Publications

    The Photochemical Mediated Ring Contraction of 4H-1,2,6-Thiadiazines To Afford 1,2,5-Thiadiazol-3(2H)-one 1-Oxides

    Emmanouil Broumidisa, Christopher G. Thomsona, Brendan Gallaghera, Lia Sotorríosa, Kenneth G. McKendricka, Stuart A. Macgregor*a, Martin J. Patersona, Janet E. Lovettb, Gareth O. Lloydc, Georgina M. Rosaira, Andreas S. Kalogiroud,e, Panayiotis A. Koutentis*e, and Filipe Vilela*a,f

    • aInstitute of Chemical Sciences, School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, United Kingdom
    • bSUPA School of Physics and Astronomy and BSRC, University of St Andrews, St. Andrews, KY16 9SS, United Kingdom
    • cJoseph Banks Laboratories, School of Chemistry, University of Lincoln, Brayford Pool, Lincoln LN6 7TS, United Kingdom
    • dDepartment of Life Sciences, School of Sciences, European University Cyprus, 6 Diogenes Str., Engomi, P.O. Box 22006, 1516 Nicosia, Cyprus
    • eDepartment of Chemistry, University of Cyprus, P.O. Box 20537, 1678 Nicosia Cyprus
    • fContinuum Flow Lab, School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, United Kingdom
    View abstract

    Development of a Continuous Flow Baldwin Rearrangement Process and Its Comparison to Traditional Batch Mode

    Arlene Bonnera, Marcus Baumanna

    • aSchool of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland D04 N2E2
    View abstract

    Continuous Flow Oxidation of Alcohols Using TEMPO/NaOCl for the Selective and Scalable Synthesis of Aldehydes

    Parth Naika, Jorge García-Lacunaa, Patrick O’Neillb, and Marcus Baumanna

    • aSchool of Chemistry, University College Dublin, Science Centre South, Belfield D04 N2E5, Ireland
    • bPfizer Ireland, Ringaskiddy P43 X336, Ireland
    View abstract

    Development of Continuous Flow Processes to Access Pyrrolo[2,1-f][1,2,4]triazin-4-amine: An RSM for the Synthesis of Antiviral Drugs

    Maksim Vasileva, Aravind S. Gangua, Praveen Gajulaa, Nathaniel D. Kaetzela, Vasudevan Natarajana, Bimbisar Desaia, Gopal Sirasania, Bo Qua, and Chris H. Senanayakea

    • aTCG GreenChem, Inc., 701 Charles Ewing Boulevard, Ewing, New Jersey 08628, United States
    View abstract

    Late-Stage C(sp2)–C(sp3) Diversification via Nickel Oxidative Addition Complexes

    Carlota Odena1,3, María Lourdes Linares4, Nahury Castellanos-Blanco1, Ryan T. McGuire1, Jose Manuel Alonso4, Alejandro Diéguez5, Eric Tan5, Jesús Alcázar4, Peter Buijnsters5 Santiago Cañellas4 and Ruben Martin1,2

    • 1Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Spain
    • 2ICREA, Passeig Lluïs Companys 23, 08010 Barcelona, Spain
    • 3Department de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, c/ Marcel·lí Domingo 1, 43007 Tarragona, Spain
    • 4Janssen Research and Development, Janssen-Cilag, S. A. c/ Rio Jarama 75, 45007 Toledo, Spain
    • 5Medicinal Chemistry, Janssen Pharmaceutica, N. V. B-2340 Beerse, Belgium
    View abstract

    Recent advances in photoredox catalytic transformations by using continuous-flow technology

    Xin Yuana, Hai-Bin Fana, Jie Liua, Long-Zhou Qina, Jian Wanga, Xiu Duana, Jiang-Kai Qiua,b, Kai Guoa,b

    • aCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, Jiangsu, China
    • bState Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211800, Jiangsu, China
    View abstract

    Metal-Free Addition of Alkyl Bromides to Access 3,3-Disubstituted Quinoxalinones Enabled by Visible-Light Photoredox Catalysis

    Jennie Liaoa, David N. Hunterb, Ugochinyere Nancy Oloyedeb, Joseph W. McLaughlinb, Cheng Wangb, and Abdellatif El Marrounib

    • aProcess Research & Development, MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States
    • bDiscovery Chemistry, MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States
    View abstract

    Direct Arylation of Thiophenes in Continuous Flow

    Alessandro Petronillia, Prof. Tommaso Carofiglioa and Dr. Paolo Zardia,b

    • aDepartment of Chemical Sciences, University of Padova, Via Francesco Marzolo 1, 35131 Padova, Italy
    • bDepartment of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi 103, 41125 Modena, Italy
    View abstract

    Metal-free synthesis of selenoesters directly from carboxylic acids using bifunctional selenoureas under batch and continuous-flow conditions

    Mouzma Mhatea, Chandra Sekhara Mahantaa, Devendra K. Dhakedb, Velyutham Ravichandirana and Sharada Prasanna Swaina

    • aDepartment of Medicinal Chemistry and Centre for Marine Therapeutics (CMT), National Institute of Pharmaceutical Education and Research-Kolkata, 168, Maniktala Main Road, Kolkata 700054, India
    • bDepartment of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research-Kolkata, 168, Maniktala Main Road, Kolkata 700054, India
    View abstract

    Continuous Flow Synthesis of Cycloparaphenylene Building‐Blocks on a Large Scale

    Jan H. Griwatza,b, Mika L. Kesslera, Hermann A. Wegnera,b

    • aInstitute of Organic Chemistry, Justus Liebig University Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany
    • bCenter for Materials Research, Justus Liebig University Giessen, Heinrich-Buff-Ring 16, 35392 Giessen, Germany
    View abstract

    Continuous Flow Chemistry: A Novel Technology for the Synthesis of Marine Drugs

    Laura F. Peñaa, Paula González-Andrésa, Lucía G. Partea, Raúl Escribanoa, Javier Guerraa, Asunción Barberoa and Enol Lópeza

    • aDepartment of Organic Chemistry, Campus Miguel Delibes, University of Valladolid, 47011 Valladolid, Spain
    View abstract

    Visible-Light-Mediated TiO2-Catalyzed Aerobic Dehydrogenation of N-Heterocycles in Batch and Flow

    Junghoon Noha, Jun-Young Choa, Mincheol Parkb, and Boyoung Y. Parka

    • aDepartment of Fundamental Pharmaceutical Science, Kyung Hee University, Seoul 02447, South Korea
    • bDepartment of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, South Korea
    View abstract

    Continuous flow synthesis of pyridinium salts accelerated by multi-objective Bayesian optimization with active learning

    John H. Dunlapab, Jeffrey G. Ethierab, Amelia A. Putnam-Neeb ac, Sanjay Iyerd, Shao-Xiong Lennon Luoe, Haosheng Fenge, Jose Antonio Garrido Torresf, Abigail G. Doyleg, Timothy M. Swagere, Richard A. Vaiaa, Peter Miraua, Christopher A. Crousea and Luke A. Baldwina

    • aMaterials and Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson AFB, OH 45433, USA.
    • bUES, Inc., Dayton, OH 45431, USA
    • cNational Research Council Research Associate, Air Force Research Laboratory, Wright-Patterson AFB, OH 45433, USA
    • dDepartment of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    • eDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    • fDepartment of Chemistry, Princeton University, Princeton, NJ 08544, USA
    • gDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA
    View abstract

    Liquid/liquid heterogeneous reaction monitoring: Insights into biphasic Suzuki-Miyaura cross-coupling

    Yusuke Sato1, Junliang Liu1, Ikenna Edward Ndukwe2, Maria Victoria Silva Elipe2, Daniel J. Griffin3, James I. Murray4,5, Jason E. Hein1,5,6,7

    • 1Department of Chemistry, The University of British Columbia, Vancouver, BC V6T 1Z1, Canada
    • 2Pivotal Attribute Sciences, Drug Substance Technologies, Amgen, Inc., Thousand Oaks, CA 91320, USA
    • 3Pivotal and Commercial Synthetics, Drug Substance Technologies, Amgen, Inc., Cambridge, MA 02142, USA
    • 4Pivotal and Commercial Synthetics, Drug Substance Technologies, Amgen, Inc., Thousand Oaks, CA 91320, USA
    • 5Acceleration Consortium, University of Toronto, Toronto, ON, Canada
    • 6Department of Chemistry, University of Bergen, Bergen, Norway
    View abstract

    Shining a Light on the Advances, Challenges and Realisation of Utilising Photoredox Catalysis in Pharmaceutical Development

    Dr. Emily E. Callard-Langdona, Dr. Alan Stevena, Dr. Rachel J. Kahana

    • aCatSci Ltd, CBTC2, Capital Business Park, Wentloog, Cardiff, CF3 2PX UK
    View abstract

    Modular Photochemical Flow Synthesis of Structurally Diverse Benzyne and Triazine Precursors

    Jorge García-Lacunaa, Marcus Baumanna

    • aSchool of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Dublin, Ireland
    View abstract

    Research Activities at Faculty of Chemical Technology, Hanoi University of Industry – 20 Years of Growth and Development

    Tuan Anh Nguyena, The Huu Nguyena, Van Dong Phama, Minh Tan Vua, Thi Mai Huong Phama

    • aHanoi University of Industry, 298 Cau Dien Street, Bac Tu Liem District, Hanoi, 10000 Viet Nam
    View abstract

    Metabolite Changes of Perna canaliculus Following a Laboratory Marine Heatwave Exposure: Insights from Metabolomic Analyses

    Awanis Azizan1, Leonie Venter1, Peet J. Jansen van Rensburg2, Jessica A. Ericson3, Norman L. C. Ragg3 and Andrea C. Alfaro1

    • 1Aquaculture Biotechnology Research Group, School of Science, Auckland University of Technology, Private Bag 92006, Auckland 1142, New Zealand
    • 2Human Metabolomics, North-West University, Potchefstroom 2520, South Africa
    • 1Cawthron Institute, Private Bag 2, Nelson 7042, New Zealand
    View abstract

    Combining Tailored Ionic Liquids with Ti3C2Tx MXenes for an Enhanced Load-Carrying Capacity Under Boundary Lubrication

    Philipp G. Grützmachera, Roman Neuhausera, Kristof Stagelb, Katharina Bica-Schröderb, Guido Boidic, Carsten Gachota, Andreas Rosenkranzd

    • aInstitute for Engineering Design and Product Development Research Unit Tribology E307-05, TU Wien, 1060 Vienna, Austria
    • bInstitut für Angewandte Synthesechemie (IAS), Sustainable Organic Synthesis and Catalysis research group, TU Wien, 1060 Vienna, Austria
    • cAC2T research GmbHViktor-Kaplan-Straße 2/C, 2700 Wiener Neustadt, Austria
    • dDepartment of Chemical Engineering, Biotechnology and Materials (FCFM), Universidad de Chile, Santiago 8370448, Chile
    View abstract

    An all-in-one multipurpose robotic platform for the self-optimization, intensification and scale-up of photocatalysis in flow

    Aidan Slatterya,Zhenghui Wena, Pauline Tenblada, Diego Pintossia, Jesus Sanjose-Ordunaa, Tim den Hartoga, b, c, Timothy Noela

    • aFlow Chemistry Group, van ’t Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
    • bZuyd University of Applied Sciences, Nieuw Eyckholt 300, 6419 DJ Heerlen, The Netherlands
    • cThe Netherlands Organisation for Applied Scientific Research (TNO), High Tech Campus 25, 5656AE Eindhoven, The Netherlands
    View abstract

    Multi-platform synthesis of ondansetron featuring process intensification in flow

    Yoshio Hatoa,b, Timothy F. Jamisona

    • aDepartment of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    • bShionogi Pharmaceutical Research Center, Shionogi & Co., Ltd., Toyonaka, Osaka 561-0825, Japan
    View abstract

    Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations

    Liang Changa, Shun Wangb, Qing Anb, Linxuan Liub, Hexiang Wangb, Yubo Lib, Kaixuan Fengb and Zhiwei Zuob

    • aSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
    • bState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
    View abstract

    Photo- and Electrochemical Cobalt Catalysed Hydrogen Atom Transfer for the Hydrofunctionalisation of Alkenes

    Samikshan Jana1, Victor Jose Mayerhofer1, Christopher Teskey2

    • 1RWTH: Rheinisch-Westfalische Technische Hochschule Aachen, Institute of Organic Chemistry, GERMANY
    • 2RWTH Aachen: Rheinisch-Westfalische Technische Hochschule Aachen, Institute of Organic Chemistry, Landoltweg 1, 52074, Aachen, GERMANY
    View abstract

    The α-alkylation of ketones in flow

    Ella Coopera, Emma Alcocka, Mark Powera, Gerard McGlackena

    • aSchool of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, T12 YN60 Cork, Ireland
    View abstract

    Continuous Flow Synthesis of Cyclobutenes Using LED Technology

    Megan Smytha, Thomas S Moodya,b, Scott Wharrya, Marcus Baumannc

    • aBiocatalysis group, Almac Sciences Ltd, Craigavon, United Kingdom of Great Britain and Northern Ireland
    • bManufacturing, Arran Chemical Company, Athlone, Ireland
    • bChemistry, University of Durham, Durham, United Kingdom of Great Britain and Northern Ireland
    View abstract

    Accelerated Chemical Reaction Optimization Using Multi-Task Learning

    Connor J. Taylor*a,b, Kobi C. Feltonc, Daniel Wighb,c, Mohammed I. Jeraald, Rachel Graingera, Gianni Chessaria, Christopher N. Johnsona, and Alexei A. Lapkin*b,c,d

    • aAstex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge, CB4 0QA, United Kingdom
    • bInnovation Centre in Digital Molecular Technologies, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom
    • cDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, United Kingdom
    • dCambridge Centre for Advanced Research and Education in Singapore Ltd., 1 Create Way, CREATE Tower #05-05, 138602, Singapore
    View abstract

    Efficient degassing and ppm-level oxygen monitoring flow chemistry system

    Paulius Baronasa, Jacob Lynge Elholma, Kasper Moth-Poulsena,b,c,d

    • aThe Institute of Materials Science of Barcelona, ICMAB-CSIC, Bellaterra, 08193, Barcelona, Spain
    • bCatalan Institution for Research & Advanced Studies, ICREA, Pg. Lluís Companys 23, 08010 Barcelona, Spain
    • cDepartment of Chemical Engineering, Universitat Politècnica de Catalunya, EEBE, Eduard Maristany 10–14, 08019 Barcelona, Spain
    • dChalmers University of Technology, Department of Chemistry and Chemical Engineering. SE-412 96 Gothenburg, Sweden
    View abstract

    Photo-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds

    Antonella Ilenia Alfanoa, Sveva Pellicciaa, Giacomo Rossinob, Orazio Chianesec, Vincenzo Summaa, Simona Collinab, and Margherita Brindisia

    • aDepartment of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy
    • bDepartment of Drug Sciences, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy
    • cGenetic S.p.A., Via Canfora, 64, 84084 Fisciano (Salerno), Italy
    View abstract

    Boronic Acids and Their Derivatives as Continuous-Flow-Friendly Alkyl Radical Precursors

    Monica Olivaa, Viktoriia V. Chernobrovkinab, Erik V. Van der Eyckena,b, Upendra Kumar Sharmaa

    • aLaboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, 3001 Leuven, Belgium
    • bPeoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya street 6, 117198 Moscow, Russia
    View abstract

    Advances in continuous polymer analysis in flow with application towards biopolymers

    Samuel B. H. Pattersona, Raymond Wongb, Graeme Barkera & Filipe Vilelaa

    • aSchool of Engineering and Physical Sciences, Institute of Chemical Sciences, Heriot Watt University, Edinburgh, EH14 4AS, UK
    • bShimadzu Centre of Excellence, Milton Keynes, UK
    View abstract

    Continuous Flow-Facilitated CB2 Agonist Synthesis, Part 1: Azidation and [3 + 2] Cycloaddition

    Peter Sagmeistera,b, Michael Prieschla,b, Dainis Kaldrec, Chethana Gadiyard, Christian Moessnerc, Joerg Sedelmeierc, Jason D. Williamsa,b, and C. Oliver Kappea,b

    • aCenter for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, AustriaM/li> bInstitute of Chemistry, NAWI Graz, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria
    • cDepartment of Process Chemistry & Catalysis, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland
    • dDepartment of Solid State Sciences, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland
    View abstract

    Continuous Flow-Facilitated CB2 Agonist Synthesis, Part 2: Cyclization, Chlorination, and Amination

    Michael Prieschla,b, Peter Sagmeistera,b, Christian Moessnerc, Joerg Sedelmeierc, Jason D. Williamsa,b, and C. Oliver Kappea,b

    • aCenter for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria
    • bInstitute of Chemistry, NAWI Graz, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria
    • cDepartment of Process Chemistry & Catalysis, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland
    View abstract

    Flow Electrochemistry for the N-Nitrosation of Secondary Amines

    Rojan Alia, Dr. Rasool Babaahmadia, Dr. Matthew Didsburyb, Dr. Rebecca Stephensb, Prof. Rebecca L. Melena, Prof. Thomas Wirtha

    • aSchool of Chemistry, Cardiff University, Park Place, Main Building, Cardiff, CF10 3AT UK
    • bBAE Systems, Glascoed, Usk, Monmouthshire, NP15 1XL UK
    View abstract

    Alkene reactions with superoxide radical anions in flow electrochemistry

    Rojan Alia, Tuhin Patraa and Thomas Wirtha

    • aSchool of Chemistry, Cardiff University, Park Place, Main Building, Cardiff CF10 3AT (UK)
    View abstract

    Antimicrobial Evaluation of New Pyrazoles, Indazoles and Pyrazolines Prepared in Continuous Flow Mode

    Adam Burke1, Mara Di Filippo1, Silvia Spiccio1, Anna Maria Schito2, Debora Caviglia2,3, Chiara Brullo3, Marcus Baumann1

    • 1Science Centre South, School of Chemistry, University College Dublin, Dublin 4, Ireland
    • 2Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, 16132 Genoa, Italy
    • 3Section of Medicinal Chemistry, Department of Pharmacy (DIFAR), University of Genoa, 16132 Genoa, Italy
    View abstract

    Photochemical Synthesis of Pyrazolines from Tetrazoles in Flow

    Adam Burkea, Silvia Spiccioa, Mara Di Filippoa, Marcus Baumanna

    • aSchool of Chemistry, University College Dublin, Science Centre South, D04 N2E2, Dublin, Ireland
    View abstract

    Continuous Flow Inter- and Intramolecular Macrolactonization under High Dilution Conditions

    Dashrat Vishambar Sutara, Neha Uttamrao Saranga, Akash Bandu Jamdadea, Boopathy Gnanaprakasama

    • aDepartment of Chemistry, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pashan, Pune 411008, India
    View abstract

    Visible-Light Photoredox-Catalyzed Giese Reaction of α-Silyl Ethers with Various Michael Acceptors

    Young Woo Kanga, Ran Hui Kima, Shafrizal Rasyid Atriardia, Sang Kook Wooa

    • aDepartment of Chemistry, University of Ulsan, 93 Daehak-Ro, Nam-Gu, Ulsan 44610, Korea
    View abstract

    Skeletal Editing Approach to Bridge-Functionalized Bicyclo[1.1.1]pentanes from Aza-Bicyclo[2.1.1]hexanes

    Brandon A. Wright1, Anastassia Matviitsuk2, Michael J. Black1, Pablo García-Reynaga2, Luke E. Hanna2, Aaron T. Herrmann2, Michael K. Ameriks2, Richmond Sarpong1, Terry P. Lebold2

    • 1Department of Chemistry, University of California, Berkeley, California 94720, United States
    • 2Janssen Research and Development, San Diego, California 92121, United States
    View abstract

    Visible-Light Photocatalysis Academic–Industrial Collaboration Retrospective: Shared Learning and Impact Analysis

    Kevin P. Colea, James J. Douglasa,b, Travis Hammerstadb, Corey R. J. Stephensonb

    • aSynthetic Molecule Design and Development, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States
    • bDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States
    View abstract

    Catalytic multi-step continuous-flow processes for scalable transformation of eugenol into potential fragrances

    Fábio M.S. Rodriguesa, Vitaliy Masliya, Madalena F.C. Silvaa, Alexandre P. Felgueirasa, Rui M.B. Carrilhoa, Mariette M. Pereiraa

    • aUniversity of Coimbra, Coimbra Chemistry Centre, Department of Chemistry, Rua Larga, 3004-535 Coimbra, Portugal
    View abstract

    Development and optimization of a continuous flow ester reduction with LiAlH4 in the synthesis of a key intermediate for a PI3Kδ inhibitor (CPL302415)

    Stanisław Michałeka,b, Anna M. Maja, Lidia Gurba-Bryśkiewicza, Wioleta Maruszaka, Marcin Zagozdaa, Zbigniew Ochalb, Krzysztof Dubiela, Maciej Wieczoreka

    • aCelon Pharma S.A., ul. Marymoncka 15, 05-152 Kazuń Nowy, Poland
    • bFaculty of Chemistry, Warsaw University of Technology, ul. Noakowskiego 3, 00-664 Warsaw, Poland
    View abstract

    Lipase-Mediated Synthesis of Oleoyl Ethanolamide Starting from High-Oleic Sunflower Oil Soapstock

    Elisabetta Brennaa, Valeria De Fabritiisa, Fabio Parmeggiania, Francesca Tentoria, Davide Tessaroa

    • aDipartimento di Chimica, Materiali ed Ingegneria Chimica “Giulio Natta”, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milano, Italy
    View abstract

    Continuous-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds

    Antonella Ilenia Alfanoa, Sveva Pellicciaa, Giacomo Rossinob, Orazio Chianesec, Vincenzo Summaa, Simona Collinab, and Margherita Brindisia

    • aDepartment of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131, Naples, Italy
    • bDepartment of Drug Sciences, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy
    • cGenetic S.p.A., Via Canfora, 64, 84084 Fisciano (Salerno), Italy
    View abstract

    Continuous Flow Synthesis of Substituted 3, 4-Propylenedioxythiophene Derivatives

    Dattatray L. Tarangea, Nagaraj Nayaka, Anil Kumara

    • aDepartment of Chemistry, Indian Institute of Technology-Bombay (IITB), Powai, Mumbai 400076, India
    View abstract

    Flow photochemistry — from microreactors to large-scale processing

    Mengxue Zhanga, Philippe Rotha

    • aCorning SAS, 7 bis avenue de Valvins, CS 70156 Samois sur Seine, 77215 Avon Cedex, France
    View abstract

    Continuous-flow photochemistry as an automated platform integrated with closed-loop AI/ML approaches

    Brenda Pijper1, Jesus Alcázar1, Gabriela Oksdath-Mansilla2, Fabricio Román Bisogno2

    • 1Discovery Chemistry, Janssen, Pharmaceutical Companies of Johnson and Johnson, Janssen-Cilag, S.A., Calle Río Jarama 75A, 45007 Toledo, Spain
    • 2INFIQC-CONICET-UNC, Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, X5000HUA Córdoba, Argentina
    View abstract

    Laboratory Scale Continuous Flow Systems for the Enantioselective Phase Transfer Catalytic Synthesis of Quaternary Amino Acids

    Milena Krstić1, Sergio Rossi1, Miguel Sanz2, Alessandra Puglisi1

    • 1Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy
    • 2Taros Chemicals, GmbH & Co. KG Emil-Figge-Str 76a, 44227 Dortmund, Germany
    View abstract

    Continuous Flow Synthesis of Non-Symmetrical Ureas from CO2

    Alexandre Labichea, Maylis Norlöffa, Dr. Sophie Feuillastrea, Dr. Frederic Tarana, Dr. Davide Audisioa

    • aUniversité Paris Saclay, CEA, Département Médicaments et Technologies pour la Santé, SCBM, 91191 Gif-sur-Yvette, France
    View abstract

    Flow photochemical Giese reaction via silane-mediated activation of alkyl bromides

    Fabiola Faniniab, Alberto Luridianaa, Daniele Mazzarellaac, Antonella Ilenia Alfanoad, Perryvan der Heidea, Juan A. Rincóne, Pablo García-Losadae, Carlos Mateose, Michael O. Frederickf, Manuel Nuñog, Timothy Noëla

    • aFlow Chemistry Group, Van ’t Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam Science Park 904, 1098 XH Amsterdam, The Netherlands
    • bDepartment of Biomolecular Sciences, University of Urbino “Carlo Bo”, Piazza Rinascimento 6, I-61029 Urbino, Italy
    • cDepartment of Chemical Sciences, University of Padova Institution, Via Francesco Marzolo, 1, 35131 Padova, Italy
    • dDepartment of Pharmacy, Department of Excellence 2018-2022, School of Medicine and Surgery, University of Naples “Federico II”, Via D. Montesano 49, I-80131 Naples, Italy
    • eCentro de Investigación Lilly S.A., Avda. de la Industria 30, Alcobendas-Madrid 28108, Spain
    • fSmall Molecule Design and Development, Eli Lilly and Company, Indianapolis, IN 46285, United States
    • gVapourtec Ltd. Park Farm Business Centre, Fornham St Genevieve, Bury St Edmunds, Suffolk IP28 6TS, United Kingdom
    View abstract

    Generation of 1,2-Difluorobenzene via a Photochemical Fluorodediazoniation Step in a Continuous Flow Mode

    Kevin Simonab, Desiree Znidarab, Julien Boutetc, Gérard Guillamotc, Jean-Yves Lenoirc, Doris Dallingerab, and C. Oliver Kappeab

    • aCenter for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, Graz 8010, Austria
    • bInstitute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, Graz 8010, Austria
    • cSeqens SAS, 21 Chemin de la Sauvegarde, 21 Ecully Parc, Ecully 69130, France
    View abstract

    Continuous flow synthesis of phenyl glucosazone and its conversion to 2H-1,2,3-Triazole building blocks

    Maria Molnara, Marcus Baumanna

    • aSchool of Chemistry, Science Centre South, University College Dublin, Dublin, D04 N2E2, Ireland
    View abstract

