, Marisa Martinelli1*

    • 1NiKem Research S.r.l., Milan, Italy
    • 2Università degli Studi di Milano,Milan, Italy
    View abstract

    Continuous flow synthesis of fullerene derivatives

    Helga Seyler, Wallace Wing Ho Wong, Dave Jones, Andrew B. Holmes

    • University Of Melbourne, Australia
    View abstract

    Preparation of fluoxetine by multiple flow processing steps

    Batoul Ahmed-Omer, Adam J. Sanderson

    • Eli Lilly and Co. Ltd.
    • Lilly Research Centre, UK.
    View abstract

    Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith

    Heiko Lange, Matthew J. Capener, Alexander X. Jones, Catherine J. Smith, Nikzad Nikbin, Ian R. Baxendale, Steven V. Ley*

    • Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
    View abstract

    Highly efficient dehydration of carbohydrates to 5-(chloromethyl)furfural (CMF), 5-(hydroxymethyl)furfural (HMF) and levulinic acid by biphasic continuous flow processing

    Malte Brasholz, Karin von Känel, Christian H. Hornung, Simon Saubern, John Tsanaktsidis

    • CSIRO Materials Science & Engineering, Victoria , Australia
    View abstract

    A General, One-Step Synthesis of Substituted Indazoles using a Flow Reactor

    Rob C. Wheeler, Emma Baxter, Ian B. Campbell, Simon J. F. Macdonald

    • GlaxoSmithKline, Stevenage, UK
    View abstract

    Controlled RAFT Polymerization in a Continuous Flow Microreactor

    Christian H. Hornung, Carlos Guerrero-Sanchez, Malte Brasholz, Simon Saubern, John Chiefari, Graeme Moad, Ezio Rizzardo, San H. Thang

    • CSIRO Materials Science & Engineering, Victoria, Australia
    View abstract

    Diastereoselective Chain-Elongation Reactions Using Microreactors for Applications in Complex Molecule Assembly

    Catherine F. Carter1, Heiko Lange1, Daiki Sakai2, Ian R. Baxendale1, Steven V. Ley1

    • 1Innovative Technology Centre, University of Cambridge, UK, CB2 1EW, UK
    • 2Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan
    View abstract

    Decarboxylative biaryl synthesis in a continuous flow reactor

    1Paul P. Lange, 1Lukas J. Gooßen, 2Philip Podmore, 2Toby Underwood, 2Nunzio Sciammetta

    • 1Technische Universität Kaiserslautern, Germany
    • 2Pfizer Global R&D, Sandwich, UK
    View abstract

    A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

    Catherine J. Smith, Nikzad Nikbin, Steven V. Ley, Heiko Lange, Ian R. Baxendale

    • Innovative Technology Centre, Cambridge, UK
    View abstract

    A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing

    Heiko Lange1, Catherine F. Carter1, Mark D. Hopkin1, Adrian Burke2, Jon G. Goode2, Ian R. Baxendale1, Steven V. Ley1

    • 1Innovative Technology Centre, University of Cambridge, UK
    • 2Mettler-Toledo AutoChem UK
    View abstract

    One-Flow, Multistep Synthesis of Nucleosides by Brønsted Acid-Catalyzed Glycosylation

    Adam Sniady, Matthew W. Bedore, Timothy F. Jamison

    • Novartis Institutes for Biomedical Research Inc., Cambridge, USA MIT, Cambridge, USA
    View abstract

    Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates

    Alexander G. O'Brien, François Lévesque, Peter H. Seeberger

    • Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
    View abstract

    Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor

    View abstract

    Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing

    Yun Zhang1, Timothy F. Jamison2, Sejal Patel1, Nello Mainolfi1, 1Novartis Institutes for Biomedical Research Inc., Cambridge, USA, 2MIT, Cambridge, USA

    View abstract

    Synthesis of β-Keto Esters In-Flow and Rapid Access to Substituted Pyrimidines

    Hannah E. Bartrum1, David C. Blakemore2, Christopher J. Moody1, Christopher J. Hayes1

    • 1School of Chemistry, University of Nottingham, UK
    • 2Pfizer Global Research and Development, Sandwich, UK
    View abstract

    Synthesis of 3-Aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole Derivatives: A Comparison between Conventional, Microwave-Assisted and Flow-Based Methodologies

    Sabrina Castellano1, Lucia Tamborini2, Monica Viviano1, Andrea Pinto2, Gianluca Sbardella1, Paola Conti2

    • 1Dipartimento di Scienze Farmaceutiche, Universit degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Italy
    • 2Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universit degli Studi di Milano , Italy
    View abstract

    Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor

    Laia Malet-Sanz, Julia Madrzak, Steven V.Ley, Ian R.Baxendale

    • Innovative Technology Centre, University of Cambridge
    View abstract

    A Gram-Scale Batch and Flow Total Synthesis of Perhydrohistrionicotoxin

    Dr. Malte Brasholz1, Dr. James M. Macdonald1, Dr. Simon Saubern1, Dr. John H. Ryan1, Prof. Dr. Andrew B. Holmes1,2

    • 1CSIRO Molecular and Health Technologies, Victoria, Australia
    • 2School of Chemistry, Bio 21 Institute, University of Melbourne, Victoria, Australia
    View abstract

    A Continuous Flow Process Using a Sequence of Microreactors with In-line IR Analysis for the Preparation of N,N-Diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a Potent and Highly Selective δ-Opioid Receptor Agonist

    Zizheng Qian, Ian R. Baxendale, Steven V. Ley

    • Innovative Technology Centre, University of Cambridge
    View abstract

    Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor

    Marcus Baumann, Ian R. Baxendale, Andreas Kirschning, Steven V. Ley*, Jens Wegner

    • Department of Chemistry, University of Cambridge
    View abstract

    KMnO4-Mediated Oxidation as a Continuous Flow Process

    Jorg Sedelmeier, Steven V. Ley, Ian R. Baxendale, Marcus Baumann

    • Innovative Technology Centre, University of Cambridge
    View abstract

    Flow synthesis of tricyclic spiropiperidines as building blocks for the histrionicotoxin family of alkaloids

    View abstract

    Effect of phase transfer chemistry, segmented fluid flow, and sonication on the synthesis of cinnamic esters

    Mauro Riccaboni, Elena La Porta, Andrea Martorana, Roberta Attanasio

    • Department of Medicinal Chemistry, NiKem Research Srl, Milan, Italy
    View abstract

    Continuous Flow Palladium(II)-Catalyzed Oxidative Heck Reactions with Arylboronic Acids

    Luke R. Odell1, Jonas Lindh1, Tomas Gustafsson2, Mats Larhed1*

    • 1Organic Pharmaceutical Chemistry, Department of MedChem, Uppsala University, Sweden
    • 2AstraZeneca R&D Mölndal, Sweden
    View abstract

    A flow-based synthesis of Imatinib: the API of Gleevec

    Mark D. Hopkin, Ian R. Baxendale, Steven V. Ley

    • Innovative Technology Centre, Department of Chemistry, University of Cambridge
    View abstract

    Reaction of Grignard reagents with carbonyl compounds under continuous flow conditions

    E. Riva1, S. Gagliardi2, M. Martinelli2, D. Passarella1, D. Vigo2, A. Rencurosi2

    • 1Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Milano, Italy
    • 2NiKem Research S.r.l., , Milan, Italy
    View abstract

    The application of flow microreactors to the preparation of a family of casein kinase I inhibitors

    Francesco Venturoni, Nikzad Nikbin, Steven V. Ley, Ian R. Baxendale

    • Innovative Technology Centre, Department of Chemistry, University of Cambridge
    View abstract

    A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT1B> Antagonist

    Zizheng Qian, Ian R. Baxendale, Steven V. Ley

    • Innovative Technology Centre, Department of Chemistry, University of Cambridge
    View abstract

    ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

    Catherine F. Carter1, Heiko Lange1, Steven V. Ley1, Ian R. Baxendale1, Brian Wittkamp2, Jon G. Goode3, Nigel L. Gaunt3

    • 1Innovative Technology Centre, Department of Chemistry, University of Cambridge
    • 2Mettler-Toledo AutoChem, USA
    • 3Mettler-Toledo AutoChem, UK
    View abstract

    A highly efficient flow reactor process for the synthesis of N-Boc-3,4-dehydro-l-proline methyl ester

    Lucia Tamborini, Paola Conti, Andrea Pinto, Carlo De Micheli

    • Dipartimento di Scienze Farmaceutiche ‘Pietro Pratesi’,
    • Università degli Studi di Milano, Italy
    View abstract

    [3+2] Dipolar cycloadditions of an unstabilised azomethine ylide under continuous flow conditions

    Mark Grafton, Andrew C. Mansfield, M. Jonathan

    • Pfizer Global Research and Development, Sandwich, UK
    View abstract

    Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of YneOnes and Their Use in Heterocycle Synthesis

    Ian R. Baxendale1, Søren C. Schou2, Jörg Sedelmeier1, Steven V. Ley1

    • 1ITC, Department of Chemistry, University of Cambridge
    • 2LEO Pharma, Medicinal Chemistry Research, Denmark
    View abstract