    Continuous Flow Epoxidation of Alkenes Using a Homogeneous Manganese Catalyst with Peracetic Acid

    Ailbhe A. Ryanabc, Seán D. Dempseyabc, Megan Smytha, Karen Faheyb, Thomas S. Moodyab, Scott Wharrya, Paul Dingwallc, David W. Rooneyc, Jillian M. Thompsonc, Peter C. Knipec, and Mark J. Muldoonc

    • aAlmac Group, Craigavon BT63 5QD, United Kingdom
    • bArran Chemical Company, Roscommon N37 DN24, Ireland
    • cQueen’s University Belfast, Belfast BT9 5AG, United Kingdom
    View abstract

    The applications of organozinc reagents in continuous flow chemistry: Negishi coupling

    Roop Varghese Ruberta, Rony Rajan Paula

    • aDepartment of Chemistry, CMS College Kottayam, Kottayam, Kerala, 686001, India
    View abstract

    Alternate end-game strategies towards Nirmatrelvir synthesis: Defining a continuous flow process for the preparation of an anti-COVID drug

    Karuna Veeramania, Manish Shindea, Vishnuvardhana Vema Reddy Edab, Bala Chennaiah Darapanenib, Rama Mohan Hindupurc, Srinivasa Rao Madarapuc, Saikat Senb, Srinivas Orugantib

    • a10X Chemical Process Automation Laboratory, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, Telangana, India
    • bCentre for Process Research and Innovation, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, Telangana, India
    • cAurigene Pharmaceutical Services Limited, JP Nagar Road, Miyapur, Hyderabad 500 049, Telangana, India
    View abstract

    Iron-catalyzed [4 + 2] annulation of amidines with α,β-unsaturated ketoxime acetates toward 2,4,6-trisubstituted pyrimidines

    Qinghuan Wua, Luchao Lia, Binyan Xua, Jie Suna, Dong Jib, Yuguang Lib, Lei Shenb, Zheng Fanga, Jindian Duana, Beining Chenc, Kai Guoa

    • aCollege of Biotechnology and Pharmaceutical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China
    • bInstitute of Nanjing Advanced Biomaterials & Processing Equipment, Nanjing, 211299, China
    • cDepartment of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK
    View abstract

    Visible-Light Photoredox Catalysis for the Synthesis of Fluorinated Aromatic Compounds

    Tomasz Kliśa

    • aFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland
    View abstract

    Process intensification of dendritic fibrous nanospheres of silica (DFNS) via continuous flow: a scalable and sustainable alternative to the conventional batch synthesis

    Karuna Veeramaniabc, Nagaraj Nayaka, Neil R. Cameronc, Anil Kumar*a

    • aDepartment of Chemistry, Indian Institute of Technology-Bombay (IITB), Powai, Mumbai-400076, India
    • bIITB-Monash Research Academy, Indian Institute of Technology-Bombay (IITB), Powai, Mumbai-400076, India
    • cIITB-Monash Research Academy, Indian Institute of Technology-Bombay (IITB), Powai, Mumbai-400076, India
    View abstract

    Continuous-flow Fe-zeolite-catalyzed temperature-directed synthesis of bioactive tetraketones and xanthenes using epoxides and cyclic-1,3-diketones via a Meinwald rearrangement

    Shankhajit Mondala, Akanksha M. Pandeya, Boopathy Gnanaprakasama

    • aDepartment of Chemistry, Indian Institute of Science Education and Research (IISER) Pune, Dr. Homi Bhabha Road, Pune 411008, Maharashtra, India
    View abstract

    Development of an automated platform for C(sp3)-C(sp3) bond formation via XAT chemistry

    Brenda Pijpera, Irini Abdiaja, Daniele Leonorib, Jesus Alcázara

    • aJanssen Cilag SA, Discovery Chemistry, Jarama 75A, 45007 Toledo, SPAIN
    • bRWTH Aachen, Institute of Organic Chemistry, GERMANY
    View abstract

    Photochemical Synthesis of Pyrazolines from Tetrazoles in Flow

    Adam Burkea, Silvia Spiccioa, Mara Di Filippoa, Marcus Baumannb

    • aChemistry, University College Dublin, Dublin, Ireland
    • bChemistry, University of Durham, Durham, United Kingdom of Great Britain and Northern Ireland
    View abstract

    Continuous Process to Safely Manufacture an Aryldiazoacetate and Its Direct Use in a Dirhodium-Catalyzed Enantioselective Cyclopropanation

    Stephen P. Lathropa, Laurie B. Mlinara, Onkar N. Manjrekara, Yong Zhoua, Kaid C. Harpera, Eric R. Saciaa, Molly Higginsa, Andrew R. Bogdanb, Zhe Wanga, Steven M. Richtera, Wei Gongc, Eric A. Voightc, Jeremy Henlea, Moiz Diwana, Jeffrey M. Kallemeyna, Jack C. Sharlandd, Bo Weid, and Huw M. L. Daviesd

    • aProcess Research and Development, AbbVie Inc., North Chicago, Illinois 60064, United States
    • bAdvanced Chemistry Technologies, AbbVie Inc., North Chicago, Illinois 60064, United States
    • cDrug Discovery Science & Technology, AbbVie Inc., North Chicago, Illinois 60064, United States
    • dDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States
    View abstract

    Multicompartment polymeric colloids from functional precursor Microgel: Synthesis in continuous process

    • aDWI – Leibniz-Institute for Interactive Materials e.V, Forckenbeckstraße 50, 52074 Aachen, Germany
    • bInstitute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 2, 52074 Aachen, Germany
    • cAachen-Maastricht Institute for Biobased Materials (AMIBM), Maastricht University, Urmonderbaan 22, 6167 RD Geleen, The Netherlands
    • dZuyd University of Applied Sciences, Nieuw Eyckholt 300, 6419 DJ Heerlen, The Netherlands
    • eJülich Centre for Neutron Science (JCNS-1), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straβe, 52428 Jülich, Germany
    • fCNRS, UMR 8232 – IPCM – Institut Parisien de Chimie Moléculaire – Polymer Chemistry Team, Sorbonne Université, 4 Pl. Jussieu, 75005 Paris, France
    View abstract

    TBADT-Mediated C-C Bond Formation Exploiting Aryl Aldehydes in a Photochemical Flow Reactor

    Adam Cruisea, Marcus Baumanna

    • aUniversity College Dublin, School Of Chemistry, Science Centre - South, Dublin 4 Belfield, IRELAND
    View abstract

    Synthesis of picramide using nitration and ammonolysis in continuous flow

    Ankit Kumar Mittala, Gaurav Prakasha, Pramod Pathaka, Debabrata Maitia

    • aIndian Institute of Technology Bombay, Chemistry, INDIA
    View abstract

    End-to-End Automated Synthesis of C(sp3)-Enriched Drug-like Molecules via Negishi Coupling and Novel, Automated Liquid–Liquid Extraction

    Irini Abdiaja, Santiago Cañellasa, Alejandro Diegueza, Maria Lourdes Linaresa, Brenda Pijpera, Alberto Fontanaa, Raquel Rodrigueza, Andres Trabancoa, Eduardo Palaoa, Jesus Alcázar*a

    • aDiscovery Chemistry, Janssen Research and Development, Janssen-Cilag, S.A., C/ Jarama 75, E-45007Toledo, Spain
    View abstract

    Flow platform for the synthesis of benzodiazepines

    Maria Ivanovaa, Thomas Poissona, Philippe Jubaulta, Julien Legrosa

    • aNormandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA, 76000, Rouen, France
    View abstract

    Mimicking natural metabolisms: cell‐free flow preparation of dopamine

    Silvia Donzellaa, Agostina Colaciccoa, Luca Nespolia, Dr. Martina L. Contentea

    • aDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria, 2, 20133 Milan, Italy
    View abstract

    Improving the Sustainability and Safety of Ursodeoxycholic Acid Synthesis in Continuous Flow Process with Water

    Hahyeon Kima, Jonghyun Leeb, Seung Jae Leec, Jeong Eun Oha, Soo Dong Kima, Yashwardhan R. Malpanic, Ye-Jin Hwangd

    • aDepartment of Biomedical and Pharmaceutical Science, Kyung Hee University, 26 Kyughee-daero, Dongdaemun-gu, Seoul 02447, Republic of Korea
    • bDepartment of Basic Pharmaceutical Science, College of Pharmacy, Kyung Hee University, 26 Kyughee-daero, Dongdaemun-gu, Seoul 02447, Republic of Korea
    • cAPI Synthesis Team, Daewoong-Bio, 29-Jeyakdanji-ro, Hyangnam-eup, Hwaseung-si, Hyeonggi-do 18608, Republic of Korea
    • dDepartment of Chemistry and Chemical Engineering, Education and Research Center for Smart energy and Materials, Inha University 100 Inha-ro, Michugol-gu, Incheon, Republic of Korea
    View abstract

    The design of experiments (DoE) in optimization of an aerobic flow Pd-catalyzed oxidation of alcohol towards an important aldehyde precursor in the synthesis of phosphatidylinositide 3-kinase inhibitor (CPL302415)

    Stanisław Michałeka,b, Lidia Gurba-Bryśkiewicza, Wioleta Maruszaka, Marcin Zagozdaa, Anna M. Maja, Zbigniew Ochalb, Krzysztof Dubiela, Maciej Wieczoreka

    • aCelon Pharma S.A., Ul. Marymoncka 15, 05-152 Kazuń Nowy, Poland
    • bFaculty of Chemistry, Warsaw University of Technology, Ul. Noakowskiego 3, 00-664 Warsaw, Poland
    View abstract

    Exploring Visible Light for Carbon–Nitrogen and Carbon–Oxygen Bond Formation via Nickel Catalysis

    Shengqing Zhua, Huan Lia, Yingying LIa, Zhonghou HUANGa, Lingling Chua

    • aState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Center for Advanced Low-Dimension Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China
    View abstract

    Consecutive photochemical reactions enabled by a dual flow reactor coil strategy

    Ruairi Crawforda, Mara Di Filippoa, Duncan Guthrieb, Marcus Baumanna

    • aSchool of Chemistry, Science Centre South, University College Dublin, D04 N2E2, Dublin, Ireland
    • bVapourtec, Fornham St Genevieve, Bury St Edmunds, Suffolk, IP28 6TS, UKM
    View abstract

    Spheroplasts preparation boosts the catalytic potential of a squalene-hopene cyclase

    Ana I. Benítez-Mateosa, Andreas Schneider, Eimear Hegartya, Bernhard Hauer, Francesca Paradisia

    • aDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012, Bern, Switzerland
    • bInstitute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart-Vaihingen, Germany
    View abstract

    Membrane-based TBADT recovery as a strategy to increase the sustainability of continuous-flow photocatalytic HAT transformations

    Zhenghui Wena, Diego Pintossia, Manuel Nuñob, Timothy Noëla

    • aFlow Chemistry Group, Van ‘t Hoff Institute for Molecular Sciences, Faculty of Science, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands
    • bVapourtec Ltd., Park Farm Business Centre, Fornham St Genevieve, Bury St Edmunds, Suffolk, IP28 6TS, UK
    View abstract

    Two-Step Continuous-Flow Synthesis of 6-Membered Cyclic Iodonium Salts via Anodic Oxidation

    Julian Spils1, Thomas Wirth2, Boris J. Nachtsheim1

    • 1Institute for Organic and Analytical Chemistry, University of Bremen, Leobener Straße 7, 28359 Bremen 2School of Chemistry, Cardiff University, Park Place, Main Building, Cardiff CF10 3AT (UK)
    View abstract

    Development of a flow process for an easy and fast access to 2-pyrone derivatives

    Grazia Isa C. Righettia, Francesca Tentoria, Elisabetta Brennaa, Cristian Gambarottia

    • aDepartment of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy
    View abstract

    Intraligand Charge Transfer Enables Visible-Light-Mediated Nickel-Catalyzed Cross-Coupling Reactions

    Cristian Cavedona,b, Sebastian Gisbertza,b,Susanne Reischauera,b, Sarah Voglc, Eric Sperlichd, John H. Burkee, Rachel F. Wallicke, Stefanie Schrottkef, Wei-Hsin Hsua, Lucia Anghileria,b, Yannik Pfeiferd, Noah Richtera, Christian Teutlofff, Henrike Müller-Werkmeisterd, Dario Cambiéa, Peter H. Seebergera,b, Josh Vura-Weise, Renske M. van der Veene,g, Arne Thomasc, Bartholomäus Piebera

    • aDepartment of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany
    • bDepartment of Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195 Berlin, Germany
    • cDepartment of Chemistry, Functional Materials, Technische Universität Berlin, Hardenbergstraße 40, 10623 Berlin, Germany
    • dInstitute of Chemistry, University of Potsdam, Karl-Liebknecht-Strasse 24–25, 14476 Potsdam, Germany
    • eDepartment of Chemistry, University of Illinois Urbana-Champaign, Urbana, Illinois, 61801 USA
    • fDepartment of Physics, Freie Universität Berlin, Arnimallee 22, 14195 Berlin, Germany
    • gHelmholtz Zentrum Berlin für Materialien und Energie GmbH, Hahn-Meitner-Platz 1, 14109 Berlin, Germany
    View abstract

    A practical flow synthesis of 1,2,3-triazoles

    Dawid Drelinkiewicza, Richard J. Whitbya

    • aSchool of Chemistry, Faculty of Engineering and Physical Sciences, The University of Southampton, Southampton, UK
    View abstract

    A simple one-pot oxidation protocol for the synthesis of dehydrohedione from Hedione

    James S. Sharleya, Guido Gambacortaa, Ana María Collado Pérezb, Estela Espinos Ferrib, Amadeo Fernandez Mirandab, Isabelle Fernández Fernándezb, Jorge Sanchez Quesadab, Ian R.Baxendalea

    • aDepartment of Chemistry, University of Durham, South Road, Durham, DH1 3LE, United Kingdom
    • bInternational Flavours & Fragrances Inc., Avda Felipe Klein 2, 12580, Benicarló, Castellón, Spain
    View abstract

    Self-healing and polymer welding of soft and stiff epoxy thermosets via silanolates

    Amelia A. Putnam-Neeba, Jordan M. Kaisera,b, Amber M. Hubbarda, Dayton P. Streeta, Matthew B. Dickersona, Dhriti Nepala, Luke A. Baldwina

    • aAir Force Research Laboratory, Wright Patterson Air Force Base, Dayton, OH, 45433, USA
    • bUES, Inc, Dayton, OH, 45432, USA
    View abstract

    Multicomponent Direct Assembly of N-Heterospirocycles Facilitated by Visible-Light-Driven Photocatalysis

    Oliver M. Griffithsa, Steven V. Leya

    • aYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
    View abstract

    Scalable synthesis of favipiravir via conventional and continuous flow chemistry

    Thanat Tiyasakulchaia, Netnapa Charoensetakula, Thitiphong Khamkhenshorngphanuchb, Chawanee Thongpanchangaa, Onsiri Srikunc, Yongyuth Yuthavonga, Nitipol Srimongkolpithaka

    • aNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand
    • bDepartment of General Education, Faculty of Science and Health Technology, Navamindradhiraj University, Bangkok, Thailand
    • cGovernment Pharmaceutical Organization (GPO), Bangkok, Thailand
    View abstract

    Merging dual photoredox/cobalt catalysis and boronic acid (derivatives) activation for the Minisci reaction

    Serena Pillitteria, Prabhat Ranjanb, Gerardo M. Ojeda-Carraleroa,c, Laura Y. Vázquez Amayaa, Javier E. Alfonso-Ramosd, Erik V. Van der Eyckena,e, Upendra K. Sharmaa

    • aLaboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001 Leuven, Belgium
    • bAachen Maastricht Institute for Biobased Materials (AMIBM), Maastricht University, Urmonderbaan 22, 6167 RD Geleen, The Netherlands
    • cDepartment of General and Inorganic Chemistry, Faculty of Chemistry, University of Havana, Zapata y G, Havana 10400, Cuba
    • dLaboratory of Computational and Theoretical Chemistry, Faculty of Chemistry, University of Havana, Zapata y G, Havana 10400, Cuba
    • ePeoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya street 6, 117198 Moscow, Russia
    View abstract

    The Merger of Benzophenone HAT Photocatalysis and Silyl Radical-Induced XAT Enables Both Nickel-Catalyzed Cross-Electrophile Coupling and 1,2-Dicarbofunctionalization of Olefins

    Alberto Luridianaa, Daniele Mazzarellaa, Luca Capaldoa, Juan A. Rincónb, Pablo García-Losadab, Carlos Mateosb, Michael O. Frederickc, Manuel Nuñod, Wybren Jan Bumae and Timothy Noëla

    • aFlow Chemistry Group, Van’t Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
    • bCentro de Investigación Lilly S.A., Avda. de la Industria 30, Alcobendas-Madrid 28108, Spain
    • cSmall Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana 46285, United States
    • dVapourtec Ltd. Park Farm Business Centre, Fornham St Genevieve, Bury St Edmunds, Suffolk IP28 6TS, U.K.
    • eMolecular Photonics, Van’t Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
    View abstract

    Taming photocatalysis in flow: easy and speedy preparation of α-aminoamide derivatives

    Ricardo I. Rodrígueza, Marina Sicignanoa, Montaña J. Garcíaa, Rodrigo G. Enríqueza, Silvia Cabrerab,c, José Alemána,c,d

    • aOrganic Chemistry Department, Science Faculty, Universidad Autónoma de Madrid, Madrid-28049, Spain
    • bInorganic Chemistry Department, Science Faculty, Universidad Autónoma de Madrid, Madrid-28049, Spain
    • cInstitute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, 28049 Madrid, Spain
    • dCenter for Innovation in Advanced Chemistry (ORFEO-CINQA), Universidad Autónoma de Madrid, Spain
    View abstract

    Synthesis of CTA and DNAN using flow chemistry

    Ankit Kumar Mittala, Gaurav Prakasha, Pramod Pathaka, Debabrata Maitia

    • aIndian Institute of Technology Bombay, Department of Chemistry, Mumbai, INDIA
    View abstract

    Flow synthesis of photocatalytic semiconductor–metal hybrid nanocrystals

    Tal Cohena,b, Nir Waiskopfa,b, Adar Levia,b, David Stonea,b, Sergei Remennikb, Uri Banina,b

    • aThe Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    • bThe Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    View abstract

    Taylor-vortex membrane reactor for continuous gas-liquid reactions

    Baldassarre Veneziaa, David C. Morrisb, Asterios Gavriilidisa

    • aDepartment of Chemical Engineering, University College London, Torrington Place, London, UK
    • bAutichem Ltd, Unit 4, Gatewarth Industrial Estate Barnard Street Warrington WA5 1DD
    View abstract

    Statistical optimization modeling of organic dye photodegradation process using slag nanocomposite

    Kingsley Safoa, Hussien Nobya,b, Mitsuhara Matatoshic, Hiroshi Naraginoc, Ahmed H. El-Shazlya,d

    • aDepartment of Chemical and Petrochemicals Engineering, Egypt-Japan University of Science and Technology, New Borg Al-Arab City, Alexandria, Egypt
    • bMaterials Engineering and Design, Faculty of Energy Engineering, Aswan University, Aswan, Egypt
    • cInterdisciplinary Graduate School of Engineering Sciences, Kyushu University, 6-1 Kasuga Kouen, Kasuga, Fukuoka, 816-8580, Japan
    • dDepartment of Chemical Engineering, Faculty of Engineering, Alexandria University, Alexandria, Egypt
    View abstract

    4,7-Diarylbenzo[c][1,2,5]thiadiazoles as fluorophores and visible light organophotocatalysts

    Dominic Taylora, Thomas Malcomsonb, Adilet Zhakeyevc, Shengxian Chengd, Georgina M. Rosaira, Jose Marques-Huesoc, Zhengtao Xue, Martin J. Patersona, Scott J. Dalgarnoa, Filipe Vilelaa

    • aInstitute of Chemical Sciences, School of Engineering and Physical Science, Heriot-Watt University, Riccarton, Edinburgh EH14 4AS, UK.
    • bDepartment of Chemistry, Lancaster University, Lancaster, LA1 4YB, UK
    • cInstitute of Sensors, Signals and Systems, School of Engineering and Physical Science, Heriot-Watt University, Riccarton, Edinburgh EH14 4AS, UK
    • dDepartment of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong
    • eInstitute of Materials Research and Engineering (IMRE), Agency of Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis, Singapore 138634
    View abstract

    Recent advances in chemical fixation of CO2 based on flow chemistry

    Hui Luoa, Jing Rena, Ying Suna, Yunlin Liub, Feng Zhoua,c, Guoyue Shia, Jian Zhoua,d

    • aSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China
    • bSchool of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou, 510006, China
    • cInstitute of Eco-Chongming, Shanghai 202162, China
    • dState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China
    View abstract

    Kinetics and hydrodynamics of Candida antartica lipase-catalyzed synthesis of glycerol dioleate (GDO) in a continuous flow packed-bed millireactor

    Nurul Nadiah Abd Razaka,b, Patrick Cognetb, Yolande Pérèsb, Lai Ti Gewa,e

    • aDepartment of Biological Sciences, School of Medical and Life Sciences, Sunway University, Petaling Jaya, Selangor, 47500, Malaysia
    • bLaboratoire de Génie Chimique, Université de Toulouse, CNRS, INPT, UPS, Toulouse, 31423, France
    • cCentre for Carbon Dioxide Capture and Utilization (CCDCU), School of Engineering and Technology, Sunway University, Petaling Jaya, Selangor, 47500, Malaysia
    • dDepartment of Engineering, Lancaster University, Lancaster, LA1 4YW, United Kingdom
    • eSunway Materials Smart Science & Engineering (SMS2E) Cluster, Sunway University, Petaling Jaya, Selangor, 47500, Malaysia
    View abstract

    Microfluidic Asymmetrical Synthesis and Chiral Analysis

    Konstantin A.Kochetkova, Nataliya A.Bystrovaa, Pavel A.Pavlovb, Maxim S.Oshchepkovb, Aleksandr S.Oshchepkovc

    • aNesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Moscow 119991, Russia
    • bMendeleev University of Chemical Technology of Russia, Miusskaya pl. 9, Moscow 125047, Russia
    • cMax Planck Institute for the Science of Light, Department of Physics, D-91058 Erlangen, Germany
    View abstract

    Evaluation of unexpected protecting group removal in solid-phase peptide synthesis: Quantified using continuous flow methods

    Victoire Laudea, Manuel Nuñoa, Roger C. Mosesa, Duncan Guthriea

    • aVapourtec Ltd, Bury Saint Edmunds, UK
    View abstract

    Synthesis of Benzothiazinones from Benzoyl Thiocarbamates: Application to Clinical Candidates for Tuberculosis Treatment

    William Connorsa, Ryan DeKortea, Simon C. C. Lucasb, Ariamala Gopalsamyb, Robert E Zieglera

    • aAstraZeneca Pharmaceuticals LP, Medicinal Chemistry, United States
    • bAstraZeneca Pharmaceuticals LP, Hit Discovery, United Kingdom
    View abstract

    Synthesis of new heterocyclic resveratrol analogues in milli- and microreactors: intensification of the Wittig reaction

    Milena Mlakića, Lucija Rajiča,b, Anabela Ljubićb, Vitomir Vušakb, Bruno Zelićc,d, Martin Gojunc, Ilijana Odake, Ivona Čulee, Ivana Šagudb, Anita Šalićc, Irena Škorića

    • aDepartment of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, HR-10 000, Zagreb, Croatia
    • bPliva R&D, Teva Pharmaceutical Industries Ltd, Prilaz baruna Filipovića 29, HR-10 000, Zagreb, Croatia
    • cDepartment of Reaction Engineering and Catalysis, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, HR-10 000, Zagreb, Croatia
    • dDepartment of Packaging, Recycling and Environmental Protection, University North, Trg dr. Žarka Dolinara 1, HR-48 000, Koprivnica, Croatia
    • eDepartment of Chemistry, Faculty of Science and Education, University of Mostar, Matice hrvatske bb, 88 000, Mostar, Bosnia and Herzegovina
    View abstract

    Multistep Continuous Flow Synthesis of Isolable NH2‐Sulfinamidines via Nucleophilic Addition to Transient Sulfurdiimide

    Michael Andresinia, Sebastien Carretb, Leonardo Degennaroa, Fulvio Ciriacoa, Jean-François Poissonb, Renzo Luisia

    • aUniversity of Bari: Universita degli Studi di Bari Aldo Moro, Pharmacy - Drug Sciences, Via E. Orabona,4, 70125 Bari, ITALY
    • bUniversite Grenoble Alpes, Chemistry, rue de la chimie, 38000 Grenoble, FRANCE
    View abstract

    A multi-step continuous flow synthesis of pomalidomide

    Maria Ivanovaa, Julien Legrosa, Thomas Poissona,b, Philippe Jubaulta

    • aNormandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA, 76000, Rouen, France
    • bInstitut Universitaire de France, Paris, France
    View abstract

    Continuous Flow Preparation of Benzylic Sodium Organometallics

    Johannes H. Harenberga, Dr. Rajasekar Reddy Annapureddya, Prof. Dr. Konstantin Karaghiosoffa, Prof. Dr. Paul Knochela

    • aDepartment Chemie, Ludwig-Maximilians-Universität München, Butenandtstraße 5–13, Haus F, 81377 München, Germany
    View abstract

    Flow Chemistry Opportunities for Drug Discovery

    María Lourdes Linaresa, Enol Lópezb, Eduardo Palaoa, Jesús Alcázara

    • aJanssen Research and Development, Janssen-Cilag, S.A., Discovery Chemistry, C/ Jarama, 75, 45007 Toledo Spain
    • bUniversidad de Castilla-La Mancha, Facultad de Ciencias y Tecnologías Químicas, Av. Camilo José Cela, 14, 13005 Ciudad Real Spain
    View abstract

    Innovative Process Development of Pharmaceutical Intermediates Under Continuous-Flow System

    Koji Machidaa, Hiroaki Yasukouchia

    • aPharma & Supplemental Nutrition Solutions Vehicle, Kaneka Corporation, Pharma Business Division Research Group, 1-8 Miyamae-cho, Takasago-cho, Takasago, Hyogo, 676-8688 Japan
    View abstract

    Flow Chemistry in Medicinal Chemistry: Applications to Bcr – Abl Kinase Inhibitors

    Paul Richardsona

    • aPfizer-La Jolla, Medicine Design, 10770 Science Center Drive, La Jolla, CA, 92121 USA
    View abstract

    Flow Chemistry at the Extremes: Turning Complex Reactions into Scalable Processes

    Andrew R. Bogdana

    • aAbbVie, Inc., Drug Discovery Science and Technology, 1 North Waukegan Rd, North Chicago, IL, 60064 USA
    View abstract

    Application of Continuous-Flow Processing in Multistep API and Drug Syntheses

    Faith M. Akwia, Paul Wattsa

    • aNelson Mandela University, Faculty of Science, Department of Chemistry, University Way, Port Elizabeth, 6031 South Africa
    View abstract

    Heterogeneous metallaphotoredox catalysis in a continuous-flow packed bed reactor

    Wei-Hsin Hsua,b, Susanne Reischauera,b, Peter H Seebergera,b, Bartholomäus Piebera, Dario Cambiéa

    • aMax Planck Institute of Colloids and Interfaces, Biomolecular Systems Department, Am Mühlenberg 1, 14476 Potsdam, Germany
    • bFreie Universität Berlin, Institute for Chemistry and Biochemistry, Arnimallee 22, 14195 Berlin, Germany
    View abstract

    An Overview on the Production of Biodiesel Enabled by Continuous Flow Methodologies

    Claudia Carluccia

    • aCNR-Institute of Nanotechnology (CNR-NANOTEC), c/o Campus Ecotekne, Via Monteroni, 73100 Lecce, Italy
    View abstract

    Continuous flow synthesis of azobenzenes via Baeyer–Mills reaction

    Jan H. Griwatza,b, Anne Kunza,b, Hermann A. Wegnera,b

    • aInstitute of Organic Chemistry, Justus Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany
    • bCenter for Material Research (ZfM/LaMa), Justus Liebig University, Heinrich-Buff-Ring 16, 35392 Giessen, Germany
    View abstract

    Synthesis of 2,4,6-Trisubstituted Pyrimidines via Iron-Catalyzed Homocoupling of α,β-Unsaturated Ketoximes

    Kai Guoa, Gaochen Xua, Xuemei Wanga, Chenglong Jiaa, Huan Yana, Sai Zhanga, Qinghuan Wua, Ning Zhua, Zheng Fanga, Jindian Duana

    • aCollege of Biotechnology and Pharmaceutical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University,30 Puzhu Rd S., Nanjing 211816, China
    View abstract

    Continuous Processing of Concentrated Organolithiums in Flow Using Static and Dynamic Spinning Disc Reactor Technologies

    Ulrich Wietelmanna, Johannes Klösenera, Peter Rittmeyera, Stefan Schnipperinga, Henk Batsb, Wouter Stamb

    • aAlbemarle Germany GmbH, Industrial Park Hoechst, D-65926 Frankfurt am Main, Germany
    • bFlowid, Achtseweg Zuid 157C, NL-5651 GW Eindhoven, The Netherlands
    View abstract

    Process Intensive Synthesis of Propofol Enabled by Continuous Flow Chemistry

    Laurent Vineta, Lorenzo Di Marcoa, Vanessa Kairouza, André B. Charettea

    • aCentre in Green Chemistry and Catalysis, Center for Continuous Flow Synthesis, Department of Chemistry, Université de Montréal, 1375, av. Thérèse Lavoie-Roux, Montréal, Québec H2V 0B3, Canada
    View abstract

    Immobilized Eosin Y for the photocatalytic oxidation of tetrahydroisoquinolines in flow

    Fabian Herbrika,b, Sergio Rossia, Miguel Sanzb, Alessandra Puglisia, Maurizio Benagliaa

    • aDipartimento di Chimica, Università degli Studi di Milano, Via Camillo Golgi 19, 20133 Milano, Italy
    • bTaros Chemicals GmbH & Co. KG, Emil-Figge-Strasse 76A, 44227 Dortmund, Germany
    View abstract

    Sn-Catalyzed Criegee-Type Rearrangement of Peroxyoxindoles Enabled by Catalytic Dual Activation of Esters and Peroxides

    Moreshwar B. Chaudharia, Krishna Jayana, Boopathy Gnanaprakasama

    • aDepartment of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India
    View abstract

    The Ugly Duckling Metamorphosis: The Ammonia/Formaldehyde Couple Made Possible in Ugi Reactions.

    Thaissa Pasquali F. Rosalbaa, Samia Sayegh A. Kasa, Ana Beatriz S. Sampaioa, Dr. Carlos Eduardo M. Salvadora, Dr. Carlos Kleber Z. Andradea

    • aInstituto de Química, Laboratório de Química Metodológica e Orgânica Sintética (LaQMOS), Universidade de Brasília, Campus Universitário, Asa Norte, 70904-970 Brasília, Brasil
    View abstract

    Continuous-Flow Hofmann Rearrangement Using Trichloroisocyanuric Acid for the Preparation of 2-Benzoxazolinone

    Guido Gambacortaa, Ian R. Baxendalea

    • a Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, U.K.
    View abstract

    Boosting the Productivity of H2-Driven Biocatalysis in a Commercial Hydrogenation Flow Reactor Using H2 From Water Electrolysis

    Barnabas Poznanskya, Sarah E. Clearya, Lisa A. Thompsona, Holly A. Reevea, Kylie A. Vincent*a

    • aInorganic Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom
    View abstract

    Continuous flow heterogeneous catalytic reductive aminations under aqueous micellar conditions enabled by an oscillatory plug flow reactor

    Michaela Wernika,b, Gellért Siposc,d, Balázs Buchholcze, Ferenc Darvasc,d, Zoltán Novákf, Sándor B. Ötvösa,b, C. Oliver Kappea,b

    • aInstitute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz, Austria
    • bCenter for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, A-8010 Graz, Austria
    • cThalesNano Inc., Záhony u. 7, 1031 Budapest, Hungary
    • dComInnex Inc., Záhony u. 7, 1031 Budapest, Hungary
    • eInnostudio Inc., Záhony u. 7, 1031 Budapest, Hungary
    • fELTE “Lendület” Catalysis and Organic Synthesis Research Group, Faculty of Science, Institute of Chemistry, Eötvös Loránd University, Pázmány Péter stny. 1/a, 1117 Budapest, Hungary
    View abstract

    Continuous flow processing of bismuth-photocatalyzed atom transfer radical addition reactions using an oscillatory flow reactor

    Pauline Bianchia, Jason D. Williamsa,b, C. Oliver Kappea,b

    • aInstitute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010 Graz, Austria
    • bCenter for Continuous Flow Synthesis and Processing (CC FLOW), Research Center Pharmaceutical Engineering (RCPE), Inffeldgasse 13, 8010 Graz, Austria
    View abstract

    Automated Chemical Solid-Phase Synthesis of Glycans

    Xiaona Lia, You Yanga

    • aShanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237 China
    View abstract

    Cutting edge of diphenyl phosphorazidate (DPPA) as a synthetic reagent–A fifty-year odyssey

    Takayuki Shioiria, Kotaro Ishiharaa, Masato Matsugia

    • aFaculty of Agriculture, Meijo University, Shiogamaguchi, Tempaku, Nagoya 468-8502, Japan
    View abstract

    Cobalt-electrocatalytic HAT for functionalization of unsaturated C–C bonds

    Samer Gnaima, Adriano Bauera, Hai-Jun Zhanga, Longrui Chena, Cara Gannettb, Christian A. Malapitc, David E. Hilld, David Vogtc, Tianhua Tangc, Ryan A. Daleya, Wei Haoa, Rui Zengb, Mathilde Quertenmonte, Wesley D. Beckc, Elya Kandaharid, Julien C. Vantourouta, Pierre-Georges Echeverriae, Hector D. Abrunab, Donna G. Blackmonda, Shelley D. Minteerc, Sarah E. Reismand, Matthew S. Sigmanc & Phil S. Barana

    • aDepartment of Chemistry, The Scripps Research Institute (TSRI), La Jolla, CA, USA
    • bDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA
    • cDepartment of Chemistry, University of Utah, Salt Lake City, UT, USA
    • dThe Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA
    • eMinakem Recherche, Beuvry-la-Forêt, France
    View abstract

    Total Synthesis of Phytotoxic Radulanin A Facilitated by the Photochemical Ring Expansion of a 2,2-Dimethylchromene in Flow

    Bruce Lockett-Waltersa, Simon Thuilliera,b, Emmanuel Baudouinb, Bastien Nay*a

    • aLaboratoire de Synthèse Organique, Ecole Polytechnique, CNRS, Institut Polytechnique de Paris, 91128 Palaiseau, France
    • bInstitut de Biologie Paris-Seine (IBPS), Laboratoire de Biologie du Développement, Sorbonne Université, CNRS, UMR7622, F-75005 Paris, France
    View abstract

    Practical Ferrioxalate Actinometry for the Determination of Photon Fluxes in Production-Oriented Photoflow Reactors

    Bavo Vandekerckhovea, Nicola Piensb, Bert Mettenb, Christian V. Stevensa, Thomas S. A. Heugebaert*a

    • aSynBioC Research Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium
    • bAjinomoto Bio-Pharma Services, Cooppallaan 91, 9230 Wetteren, Belgium
    View abstract

    Continuous Flow Technology as an Enabler for Innovative Transformations Exploiting Carbenes, Nitrenes, and Benzynes

    Kian Donnellya, Marcus Baumanna

    • aSchool of Chemistry, Science Centre South, University College Dublin, D04 N2E2 Dublin, Ireland
    View abstract

    Online reaction monitoring with fast and flow-compatible diffusion NMR spectroscopy

    Achille Marchanda, Rituraj Mishraa, Aurélie Bernarda, Jean-Nicolas Dumeza

    • aUniversité,CNRS, CEISAM UMR6230,F-44000 Nantes, France
    View abstract

    Analytical Tools Integrated in Continuous-Flow Reactors: Which One for What?

    Mireia Rodriguez-Zubiria, François-Xavier Felpina

    • aNantes Université, CNRS, CEISAM, UMR 6230, F-44000 Nantes, France
    View abstract

    Development of a palladium-catalyzed decarboxylative arene cross-coupling of pyrrole derivatives in a flow reactor

    Cindy Buonomanoa,b, Michael Holtz-Mulhollanda,b, Sydney Sullivana,b, Pat Forgionea,b

    • aDepartment of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke O, Montréal, QC, H4B 1R6, Canada
    • bCentre in Green Chemistry and Catalysis, Montréal, QC, H3C 3J7, Canada
    View abstract

    Continuous synthesis of benzaldehyde by ozonolysis of styrene in a micro-packed bed reactor

    Fengyan Loua,b,c, Qiang Caoa, Chenghao Zhanga, Ning Aic, Qining Wangb, Jisong Zhanga

    • aThe State Key Lab of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, 100084, Beijing, China
    • bCollege of Chemical Engineering, Zhejiang University of Technology, 310014, Hangzhou, Zhejiang, China
    • cCollege of Biological, Chemical Science and Engineering, Jiaxing University, 314001, Jiaxing, Zhejiang, China
    View abstract

    α-Amino Radical Halogen Atom Transfer Agents for Metallaphotoredox Catalyzed Cross-Electrophile Couplings of Distinct Organic Halides

    Xianhai Tiana, Jaspreet Kaura, Shahboz Yakubova, Joshua P. Barhama

    • aInstitute of Organic Chemistry, University of Regensburg Universitätsstr. 31, 93053 Regensburg (Germany)
    View abstract

    Enzymatic continuous-flow preparation of nature-inspired phenolic esters as antiradical and antimicrobial agents

    Francesca Annunziataa, Martina L.Contenteb, Valentina Anzia, Silvia Donzellab, Paola Contia, Francesco Molinarib, Piera Anna Martinoc, Gabriele Meronic, Valerio Massimo Sorac, Lucia Tamborinia, Andrea Pintob

    • aDepartment of Pharmaceutical Sciences (DISFARM), University of Milan, via Mangiagalli 25, 20133 Milan, Italy
    • bDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, Italy
    • cDepartment of Biomedical, Surgical and Dental Sciences (DSBCO), One Health Unit, University of Milan, via Pascal 36, 20133 Milan, Italy
    View abstract

    Integration of Liquid–Liquid Biphasic Flow Alkylation and Continuous Crystallization Using Taylor Vortex Flow Reactors

    Masahiro Hosoyaa, Masashi Tanakaa, Atsushi Manakaa, Shogo Nishijimaa, Naoki Tsunoa

    • a API R&D Laboratory, CMC R&D Division, Shionogi and Company Ltd., 1-3, Kuise Terajima 2-chome, Amagasaki, Hyogo 660-0813, Japan
    View abstract

    Cutting edge of diphenyl phosphorazidate (DPPA) as a synthetic reagent – A fifty-year odyssey

    Takayuki Shioiria, Kotaro Ishiharaa, and Masato Matsugia

    • aFaculty of Agriculture, Meijo University, Shiogamaguchi, Tempaku, Nagoya 468- 8502, Japan
    View abstract

    Total synthesis of phytotoxic radulanin A facilitated by the photochemical ring expansion of a 2,2-dimethylchromene in flow

    Bruce Lockett-Walters1, Simon Thuillier1,2, Emmanuel Baudouin2, Bastien Nay*1

    • 1Laboratoire de Synthèse Organique, Ecole Polytechnique, CNRS, Institut Polytechnique de Paris, 91128 Palaiseau, France
    • 2Sorbonne Université, CNRS, Institut de Biologie Paris-Seine (IBPS), Laboratoire de Biologie du Développement, UMR7622, F-75005, Paris, France
    View abstract

    An environmentally benign and high-rate Appel type reaction

    Nicolas Mattias Del Rio Fuenzalidaa, Eirin Almea, Frida Johanne Lundevalla, Hans-René Bjørsvika

    • aDepartment of Chemistry, University of Bergen, Allégaten 41, 5007 Bergen, Norway
    View abstract

    Selective Photochemical Continuous Flow Benzylic Monochlorination

    Robbie Radjagobaloua, Miguel Imbrattab, Julie Bergraserb, Marion Gaudeaub, Gildas Lyvinecb, Dominique Delbrayelleb, Olivier Jentzerb, Jérémy Roudina, Benjamin Larochea, Stéphanie Ogniera, Michael Tatouliana, Janine Cossya, Pierre-Georges Echeverriab

    • aParis FLOW Tech − PSL, ENSCP, 11 rue Pierre et Marie Curie, Paris 75005, France
    • bMinakem Recherche, 145 Chemin des Lilas, Beuvry-La-Forêt 59310, France
    View abstract

    Continuous flow process for preparing budesonide

    Manjinder Singh Phulla,b, Surender Singh Jadavc,d, Chander Singh Boharab, Rambabu Gundlaa, Prathama S Mainkarc,d

    • aDepartment of Chemistry, School of Science, GITAM (Deemed to Be University), Hyderabad, Telangana, 502329, India
    • bCipla Limited Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai, 400013, India
    • cDepartment of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India
    • dAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India
    View abstract

    Chemical Recycling of Polystyrene to Valuable Chemicals via Selective Acid-Catalyzed Aerobic Oxidation under Visible Light

    Zhiliang Huanga, Muralidharan Shanmugamb, Zhao Liuc, Adam Brookfieldb, Elliot L. Bennetta, Renpeng Guana, David E. Vega Herreraa, Jose A. Lopez-Sancheza, Anna G. Slatera, Eric J. L. McInnesb, Xiaotian Qi*c, Jianliang Xiaoa

    • aDepartment of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K.
    • bDepartment of Chemistry and Photon Science Institute, The University of Manchester, Manchester M13 9PL, U.K.
    • cEngineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China
    View abstract

    Sustainable Synthesis of Noroxymorphone via a Key Electrochemical N-Demethylation Step

    Florian Sommera,b, Roman Gerber Aeschbacherc, Urs Thurnheerc, C. Oliver Kappea,b, David Cantilloa,b

    • aInstitute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010, Graz, Austria
    • bCenter for Continuous Flow Synthesis and Processing (CCFLOW), Research Center, Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria.
    • bAZAD Pharma AG, Durachweg 15, CH-8200 Schaffhausen, Switzerland
    View abstract

    Photocatalytic Approach to α,α-Difluoroalkyl Alcohols

    Georgii Kachkovskyia, Marcin Cieślaka, Piotr Graczyka, Przemysław Zawadzkia, Justyna Kalinowska-Tłuścikb, Mateusz Werłosa,b

    • aSelvita SA., Bobrzyńskiego 14, 30-348 Kraków, Poland
    • bFaculty of Chemistry Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland
    View abstract

    Spheroplasts preparation boosts the catalytic potential of a terpene cyclase

    Ana I. Benítez-Mateos1, Andreas Schneider2, Eimear Hegarty1, Bernhard Hauer2, Francesca Paradisi1

    • 1 Department of Chemistry, Biochemistry and Pharmaceutical Sciences. University of Bern Freiestrasse 3, 3012 Bern (Switzerland)
    • 2Institute of Biochemistry and Technical Biochemistry, University of Stuttgart Allmandring 31, 70569 Stuttgart-Vaihingen (Germany)
    View abstract

    Scale-Up of Diazonium Salts and Azides in a Three-Step Continuous Flow Sequence

    Hansjoerg Lehmanna, Thomas Ruppena, Thomas Knoepfela

    • aGlobal Discovery Chemistry, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland
    View abstract

    Quantitative and convenient real-time reaction monitoring using stopped-flow benchtop NMR

    Tristan Maschmeyera, Lars P. E. Yunkera, Jason E. Heina

    • aDepartment of Chemistry, The University of British Columbia, Vancouver, BC V6T 1Z1, Canada
    View abstract

    Amino Alcohols as Potential Antibiotic and Antifungal Leads

    Jennifer R. Baker1, Peter J. Cossar1, Mark A. T. Blaskovich2, Alysha G. Elliott2, Johannes Zuegg2, Matthew A. Cooper2, Peter J. Lewis3,4, Adam McCluskey1

    • 1Chemistry, School of Environmental & Life Sciences, The University of Newcastle, University Drive Callaghan, Newcastle, NSW 2308, Australia
    • 2Community for Open Antimicrobial Drug Discovery, Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    • 3Biology, School of Environmental & Life Sciences, The University of Newcastle, University Drive Callaghan, Newcastle, NSW 2308, Australia
    • 4Molecular Horizons, School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia
    View abstract

    Continuous-Flow Synthesis of Alkyl Zinc Sulfinates for the Direct Photofunctionalization of Heterocycles

    José Luis Nova-Fernándeza,b, Montaña J. Garcíaa, Leonardo Mollaria, Gustavo Pascual-Cocab, Silvia Cabrerac,d,e, José Alemánad,e

    • aOrganic Chemistry Department, M1, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
    • bSynthelia Organics Labs, C/ Faraday, 7, Labs 2.05 and 0.03, Parque Científico de Madrid, 28049, Madrid, Spain.
    • cInorganic Chemistry Department, M7, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
    • dInstitute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, 28049, Madrid, Spain.
    • eCenter for Innovation in Advanced Chemistry (ORFEO-CINQA), Universidad Autónoma de Madrid.
    View abstract

    Continuous flow Meerwein–Ponndorf–Verley reduction of HMF and furfural using basic zirconium carbonate

    Henrique Magri Marçona, Julio Cezar Pastrea

    • aInstitute of Chemistry, University of Campinas – UNICAMP, PO Box 6154, Zip Code 13083-970, Campinas, SP, Brazil
    View abstract

    “Green Is the Color”: An Update on Ecofriendly Aspects of Organoselenium Chemistry

    Juliano B. Azeredo1, Filipe Penteado2, Vanessa Nascimento3, Luca Sancineto4, Antonio L. Braga5, Eder João Lenardao2, Claudio Santi4

    • 1Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pampa, Uruguaiana, Uruguaiana 97501-970, RS, Brazil
    • 2Laboratório de Síntese Orgânica Limpa-LaSOL-CCQFA, Universidade Federal de Pelotas-UFPel, P.O. Box 354, Pelotas 96010-900, RS, Brazil
    • 3Laboratório SupraSelen, Departamento de Química Orgânica, Instituto de Química, Campus do Valonguinho, Universidade Federal Fluminense, Niteroi 24020-150, RJ, Brazil
    • 4Group of Catalysis Synthesis and Organic Green Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06100 Perugia, Italy
    • 5Departamento de Química, Universidade Federal de Santa Catarina—UFSC, Florianopolis 88040-900, SC, Brazil
    View abstract

    An electrochemical γ-C–H arylation of amines in continuous flow

    José A.Fornia, Milena L.Czyza, David W.Luptonb, Anastasios Polyzosa,c

    • aSchool of Chemistry, The University of Melbourne, Parkville 3010, Victoria, Australia
    • bSchool of Chemistry, Monash University, Clayton 3800, Victoria, Australia
    • cCSIRO Manufacturing, Research Way, Clayton VIC 3168, Australia
    View abstract

    Chip-Scale Solar-Thermal-Electrical Power Generation

    Zhihang Wang1, Zhenhua Wu2, Zhiyu Hu2, Jessica Orrego-Hernandez1, Erzhen Mu3, Zhao-Yang Zhang4, Martyn Jevric1, Yang Liu2, Xuecheng Fu5, Fengdan Wang5, Tao Li4, Kasper Moth-Poulsen1

    • 1Chalmers University of Technology - Department of Chemistry and Chemical Engineering
    • 2Shanghai Jiao Tong University (SJTU) - National Key Laboratory of Science and Technology on Micro/Nano Fabrication
    • 3Henan Polytechnic University - School of Materials Science and Engineering
    • 4Shanghai Jiao Tong University (SJTU) - Shanghai Key Laboratory of Electrical Insulation and Thermal Aging
    • 5Shanghai Jiao Tong University (SJTU) - Center for Advanced Electronic, Materials and Devices (AEMD)
    View abstract

    A continuous-flow protocol for photoredox-catalyzed multicomponent Petasis reaction

    Monica Oliva1, Frederick Martens1, Erik V.Van der Eycken1,2, Upendra Kumar Sharma1

    • 1Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium
    • 2Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya street 6, Moscow 117198, Russia
    View abstract

    Continuous-Flow Preparation of Benzotropolones: Combined Batch and Flow Synthesis of Epigenetic Modulators of the (JmjC)-Containing Domain

    Dr. José A. Soutoa

    • aDepartamento de Química Orgánica, Facultade de Química, Centro de Investigacións Biomédicas (CINBIO) and IIS Galicia Sur., Universidade de Vigo, 36310 Vigo, Spain
    View abstract

    Continuous flow synthesis of Celecoxib from 2-bromo-3,3,3-trifluoropropene

    Maria Ivanova1, Julien Legros1, Thomas Poisson1,2, Philippe Jubault1

    • 1INSA Rouen, CNRS, UNIROUEN, COBRA, Normandie Univ, 76000 Rouen, France
    • 2Institut Universitaire de France, 1 Rue Descartes, 75231 Paris, France
    View abstract

    Scalable Synthesis of Norbornadienes via in situ Cracking of Dicyclopentadiene Using Continuous Flow Chemistry

    Jessica Orrego-Hernández[a], Helen Hölzel[a], Maria Quant[a], Zhihang Wang[a], KasperMoth-Poulsen[a]

    • [a]Departmentof Chemistry and Chemical Engineering, Chalmers University of Technology, Kemigården4, 412 96 Gothenburg, Sweden
    View abstract

    Photoredox Iridium–Nickel Dual Catalyzed Cross-Electrophile Coupling: From a Batch to a Continuous Stirred-Tank Reactor via an Automated Segmented Flow Reactor

    Rohit Duvadiea, Alexander Pombergerb, Yiming Mob, Erhan I. Altinogluc, Hsiao-Wu Hsieha, Kakasaheb Y. Nandiwalea, Victor L. Schultzb, Klavs F. Jensenb, Richard I. Robinsona

    •   aGlobal Discovery Chemistry, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    • bDepartment of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    • cChemical and Pharmaceutical Profiling, Novartis Global Drug Development, 700 Main Street South, Cambridge, Massachusetts 02139, United States
    View abstract

    Optimizing the Performance of the Meso-Scale Continuous-Flow Photoreactor for Efficient Photocatalytic CO2 Reduction with Water Over Pt/TiO2/RGO Composites

    Samar Nabila, Elsayed A. Shalabya, Marwa F. Elkadyb,c, Yoshihisa Matsushitad, Ahmed H. El-Shazlyb,e

    • aDepartment of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria, 21526, Egypt
    • bChemical and Petrochemicals Engineering Department, Egypt-Japan University of Science and Technology, Alexandria, 21934, Egypt
    • cFabrication Technology Department, Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications, Alexandria, Egypt
    • dEgypt-Japan University of Science and Technology, 179 New Borg El‐Arab, Alexandria, 21934, Egypt
    • eChemical Engineering Department, Faculty of Engineering, Alexandria University, Alexandria, 21544, Egypt
    View abstract

    From Platform to Knowledge Graph: Evolution of Laboratory Automation

    Jiaru Baia, Liwei Caoa, Sebastian Mosbacha,b, Jethro Akroyda,b

    • aDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, United Kingdom
    • bCambridge Centre for Advanced Research and Education in Singapore (CARES), CREATE Tower #05-05, 1 Create Way, 138602 Singapore
    • cCambridge Centre for Advanced Research and Education in Singapore (CARES), CREATE Tower #05-05, 1 Create Way, 138602 Singapore
    • dThe Alan Turing Institute, London NW1 2DB, United Kingdom
    View abstract