    A safe and reliable procedure for the iododeamination of aromatic and heteroaromatic amines in a continuous flow reactor

    Laia Malet-Sanz, Julia Madrzak, Rhian S. Holvey, Toby Underwood

    • Research Chemistry, Pfizer Global Research and Development, Sandwich, UK
    View abstract

    Development of fluorination methods using continuous-flow microreactors

    Marcus Baumann, Ian R. Baxendale, Laetitia J. Martin, Steven V. Ley

    • Innovative Technology Centre, Cambridge, UK
    View abstract

    Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles

    Ian R. Baxendale1, Steven V. Ley1, Andrew C. Mansfield2, Christopher D. Smith1

    • 1ITC, Department of Chemistry, University of Cambridge,
    • 2Pfizer Global R&D Research Centre, Sandwich, (UK)
    View abstract

    Efficient Continuous Flow Synthesis of Hydroxamic Acids and Suberoylanilide Hydroxamic Acid Preparation

    E. Riva1, S. Gagliardi2, Caterina Mazzoni2, M. Martinelli2, D. Passarella1, D. Vigo2, A. Rencurosi2

    • 1Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Italy
    • 2NiKem Research S.r.l., Milan, Italy
    View abstract

    A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor

    Ian R. Baxendale, Steven V. Ley, Christopher D. Smith, Lucia Tamborini, Ana-Florina Voica

    • Innovative Technology Centre, Cambridge, UK
    View abstract

    The Use of Diethylaminosulfur Trifluoride (DAST) for Fluorination in a Continuous-Flow Microreactor

    Baumann, Marcus, Baxendale, Ian R., Ley, Steven V.

    • Innovative Technology Centre, Cambridge, UK
    View abstract

    A modular flow reactor for performing Curtius rearrangements as a continuous flow process

    Marcus Baumann1, Ian R. Baxendale1, Steven V. Ley1, Nikzad Nikbin1, Christopher D. Smith1, Jason P. Tierney2

    • 1Innovative Technology Centre, Department of Chemistry, University of Cambridge
    • 2Neurology Lead Discovery Chemistry, GlaxoSmithKline R and D, Harlow, UK
    View abstract

    Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions

    Marcus Baumann, Ian R. Baxendale, Steven V. Ley, Nikzad Nikbin, Christopher D. Smith

    • Innovative Technology Centre, Cambridge, UK
    View abstract

    A Microcapillary Flow Disc Reactor for Organic Synthesis

    Christian H. Hornung1, Malcolm R. Mackley2, Ian R. Baxendale1, Steven V. Ley1

    • 1Department of Chemistry, University of Cambridge
    • 2Department of Chemical Engineering, University of Cambridge
    View abstract

    Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

    Christopher D. Smith, Ian Baxendale, Geoffrey Tranmer, Marcus Baumann, Stephen Smith, Russell Lewthwaite, Steven V. Ley

    • Department of Chemistry, University of Cambridge, UK
    View abstract

    [3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor

    Christopher D. Smith1, Ian R. Baxendale1, Steve Lanners1, John J. Hayward1, Steven V. Ley1, Stephen C. Smith2

    • 1Innovative Technology Centre, University of Cambridge, UK
    • 2Syngenta, Jealots Hill International Research Centre, UK
    View abstract

    Continuous Flow Ligand-Free Heck Reactions Using Monolithic Pd [0] Nanoparticles

    Nikzad Nikbin, Mark Ladlow, Steven V. Ley

    • Department of Chemistry, University of Cambridge, UK
    View abstract

    Fully Automated Flow-Through Synthesis of Secondary Sulfonamides in a Binary Reactor System

    Charlotte M. Griffiths-Jones, Mark D. Hopkin, Daniel Jönsson, Steven V. Ley, David J. Tapolczay, Emma Vickerstaffe, Mark Ladlow

    • GlaxoSmithKline Cambridge Technology Centre, Cambridge
    View abstract

    Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles

    Marcus Baumann, Ian R. Baxendale, Steven V. Ley, Christoper D. Smith, Geoffrey K. Tranmer

    • Innovative Technology Center, University of Cambridge
    View abstract

    A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

    Ian R. Baxendale, Steven V. Ley, Christopher D. Smith, Geoffrey K. Tranmer

    • Innovative Technology Centre, Cambridge, UK
    View abstract

    A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly

    Ian R. Baxendale, Jon Deeley, Charlotte M. Griffiths-Jones, Steven V. Ley, Steen Saaby, Geoffrey K. Tranmer

    • Innovative Technology Centre, University of Cambridge
    View abstract

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