    Continuous flow technology-a tool for safer oxidation chemistry

    Li Wana, Meifen Jianga, Dang Chenga, Minjie Liua, Fener Chen*ab

    • aEngineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China
    • bShanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China
    View abstract

    Continuous Flow Synthesis of a Blocked Polyisocyanate: Process Intensification, Reaction Monitoring Via In-Line FTIR Analysis, and Comparative Life Cycle Assessment

    Gabriel Glotza,b, Katharina Wanieka,c, Josef-Peter Schögglc, David Cantilloa,b, Clemens Stuecklerd, Anton Arztd, Andreas Gollnerd, Rudolf Schipferd, Rupert J. Baumgartnerc, C. Oliver Kappea,b

    • aInstitute of Chemistry, NAWI Graz, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria
    • bCenter for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria
    • cChristian Doppler Laboratory for Sustainable Product Management, Institute of Systems Sciences, Innovation and Sustainability Research, University of Graz, Merangasse 18/I, 8010 Graz, Austria
    • dAllnex Austria GmbH, Bundesstrasse 175, 8402 Werndorf, Austria
    View abstract

    Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

    Cloudius R. Sagandiraa, Sinazo Nqeketoa, Kanyisile Mhlanaa, Thembela Sontia, Sibongiseni Gaqaa, Paul Watts*a

    • aNelson Mandela University, University Way, Port Elizabeth, South Africa
    View abstract

    Flow-Assisted Synthesis of Alkyl Citrate Natural Products

    Nikolai Piers Rossouwa, Mark A. Rizzacasa*a, Anastasios Polyzos*a,b

    • aSchool of Chemistry, The University of Melbourne, Parkville 3010, Victoria, Australia
    • bCSIRO Manufacturing, Research Way, Clayton 3168, Victoria, Australia
    View abstract

    Continuous Flow Acylation of (Hetero)aryllithiums with Polyfunctional N,N-Dimethylamides and Tetramethylurea in Toluene

    Dimitrije Djukanovica, Benjamin Heinza, Dr. Francesca Mandrellib, Dr. Serena Mostardab, Dr. Paolo Filipponib, Dr. Benjamin Martinb, Prof. Dr. Paul Knochela, , aDepartment Chemie, Ludwig-Maximilians-Universität München, Butenandtstraße 5–13, Haus F, 81377 Munich, Germany, bNovartis Pharma AG, Chemical Development Fabrikstraße, 4002 Basel, Switzerland

    View abstract

    In Situ Investigation of Multicomponent MOF Crystallization during Rapid Continuous Flow Synthesis

    Brandon Hea,b, Lauren K. Macreadiec,d, James Gardinerb, Shane G. Telferd, Matthew R. Hill*a,b

    • aDepartment of Chemical Engineering, Monash University, Clayton, VIC 3800, Australia
    • bCSIRO Private Bag 10, Clayton South, VIC 3169, Australia
    • c,School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia
    • dMacDiarmid Institute for Advanced Materials and Nanotechnology Institute of Fundamental Sciences, Massey University, Palmerston North 4442, New Zealand
    View abstract

    Automated Synthesis of Chondroitin Sulfate Oligosaccharides

    Chien-Fu Lianga, Heung Sik Hahma,b, Narayana Murthy Sabbavarapu, Peter H. Seeberger

    • aDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
    • bDepartment of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany
    View abstract

    Biocatalyzed Synthesis of Vanillamides and Evaluation of Their Antimicrobial Activity

    Cecilia Pinna1, Piera Anna Martino2, Gabriele Meroni2, Valerio Massimo Sora2, Lucia Tamborini3, Sabrina Dallavalle1, Martina L. Contente*1, Andrea Pinto1

    • 1Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, Italy
    • 2Department of Biomedical, Surgical and Dental Sciences (DSBCO), One Health Unit, University of Milan, via Pascal 36, 20133 Milan, Italy
    • 3Department of Pharmaceutical Sciences (DISFARM), University of Milan, via Mangiagalli 25, 20133 Milan, Italy
    View abstract

    Multi-gram preparation of cinnamoyl tryptamines as skin whitening agents through a chemo-enzymatic flow process

    David Roura Padrosaa, Martina L. Contenteb

    • aDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    • bDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133, Milan, Italy
    View abstract

    Flow Chemistry as an Enabling Technology for Synthetic Organic Chemistry

    Nicholas E. Leadbeater

    • Department of Chemistry, University of Connecticut, Storrs, USA
    View abstract

    Synthesis and chemical reactions of thieno[3,2-c]quinolines from arylamine derivatives, part (V): a review

    Ameen A. Abu-Hashema, b, A. B. A. El-Gazzara, Ahmed A. M. Abdelgawadb, c, Moustafa A. Goudad, e

    • aPhotochemistry Department (Heterocyclic Unit), National Research Centre, Dokki, Giza, Egypt
    • bChemistry Department, Faculty of Science, Jazan University, Jazan, Saudi Arabia
    • cMedicinal and Aromatic Plants Department, Desert Research Center, Cairo, Egypt
    • dDepartment of Chemistry, Faculty of Science and Arts, Taibah University, Ulla, Medina, Saudi Arabia
    • eDepartment of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt
    View abstract

    From Platform to Knowledge Graph: Evolution of Laboratory Automation

    Jiaru Bai1, Liwei Cao1, Sebastian Mosbach1, 2, Jethro Akroyd1, 2, Alexei A. Lapkin1, 2, Markus Kraft1, 2, 3, 4

    • 1Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge, CB3 0AS, United Kingdom
    • 2CARES, Cambridge Centre for Advanced, Research and Education in Singapore, 1 Create Way, CREATE Tower, #05-05, Singapore, 138602
    • 3School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459
    • 4The Alan Turing Institute, London, NW1 2DB, United Kingdom
    View abstract

    Dimeric cyclobutane formation under continuous flow conditions using organophotoredox catalysed [2+2]-cycloaddition

    Helena F. Granthama, Marc C. Kimbera

    • aSchool of Science, Department of Chemistry, Loughborough University, LE11 3TU, UK
    View abstract

    Synthesis of 2H-Indazoles via the Cadogan Reaction in Batch and Flow Mode

    Matilda Duffya, Mara Di Filippoa, Marcus Baumanna

    • aUniversity College Dublin, School of Chemistry, Science Centre South, Dublin D04 N2E5, Ireland
    View abstract

    DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis

    Charles E. Mowbray*1, Stéphanie Braillard1, Paul A. Glossop2, Gavin A. Whitlock2, Robert T. Jacobs3, Jason Speake3, Bharathi Pandi3, Bakela Nare3, Louis Maes4, Vanessa Yardley5, Yvonne Freund6, Richard J. Wall7, Sandra Carvalho7, Davide Bello7, Magali Van den Kerkhof4, Guy Caljon4, Ian H. Gilbert7, Victoriano Corpas-Lopez7, Iva Lukac7, Stephen Patterson7, Fabio Zuccotto7, Susan Wyllie*7

    • 1Drugs for Neglected Diseases initiative (DNDi), 15 Chemin Louis-Dunant, 1202 Geneva, Switzerland
    • 2Sandexis Medicinal Chemistry Ltd, Innovation House, Discovery Park, Ramsgate Road, Sandwich, Kent CT13 9ND, U.K.
    • 3Scynexis, 3501 C Tricenter Boulevard, Durham, North Carolina 27713, United States
    • 4Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium
    • 5Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, U.K.
    • 6Anacor Pharmaceuticals, 1020 East Meadow Circle, Palo Alto, California 94303, United States
    • 7Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
    View abstract

    SBA15-Supported Nano-ruthenium Catalyst for the Oxidative Cleavage of Alkenes to Aldehydes under Flow Conditions

    Alessandro Di Michelea, Stefano Giovagnolib, Paolo Filipponib, Francesco Venturonib, Antimo Gioiellob

    • aDepartment of Physics and Geology, University of Perugia, Via A. Pascoli 1, 06123 Perugia, Italy
    • bDepartment of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06122 Perugia, Italy
    View abstract

    Iron-catalyzed synthesis of pyridines from α,β-unsaturated ketoxime acetates and N-acetyl enamides

    Gaochen Xu1, Huan Yan1, Sai Zhang1, Qinghuan Wu1, Jindian Duan1, Kai Guo1

    • 1College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China
    View abstract

    Photoredox Iridium–Nickel Dual Catalyzed Cross-Electrophile Coupling: From a Batch to a Continuous Stirred-Tank Reactor via an Automated Segmented Flow Reactor

    Rohit Duvadie1, Alexander Pomberger1, Yiming Mo1, Erhan I. Altinoglu2, Hsiao-Wu Hsieh3, Kakasaheb Y. Nandiwale1, Victor L. Schultz1, Klavs F. Jensen*1, Richard I. Robinson3

    • 1Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    • 2Chemical and Pharmaceutical Profiling, Novartis Global Drug Development, 700 Main Street South, Cambridge, Massachusetts 02139, United States
    • 3Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    View abstract

    Method for preparing epoxidized trans-1, 4-polyisoprene by using micro-reaction device

    Inventor: 乔凯, 张锴, 李玉光, 何伟, 郭凯

    • Assignee: Nanjing Advanced Biomaterials And Process Equipment Research Institute Co ltd
    View abstract

    Lithium aluminum hydride in flow: overcoming exotherms, solids, and gas evolution en route to chemoselective reductions

    Aliakbar Mohammadzadeha, Sepideh Sharifa, Volodymyr Semeniuchenkoa, Norman Townsendb, Andrew D. Corbettb, Michael G. Organa

    • aFlow Chemistry Core Facility, Centre for Catalysis Research and Innovation (CCRI)Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, K1N 6N5, Canada
    • bToronto Research Chemicals, a Subsidiary of LGC, 20 Martin Ross Avenue, Toronto, ON, M3J 2K8, Canada
    View abstract

    Synthesis of 7-Chloroquinoline Derivatives Using Mixed Lithium-Magnesium Reagents

    Valter E. Muriea, Paula V. Nicolinoa, Thiago dos Santosa, Guido Gambacortab, Rodolfo H. V. Nishimuraa, Icaro S. Perovanic, Luciana C. Furtadod, Leticia V. Costa-Lotufod, Anderson Moraes de Oliveirac, Ricardo Vessecchic, Ian R. Baxendaleb, Giuliano C. Clososkib, c

    • aDepartamento de Ciências BioMoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café S/N, Ribeirão Preto 14040-903, Brazil
    • bDepartment of Chemistry, Durham University, South Road, Durham DH1 3LE, United Kingdom
    • cDepartamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14040-901, Brazil
    • dDepartamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Prof. Lineu Prestes 1524, São Paulo 05508-900, Brazil
    View abstract

    Photocatalytic Hydroaminoalkylation of Styrenes with Unprotected Primary Alkylamines

    Hannah E. Askeya, James D. Graysona, Joshua D. Tibbettsa, Jacob C. Turner-Dorea, Jake M. Holmesa, Gabriele Kociok-Kohnb, Gail L. Wrigleyc, Alexander J. Cresswella

    • aDepartment of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, U.K.
    • bMaterials and Chemical Characterisation Facility (MC), University of Bath, Claverton Down, Bath BA2 7AY, U.K.
    • cOncology R&D, Research & Early Development, AstraZeneca, Darwin Building, 310, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.
    View abstract

    Photocatalysis in the Life Science Industry

    Lisa Candisha, Karl D. Collinsb, Gemma C. Cookc, James J. Douglasd, Adrián Gómez-Suáreze, Anais Jolitf, Sebastian Keessf

    • aDrug Discovery Sciences, Pharmaceuticals, Bayer AG, 42113 Wuppertal, Germany
    • bBayer Foundation, Public Affairs, Science and Sustainability, Bayer AG, 51368 Leverkusen, Germany
    • cDiscovery High-Throughput Chemistry, Medicinal Science and Technology, GlaxoSmithKline, Stevenage SG1 2NY, U.K.
    • dEarly Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield SK10 2NA, U.K.
    • eOrganic Chemistry, Bergische Universität Wuppertal, 42119 Wuppertal, Germany
    • fMedicinal Chemistry Department, Neuroscience Discovery Research, AbbVie Deutschland GmbH & Co. KG, 67061 Ludwigshafen, Germany
    View abstract

    Continuous slurry plug flow Fe/ppm Pd nanoparticle-catalyzed Suzuki–Miyaura couplings in water utilizing novel solid handling equipment

    Alex B. Wooda, Scott Plummerb, Richard I. Robinsonb, Marie Smithc, Jim Changc, Fabrice Galloud, Bruce H. Lipshutza

    • aDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA
    • bGlobal Discovery Chemistry – Chemistry Technology Group, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA
    • cGenomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Dr., San Diego, CA 92121, USA
    • dNovartis Pharma AH, CH-4057 Basel, Switzerland
    View abstract

    Photoredox-Catalyzed Multicomponent Petasis Reaction in Batch and Continuous Flow with Alkyl Boronic Acids

    Monica Oliva1, Prabhat Ranjan1, Serena Pillitteri1, Guglielmo Attilio Coppola1, Monica Messina1, Erik V. Van der Eycken1,2, Upendra Kumar Sharma1

    • 1Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven B-3001, Belgium
    • 2Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya street 6, Moscow RU-117198, Russia
    View abstract

    Photoredox-Catalyzed Dehydrogenative Csp3–Csp2 Cross-Coupling of Alkylarenes to Aldehydes in Flow

    Oliver M. Griffithsa, Henrique A. Estevesa, Yiding Chena, Karin Sowaa,b, Oliver S. Maya, Peter Morsec, David C. Blakemorec, Steven V. Ley*a

    • aYusuf Hamied Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, U.K.
    • bDepartment of Chemistry, University of Münster, 48149 Münster, Germany
    • cMedicine Design, Pfizer, Inc., Groton, Connecticut 06340, United States
    View abstract

    Drug Discovery Automation and Library Synthesis in Flow

    Paul Richardson1, Irini Abdiaj2

    • 1Pfizer Medicine Design, Pfizer, La Jolla, USA
    • 2Janssen Research and Development, Toledo, Spain
    View abstract

    Homogeneous Catalytic C(sp3 )–H Functionalization of Gaseous Alkanes

    Antonio Pulcinellaa, Daniele Mazzarellaa, Timothy Noëla

    • aFlow Chemistry Group, Van ’t Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam
    View abstract

    Telescoped Lithiation, C-Arylation and Methoxylation in Flow-Batch Hybrid toward the Synthesis of Canagliflozin

    Dominik Polterauera,b, Jason D. Williamsa,b, Christopher A.Honea,b, C. Oliver Kappea,b

    • aCenter for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering (RCPE), Inffeldgasse 13, A-8010 Graz, Austria
    • bInstitute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz, Austria
    View abstract

    A small footprint oxycodone generator based on continuous flow technology and real-time analytics

    Florian Sommera,b, David Cantilloa,b, C. Oliver Kappea,b

    • aInstitute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010, Graz, Austria
    • bCenter for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010, Graz, Austria
    View abstract

    Unlocking the Accessibility of Alkyl Radicals from Boronic Acids through Solvent-Assisted Organophotoredox Activation

    Prabhat Ranjana, Serena Pillitteria, Guglielmo Coppolaa, Monica Olivaa, Erik V. Van der Eyckena,b, Upendra K. Sharmaa

    • aLaboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001 Leuven, Belgium
    • bPeoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya Street 6, 117198 Moscow, Russia
    View abstract

    Organic–inorganic hybrid electro-optic material with Disperse Red 1 chromophore fabricated by flow chemistry

    Yoonseok Koa, Minsang Kima, Changho Noha, Mi-Jeong Kima, Keechang Leea, Jongback Kimb, Sung Dug Kima, Sang Soo Jeea

    • aPolymer Research Lab, Samsung Advanced Institutes of Technology (SAIT), Samsung Electronics, Suwon-si, Gyeonggi-do, Korea
    • bAnalytical Engineering Group, Samsung Advanced Institutes of Technology (SAIT), Samsung Electronics, Suwon-si, Gyeonggi-do, Korea
    View abstract

    Technological Innovations in Photochemistry for Organic Synthesis: Flow Chemistry, High-Throughput Experimentation, Scale-up, and Photoelectrochemistry

    Laura Buglionia,b, Fabian Raymenantsa, Aidan Slatterya, Stefan D. A. Zondaga, Timothy Noëla

    • aFlow Chemistry Group, van ’t Hoff Institute for Molecular Sciences (HIMS), Universiteit van Amsterdam (UvA), Science Park 904, 1098 XH, Amsterdam, The Netherlands
    • bMicro Flow Chemistry and Synthetic Methodology, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld, Bldg 14—Helix, 5600 MB, Eindhoven, The Netherlands
    View abstract

    Pyrrolidine and bicycloheteroaryl containing oga inhibitor compounds

    Inventor: José Manuel Bartolomé-Nebreda, Andrés Avelino TRABANCO-SUÁREZ, Ana Isabel De Lucas Olivares, Sergio-Alvar Alonso-De Diego

    • Assignee: Janssen Pharmaceutica Nv
    View abstract

    Flow chemistry synthesis of isocyanates

    Inventors: Michael D. BurkartThien An PHUNG HAI

    • Assignee: The Regents Of The University Of California
    View abstract

    Cyclodextrin

    Inventors: Tammy Savage, Stephen Wicks, John Mitchell

    • Assignee: CURADEV PHARMA PRIVATE Ltd
    View abstract

    Compounds and compositions as inhibitors of endosomal toll-like receptors

    Inventors: Phillip Alper, Jonathan DEANE, Songchun Jiang, Tao Jiang, Thomas Knoepfel, Pierre-Yves Michellys, Daniel Mutnick, Wei Pei, Peter SYKA, Guobao Zhang, Yi Zhang

    • Assignee: Novartis AG, Novartis Institutes for BioMedical Research Inc
    View abstract

    High-Yielding Flow Synthesis of a Macrocyclic Molecular Hinge

    Christopher D. Jonesa, Laurence J. Kershaw Cooka, David Marquez-Gameza, Konstantin V. Luzyanina, Jonathan W. Steedb, Anna G. Slatera

    • aDepartment of Chemistry and Materials Innovation Factory, University of Liverpool, Crown Street, Liverpool L69 7ZD, U.K.
    • bDepartment of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.
    View abstract

    Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1-Oxa-8-azaspiro [4.5] decan-3-amine

    Jeffrey T. Kohrta, Peter H. Dorffa, Michael Burnsb, Chewah Leeb, Steven V. O’Neilb, Robert J. Maguireb, Rajesh Kumarb, Melissa Wagenaarb, Loren Pricea, Manjinder S. Lalla

    • aMedicine Design, Pfizer Inc., 445 Eastern Point Road, Groton, Connecticut 06340, United States
    • bChemical Research and Development, Pfizer Inc., 445 Eastern Point Road, Groton, Connecticut 06340, United States
    View abstract

    Scalable Synthesis of Norbornadienes via in situ Cracking of Dicyclopentadiene using Continuous Flow Chemistry

    Jessica Orrego-Hernándeza, Helen Hölzela, Maria Quanta, Zhihang Wanga, Kasper Moth-Poulsena

    • aChalmers University of Technology: Chalmers tekniska hogskola, Chemistry, Sweden
    View abstract

    Delineating a green, catalyst free synthesis of a popular nutraceutical methylsulfonylmethane (MSM) in continuous flow

    Chinmay A. Shuklaa, Bantu Udaykumara, Y. Saisivanarayanaa, Arsh Ismailia, T Haripriyaa, Manish M. Shindeb, Srinivasan Netic, Maheshkumar Uppadaa, Vishnuvardhana Edac, Saikat Senc, Srinivas Orugantia,b,c

    • a10X Chemical Process Automation Laboratory, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India
    • bFlow Chemistry Technology Hub, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India
    • cCentre for Process Research and Innovation, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India
    View abstract

    Evaluation of a Continuous-Flow Photo-Bromination Using N-Bromosuccinimide for Use in Chemical Manufacture

    Matthew Waterforda, Simon Sauberna, Christian H. Hornunga

    • aCSIRO Manufacturing, Bag 10, Clayton South, Vic. 3169, Australia.
    View abstract

    Scalability of photochemical reactions in continuous flow mode

    Kian Donnellya, Marcus Baumanna

    • aSchool of Chemistry, Science Centre South, University College Dublin, D04 N2E2, Dublin, Ireland
    View abstract

    Synthesis of Enantiopure Unnatural Amino Acids by Metallaphotoredox Catalysis

    Tomer M. Faraggia, Caroline Rouget-Virbela, Juan A. Rincónb, Mario Barberisb, Carlos Mateosb, Susana García-Cerradab, Javier Agejasb, Oscar de Frutosb, David W. C. MacMillana

    • aMerck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States
    • bCentro de Investigación Eli Lilly, S. A. Avda de la Industria 30, Alcobendas-Madrid 28108, Spain
    View abstract

    Biocatalyzed Flow Oxidation of Tyrosol to Hydroxytyrosol and Efficient Production of Their Acetate Esters

    Francesca Annunziata1, Martina L. Contente2, Cecilia Pinna2, Lucia Tamborini1, Andrea Pinto2

    • 1Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
    • 2Department of Food, Environmental and Nutritional Sciences, University of Milan, Via Celoria 2, 20133 Milan, Italy
    View abstract

    Supporting-Electrolyte-Free Anodic Oxidation of Oxamic Acids into Isocyanates: An Expedient Way to Access Ureas, Carbamates, and Thiocarbamates

    Alessia Pettia, Corentin Fagnana, Carlo G. W. van Melisa, Nour Tanbouzab, Anthony D. Garciaa, Andrea Mastrodonatoa, Matthew C. Leecha, Iain C. A. Goodalla, Adrian P. Dobbsa, Thierry Ollevierb, Kevin Lam*a

    • aSchool of Science, University of Greenwich, Chatham Maritime, Chatham, Kent ME4 4TB, U.K.
    • bDépartement de Chimie, Université Laval, 1045 avenue de la Médecine, Québec, QC G1V 0A6, Canada
    View abstract

    Application of reactor engineering concepts in continuous flow chemistry: a review

    Nicole C. Neyta, Darren L. Riley*a

    • aFaculty of Natural and Agricultural Sciences, Department of Chemistry, University of Pretoria, South Africa
    View abstract

    In situ sensors for flow reactors – a review

    Jun Lia, Helena Šimekb, David Ilioaec, Nicole Jungb, Stefan Bräseb, Hans Zappec, Roland Dittmeyera, Bradley P. Ladewig*a

    • aInstitute for Micro Process Engineering (IMVT), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, Germany
    • bInstitute of Biological and Chemical Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, Germany
    • cGisela and Erwin Sick Laboratory for Micro-optics, Department of Microsystems Engineering, University of Freiburg, Germany
    View abstract

    Mechanism and kinetics of the aerobic oxidation of benzyl alcohol to benzaldehyde catalyzed by cobalt porphyrin in a membrane microchannel reactor

    Qi Hana, Xian-Tai Zhoua, Xiao-Qi Hed, Hong-Bing Jib, c

    • aFine Chemical Industry Research Institute, School of Chemical Engineering and Technology, Sun Yat-sen University, Zhuhai 519082, China
    • bFine Chemical Industry Research Institute, School of Chemistry, Sun Yat -sen University, Guangzhou 510275, China
    • cSchool of Chemical Engineering, Guangdong University of Petrochemical Technology, Maoming 525000, China
    • dHuizhou Research Institute, Sun Yat-sen University, Huizhou 516081, China
    View abstract

    Expanding the Tool Kit of Automated Flow Synthesis: Development of In-line Flash Chromatography Purification

    Christopher G. Thomsona, Colin Banksb, Mark Allenc, Graeme Barkera, d, Christopher R. Coxona, Ai-Lan Lee*a, Filipe Vilela*a, d

    • aInstitute of Chemical Sciences, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, Scotland EH14 4AS, United Kingdom
    • bCheshire Sciences (UK) Limited, Kao Hockham Building, Edinburgh Way, Harlow, Essex, England CM20 2NQ, United Kingdom
    • cAdvion (UK) Limited, Kao Hockham Building, Edinburgh Way, Harlow, Essex, England CM20 2NQ, United Kingdom
    • dContinuum Flow Lab, Heriot-Watt University, Edinburgh, Scotland EH14 4AS, United Kingdom
    View abstract

    The integration of catalyst design and process intensification in the efficient synthesis of 5-hydroxymethyl-2-furancarboxylic acid from fructose

    Wei Hea1, Congcong Zhangb1, Wenyan Zhanga, YuchenZhuc, Zheng Fanga, Lili Zhaob, Kai Guoa, d

    • aCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, PR China
    • bInstitute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China
    • cSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China
    • dState Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 210009, PR China
    View abstract

    (Trifluoromethylselenyl)methylchalcogenyl as Emerging Fluorinated Groups: Synthesis under Photoredox Catalysis and Determination of the Lipophilicity

    Kevin Grollier[a], Arnaud De Zordo-Banliat[b], Flavien Bourdreux[b], Bruce Pegot[b], Guillaume Dagousset[b], Emmanuel Magnier*[b], Thierry Billard*[a, c]

    • [a]Institute of Chemistry and Biochemistry (ICBMS, UMR CNRS 5246) Univ Lyon, Universite Lyon 1, CNRS,CPE, INSA43 Bd du 11 novembre 1918, 69622 Villeurbanne (France)
    • [b]InstitutLavoisierdeVersailles (UMR CNRS 8180)Universit Paris-Saclay,UVSQ,CNRS78035 Versailles (France)
    • [c]CERMEP-In vivo imaging59 Bd Pinel, 69677 Lyon (France)
    View abstract

    «Quick, convenient, and clean»: Advancing education in green chemistry and nanocatalysis using sol-gel catalysts under flow

    Antonino Scurriaa, Mario Pagliaroa, Rosaria Ciriminnaa

    • aIstituto per lo Studio dei Materiali Nanostrutturati, CNR, via U. La Malfa 153, 90146 Palermo, Italy
    View abstract

    Scale-Up and Optimization of a Continuous Flow Carboxylation of N-Boc-4,4-difluoropiperidine Using s-BuLi in THF

    Jean-Paul Kestemonta, James R. Frostb, Jérôme Jacqa, Patrick Pasaua, Frédéric Perla, Julien Brownb, Matthieu Tissot*a

    • aUCB Biopharma SPRL, Avenue de l’industrie, 1420 Braine l’Alleud, Belgium
    • bUCB, 216 Bath Road, Slough SL1 3WE, United Kingdom
    View abstract

    Exploration of continuous-flow benchtop NMR acquisition parameters and considerations for reaction monitoring

    Tristan Maschmeyera, Paloma L. Prietoa, Shad Grunerta, Jason E. Heina

    • aDepartment of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada
    View abstract

    Amino alcohol acrylonitriles as broad spectrum and tumour selective cytotoxic agents

    Jennifer R. Bakera, Cecilia C. Russella, Jayne Gilbertb, Adam McCluskeya, Jennette A. Sakoffb

    • aChemistry, School of Environmental & Life Sciences, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
    • bExperimental Therapeutics Group, Department of Medical Oncology, Calvary Mater Newcastle Hospital, Edith Street, Waratah, NSW 2298, Australia
    View abstract

    Ozone-Mediated Amine Oxidation and Beyond: A Solvent Free, Flow-Chemistry Approach

    Eric A. Skrotzkia, Jaya Kishore Vandavasia, Stephen G. Newmana

    • aCentre for Catalysis Research and Innovation, Department of Chemistry and Biomolecular Sciences, University of Ottawa, 10 Marie-Curie, Ottawa, Ontario K1N 6N5, Canada.
    View abstract

    A sustainable and scalable multicomponent continuous flow process to access fused imidazoheterocycle pharmacophores

    Blake J. M. Bakera, b, William J. Kerr*b, David M. Lindsayb, Vipul kumar K. Patela, Darren L. Poolea

    • aGlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK
    • bDepartment of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, UK
    View abstract

    Reproducible and rapid synthesis of a conjugated polymer by Stille polycondensation in flow: Effects of reaction parameters on molecular weight

    Woojin Shina, 1, Wonyoung Koa, 1, Seung-Hwan Jina, Taeshik Earmmeb, Ye-Jin Hwanga

    • aDepartment of Chemistry and Chemical Engineering, Education and Research Center for Smart Energy and Materials, Inha University, 100 Inha-ro, Michuhol-gu, Incheon, Republic of Korea
    • bDepartment of Chemical Engineering, Hongik University, 94 Wausan-ro, Mapo-gu, Seoul 04066, Republic of Korea
    View abstract

    Innovation in delivering synthetically challenging bicyclic arginase inhibitors to enhance immunotherapy

    Derun Lia, Hongjun Zhanga, Thomas W. Lyonsa, Theodore A. Martinota, Abdelghani Achaba, Min lua, Lisa M. Noglea, Spencer McMinna, Matthew J. Mitcheltreea, Matthew Childersa, Qinglin Pua, Symon Gathiakaa, Anand Palania, Kalyan Chakravarthya, Amy D. DeCastroa, Jennifer O'Neila, Roshi Afshara, Nicole C. Walsha, Peter W. Fana, Mangeng Chenga, Richard Millera, Amy Dotya, Rachel Paltea, Hai-Young Kima, Josep Sauría, Adam Bearda, Christopher Brynczkaa and Christian Fischera

    • aMerck Research Laboratory, Boston, MA.
    View abstract

    A revised 1D equivalent model for the determination of incident photon flux density in a continuous-flow LED-driven spiral-shaped microreactor using the actinometry method with Reinecke’s salt

    Robbie Radjagobaloua, Victoria Dias Da Silva Freitasa, Jean-François Blancoa, Fabrice Grosb, Jérémy Dauchetb, Jean-François Cornetb, Karine Loubierea

    • aLaboratoire de Génie Chimique (LGC), Université de Toulouse, CNRS, INPT, UPS, 4 allée Emile Monso, CS 84234, 31 432, Toulouse, France
    • bUniversité Clermont Auvergne, Clermont Auvergne INP, CNRS, Institut Pascal, F-63000, Clermont-Ferrand, France
    View abstract

    Interrupted Curtius Rearrangements of Quaternary Proline Derivatives: A Flow Route to Acyclic Ketones and Unsaturated Pyrrolidines

    Marcus Baumanna, Thomas S. Moodyb, c, Megan Smythb, Scott Wharryb

    • aSchool of Chemistry, University College Dublin, Science Centre South, Belfield D04 N2E2, Ireland
    • bDepartment of Technology, Almac Sciences, 20 Seagoe Industrial Estate, Craigavon BT63 5QD, United Kingdom
    • cArran Chemical Company, Roscommon N37 DN24, Ireland
    View abstract

    Flow electrochemistry: a safe tool for fluorine chemistry

    Bethan Wintersona, Tim Rennigholtza, Thomas Wirtha

    • aSchool of Chemistry, Cardiff University, Park Place, Main Building, Cardiff, Cymru/Wales, UK
    View abstract

    Flow Electrosynthesis of Sulfoxides, Sulfones, and Sulfoximines without Supporting Electrolytes

    Nasser Amri1 and Thomas Wirth1

    • 1School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, United Kingdom
    View abstract

    Discrete Ti−O−Ti Complexes: Visible-Light-Activated, Homogeneous Alternative to TiO2 Photosensitisers

    Kira Behma, Dr. Eszter Fazekasa, Prof. Martin J. Patersona, Dr. Filipe Vilelaa, Dr. Ruaraidh D. McIntosha

    • aInstitute of Chemical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS UK
    View abstract

    Stereospecific amination of mesylated cyclobutanol in continuous flow

    Matthieu Tissota, Jérôme Jacqa, Patrick Pasaua

    • UCB Biopharma SPRL, Avenue de l’industrie, 1420 Braine l’Alleud, Belgiuma
    View abstract

    Chemo-enzymatic oxidative cleavage of isosafrole for the synthesis of piperonal

    Francesca Tentori*a, Elisabetta Brenna*a, Chiara Ferraria, Francesco G. Gattia, Maria Chiara Ghezzia, Fabio Parmeggiania

    • aDipartimento di Chimica, Materiali ed Ingegneria Chimica “Giulio Natta”, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milano, Italy.
    View abstract

    Radical alpha-Trifluoromethoxylation of Ketones by Means of Organic Photoredox Catalysis

    Thibaut Duhail[a]†, Tommaso Bortolato[b]†, Javier Mateos[b], Elsa Anselmi[a,c], Benson Jelier[d], Antonio Togni[d], Emmanuel Magnier[a], Guillaume Dagousset[a], Luca Dell’Amico[b]

    • [a] Université Paris-Saclay, UVSQ, CNRS, UMR 8180, Institut Lavoisier de Versailles, 78035 Versailles Cedex (France)
    • [b]Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131, Padova (Italy)
    • [c] Université de Tours, Faculté des Sciences et Techniques, 37200 Tours (France)
    • [d]Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zurich, Vladimir-Prelog-Weg 2, 8093 Zurich (Switzerland)
    View abstract

    Rapid Optimization of Photoredox Reactions for Continuous-Flow Systems Using Microscale Batch Technology

    María González-Esguevillasa, David F. Fernándeza, Juan A. Rincónb, Mario Barberisb, Oscar de Frutosb, Carlos Mateosb, Susana García-Cerradab, Javier Agejasb, David W. C. MacMillan*a

    • aMerck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States
    • bCentro de Investigación Eli Lilly, S. A., Avda. de la Industria 30, 28108 Alcobendas, Madrid, Spain
    View abstract

    Microfluidic synthesis of CsPbBr3/Cs4PbBr6 nanocrystals for inkjet printing of mini-LEDs

    Zhen Baoa,1, Jian-Wen Luob,1, Yu-Sin Wangc, Ting-Chou Huc, Sung-Yu Tsaic, Yi-Ting Tsaid, Huang-Chia Wangd, Fu-Hsin Chend, Yu-Chun Leed, Tzong-Liang Tsaid, Ren-Jei Chungb, Ru-Shi Liua,e

    • aDepartment of Chemistry, National Taiwan University, Taipei 106, Taiwan
    • bDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan
    • cChina Glaze Co., Ltd., Hsinchu 310, Taiwan
    • dLextar Electronics Corporation, Hsinchu 300, Taiwan
    • eAdvanced Research Center of Green Materials Science and Technology, National Taiwan University, Taipei 106, Taiwan
    View abstract

    Modular allylation of C(sp3)−H bonds by combining decatungstate photocatalysis and HWE olefination in flow

    Luca Capaldo1, Stefano Bonciolini1, Antonio Pulcinella1, Manuel Nuño2, Timothy Noël1

    • 1 Flow Chemistry Group, van ’t Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
    • 2Vapourtec Ltd., Park Farm Business Centre, Fornham St Genevieve, Bury St Edmunds, Suffolk IP28 6TS, United Kingdom
    View abstract

    Decatungstate-mediated C(sp3 )‒H Heteroarylation via Radical Polar Crossover in Batch and Flow

    Ting Wana, Luca Capaldoa, Gabriele Laudadioa, Alexander V. Nyuchevb, Juan A. Rincónc, Pablo García-Losadac, Carlos Mateosc, Michael O. Frederickd, Manuel Nuñoe, Timothy Noël*a

    • aFlow Chemistry Group, Van ’t Hoff Institute for Molecular Sciences(HIMS), University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands
    • bDepartment of Organic Chemistry, Lobachevsky State University of Nizhny Novgorod Gagarina Avenue 23, 603950, Nizhny Novgorod, Russia
    • cCentro de Investigación Lilly S.A. Avda. de la Industria 30, Alcobendas-Madrid 28108, Spain.
    • dSmall Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
    • eVapourtec Ltd., Park Farm Business Centre, Fornham St Genevieve, Bury St Edmunds, Suffolk IP28 6TS, United Kingdom.
    View abstract

    Highly Permeable Fluorinated Polymer Nanocomposites for Plasmonic Hydrogen Sensing

    Ida Östergren1, Amir Masoud Pourrahimi1, Iwan Darmadi2, Robson da Silva1, Alicja Stolaś1, Sarah Lerch1, Barbara Berke2, Manuel Guizar-Sicairos3, Marianne Liebi2, Giacomo Foli4, Vincenzo Palermo4,5, Matteo Minelli6, Kasper Moth-Poulsen1, Christoph Langhammer2, and Christian Müller1

    • 1Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Göteborg 412 96, Sweden
    • 2Department of Physics, Chalmers University of Technology, Göteborg 412 96, Sweden
    • 3Paul Scherrer Institut, Villigen PSI 5232, Switzerland
    • 4Institute of Organic Synthesis and Photoreactivity, National Research Council, Bologna 40129, Italy
    • 5Department of Industrial and Materials Science, Chalmers University of Technology, Göteborg 412 96, Sweden
    • 6Department of Civil, Chemical, Environmental and Materials Engineering, Alma Mater Studiorum—University of Bologna, Bologna 40131, Italy
    View abstract

    Efficient Amino Donor Recycling in Amination Reactions: Development of a New Alanine Dehydrogenase in Continuous Flow and Dialysis Membrane Reactors

    David Roura Padrosa1, Zoya Nisar2, Francesca Paradisi1,2

    • 1Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    • 2School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    View abstract

    Iron-catalyzed [4 + 2] annulation of α,β-unsaturated ketoxime acetates with enaminones toward functionalized pyridines

    Jindian Duan, Gaochen Xu, Binsen Rong, Huan Yan, Sai Zhang, Qinghuan Wu, Ning Zhu, Kai Guo

    • College of Biotechnology and Pharmaceutical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China
    View abstract

    Enzyme-electrochemical continuous flow cascades synthesis of substituted benzimidazoles

    Ting-Ting Shia,b, Shu-Zhan Wanga, Zhao Yangc, Yilin Wanga, Chengkou Liua, Wei He*a, Zheng Fang*a,d, Kai Guoad

    • aCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, P. R. China.
    • bDepartment of Chemistry, Bengbu Medical College, 233030, P. R. China.
    • cSchool of Engineering, China Pharmaceutical University, No.639 Longmian Avenue, Nanjing 211198, China
    • dState Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, P. R. China.
    View abstract

    A Practical Transferring Method from Batch to Flow Synthesis of Dipeptides via Acid Chloride Assisted by Simulation of the Reaction Rate

    Masahiro Hosoya, *Go Shiino, Naoki Tsuno

    • API R&D Laboratory, CMC R&D Division, Shionogi and Co., Ltd., 1-3, Kuise Terajima 2-chome, Amagasaki, Hyogo 660-0813, Japan
    View abstract

    Synthesis of the Lipophilic Amine Tail of Abediterol Enabled by Multiphase Flow Transformations

    Jorge García-Lacuna1, Tobias Fleiß1,2, Rachel Munday3, Kevin Leslie3, Anne O’Kearney-McMullan3, Christopher A. Hone*1,2, C. Oliver Kappe*1,2

    • 1Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz, Austria
    • 2Center for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria
    • 3Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, United Kingdom
    View abstract

    The CO2 photoconversion over reduced graphene oxide based on Ag/TiO2 photocatalyst in an advanced meso-scale continuous-flow photochemical reactor

    Samar Nabil1, Ahmed S. Hammad2, Haitham M. El-Bery3, Elsayed A. Shalaby1, Ahmed H. El-Shazly4,5

    • 1Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria, 21526, Egypt
    • 2Chemical Engineering Department, Faculty of Engineering, Port Said University, Port Said, Egypt
    • 3Advanced Functional Materials Laboratory, Chemistry Department, Faculty of Science, Assiut University, Assiut, 71515, Egypt
    • 4Chemical and Petrochemicals Engineering Department, Egypt-Japan University of Science and Technology, Alexandria, 21934, Egypt
    • 5Chemical Engineering Department, Faculty of Engineering, Alexandria University, Alexandria, 21544, Egypt
    View abstract

    Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicity

    Hsien-Ya Lin1,2,7, Chia-Yu Chen1,2,7, Ting-Chien Lin1,2,7, Lun-Fu Yeh1, Wei-Che Hsieh1, Shijay Gao1, Pierre-Alain Burnouf3, Bing-Mae Chen3, Tung-Ju Hsieh1, Punsaldulam Dashnyam1, Yen-Hsi Kuo1, Zhijay Tu1, Steve R. Roffler3,4, Chun-Hung Lin1,2,5,6

    • 1Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    • 2Department of Chemistry, National Taiwan University, Taipei, Taiwan
    • 3Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    • 4Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • 5Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan
    • 6The Genomics Research Center, Academia Sinica, Taipei, Taiwan
    • 7These authors contributed equally
    View abstract

    Enantio-Complementary Continuous-Flow Synthesis of 2-Aminobutane Using Covalently Immobilized Transaminases

    Christian M. Heckmanna, Beatriz Dominguezb, Francesca Paradisia,c

    • aSchool of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom
    • bJohnson Matthey, 28 Cambridge Science Park, Milton Road, Cambridge, CB4 0FP, United Kingdom
    • cDept. of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012, Bern, Switzerland
    View abstract

    A Machine Learning‐Enabled Autonomous Flow Chemistry Platform for Process Optimization of Multiple Reaction Metrics

    Dr. Mohammed I. Jeraala, Dr. Simon Sunga, Prof. Alexei A. Lapkina,b

    • aCambridge Centre for Advanced Research and Education in Singapore Ltd., 1 Create Way, CREATE Tower #05-05, 138602 Singapore
    • bDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, CB3 0AS UK
    View abstract

    Enzymatic esterification of lauric acid to give monolaurin in a microreactor

    Shanshan Miao, Xin Li

    • College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, P.R. China
    View abstract

    A continuous flow synthesis of [1.1.1]propellane and bicyclo[1.1.1]pentane derivatives

    Kian Donnelly, Marcus Baumann

    • School of Chemistry, University College Dublin, Science Centre South, Belfield, Ireland
    View abstract

    A Process for Making Brominating Agents in Flow

    Inventors:, Dermaut, Wim (Mortsel, BE), Cappuyns, Bart (Mortsel, BE), Moens, Matthias (Mortsel, BE), Stevens, Christian (Mortsel, BE)

    • Assignee:
    • AGFA NV
    • UNIVERSITEIT GENT
    View abstract

    Dimethyl Fumarate: Heterogeneous Catalysis for the Development of an Innovative Flow Synthesis

    Fabiana Dedè1, Oreste Piccolo2, Daniele Vigo1

    • 1Cambrex Profarmaco Milano S.r.l., via Curiel 34, 20067 Milan, Paullo, Italy
    • 2Studio di Consulenza scientifica, via Bornò 5, 23896 Lecco, Sirtori, Italy
    View abstract

    Flow Biocatalysis 101: design, development and applications

    Ana I. Benítez-Mateos, Martina Letizia Contente, David Roura Padrosa, Francesca Paradisi

    • Department of Chemistry and Biochemistry University of Bern, Freiestrasse 3, Bern (Switzerland)
    View abstract

    Coupling biocatalysis with high-energy flow reactions for the synthesis of carbamates and β-amino acid derivatives

    Alexander Leslie1, Thomas S. Moody2,3, Megan Smyth2, Scott Wharry2, Marcus Baumann1

    • 1School of Chemistry, University College Dublin, D04 N2E2, Ireland
    • 2Almac Group Ltd., Craigavon BT63 5QD, United Kingdom
    • 3Arran Chemical Company, Athlone, Co. Roscommon N37 DN24, Ireland
    View abstract

    Development of a Continuous Photochemical Benzyne-Forming Process

    Cormac Brackena, Andrei S. Batsanovb, Marcus Baumanna

    • aSchool of Chemistry, University College Dublin, Science Centre South, D04 N2E2, Dublin, Ireland
    • bDepartment of Chemistry, University of Durham, South Road, DH1 3LE, Durham, UK
    View abstract

    Photocatalytic (Het)arylation of C(sp3)–H Bonds with Carbon Nitride

    Saikat Dasa, Kathiravan Murugesana, Gonzalo J. Villegas Rodrígueza, Jaspreet Kaura, Joshua. P. Barhama, Aleksandr Savateevb, Markus Antoniettib, Burkhard Königa

    • aFakultät für Chemie und Pharmazie, Universität Regensburg, 93040 Regensburg, Germany
    • bDepartment of Colloid Chemistry, Max-Planck Institute of Colloids and Interfaces, Research Campus Golm, 14424 Potsdam, Germany
    View abstract

    The rise of continuous flow biocatalysis – fundamentals, very recent developments and future perspectives

    Piera De Santisa, Lars-Erik Meyera, Selin Karaa

    • aAarhus University, Department of Engineering, Biological and Chemical Engineering Section, Biocatalysis and Bioprocessing Group, Gustav Wieds Vej 10, DK 8000 Aarhus, Denmark
    View abstract

    Corymbia citriodora: A Valuable Resource from Australian Flora for the Production of Fragrances, Repellents, and Bioactive Compounds

    Tyler Goodinea, Michael Oelgemöllera,b

    • aJames Cook University, College of Science and Engineering, 1 James Cook Drive, 4811 Townsville, Queensland, Australia
    • bGhent University, Department of Organic and Macromolecular Chemistry, Krijgslaan 281 S4, 9000 Gent, Belgium
    View abstract

    Combining Radial and Continuous Flow Synthesis to Optimize and Scale-up the Production of Medicines

    Mara Guidia,b, Sooyeon Moona,b, Lucia Anghileria,b, Dario Cambiéa, Peter H. Seeberger*a,b, Kerry Gilmore*a,c

    • aDepartment of Biomolecular Systems Max Planck Institute of Colloids and Interfaces Am Mühlenberg 1, 14476 Potsdam (Germany)
    • bDepartment of Chemistry and Biochemistry Freie Universität Berlin Arnimallee 22, 14195 Berlin (Germany)
    • cUniversity of Connecticut, Storrs, CT 06269 (United States)
    View abstract

    Additive manufacturing of intricate and inherently photocatalytic flow reactor components

    Adilet Zhakeyeva,b, Mary C.Jonesb, Christopher G.Thomsonb, John M.Tobinc, Huizhi Wangd, Filipe Vilelab, Jin Xuana

    • aDepartment of Chemical Engineering, Loughborough University, Loughborough, LE11 3TU, UK
    • bSchool of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK
    • cSchool of Chemistry, The University of Edinburgh, Edinburgh, EH9 3FJ, UK
    • dDepartment of Mechanical Engineering, Imperial College London, Exhibition Road, South Kensington Campus, London, SW7 2AZ, UK
    View abstract

    Continuous Flow Synthesis and Antimicrobial Evaluation of NHC* Silver Carboxylate Derivatives of SBC3 in vitro and in vivo

    Cillian O’Beirne†a, Magdalena E. Piatekb, Jen Fossenc, Helge Müller-Bunza, David R. Andesc, Kevin Kavanaghb, Siddappa A. Patild, Marcus Baumanna, Matthias Tacke†a

    • aSchool of Chemistry, University College Dublin, Belfield, Stillorgan, Dublin 4, Republic of Ireland
    • bSSPC Pharma Research Centre, Department of Biology, Maynooth University, Maynooth, W23F2H6, Co. Kildare, Republic of Ireland
    • cJ. Fossen, Prof. D. R. Andes, Department of Medicine, 600 Highland Avenue, University of Wisconsin, Madison, USA
    • dCentre for Nano and Material Sciences, Jain University, Bangalore, Karnataka, India
    View abstract

    γ-Amino phosphonates via the photocatalytic α-C–H alkylation of primary amines

    James D. Grayson, Alexander J. Cresswell

    • Department of Chemistry, University of Bath, 1 South, Claverton Down, Bath, BA2 7AY, UK
    View abstract

    Development and Proof of Concept for a Large-Scale Photoredox Additive-Free Minisci Reaction

    Mark A. Graham*a, Gary Noonan*a, Janette H. Cherrymana, Miguel Gonzalezb, Lucinda V. Jacksona, Kevin Lesliea, Zhi-qing Liub, David McKinneya, Rachel H. Mundaya, Chris D. Parsonsc, David T. E. Whittakerc, En-xuan Zhangb, Jun-wang Zhangb

    • aChemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield SK10 2NA, U.K.
    • bAsymchem Laboratories (Tianjin) Co. Ltd., TEDA, Tianjin 300457, P. R. China
    • cEarly Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield SK10 2NA, U.K.
    View abstract

    Achieving selectivity in porphyrin bromination through a DoE-driven optimization under continuous flow conditions

    Paolo Zardi, Michele Maggini, Tommaso Carofiglio

    • Dipartimento di Scienze Chimiche, Università degli Studi di Padova, Via Marzolo 1, 35131, Padova, Italy
    View abstract

    A scalable continuous photochemical process for the generation of aminopropylsulfones

    Stefano Bonciolinia, Mara Di Filippoa, Marcus Baumanna

    • aSchool of Chemistry, University College Dublin, Science Centre South, Belfield, Ireland
    View abstract

    Recent Advances in Continuous-Flow Reactions Using Metal-Free Homogeneous Catalysts

    Naoto Sugisawa1,2, Hiroyuki Nakamura>1, Shinichiro Fuse3

    • 1Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8503, Japan
    • 2School of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan
    • 3Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya 464-8601, Japan
    View abstract

    Continuous Flow Photo-RAFT and Light-PISA

    Jian Wanga,c, Xin Hub,c, Ning Zhua,c, Kai Guoc

    • aCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu 211800, China
    • bCollege of Materials Science and Engineering, Nanjing Tech University, Nanjing, Jiangsu 211800, China
    • cState Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, Jiangsu 211800, China
    View abstract

    Tandem Continuous Flow Curtius Rearrangement and Subsequent Enzyme-Mediated Impurity Tagging

    Marcus Baumann1, Alexander Leslie1, Thomas S. Moody2, 3, Megan Smyth*2, Scott Wharry2

    • 1School of Chemistry, Science Centre, University College Dublin, South Belfield, Dublin 4, Ireland
    • 2Almac Group Ltd., 20 Seagoe Industrial Estate, Craigavon BT63 5QD, United Kingdom
    • 3Arran Chemical Company, Unit 1 Monksland Industrial Estate, Athlone, Co. Roscommon N37 DN24, Ireland
    View abstract

    An open source toolkit for 3D printed fluidics

    Adam J. N. Price1, Andrew J. Capel2, Robert J. Lee1, Patrick Pradel3, Steven D. R. Christie1

    • 1School of Science, Loughborough University, Loughborough LE11 3TU, UK
    • 2School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK
    • 3Design School, Loughborough University, Loughborough LE11 3TU, UK
    View abstract

    Bicyclic Quinazolinone Derivatives

    Inventors:, Hert, Jerome (Basel, CH), Hunziker, Daniel (Basel, CH), Kuratli, Christoph (Basel, CH), Martin, Rainer E. (Basel, CH), Mattei, Patrizio (Basel, CH), Satz, Alexander Lee (Basel, CH)

    • Assignee: Hoffmann-La Roche Inc. (Little Falls, NJ, US)
    View abstract

    Characterization of reaction enthalpy and kinetics in a microscale flow platform.

    Agnieszka Ladosz, Christina Kuhnle, Klavs F Jensen

    • Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    View abstract

    Photochemical Flow Oximation of Alkanes

    Oliver M. Griffithsa, b, Michele Ruggeria, Ian R. Baxendale∗a

    • aDepartment of Chemistry, University of Durham, South Road, Durham, Durham, DH1 3LE, UK
    • bDepartment of Chemistry, Cambridge University, South Road, Cambridge, Cambridgeshire, CB2 1EW, UK
    View abstract

    Development of a packed-bed flow process for the production scale hydrogenation of 7-oxo-lithocholic acid to ursodeoxycholic acid

    Seung Jae Lee1, 2, Yashwardhan R. Malpani2, Il Won Kim1

    • 1Department of Chemical Engineering, Soongsil University, 369 Sangdo-ro, Dongjak-gu 06978 Seoul, Republic of Korea
    • 2API Synthesis Team, Daewoong-Bio, 29-Jeyakdanji-ro, Hyangnam-eup, Hwaseung-si, Gyeonggi-do 18608, Republic of Korea
    View abstract

    A Vilsmeier Chloroformylation by Continuous Flow Chemistry

    Manuel Carrera1, Laurens De Coen1, Michelle Coppens2, Wim Dermaut2, Christian V. Stevens2

    • 1Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Campus Coupure, Coupure Links 653, Gent B-9000, Belgium
    • 2Agfa-Gevaert NV, Septestraat 27, Mortsel B-2640, Belgium
    View abstract

    Exploration of continuous flow benchtop NMR acquisition parameters and considerations for reaction monitoring

    Tristan Maschmeyer, Paloma L. Prieto, Shad Grunert Jason E. Hein

    • Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada
    View abstract

    Predicting performance of photochemical transformations for scaling up in different platforms by combining high-throughput experimentation with computational modeling

    Melda Sezen-Edmonds1,‡,*, Jose E. Tabora1, Benjamin M. Cohen1, Serge Zaretsky1, Eric M. Simmons1, Trevor C. Sherwood2, Antonio Ramirez1

    • 1Chemical Process Development, Bristol Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States
    • 2Discovery Chemistry, Bristol Myers Squibb, Lawrenceville, New Jersey 08543, United States
    • These authors contributed equally to this work.
    View abstract

    Application of a Dual Catalytic Nickel/Iridium-Based Photoredox Reaction to Synthesize 2-Alkyl-N-Arylindoles in a Continuous Flow

    Jasmin C. Wilson, Michael J. Boyd, Simon Giroux, Upul K. Bandarage*

    • Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, Massachusetts 02210, United States
    View abstract

    Convenient Continuous Flow Synthesis of N-Methyl Secondary Amines from Alkyl Mesylates and Epoxides

    Gary Mathieu, Heena Patel, Hélène Lebel

    • Department of Chemistry and Center in Green Chemistry and Catalysis (CGCC), Université de Montréal, P.O. Box 6128, Station, Downtown, Montréal, QC H3C 3J7, Canada
    View abstract

    Synthesis of metal-organic frameworks (MOFs) and its application in food packaging: A critical review

    P.S.Sharanyakanth, R.Mahendran

    • Centre of Excellence in Nonthermal Processing, Indian Institute of Food Processing Technology (IIFPT), Pudukkottai Road, Thanjavur, India
    View abstract

    Flow chemistry as a tool to access novel chemical space for drug discovery

    Enol Lópeza, María Lourdes Linaresb, Jesús Alcázarb

    • aFacultad de Ciencias y Tecnologías Químicas, Universidad de Castilla-La Mancha, Av. Camilo José Cela, 14, Ciudad Real, 13005, Spain
    • bJanssen Research & Development, Janssen-Cilag, S.A., Jarama, 75A, Toledo, 45007, Spain
    View abstract

    Continuous flow synthesis of lipophilic cations derived from benzoic acid as new cytotoxic chemical entities in human head and neck carcinoma cell lines

    Mabel Catalán,‡a, Vicente Castro-Castillo,‡§b, Javier Gajardo-de la Fuenteb, Jocelyn Aguilerac, Jorge Ferreiraa, Ricardo Ramires-Fernandezd, Ivonne Olmedoe, Alfredo Molina-Berríosc, Charlotte Palominosa, Marcelo Valenciaa, Marta Domínguezf, José A. Souto*f, José A. Jara*c

    • *Corresponding authors
    • aClinical and Molecular Pharmacology Program, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Universidad de Chile, Santiago, Chile
    • bDepartment of Organic and Physical Chemistry, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile, Santos Dumont 964, Santiago 8380494, Chile
    • cInstitute for Research in Dental Sciences (ICOD), Faculty of Dentistry, Universidad de Chile, Santiago, Chile
    • dDentistry School, Universidad Mayor, Santiago 8340585, Chile
    • ePhysiopathology Program, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile
    • fDepartamento de Química Orgánica, Facultad de Química, CINBIO and IIS Galicia Sur, Universidade de Vigo, Vigo, Spain
    View abstract

    Antibody Conjugation Method

    Inventor: Spedaliere, Christopher J. (Allentown, PA, US)

    • Assignee: FUJIREBIO DIAGNOSTICS, INC. (MALVERN, PA, US)
    View abstract

    Novel Applications of α-Diazocarbonyl Compounds and Enabling Technologies in Stereoselective Synthesis

    Micol Santi

    • PhD Thesis, May 2020, Cardiff University
    View abstract

    Efficient Chemo-Enzymatic Flow Synthesis of High Value Amides and Esters

    Francesca Annunziata1, Martina Letizia Contente2, Daniele Betti1, Cecilia Pinna1, Francesco Molinari3, Lucia Tamborini1*, Andrea Pinto3

    • 1Department of Pharmaceutical Sciences (DISFARM), University of Milan, via Mangiagalli 25, 20133 Milan, Italy
    • 2School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    • 3 Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, Italy
    View abstract

    Continuous Flow Synthesis of Quinolines via a Scalable Tandem Photoisomerization-Cyclization Process

    Mara Di Filippo, Marcus Baumann

    • School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin D04 N2E2, Ireland
    View abstract

    Toward Secure Supply of Remdesivir via a 2-Pot Triazine Synthesis: Supply Centered Synthesis

    Dinesh J. Paymodea, Flavio S. P. Cardosoa, Joshua D. Siebera, John W. Tomlina, Daniel W. Cookb, Justina Burnsb, Rodger W. Stringhamb, B. Frank Guptona, David Sneada, Toolika Agrawala

    • aChemical Development, Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond VA, 23298-0100
    • bAnalytical Development, Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond VA, 23298-0100
    View abstract

    Process of Manufacturing Polyols

    Inventors: Raghuraman, Arjun (Pearland, TX, US) Heath, William H. (Lake Jackson, TX, US), Mukhopadhyay, Sukrit (Midland, MI, US), Spinney, Heather A. (Midland, MI, US), Wilson, David R. (Midland, MI, US), Gies, Anthony P. (Lake Jackson, TX, US), Paradkar, Manjiri R. (Lake Jackson, TX, US), Notestein, Justin M. (Evanston, IL, US), Nguyen, Sonbinh T. (Evanston, IL, US)

    • Assignees:
    • Dow Global Technologies LLC (Midland, MI, US)
    • Northwestern University (Evanston, IL, US)
    View abstract

    Accelerating gas–liquid chemical reactions in flow

    Suyong Hana, Marjan Alsadat Kashfipoura, Mahdi Ramezania, Milad Abolhasani*a

    • aDepartment of Chemical and Biomolecular Engineering, North Carolina State University, 911 Partners Way, Raleigh, NC, USA
    View abstract

    Manganese-Catalyzed Synthesis of Quaternary Peroxides: Application in Catalytic Deperoxidation and Rearrangement Reactions

    Akash S. Ubale, Moreshwar B. Chaudhari, Moseen A. Shaikh, Boopathy Gnanaprakasam*

    • Department of Chemistry, Indian Institute of Science Education and Research, Pune-411008, India.
    View abstract

    Chemoenzymatic Synthesis of Arabinomannane (AM) Glycoconjugates as Potential Vaccines for Tuberculosis

    Zhihao Lia, Teodora Bavarob, Sara Tengattinib, Roberta Bernardinic, Maurizio Matteic,d, Francesca Annunziatae, Richard B. Colea, Changping Zhenga, Matthieu Sollogouba, Lucia Tamborinie, Marco Terrenib, Yongmin Zhanga

    • aSorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire, UMR 8232, 4 Place Jussieu, 75005 Paris, France.
    • bDrug Sciences Department, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
    • cItaly Centro Servizi Interdipartimentale – STA, University of Rome “Tor Vergata”, Rome, Italy.
    • dDept. of Biology, University of Rome “Tor Vergata”, Rome, Italy.
    • eDepartment of Pharmaceutical Sciences, University of Milan, via Mangiagalli 25, 20133 Milan, Italy.
    View abstract

    Automation of Synthesis in Medicinal Chemistry: Progress and Challenges

    Elizabeth Farrant*

    • New Path Molecular Research Ltd, Building 580, Babraham Research Campus, Cambridge CB22 3AT, UK.
    View abstract

    Practical Considerations and Examples in Adapting Amidations to Continuous Flow Processing in Early Development

    Bryan Li*, Gerald A. Weisenburger, J. Christopher McWilliams

    • Chemical Research & Development, Pharmaceutical Science Small Molecules Division, Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States
    View abstract

    Two Colour Photoflow Chemistry for Macromolecular Design

    Matthias Van De Walle, Kevin De Bruycker, James P. Blinco, Christopher Barner-Kowollik

    • Centre for Materials Science, School of Chemistry and Physics, Queensland University of Technology (QUT)2 George St., Brisbane, QLD 4000 (Australia)
    View abstract

    Photocatalytic α‐Tertiary Amine Synthesis via C−H Alkylation of Unmasked Primary Amines

    Alison S. H. Ryder1 William B. Cunningham2, George Ballantyne2, Tom Mules2, Anna G. Kinsella2, Jacob Turner-Dore2, Catherine M. Alder3, Lee J. Edwards3, Blandine S. J. McKay3, Matthew N. Grayson2, Alexander J. Cresswell2

    • 1Centre for Sustainable Chemical Technologies, University of Bath 1 South, Claverton Down, Bath, BA2 7AY (UK)
    • 2Department of Chemistry, University of Bath 1 South, Claverton Down, Bath, BA2 7AY (UK) E-Mail: [email protected]
    • 3Medicines Design, GSK Medicines Research Centre Gunnels Wood Rd, Stevenage, SG1 2NY (UK)
    View abstract

    Lewis Acid Polymerization Catalyst

    Inventors: Raghuraman, Arjun (Pearland, TX, US), Heath, William H. (Lake Jackson, TX, US), Mukhopadhyay, Sukrit (Midland, MI, US), Spinney, Heather A. (Midland, MI, US), Wilson, David R. (Midland, MI, US)

    • Assignee: Dow Global Technologies LLC (Midland, MI, US)
    View abstract

    Automated Glycan Assembly of Plant Cell Wall Oligosaccharides

    Fabian Pfrengle

    • Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
    View abstract

    Process of Manufacturing Surfactants and Lubricants

    Raghuraman, Arjun (Pearland, TX, US), Heath, William H. (Lake Jackson, TX, US), Hook, Bruce D. (Lake Jackson, TX, US), Yu, Wanglin (Pearland, TX, US), Mukhopadhyay, Sukrit (Midland, MI, US), Spinney, Heather A. (Midland, MI, US), Wilson, David R. (Midland, MI, US), Notestein, Justin M. (Evanston, IL, US), Nguyen, Sonbinh T. (Evanston, IL, US)

    • Dow Global Technologies LLC (Midland, MI, US)
    • Northwestern University (Evanston, IL, US)
    View abstract

    Preparation of Diorganomagnesium Reagents by Halogen–Lithium Exchange of Functionalized Heteroaryl Halides and Subsequent in situ Trapping with MgCl2·LiCl in Continuous Flow

    Rodolfo Hideki Vicente Nishimuraa, Niels Weidmannb, Paul Knochel∗b

    • aColegiado de Ciências Farmacêuticas, Universidade Federal do Vale do São Francisco, Avenue José de Sá Maniçoba, Petrolina, 56304-205 Petrolina, Brazil
    • bLudwig-Maximilians-Universität München, Department Chemie, Butenandtstraße 5–13, 81377 München, Germany
    View abstract

    C(sp3)–H functionalizations of light hydrocarbons using decatungstate photocatalysis in flow

    Gabriele Laudadio1*, Yuchao Deng1,2,3,*, Klaas van der Wal1, Davide Ravelli4, Manuel Nuño5, Maurizio Fagnoni4, Duncan Guthrie5, Yuhan Sun2,3, Timothy Noël1,†

    • 1Micro Flow Chemistry and Synthetic Methodology, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Eindhoven, Netherlands.
    • 2School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, P. R. China.
    • 3Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, P. R. China.
    • 4PhotoGreen Lab, Department of Chemistry, University of Pavia, Pavia 27100, Italy.
    • 5Vapourtec, Fornham St Genevieve, Bury St Edmunds, Suffolk IP28 6TS, UK.
    • Corresponding author. Email: [email protected]
    • *These authors contributed equally to this work.
    View abstract

    Disposable cartridge concept for the on-demand synthesis of turbo Grignards, Knochel–Hauser amides, and magnesium alkoxides

    Mateo Berton1, Kevin Sheehan2, Andrea Adamo2, D. Tyler McQuade1

    • 1Department of Chemical and Life Sciences Engineering, Virginia Commonwealth University, Biotech Eight, 737 N. 5th St., Box 980100, Richmond, VA 23219, USA
    • 2Zaiput Flow Technologies, 300 2nd Avenue, Waltham, MA 02451, USA
    View abstract

    Flow Chemistry System for Carbohydrate Analysis by Rapid Labeling of Saccharides after Glycan Hydrolysis

    Wei-Ting Hung1, Yi-Ting Chen1, Chung-Hsuan Chen1, Yuan Chuan Lee2, Jim-Min Fang1, 3, Wen-Bin Yang1

    • 1The Genomics Research Center, Academia Sinica, Taipei
    • 2Department of Biology, Johns Hopkins University, Baltimore, MD, USA
    • 3Department of Chemistry, National Taiwan University, Taipei
    View abstract

    Continuous-Flow Approach for the Multi-Gram Scale Synthesis of C2-Alkyl- or β-Amino Functionalized 1,3-Dicarbonyl Derivatives and Ondansetron Drug Using 1,3-Dicarbonyls

    Nirmala Mohant, Krishna Nair, Dasharath Vishambar Sutar, Boopathy Gnanaprakasam*

    • Department of Chemistry, Indian Institute of Science Education and Research (IISER) Pune, Dr. Homi Bhabha Road, Pune 411008, Maharashtra, (India).
    View abstract

    Preparation of Mono- and Diisocyanates in Flow from Renewable Carboxylic Acids

    Michael D. Burkar1, Thien An Phung Hai1, Laurent J. S. De Backer2, Nicholas D. P. Cosford2

    • 1Department of Chemistry and Biochemistry and The California Center for Algae Biotechnology, University of California, San Diego, La Jolla, California 92093-0358, United States
    • 2Cancer Metabolism & Signaling Networks Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States
    View abstract

    Accelerating Electrochemical Synthesis through Automated Flow: Efficient Synthesis of Chalcogenophosphites

    Nasser Amri, Thomas Wirth*

    • School of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, UK
    View abstract

    Rearrangement of 3-Hydroxyazetidines into 2-Oxazolines

    Ian R. Baxendale1, Michele Ruggeri1, Amanda W. Dombrowski2, Stevan W. Djuric3

    • 1Department of Chemistry, University of Durham, Durham DH1 3LE, United Kingdom
    • 2 Discovery Chemistry and Technology AbbVie Inc., North Chicago, Illinois 60064, United States
    • 3Discovery Chemistry and Technology Consulting LLC, New Bern, North Carolina 28562, United States
    View abstract

    Selective DIBAL‑H Monoreduction of a Diester Using Continuous Flow Chemistry: From Benchtop to Kilo Lab

    Nick Uhlig1, Andrew Martins1, Detian Gao2

    • 1Process Development, Gilead Alberta ULC,Edmonton, Alberta T6S 1A1, Canada
    • 2Commercial API Process Optimization, Gilead Alberta ULC, Edmonton, Alberta T6S 1A1, Canada
    View abstract

    Flow Reactor Synthesis of Bio-Based Polyol from Soybean Oil for the Production of Rigid Polyurethane Foam

    Kai Guo1, Zheng Fang2, Wei He2, Peng Kang3, Jingying Hao4, Hao Wu2, Yuchen Zhu5

    • 1College of Biotechnology and Pharmaceutical Engineering and State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, China
    • 2College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China
    • 3SINOPEC Beijing Research Institute of Chemical Industry, Beijing 100013, China
    • 4The Research Institute of SINOPEC Co., Ltd, Tianjin Branch, Tianjin 10000, China
    • 5School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China
    View abstract

    Bicyclic quinazolinone derivatives

    Inventors: Jerome HertDaniel, HunzikerChristoph Kuratli, Rainer E. Martin, Patrizio Mattei, Alexander Lee Satz

    • Assignee: Hoffmann La Roche Inc
    View abstract

    Ir/Ni Photoredox Dual Catalysis with Heterogeneous Base Enabled by an Oscillatory Plug Flow Photoreactor

    Wouter Debrouwer,a*, Wim Kimpea, Ruben Dangreau,a, Kevin Huvaere,a, Hannes P.L. Gemoets,b, Milad Mottaghi,c, Simon Kuhn,c, Koen Van Akenab

    • aEcoSynth, Industrielaan 12, 9800 Deinze, Belgium
    • bCreaflow, Industrielaan 12, 9800 Deinze, Belgium
    • c Department of Chemical Engineering, KU Leuven, Celestijnenlaan 200F, 3001, Leuven, Belgium
    View abstract

    Visible Light Mediated N-Desulfonylation of N-Heterocycles using a Heteroleptic Copper (I) Complex as a Photocatalyst

    Cameron J. Hunter, Michael J. Boyd, Gregory D. May, Robert Fimognari*

    • Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, Massachusetts 02210, United States
    View abstract

    A Flow Process Built upon a Batch Foundation—Preparation of a Key Amino Alcohol Intermediate via Multistage Continuous Synthesis

    John Jin Lim,*,†, Kenneth Arrington,*,†, Anna L. Dunn,, David C. Leitch,‡,†, Ian Andrews,, Neil R. Curtis,§, Mark J. Hughes,§, Daniel R. Tray,§, Charles E. Wade,§, Matthew P. Whiting,§, Charles Goss,, Yangmu Chloe Liu,§, Brian M. Roesch§

    • Chemical Development, API Chemistry, GlaxoSmithKline, Upper Providence, Pennsylvania 19426, United States
    • Department of Chemistry, University of Victoria, Victoria, BC V8P 5C2, Canada
    • §Chemical Development, API Chemistry, GlaxoSmithKline, Stevenage SG1 2NY, U.K.
    • Chemical Development, Product and Process Engineering, GlaxoSmithKline, Upper Providence, Pennsylvania 19426, United States
    View abstract

    Streamlined Synthesis of Fluoroquinolones

    Gupton, Frank B. (Midlothian, VA, US) Tosso, Perrer N. (Glen Allen, VA, US)

    • VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, VA, US)
    View abstract

    Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry en Route to the Synthesis of Remdesivir

    Tiago Vieira1*, Andrew C. Stevens1*, Andrei Chtchemelinine2, Detian Gao1, Pavel Badalov1, Lars Heumann2

    • 1Gilead Alberta ULC, 1021 Hayter Road, Edmonton, Alberta T6S 1A1, Canada
    • 2Gilead Sciences, Inc. 333 Lakeside Drive, Foster City, California 94404, United States
    View abstract

    A Metallaphotoredox Method for the Expansion of Benzyl SAR on Electron-Deficient Amines

    Meghan D. Shea, Umar Faruk Mansoor, Brett A. Hopkins*

    • Discovery Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States
    View abstract

    Tropylium-promoted prenylation reactions of phenols in continuous flow

    Klaus Omoregbee1,2, Kevin N. H. Luc1, An H. Dinh1, Thanh Vinh Nguyen1

    • 1School of Chemistry, University of New South Wales, Sydney, Australia
    • 2Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin, Berlin, Germany
    View abstract

    Continuous-Flow Accelerated Sulfation of Heparan Sulfate Intermediates

    Saurabh Anand, Sandhya Mardhekar, Rakesh Raigawali, Nirmala Mohanta, Prashant Jain, Chethan D. Shanthamurthy, Boopathy Gnanaprakasam*, Raghavendra Kikkeri*

    • Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411 008, India
    View abstract

    Electrochemistry in continuous systems

    Thomas P. Nicholls, Christiane Schotten, Charlotte E. Willans

    • School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK
    View abstract

    Continuous Flow Aminolysis of RAFT Polymers Using Multistep Processing and Inline Analysis

    Christian H. Hornung*, Karin von Känel, Ivan Martinez-Botella, Maria Espiritu, Xuan Nguyen, Almar Postma, Simon Saubern, John Chiefari, San H. Thang

    • CSIRO Manufacturing Flagship, Bag 33, Clayton South, Victoria 3169, Australia
    View abstract

    Making electrochemistry easily accessible to the synthetic chemist

    Christiane Schotten*a, Thomas P. Nichollsa, Richard A. Bourneb, Nikil Kapurc, Bao N. Nguyena, Charlotte E. Willans*a

    • aSchool of Chemistry, University of Leeds, Leeds LS2 9JT, UK.
    • bSchool of Chemical and Process Engineering, University of Leeds, Leeds LS2 9JT, UK
    • cSchool of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK
    View abstract

    Scale-up and Optimization of a Continuous Flow Synthesis of an α-Thio-β-chloroacrylamide

    Olga C. Dennehy1, Denis Lynch1, Stuart G. Collins1*, Anita R. Maguire2*, Humphrey A. Moynihan1*

    • 1School of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork T12 K8AF, Ireland.
    • 2School of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork T12 K8AF, Ireland
    View abstract

    Automated Glycan Assembly in a Variable-Bed Flow Reactor Provides Insights into Oligosaccharide–Resin Interactions

    Eric T. Sletten1, José Danglad-Flores1, Manuel Nuño2, Duncan Guthrie2, Peter H. Seeberger1

    • 1Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany
    • 2Vapourtec, Ltd., Park Farm Business Centre, Fornham St. Genevieve, Bury St. Edmunds, Suffolk IP28 6TS, United Kingdom
    View abstract

    Photocatalytic α‐Tertiary Amine Synthesis via C–H Alkylation of Unmasked Primary Amines

    Alison S. H. Rydera, William B. Cunninghamb, George Ballantyneb, Tom Mulesb, Anna G. Kinsellab, Jacob Turner-Doreb, Catherine M. Alderc, Lee J. Edwardsc, Blandine S. J. McKayc, Matthew N. Graysonb, Alexander J. Cresswellb*

    • aCentre for Sustainable Chemical Technologies, 1 South, University of Bath, Claverton Down, Bath, BA2 7AY (UK)
    • bDepartment of Chemistry, 1 South, University of Bath, Claverton Down, Bath, BA2 7AY (UK)
    • cMedicines Design, GSK Medicines Research Centre, Gunnels Wood Rd, Stevenage, SG1 2NY (UK)
    View abstract

    Dynamic Crystallization Pathways of Polymorphic Pharmaceuticals Revealed in Segmented Flow with Inline Powder XRD

    Mark Alan Levenstein1, 2, Lois E Wayment3, 4, 5, C. Daniel Scott3, 6, Ruth A Lunt3, 4, Pierre-Baptiste Flandrin3, Sarah Day5, Chiu Tang5, Chick C. Wilson3, Fiona C. Meldrum2, Nikil Kapur1, Karen Robertson3

    • 1School of Mechanical Engineering, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK
    • 2School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK
    • 3Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    • 4CMAC Future Manufacturing Hub, University of Bath, Claverton Down, Bath BA2 7AY, UK
    • 5Diamond Light Source, Harwell Campus, Didcot, Oxfordshire OX11 0DE, UK
    • 6Centre for Sustainable Chemical Technologies, University of Bath, Claverton Down, Bath BA2 7AY, UK
    View abstract

    Management of the Heat of Reaction under Continuous Flow Conditions Using In-Line Monitoring Technologies

    Masahiro Hosoya, Shogo Nishijima, Noriyuki Kurose

    • API R&D Laboratory, CMC R&D Division, Shionogi and Co., Ltd., 1-3, Kuise Terajima 2-chome, Amagasaki, Hyogo 660-0813, Japan
    View abstract

    Improving Efficiency by Using Continuous Flow to Enable Cycles: Pseudo-Catalysis, Catalysis and Kinetics

    Ryan Sullivan, Ottawa, Canada

    • Thesis submitted to the University of Ottawa, 2020
    View abstract

    Production of Metal-Organic Frameworks

    Rubio Martinez, Marta (Clayton South, AU), Hill, Matthew Roland (Clayton South, AU), Batten, Michael (Clayton South, AU), Lim, Kok Seng (Clayton South, AU), Polyzos, Anastasios (Clayton South, AU), Barton, Timothy Raymond (Clayton South, AU), Hadley, Trevor Deon (Clayton South, AU), Monch, Andreas Alexander (Clayton South, AU)

    • Commonwealth Scientific and Industrial Research Organisation, Acton (AU)
    View abstract

    Continuous-Flow Synthesis of Tramadol from Cyclohexanone

    Timothy M. Monosa, Jonathan N. Jaworskia, John C. Stephensb, c, Timothy F. Jamison*a

    • aDepartment of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    • bDepartment of Chemistry, Maynooth University, Maynooth, Co. Kildare, Ireland
    • cThe Kathleen Lonsdale Institute of Human Health Research, Maynooth University, Maynooth, Co. Kildare, Ireland
    View abstract

    Photon Equivalents as a Parameter for Scaling Photoredox Reactions in Flow: Translation of Photocatalytic C−N Cross‐Coupling from Lab Scale to Multikilogram Scale

    Emily B. Corcoran*a, Jonathan P. McMullen*b, François Lévesqueb, Michael K. Wismerc, John R. Naberb

    • aProcess Research & Development, Merck & Co., Inc., Boston, MA 02115 (USA)
    • bProcess Research & Development, Merck & Co., Inc., Rahway, NJ 07065 (USA)
    • cScientific Engineering & Design, Merck & Co., Inc., Kenilworth, NJ 07033 (USA)
    View abstract

    Rapid, Heterogeneous Biocatalytic Hydrogenation and Deuteration in a Continuous Flow Reactor

    Lisa A. Thompsona, Jack S. Rowbothama, Jake H. Nicholsona, Miguel A Ramireza, Ceren Zorb, Holly A. Reevea, Nicole Grobertb, Kylie A. Vincenta*

    • aDepartment of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford, OX1 3QR, UK
    • bDepartment of Materials, University of Oxford, Parks Road, Oxford, OX1 3PH, UK
    View abstract

    A Continuous Flow Sulfuryl Chloride Based Reaction – Synthesis of a Key Intermediate in a New Route Toward Emtricitabine and Lamivudine

    Juliana M. de Souza, Mateo Berton, David R. Snead*, D. Tyler McQuade

    • Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, 23284-3068, USA.
    View abstract

    Automated Electrochemical Selenenylations

    Nasser Amri, Thomas Wirth

    • School of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, UK
    View abstract

    Automated radial synthesis of organic molecules

    Sourav Chatterjee1, Mara Guidi1, 2, Peter H. Seeberger1, 2, Kerry Gilmore1

    • 1Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany
    • 2Freie Universität Berlin, Institute of Chemistry and Biochemistry, Berlin, Germany
    View abstract

    An Enzymatic Flow-Based Preparative Route to Vidarabine

    Lucia Tamborini1*, Clelia Previtali1, Francesca Annunziata1, Teodora Bavaro2, Marco Terreni2, Enrica Calleri2, Francesca Rinaldi2, Andrea Pinto3, Giovanna Speranza4, Daniela Ubiali2*, Paola Conti1

    • 1Department of Pharmaceutical Sciences, University of Milan, via Mangiagalli 25, 20133 Milano, Italy
    • 2Department of Drug Sciences, University of Pavia, viale Taramelli 12, 27100 Pavia, Italy
    • 3Department of Food, Environmental and Nutritional Sciences, University of Milan, via Celoria 2, 20133 Milano, Italy
    • 4Department of Chemistry, University of Milan, via Golgi 19, 20133 Milano, Italy
    View abstract

    Preparation of 5-Hydroxymethylfurfural from High Fructose Corn Syrup Using Organic Weak Acid in Situ as Catalyst

    Changqu Lin, Hongli Wu, Junyi Wang, Jinsha Huang, Fei Cao*, Wei Zhuang*, Yanyu Lu, Jiao Chen, Honghua Jia, Pingkai Ouyang

    • College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, P. R. China
    View abstract

    Amino Alcohol Acrylonitriles as Activators of the Aryl hydrocarbon Receptor Pathway, An Unexpected MTT Phenotypic Screening Outcome

    Jennifer Baker 1, Cecilia C Russel 1, Jayne Gilbert 2, Jennette Sakoff 2, Adam McCluskey 1

    • 1 The University of Newcastle, Chemistry, University Drive, Callaghan, 2308 Newcastle, AUSTRALIA
    • 2 Calvary Mater Hospital, Medical Oncology, Eidith Street, Waratah, 2298 Newcastle, AUSTRALIA
    View abstract

    Continuous flow aminolysis under high temperature and pressure

    Bryan Li1, Scott Bader1, 2, Steve M. Guinness1, Sally Gut Ruggeri1, Cheryl M. Hayward1, Steve Hoagland1, John Lucas1, 3, Ruizhi Li1, David Limburg1, J. Christopher McWilliams1, Jeffrey Raggo1, John Van Alsten1, 4

    • 1Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT, 06340, USA
    • 2Celgene Corporation, 556 Morris Ave, Summit, NJ, USA
    • 3Rhodes Technologies, 498 Washington Street, Coventry, RI, USA
    • 4Nitto Denko Avecia Inc, 155 Fortune Blvd., Milford, MA, USA
    View abstract

    Continuous Flow Photochemistry for the Preparation of Bioactive Molecules

    Mara Di Filippo, Cormac Bracken, Marcus Baumann*

    • School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland
    View abstract

    Development of a Continuous Flow Photoisomerization Reaction Converting Isoxazoles into Diverse Oxazole Products

    Cormac Bracken, Marcus Baumann*

    • School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland
    View abstract

    Continuous-Flow Biocatalytic Process for the Synthesis of the Best Stereoisomers of the Commercial Fragrances Leather Cyclohexanol (4-Isopropylcyclohexanol) and Woody Acetate (4-(Tert-Butyl)Cyclohexyl Acetate)

    Francesca Tentori 1,†, Elisabetta Brenna 1,2,*, Michele Crotti 1, Giuseppe Pedrocchi-Fantoni 2, Maria Chiara Ghezzi 1, and Davide Tessaro 1

    • 1 Dipartimento di Chimica, Materiali ed Ingegneria Chimica “Giulio Natta”, Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy
    • 2 Istituto di Scienze e Tecnologie Chimiche – CNR, Via Mancinelli 7, 20131 Milano, Italy
    View abstract

    Visible Light-Mediated (Hetero)aryl Amination Using Ni(II) Salts and Photoredox Catalysis in Flow: A Synthesis of Tetracaine

    Boyoung Y. Park, Michael T. Pirnot andStephen L. Buchwald*

    • Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    View abstract

    In-Line Purification: A Key Component to Facilitate Drug Synthesis and Process Development in Medicinal Chemistry

    Nopphon Weeranoppanant1, 2, Andrea Adamo3

    • 1Department of Chemical Engineering, Faculty of Engineering, Burapha University, 169 Longhard Bangsaen Road, Muang, Chonburi 02131, Thailand
    • 2School of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Wangchan Valley 555 Moo 1 Payupnai, Wangchan, Rayong 21210 Thailand
    • 3Zaiput Flow Technologies, 300 Second Avenue, Waltham, Massachusetts 02451, United States
    View abstract

    Preparation of HMF from High Fructose Corn Syrup Using Organic Weak Acid in situ as Catalyst

    Changqu Lin, Hongli Wu, Junyi Wang, Jinsha Huang, Fei Cao*, Wei Zhuang*, Yanyu Lu, Jiao Chen, Honghua Jia, Pingkai Ouyang

    • College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing, 211816 (P. R. China)
    View abstract

    Continuous flow aminolysis under high temperature and pressure

    Bryan Li, Scott Bader, Steve M. Guinness, Sally Gut Ruggeri, Cheryl M. Hayward, Steve Hoagland, John Lucas, Ruizhi Li, David Limburg, J. Christopher McWilliams, Jeffrey Raggon, John Van Alsten

    • Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT, 06340, USA
    View abstract

    Amino Alcohol Acrylonitriles as Activators of the Aryl hydrocarbon Receptor Pathway, An Unexpected MTT Phenotypic Screening Outcome

    Jennifer Bakera, Cecilia C Russela, Jayne Gilbertb, Jennette Sakoff*b, Adam McCluskey*a

    • aChemistry, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
    • bExperimental Therapeutics Group, Department of Medical Oncology, Calvary Mater Hospital, Edith Street, Waratah NSW 2298, Australia
    View abstract

    Development of a Continuous Flow Photoisomerization Reaction Converting Isoxazoles into Diverse Oxazole Products

    Cormac Bracken, Marcus Baumann

    • School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland
    View abstract

    Visible Light-Mediated (Hetero)aryl Amination Using Ni(II) Salts and Photoredox Catalysis in Flow: A Synthesis of Tetracaine

    Boyoung Y. Park, Michael T. Pirnot, Stephen L. Buchwald*

    • Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    View abstract

    Use of Immobilized Amine Transaminase from Vibrio fluvialis under Flow Conditions for the Synthesis of (S)‐1‐(5‐Fluoropyrimidin‐2‐yl)‐ethanamine

    Riccardo Semproli [a], Gianmarco Vaccaro [a],[b], Erica E. Ferrandi [c], Marta Vanoni [c], Teodora Bavaro [a], Giorgio Marrubini [a], Francesca Annunziata [b], Paola Conti [b], Giovanna Speranza [d], Daniela Monti [*c], Lucia Tamborini [*b], Daniela Ubiali [*a]

    • [a] R. Semproli, G. Vaccaro, Dr. G. Marrubini, Dr. T. Bavaro, Prof. D. Ubiali, Department of Drug Sciences, University of Pavia, Viale Taramelli 12, I-27100 Pavia, Italy
    • [b] G. Vaccaro, F. Annunziata, Prof. P. Conti, Prof. L. Tamborini, Department of Pharmaceutical Sciences, University of Milano, Via Mangiagalli 25, I-20133 Milano, Italy
    • [c] Dr. E. E. Ferrandi, M. Vanoni, Dr. D. Monti, Istituto di Scienze e Tecnologie Chimiche "Giulio Natta" (SCITEC) – CNR, Via Bianco 9, I-20131 Milano, Italy
    • [d] Prof. G. Speranza, Department of Chemistry, University of Milano, Via Golgi 19, I-20133 Milano, Italy
    View abstract

    Continuous Flow Enables Metallaphotoredox Catalysis in a Medicinal Chemistry Setting: Accelerated Optimization and Library Execution of a Reductive Coupling between Benzylic Chlorides and Aryl Bromides

    Zachary G. Brill, Casey B. Ritts, Umar Faruk Mansoor, Nunzio Sciammetta

    • Department of Discovery Chemistry, MRL, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115 USA
    View abstract

    Continuous Flow Synthesis of Methyl Oximino Acetoacetate: Accessing Greener Purification Methods with Inline Liquid-Liquid Extraction and Membrane Separation Technology

    René Lebl1, 2, Trevor Murray3, Andrea Adamo3, David Cantillo1, 2, C. Oliver Kappe1, 2

    • 1Center for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria
    • 2Institute of Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria
    • 3Zaiput Flow Technologies, 300 2nd Avenue, Waltham, Massachusetts 02451, United States
    View abstract

    Cellulose fast pyrolysis for platform chemicals: assessment of potential targets and suitable reactor technology

    Anurag Parihar, Sankar Bhattacharya

    • Department of Chemical Engineering, Monash University, Clayton, VIC, Australia
    View abstract

    Continuous and green microflow synthesis of azobenzene compounds catalyzed by consecutively prepared tetrahedron CuBr

    Hong Qina,1, Chengkou Liua,1, Niuniu Lva2, Wei Hea, Jingjing Menga, Zheng Fanga, Kai Guoa,b

    • a College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30 Puzhu South Road, Nanjing, China
    • b State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China
    View abstract

    Safe and Scalable Continuous Flow Azidophenylselenylation of Galactal to Prepare Galactosamine Building Blocks

    Mónica Gubermana,b, Bartholomäus Piebera, Peter H. Seebergera,b

    • aDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany
    • bDepartment of Chemistry and Biochemistry, Freie Universitat Berlin, Arnimalle 22, 14195 Berlin, Germany
    View abstract

    A practical method for continuous production of sp3-rich compounds from (hetero)aryl halides and redox-active esters

    Eiichi Watanabea, Yiding Chenb, Oliver Mayb, Steven V. Ley*b

    • aNew Path Molecular Ltd. Building 580, Babraham Research Campus, Cambridge (UK)
    • bDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge (UK)
    View abstract

    Metal‐Free Visible‐Light‐Mediated Hydrotrifluoromethylation of Unactivated Alkenes and Alkynes in Continuous Flow

    Anne‐Laure Barthelemy Guillaume Dagousset Emmanuel Magnier

    View abstract

    A new formulation for symbolic regression to identify physico-chemical laws from experimental data

    Pascal Neumannab, Liwei Cao bc, Danilo Russob, Vassilios S. Vassiliadisb, Alexei A.Lapkinbc

    • a Aachener Verfahrenstchnik – Process Systems Engineering, RWTH Aachen University, Aachen, Germany
    • b Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK
    • c Cambridge Centre for Advanced Research and Education in Singapore, CARES Ltd., 1 CREATE Way, CREATE Tower #05-05, 138602 Singapore, Singapore
    View abstract

    Real-Time Monitoring of Solid-Phase Peptide Synthesis Using a Variable Bed Flow Reactor

    Eric T. Slettena, Manuel Nunob, Duncan Guthrieb, Peter Seebergera,c

    • aDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany
    • bVapourtec Ltd, Park Farm Business Centre, Fornham St Genevieve, Bury St Edmunds, Suffolk IP28 6TS, U.K
    • cDepartment of Chemistry and Biochemistry, Freie Universität Berlin, Arnimalle 22, 14195, Berlin, Germany
    View abstract

    Electroorganic Synthesis under Flow Conditions

    Mohamed Elsherbini, Thomas Wirth

    • School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, United Kingdom
    View abstract

    Lilly Research Award Program (LRAP): A Successful Academia–Industry Partnership Model in the Context of Flow Chemistry for Drug Discovery

    Mateos, Carlos

    View abstract

    In situ non-invasive Raman spectroscopic characterisation of succinic acid polymorphism during segmented flow crystallisation

    Anuradha R. Pallipuratha, Pierre-Baptiste Flandrina, Lois E. Waymenta, b, c, Chick C. Wilsona, b, Karen Robertsona

    • aDepartment of Chemistry, University of Bath, Claverton Down, BA2 7AY, UK
    • bCMAC Future Manufacturing Hub, University of Bath, Claverton Down, Bath BA2 7AY, UK
    • c.Diamond Light Source, Harwell Campus, Didcot, Oxfordshire OX11 0DE, UK
    View abstract

    Trypanosomes inhibitors

    Inventors: Maude Giroud, Wolfgang Haap, Bernd Kuhn, Rainer E. Martin

    • Assignee: Hoffmann La Roche Inc
    View abstract

    Microfluidic synthesis of fatty acid esters: Integration of dynamic combinatorial chemistry and scale effect

    Wei He a,1, Yuan Gao a,1, Guiqin Zhu a, Hao Wu a, Zheng Fang a, Kai Guo a,b

    • a College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, PR China
    • b State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 210009, PR China
    View abstract

    MnO2@Fe3O4 Magnetic Nanoparticles as Efficient and Recyclable Heterogeneous Catalyst for Benzylic sp3 C−H Oxidation

    Akanksha M. Pandeya, Dr. Sandip G. Agalavea, Dr. Chathakudath P. Vinodb, Dr. Boopathy Gnanaprakasama

    • aDepartment of Chemistry, Indian Institute of Science Education and Research, Pune-, 411008 India
    • bCSIR-NCL Catalysis and Inorganic Chemistry Division, Pune, India
    View abstract

    Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction

    Sonia De Angelis1, 2, Paolo Celestini3, Rosa Purgatorio1, Leonardo Degennaro1, 2, Gabriele Rebuzzini3, Renzo Luisi1, 2, Claudia Carlucci1, 2

    • 1Department of Pharmacy - Drug Sciences, University of Bari "A. Moro" Via E. Orabona 4, Bari, Italy
    • 2Flow Chemistry and Microreactor Technology FLAME-Lab, Bari, Italy
    • 3COSMA S.p.A, Ciserano Italy
    View abstract

    Photochemical flow synthesis of 3‐hydroxyazetidines

    Michele Ruggeri1, Amanda Worthy Dombrowski2, Stevan W. Djuric2, Ian Richard Baxendale1

    • 1University of Durham, Department of Chemistry, South Road, DH1 3LE Durham, UNITED KINGDOM
    • 2AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064 Chicago, UNITED STATES
    View abstract

    Flow nanoprecipitation of size-controlled D-leucine nanoparticles for spray-drying formulations

    Bruno Cerra, Gabriele Mosca, Maurizio Ricci, Aurélie Schoubben and Antimo Gioiello

    • Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, I-06122 Perugia, Italy
    View abstract

    Visible‐Light‐Mediated Cross‐Couplings and C–H Activation via Dual Photoredox/Transition‐Metal Catalysis in Continuous‐Flow Processes

    Soo Dong Kim, Jonghyun Lee, Nam-Jung Kim, Boyoung Park

    • Kyung Hee University, Department of Pharmacy, Kyungheedaero 26, 02447 Seoul, Republic of Korea
    View abstract

    A flow platform for degradation-free CuAAC bioconjugation

    Marine Z. C. Hatit1, Linus F. Reichenbach1, John M. Tobin2, Filipe Vilela2, Glenn A. Burley1, Allan J. B. Watson3

    • 1Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, UK
    • 2Chemical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK
    • 3School of Chemistry, University of St Andrews, North Haugh, St Andrews
    View abstract

    Batch Versus Flow Lithiation‐Substitution of 1,3,4‐Oxadiazoles: Exploitation of Unstable Intermediates Using Flow Chemistry

    Jeff Y. F. Wong, John M. Tobin, Filipe Vilela, Graeme Barker

    • Institute of Chemical Sciences, Heriot-Watt University, Edinburgh EH11 4AS, Scotland, UK
    View abstract

    A Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow

    Yiding Chen, Oliver May, David C. Blakemore, and Steven V. Ley†*

    • Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
    • †‡ Medicine Design, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States
    View abstract

    Heumann Indole Flow Chemistry Process

    Cynthia Crifar, Fenja Leena Dücker, Sacha Nguyen Thanh, Vanessa Kairouz, William D. Lubell

    • Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montreal, Quebec H3C 3J7, Canada
    View abstract

    Integrated plug flow synthesis and crystallisation of pyrazinamide

    C. Daniel Scotta, Ricardo Labesb, Martin Depardieuc, Claudio Battilocchiob, Matthew G. Davidsona, Steven V. Leyb, Chick C. Wilsonad, and Karen Robertson*c

    • a Centre for Sustainable Chemical Technologies, Department of Chemistry, University of Bath, UK
    • b Department of Chemistry, University of Cambridge, UK
    • c Department of Chemistry, University of Bath, UK
    • d EPSRC Future Continuous Manufacturing and Advanced Crystallisation Research Hub, University of Bath, UK
    View abstract

    Conjugated porous polymers for photocatalytic applications

    Y. L. Wonga, J. M. Tobinb, Z. Xua, F. Vilela*b

    • aDepartment of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong
    • bSchool of Engineering and Physical Sciences, Heriot Watt University, Edinburgh, UK
    View abstract

    In-Flow Flash Nanoprecipitation of Size-Controlled D-Leucine Nanoparticles for Spray-Drying Formulations

    Bruno Cerraa, Gabriele Moscaa, Maurizio Riccia, Aurélie Schoubbena, Antimo Gioielloa

    • aDepartment of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, I-06122 Perugia, Italy.
    View abstract

    The Role of Single-Atom Catalysis in Potentially Disruptive Technologies

    Mario Pagliaro

    • Instituto per lo Studio dei Materiali Nanostrutturati, CNR, Palermo, Italy
    View abstract

    A Simple and Efficient Flow Preparation of Pyocyanin a Virulence Factor of Pseudomonas aeruginosa

    Frederik B. Mortzfelda,b, Jörg Pietruszkab, Ian R. Baxendale*a

    • aDepartment of Chemistry, University of Durham, South Road, Durham, Durham, DH1 3LE, UK
    • bInstitut für Bioorganische Chemie, Heinrich‐Heine‐Universität Düsseldorf im Forschungszentrum Jülich, 52425, Jülich, Deutschland
    View abstract

    Electrophilic Bromination in Flow: A Safe and Sustainable Alternative to the Use of Molecular Bromine in Batch

    Reinout Van Kerrebroeck, Pieter Naert, Thomas S. A. Heugebaert, Matthias D'hooghe, Christian V. Stevens*

    • SynBioC research Group, Department of Green Chemistry and Technology, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    View abstract

    Microfluidic process intensification for synthesis and formulation in the pharmaceutical industry

    Aliaa I. Shallana,b,*, Craig Priesta,c

    • aFuture Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia
    • bFaculty of Pharmacy, Helwan University, Cairo, 11795, Egypt
    • cSchool of Engineering, University of South Australia, Mawson Lakes, SA, 5095, Australia
    View abstract

    Continuous Flow Chemo-Enzymatic Baeyer–Villiger Oxidation with Superactive and Extra-Stable Enzyme/Carbon Nanotube Catalyst: An Efficient Upgrade from Batch to Flow

    Anna Szelwickaa, Przemysław Zawadzkib, Magdalena Sitkoa, Sławomir Boncelc, Wojciech Czardybonb, Anna Chrobok*a

    • aDepartment of Chemical Organic Technology and Petrochemistry, Silesian University of Technology, Krzywoustego 4, 44-100 Gliwice, Poland
    • bSelvita S.A., Bobrzynskiego 14, 30-348 Cracow, Poland
    • cDepartment of Organic Chemistry, Bioorganic Chemistry, and Biotechnology, Silesian University of Technology, Krzywoustego 4, 44-100 Gliwice, Poland
    View abstract

    Synthetic Route Design of AZD4635, an A2AR Antagonist

    Mairi M. Littleson *†, Andrew D. Campbell , Adam Clarke , Mark Dow , Gareth Ensor , Matthew C. Evans , Adam Herring ,Bethany A. Jackson , Lucinda V. Jackson , Staffan Karlsson , David J. Klauber , Danny H. Legg §, Kevin W. Leslie , Štefan Moravcí̌k , Chris D. Parsons §, Thomas O. Ronson , Rebecca E. Meadows

    • Chemical Development, Pharmaceutical Technology and Development, AstraZeneca, Macclesfield Campus, SK10 2NA, Macclesfield, U.K.
    • Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, SE-431 83 Mölndal, Sweden
    • § Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Macclesfield Campus, SK10 2NA, Macclesfield, U.K.
    View abstract

    Continuous flow knitting of a triptycene hypercrosslinked polymer

    Cher Hon Lau *a, Tian-dan Lu b, Shi-Peng Sun b, Xianfeng Chen a, Mariolino Carta c, Daniel M. Dawson d

    • a School of Engineering, The University of Edinburgh, Robert Stevenson Road,Edinburgh EH9 3FB, UK
    • b State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech. University, Nanjing 210009, China
    • c Department of Chemistry, College of Science, Swansea University, Grove Building, Singleton Park, Swansea SA2 8PP, UK
    • d School of Chemistry, EaStCHEM and Centre of Magnetic Resonance, University of St. Andrews, KY16 9ST, UK
    View abstract

    Transaminase‐catalyzed continuous synthesis of biogenic aldehydes

    Martina L. Contente a, Francesca Paradisi *a,b

    • a School of Chemistry, University of Nottingham, University Park, Nottingham, NG7, 2RD, United Kingdom
    • b Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern
    View abstract

    Optimisation by Design of Experiment of Benzimidazol-2-One Synthesis under Flow Conditions

    Serena Mostarda1,2, Tugçe Gür Maz3, Alessandro Piccinno1, Bruno Cerra1, Erden Banoglu3

    • 1Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy
    • 2Current affiliation: Novartis Pharma AG, CH-4002 Basel, Switzerland
    • 3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Etiler, 06560 Ankara, Turkey
    View abstract

    A Novel and Efficient Continuous-Flow Route To Prepare Trifluoromethylated N‑Fused Heterocycles for Drug Discovery and Pharmaceutical Manufacturing

    Lara Amini-Rentsch1,2, Ennio Vanoli2, Sylvia Richard-Bildstein1, Roger Marti2, Gianvito Vilé1

    • 1 Idorsia Pharmaceuticals Ltd., Chemistry Technologies & Lead Discovery, Department of Drug Discovery Chemistry, Hegenheimermattweg 91, CH-4123 Allschwil, Switzerland
    • 2 University of Applied Sciences Western Switzerland (HES-SO), Haute Ecole d’Ingénierie et d’Architecture de Fribourg, Institute of Chemical Technology, 80 boulevard de Pérolles, CH-1700 Fribourg, Switzerland
    View abstract

    A robust and scalable continuous flow process for glycerol carbonate

    Seger Van Mileghema,b, Wim M. De Borggraeveb, Ian R. Baxendalea

    • aUniversity of Durham, Department of Chemistry, South Road, DH1 3LE Durham, UK
    • bKU Leuven, Division of Molecular Design and Synthesis, Department of Chemistry, Celestijnenlaan 200F, 3001 Heverlee, Belgium
    View abstract

    Flow Hydrodediazoniation of Aromatic Heterocycles

    Liesa Röder1, Alexander J. Nicholls2, Ian R. Baxendale2

    • 1 Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany
    • 2 Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK
    View abstract

    Continuous-Flow Electrochemical Generator of Hypervalent Iodine Reagents: Synthetic Applications

    Dr Mohamed Elsherbini, Bethan Winterson, Haifa Alharbi, Ana A. Folgueiras-Amador, Clina Gnot, Thomas Wirth

    • School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT UK
    View abstract

    Definitive screening designs for multistep kinetic models in flow

    Christopher A. Honea, Alistair Boydb, Anne O’Kearney-McMullanb, Richard A. Bournea*, Frans L. Mullera*

    • a Institute of Process Research and Development (iPRD), School of Chemistry and School of Chemical and Process Engineering, University of Leeds, LS2 9JT, UK
    • b Global Development, AstraZeneca, Macclesfield, Cheshire, UK, SK10 2NA, UK
    View abstract

    Visible light‐promoted Fe‐catalyzed Csp2‐Csp3 Kumada cross‐coupling in flow

    Xiao-Jing Weia, Irini Abdiajb, Carlo Sambiagioa, Chenfei Lic, Eli Zysman-Colmanc, Jesús Alcázarb, Timothy Noëla

    • a Department of Chemical Engineering and Chemistry Micro Flow Chemistry and Synthetic Methodology Eindhoven University of Technology Den Dolech 2, 5612 AZ Eindhoven (The Netherlands)
    • b Discovery Sciences, Janssen Research and Development Jannsen-Cilag, S.A. Jarama 75A, 45007 Toledo (Spain)
    • c Organic Semiconductor Center, EaStCHEM School of ChemistryUniversity of St Andrews, St Andrews, Fife, KY16 9ST (UK).
    View abstract

    Experimental Methods in Chemical Engineering: Micro‐Reactors

    Arturo Macchi a, Patrick Plouffe a, Gregory S. Patience b, Dominique M. Roberge c

    • a Centre for Catalysis Research and Innovation, Department of Chemical and Biological Engineering, University of Ottawa, Ottawa, ON, K1N 6N5 Canada
    • b Department of Chemical Engineering ‐ Ecole Polytechnique de Montreal, QC, H3C 3A7 Canada
    • c Chemical Manufacturing Technologies, Lonza AG, CH‐, 3930 Visp, Switzerland
    View abstract

    Continuous Flow Synthesis of Highly Substituted Tetrahydrofurans

    Patrick Hoffmeyer, Christoph Schneider

    • Institute of Organic Chemistry, University of Leipzig, Johannisallee 29, D, ‐04103 Leipzig Germany
    View abstract

    Peroxidation of 2-oxindole and barbituric acid derivatives under batch and continuous flow using an eco-friendly ethyl acetate solvent

    Moreshwar B. Chaudhari a, Nirmala Mohanta a, Akanksha M. Pandey a, Madhusoodhanan Vandana b, Krishanpal Karmodiya b, Boopathy Gnanaprakasam*a

    • a Department of Chemistry, Indian Institute of Science Education and Research (IISER) Pune, Dr. Homi Bhabha Road, Pune 411008, India
    • b Department of Biology, Indian Institute of Science Education and Research (IISER) Pune, Dr. Homi Bhabha Road, Pune 411008, India
    View abstract

    Rapid and Multigram Synthesis of Vinylogous Esters under Continuous Flow: An Access to Transetherification and Reverse Reaction of Vinylogous Esters

    Nirmala Mohanta, Moreshwar B. Chaudhari, Naveen Kumar Digrawal, Boopathy Gnanaprakasam*

    • Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India
    View abstract

    Continuous manufacturing – the Green Chemistry promise?

    Luke Rogers and Klavs F. Jensen

    • Department of Chemical Engineering, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139-4307, USA
    View abstract

    Practical and regioselective amination of arenes using alkyl amines

    Alessandro Ruffoni 1, Fabio Juliá 1, Thomas D. Svejstrup 1, Alastair J. McMillan 1, James J. Douglas 2, Daniele Leonori 1

    • 1 School of Chemistry, University of Manchester, Manchester, UK.
    • 2 Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit,AstraZeneca, Macclesfield, UK
    View abstract

    The Influence of Residence Time Distribution on Continuous-Flow Polymerization

    Marcus H. Reis, Travis P. Varner, Frank A. Leibfarth

    • Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    View abstract

    Additive manufacturing of photoactive polymers for visible light harvesting

    Adilet Zhakeyevac, John Tobina, Huizhi Wangb, Filipe Vilelaa, Jin Xuanac

    • a School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK
    • b Department of Mechanical Engineering, Imperial College London, Exhibition Road, South Kensington Campus, London, SW7 2AZ, UK
    • c Department of Chemical Engineering, Loughborough University, Loughborough, UK
    View abstract

    Modeling and Design of a Flow-Microreactor-Based Process for Synthesizing Ionic Liquids

    Yuichi Nakahara *†⊥, Bert Metten , Osamu Tonomura §⊥, Aiichiro Nagaki ∥⊥, Shinji Hasebe §⊥, Jun-ichi Yoshida ⊥#, Francesco Molinari 1

    • New Frontiers Research Group, Frontier Research Laboratories, Institute For Innovation, Ajinomoto Co., Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki, Kanagawa 210-8681, Japan
    • Ajinomoto Bio Pharma Services, Cooppallaan 91, B-9230 Wetteren, Belgium
    • § Department of Chemical Engineering, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
    • Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
    • Micro Chemical Production Study Consortium in Kyoto University, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
    • # National Institute of Technology, Suzuka College, Shiroko-cho, Suzuka, Mie 510-0294, Japan
    View abstract

    Synthesis of a Renewable Macrocyclic Musk: Evaluation of Batch, Microwave, and Continuous Flow Strategies

    Émilie Morin §, Johann Sosoe §, Michaël Raymond §, Benjamin Amorelli †*, Richard M. Boden , Shawn K. Collins

    • § Department of Chemistry and Centre for Green Chemistry and Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, Canada H3C 3J7
    • Research & Development, International Flavors & Fragrances Inc., 1515 State Route 36, Union Beach, New Jersey, 07735, United States
    View abstract

    Bioprocess Intensification Using Flow Reactors: Stereoselective Oxidation of Achiral 1,3-diols with Immobilized Acetobacter Aceti

    Valerio De Vitis 1, Federica Dall’Oglio 2, Francesca Tentori 3, Martina Letizia Contente 4, Elisabetta Brenna 3, Lucia Tamborini 2, Francesco Molinari 1

    • 1 Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, Via Celoria 2, 20133 Milan, Italy
    • 2 Department of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy
    • 3 Dipartimento di Chimica, Materiali ed Ingegneria Chimica “Giulio Natta” Politecnico di Milano, Via Mancinelli 7, I-20131 Milan, Italy
    • 4 School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
    View abstract

    Reversible chemoselective transetherification of vinylogous esters using Fe-catalyst under additive free conditions

    Nenavath Parvathalu, Sandip G. Agalave, Nirmala Mohanta and Boopathy Gnanaprakasam

    • Department of Chemistry, Indian Institute of Science Education and Research, Pune-411008, India
    View abstract

    Investigation of a Weak Temperature–Rate Relationship in the Carbamoylation of a Barbituric Acid Pharmaceutical Intermediate

    Alexander G. O’Brien *†, Yangmu Chloe Liu *†, Mark J. Hughes , John Jin Lim , Neil S. Hodnett , Nicholas Falco

    • GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States
    • GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom
    View abstract

    Protection‐Group‐Free Synthesis of Sequence‐Defined Macromolecules via Precision λ‐Orthogonal Photochemistry

    Waldemar Konrad1,2, Christian Fengler1,2, Sarrah Putwa1, Christopher Barner-Kowollik1,2

    • 1Macromolecular Architectures, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology (KIT), Engesserstr. 18, 76131 Karlsruhe, Germany
    • 2School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology (QUT), 2 George Street, QLD, 4000 Brisbane, Australia
    View abstract

    Decarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)phthalimides, an Organic Photocatalyst, and Visible Light

    Trevor C. Sherwood*†, Hai-Yun Xiao*†, Roshan G. Bhaskar, Eric M. Simmons, Serge Zaretsky, Martin P. Rauch§, Robert R. Knowles§, T. G. Murali Dhar

    • Research and Development, Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States
    • Chemical and Synthetic Development, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States
    • §Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States
    View abstract

    Flow Electrochemical Cyclizations via Amidyl Radicals: Easy Access to Cyclic Ureas

    Nisar Ahmeda,b*, Aggeliki Vgenopouloua

    • a School of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, UK
    • b School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK
    View abstract

    Efficient Flow Electrochemical Alkoxylation of Pyrrolidine-1-Carbaldehyde

    Nasser Amria, Ryan A. Skiltonb, Duncan Guthrieb, Thomas Wirth*a

    • a School of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, UK
    • b Vapourtec Ltd., 21 Park Farm Business Centre, Bury St Edmunds, IP28 6TS, UK
    View abstract

    Overcoming Water Insolubility in Flow: Enantioselective Hydrolysis of Naproxen Ester

    David Roura Padrosa1, Valerio De Vitis2, Martina Letizia Contente1*, Francesco Molinari2, Francesca Paradisi1*

    • 1 School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    • 2 Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli studi di Milano, Via Mongiagalli 25, 20133 Milan, Italy;
    View abstract

    A solid-supported arylboronic acid catalyst for direct amidation

    Yihao Dua,, Thomas Barbera,, Sol Ee Lima,, Henry S. Rzepab,, Ian R. Baxendale*a,, Andrew Whiting*a,

    • a Centre for Sustainable Chemical Processes, Department of Chemistry, Durham University, Science Laboratories, South Road, Durham, UK
    • a Department of Chemistry, Imperial College, South Kensington Campus, London, UK
    View abstract

    Visible Light‐Promoted Beckmann Rearrangements: Separating Sequential Photochemical and Thermal Phenomena in a Continuous Flow Reactor

    Yuesu Chen, David Cantillo, C. Oliver Kappe

    • Karl-Franzens-Universitat Graz, Institute of Chemistry, 8010 Graz, AUSTRIA
    View abstract

    A Consolidated and Continuous Synthesis of Ciprofloxacin from a Vinylogous Cyclopropyl Amide

    N. Perrer Tosso, Bimbisar K. Desai, Eliseu De Oliveira, Juekun Wen, John Tomlin, and B. Frank Gupton*

    • Department of Chemistry and Department of Chemical and Life Science Engineering, Virginia Commonwealth University, 601 West Main Street, Richmond, Virginia 23220, United States
    View abstract

    Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry

    Andrew R Bogdan, Amanda W Dombrowski

    • Discovery Chemistry and Technologies, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States
    View abstract

    Towards a Scalable Synthesis of 2‐Oxabicyclo[2.2.0]hex‐5‐en‐3‐one Using Flow Photochemistry

    Jason D. Williamsa,b, Yuma Otakea, Guilhem Coussanesc, Iakovos Saridakiscc, Nuno Maulidecc, C. Oliver Kappeaa,b

    • a Center for Continuous Flow Synthesis and Processing (CC FLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria
    • b Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010 Graz, Austria
    • c Institute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090 Vienna, Austria
    View abstract

    Continuous flow processing as a tool for the generation of terpene-derived monomer libraries

    Renan Galavernaa, Lucas P. Fernandesa, Duncan L. Browneb, Julio C. Pastrea

    • a Institute of Chemistry, University of Campinas – UNICAMP, Campinas, Brazil
    • b School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK
    View abstract

    Rapid Photochemical Reaction Studies under Continuous-flow Conditions in the Vapourtec UV-150 Reactor-A Technical Note

    Richard Huntera, Sam Joslanda, Joseph Mooreb, Duncan Guthrieb, Mark J. Robertsona, Michael Oelgemöllera

    • a College of Science and Engineering, James Cook University, Townsville, QLD 4911, Australia
    • b Vapourtec Ltd, Park Farm Business Centre, Fornham St Genevieve, Bury St Edmunds, Suffolk, IP28 6TS, UK
    View abstract

    Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines

    Rachel Grainger*a, Tom D. Heightmana, Steven V. Leyb, Fabio Limab,c, Christopher N. Johnson*a

    • a Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge, UK
    • b Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    • c Novartis Pharma AG, Novartis Campus, 4002 Basel, Switzerland
    View abstract

    Enhanced mixing of biphasic liquid-liquid systems for the synthesis of gem-dihalocyclopropanes using packed bed reactors

    T von Keutz1,2, D Cantillo1,2, CO Kappe1,2

    • 1 Center for Continuous Flow Synthesis and Processing (CCFLOW) Research Center Pharmaceutical Engineering GmbH (RCPE) Graz, Austria
    • 2 Institute of Chemistry, NAWI Graz, University of Graz, Graz, Austria
    View abstract

    Deprotection of N-Boc Groups Under Continuous Flow High Temperature Conditions

    Bryan Li, Ruizhi Li, Peter Dorff, James Christopher McWilliams, Robert M Guinn, Steven M. Guinness, Lu Han, Ke Wang, Shu Yu

    • Medicinal Science, Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States
    View abstract

    A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light

    Kaid C. Harper, Eric G. Moschetta, Shailendra V. Bordawekar, Steven J. Wittenberger

    • Process Research and Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States
    View abstract

    De novo design of organic photocatalysts: bithiophene derivatives for the visible‐light induced C‐H functionalization of heteroarenes

    Cecilia Bottecchia1, Raul Martin2, Irini Abdiaj3, Ettore Crovini4, Jesus Alcazar3, Jesus Jorduna, Maria Blesa, Jose Carrillo3, Pilar Prieto, Timothy Noel1

    • 1 TU Eindhoven, Netherlands
    • 2 Universidad de Castilla-La Mancha Facultad de Ciencias y Tecnologias Quimicas de Ciudad Real, Spain
    • 3 Janssen Research and Development, Spain
    • 4 University of Saint Andrews School of Chemistry, United Kingdom
    View abstract

    Integrating reactive distillation with continuous flow processing

    Marcus Baumann

    • School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland
    View abstract

    Enabling tools for continuous-flow biphasic liquid–liquid reaction

    Nopphon Weeranoppanant a

    • a Department of Chemical Engineering, Faculty of Engineering, Burapha University, 169 Longhard Bangsaen, Saensook, Muang, Thailand
    View abstract

    High-Throughput Template-Free Continuous Flow Synthesis of Polyaniline Nanofibers

    Rekha Singh†#, Karuna Veeramani†‡#, Rishab Bajpai, Anil Kumar*†‡§

    • Department of Chemistry, IITB-Monash Research Academy,§ National Centre for Excellence in Technologies for Internal Security (NCETIS), Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India
    View abstract

    A Continuous Flow Strategy for the Facile Synthesis and Elaboration of Semi‐Saturated Heterobicyclic Fragments

    Nicola Luise, Eleanor Wyatt, Gary Tarver, Paul Graham Wyatt

    • University of Dundee, School of Life Sciences, DD1 5EH Dundee, UNITED KINGDOM
    View abstract

    Continuous Flow Chlorination of Alkenyl Iodides Promoted by Copper Tubing

    Antoine Niteleta, Vanessa Kairouzb, Hélène Lebelb, André B. Charetteb, Gwilherm Evanoa

    • a  Laboratoire de Chimie Organique, Service de Chimie et Physico, Chimie Organiques, Université libre de Bruxelles (ULB), Avenue F. D. Roosevelt 50, CP160/06, 1050 Brussels, Belgium
    • b  Centre in Green Chemistry and Catalysis, Faculty of Arts and Sciences, Department of Chemistry, Université de Montréal, P.O. Box 6128, Station Downtown, Montréal, Québec, H3C 3J7, Canada
    View abstract

    Continuous flow palladium-catalyzed trifluoromethylthiolation of C-H bonds

    Alexanne Bouchard 1, Vanessa Kairouz 1, Maxime Manneveau 2, Heng-Ying Xiong 2, Tatiana Besset 2

    • 1 Department of Chemistry and Continuous Flow Synthesis Laboratory, Université de Montréal, Montréal, Canada
    • 2 INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), Normandie Université, Rouen, France
    View abstract

    Continuous preparation for rifampicin

    Xin Li 1, Zhuang Liu 1, Zheng Fang 1, Hao Qi 1, Siyu Huang 1, Shanshan Miao 1, Kai Guo 1,2

    • 1 College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China
    • 2 State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, China
    View abstract

    Using Carbon Dioxide as a Building Block in Continuous Flow Synthesis

    Hyowon Seo, Long V. Nguyen, Timothy F. Jamison

    • Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts
    View abstract

    Chemoselective Synthesis of Amines from Ammonium Hydroxide and Hydroxylamine in Continuous Flow

    Clément Audubert, Alexanne Bouchard, Gary Mathieu, Hélène Lebel

    • Department of Chemistry and Centre in Green Chemistry and Catalysis (CGCC), Université de Montréal, P.O. Box 6128, Station Downtown, Montréal, QC H3C 3J7, Canada
    View abstract

    Enantiospecific cyclization of methyl N-(tert-butoxycarbonyl)-N-(3-chloropropyl)-D-alaninate to 2-methylproline derivative via ‘memory of chirality’ in flow

    Gianvito Vilé 1, Gunther Schmidt 2, Sylvia Richard-Bildstein 1, Stefan Abele 2,

    • 1 Drug Discovery Chemistry, Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
    • 2 Chemical Development, Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
    View abstract

    Mg-Catalyzed OPPenauer Oxidation—Application to the Flow Synthesis of a Natural Pheromone

    Virginie Liautard, Mélodie Birepinte, Camille Bettoli, Mathieu Pucheault

    • Institut des Sciences Moléculaires (ISM), UMR 5255 CNRS—Université de Bordeaux, 351 Cours de la Libération, 33405 Talence CEDEX, France
    View abstract

    Dehydration of an Insoluble Urea Byproduct Enables the Condensation of DCC and Malonic Acid in Flow

    Alexander G. O’Brien, Eric M. Ricci, Michel Journet

    • GlaxoSmithKline, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States
    View abstract

    Self-Sufficient Flow-Biocatalysis by Coimmobilization of Pyridoxal 5′-Phosphate and ω-Transaminases onto Porous Carriers

    Ana I. Benítez-Mateos , Martina L. Contente §, Susana Velasco-Lozano , Francesca Paradisi , Fernando López-Gallego *⊥‡

    • Heterogeneous Biocatalysis Laboratory, CICbiomaGUNE, Paseo Miramón 182, Edificio empresarial C”, 20014 San Sebastián, Spain
    • § School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K
    • Heterogeneous biocatalysis laboratory, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH−CSIC), University of Zaragoza, C/Pedro Cerbuna 12, 50009 Zaragoza, Spain
    • ARAID, Aragon I+D foundation, Zaragoza, Spain
    View abstract

    A Convergent Continuous Multistep Process for the Preparation of C4-Oxime-Substituted Thiazoles

    Edouard Godineau *†, Claudio Battilocchio †‡, Matthias Lehmann , Steven V. Ley , Ricardo Labes , Letitia Birnoschi , Srinivas Subramanian §, C.S Prasanna § , Amol Gorde §, Mahesh Kalbagh §, Vivek Khade §, Anton Scherrer , Anthony C. O’Sullivan

    • Syngenta Crop Protection, Process Research, Schaffhauserstrasse 101, CH-4332, Switzerland
    • Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, UK
    • § Syngenta Research and Technology Centre, Santa Monica Works, Corlim, Goa India, 403110
    View abstract

    Additive Free Fe-Catalyzed Conversion of Nitro to Aldehyde under Continuous Flow Module

    Sandip G. Agalave, Moreshwar B. Chaudhari, Girish Singh Bisht, Boopathy Gnanaprakasam*

    • Department of Chemistry, Indian Institute of Science Education and Research Pune-411008, India
    View abstract

    Recent Advances in Photodecarboxylations Involving Phthalimides

    Saira Mumtaz, Mark J. Robertson, Michael Oelgemöller

    • James Cook University, College of Science and Engineering, Townsville, Qld 4811, Australia.
    View abstract

    C–H functionalisation of aldehydes using light generated, non-stabilised diazo compounds in flow

    Paul Dingwall a, Andreas Greb a, Lorène N. S. Crespin a, Ricardo Labes a, Biagia Musio a, Jian-Siang Poh a, Patrick Pasau b, David C. Blakemore c, Steven V. Ley *a

    • a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
    • b UCB Biopharma SPRL, Chemical Research R5, Chemin du Foriest 1420, Braine-L’Alleud, Belgium
    • c Medicine Design, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, USA
    View abstract

    Catalytic Static Mixers for the Continuous Flow Hydrogenation of a Key Intermediate of Linezolid (Zyvox)

    James Gardiner a*, Xuan Nguyen a, Charlotte Genet a, Mike D. Horne b, Christian Hornung a, John Tsanaktsidis a

    • a CSIRO Manufacturing Flagship, Bayview Avenue, Clayton, Australia
    • b CSIRO Mineral Resources, Bayview Avenue, Clayton, VIC 3169, Australia
    View abstract

    Photoinduced Palladium Negishi Cross-Coupling Through Visible Light Absorption of Palladium-Organozinc complexes

    Irini Abdiaj a, Lena Huck a,b, José Miguel Mateo b, Antonio de la Hoz b, M. Victoria Gomez c, Angel Díaz-Ortiz b, Jesús Alcázar a

    • a Lead Discovery, Janssen Research and Development, Janssen-Cilag, S.A., Jarama 75A, 45007 Toledo, Spain
    • b Facultad de Ciencias y Tecnologías Químicas, Universidad de Castilla-La Mancha, Av. Camilo José Cela 10, 13071 Ciudad Real, Spain
    • c Instituto Regional de Investigación Científica Aplicada, Universidad de Castilla-La Mancha, Av. Camilo José Cela, sn, 13071 Ciudad Real, Spain
    View abstract

    Three-Component Assembly of Multiply Substituted Homoallylic Alcohols and Amines Using a Flow Chemistry Photoreactor

    Yiding Chen , David Blakemore , Patrick Pasau §, Steven V. Ley

    • Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
    • Medicine Design, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States
    • § UCB Biopharma SPRL, Chemical Research R5, Chemin du Foriest, 1420 Braine-L’Alleud, Belgium
    View abstract

    Mild Homologation of Esters via Continuous Flow Chloroacetate Claisen Reactions

    Maximilian A. Ganiek, Maria V. Ivanova, Benjamin Martin*, Paul Knochel*

    • Department of Chemistry, Ludwig-Maximilians-Universität Munich, Butenandtstr. 5 – 13, 81377 Munich, Germany
    View abstract

    Regioselective Chlorination of Quinoline Derivatives via Fluorine Mediation in a Microfluidic Reactor

    Hao Qi, Xin Li, Zhuang Liu, Shan‐Shan Miao, Prof. Zheng Fang, Lin Chen, Zheng Fang, Prof. Kai Guo

    • College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, China
    View abstract

    Molecular machines

    Inventors: Colin Scott, Carol HARTLEY, Charlotte Williams, Quentin CHURCHES, Judith SCOBLE, Nicholas Turner, Nigel French

    • Assignee: Commonwealth Scientific and Industrial Research Organization CSIRO
    View abstract

    Continuous flow synthesis of a carbon-based molecular cage macrocycle via a three-fold homocoupling reaction

    Melanie Kitchinab, Kristina Konstasa, Christopher J. Sumbyb, Milena L. Czyza, Peter Valenteb, Matthew R. Hill*ab, Anastasios Polyzos*ac, Christian J. Doonan*ab

    • * Corresponding authors
    • a CSIRO Manufacturing Flagship, Bayview Avenue, Clayton, Australia
    • b Centre for Advanced Nanomaterials and the School of Physical Sciences, The University of Adelaide, Adelaide, Australia
    View abstract

    Flow-based biocatalysis: Application to peracetylated arabinofuranosyl-1,5-arabinofuranose synthesis

    Teodora Bavaroa, Andrea Pintob, Federica Dall’Oglioc, María J. Hernáizd, Carlo F. Morellie, Paolo Zambellib, Carlo De Michelic, Paola Contic, Lucia Tamborinic, Marco Terrenia

    • a Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy
    • b Department of Food Environmental and Nutritional Science (DeFENS), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
    • c Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
    • d Department of Pharmaceutical and Organic Chemistry, Faculty of Pharmacy, Complutense University of Madrid, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain
    • e Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milan, Italy
    View abstract

    Continuous Flow Photochemical Benzylic Bromination of a Key Intermediate in the Synthesis of a 2‐Oxazolidinone

    Yuesu Chena, b, Oscar de Frutosc, Carlos Mateosc, Juan A. Rinconc, David Cantillo*a, b, C. Oliver Kappe*a, b

    • a Center for Continuous Flow Synthesis and Processing (CC FLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz (Austria)
    • b Institute of Chemistry, University of Graz, Heinrichstrasse 28, 8010, Graz (Austria)
    • c Centro de Investigacin Lilly S. A. Avda. de la Industria 30, 28108 Alcobendas-Madrid (Spain)
    View abstract

    Native Chemical Ligation–Photodesulfurization in Flow

    Timothy S. Chisholm, Daniel Clayton, Luke J. Dowman, Jessica Sayers, Richard J. Payne

    • School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia
    View abstract

    Continuous flow biocatalysis

    Joshua Britton, Sudpta Majumdar, Gregory A. Weiss

    • Department of Chemistry, Molecular Biology and Biochemistry, University of California, Irvine, USA
    View abstract

    Reductive aminations using a 3D printed supported metal(0) catalyst system

    Charlotte Genet1, Xuan Nguyen1, Bita Bayatsarmadi2, Mike D. Horne2, James Gardiner1, Christian H. Hornung1

    • 1 CSIRO Manufacturing, Clayton, South Australia
    • 2 CSIRO Minerals Resources, Clayton, South Australia
    View abstract

    Flow Synthesis of Coumalic Acid and its Derivatization

    Laura K. Smith and Ian R. Baxendale

    • Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK.
    View abstract

    Production of metal-organic frameworks

    Inventors:, Marta RUBIO MARTINEZ, Matthew Roland Hill, Michael Batten, Kok Seng Lim, Anastasios POLYZOS, Timothy Raymond Barton, Trevor Deon HADLEY, Andreas Alexander MONCH

    • Assignee: Commonwealth Scientific and Industrial Research Organization CSIRO
    View abstract

    Combining CH functionalisation and flow photochemical heterocyclic metamorphosis (FP-HM) for the synthesis of benzo [1, 3] oxazepines

    Jasraj S. Babra, Andrew T. Russell, Christopher D. Smith, Yuxiong Zhang

    • Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK
    View abstract

    Studies toward the scaling of gas‐liquid photocycloadditions

    Dr. Emily B. Corcoran, Dr. François Lévesque, Dr. Jonathan P. McMullen, Dr. John R. Naber

    • Department of Process Research and Development, Merck Sharp & Dohme Corp., Rahway, USA
    View abstract

    Photooxygenation in an advanced led-driven flow reactor module: Experimental investigations and modelling

    Robbie Radjagobalouab, Jean-François Blancoa, Odile Dechy-Cabaretb, Michael Oelgemöllerc, Karine Loubièrea

    • a Laboratoire de Génie Chimique LGC, Université de Toulouse, CNRS, Toulouse, France
    • b Laboratoire de Chimie de Coordination LCC, CNRS, Toulouse, France
    • c James Cook University, College of Science and Engineering, Townsville, Queensland 4811, Australia
    View abstract

    P‐121: Successive and scalable synthesis of highly stable Cs4PbBr6 perovskite microcrystal by microfluidic system and their application in backlight display

    Hung-Chia Wang1, Zhen Bao1, Ru-Shi Liu1,2

    • 1 Department of Chemistry, National Taiwan University, Taipei, Taiwan
    • 2 Department of Mechanical Engineering and Graduate Institute of Manufacturing Technology, National Taipei University of Technology, Taipei, Taiwan
    View abstract

    Self-sustaining closed-loop multienzyme-mediated conversion of amines into alcohols in continuous reactions

    Martina L. Contente, Francesca Paradisi

    • School of Chemistry, University of Nottingham, Nottingham, United Kingdom
    View abstract

    Dichlorophenylacrylonitriles as AhR Ligands displaying selective breast cancer cytotoxicity in vitro

    Jennifer R Baker1, Jayne Gilbert2, Stefan Paula3, Xiao Zhu3, Jennette A Sakoff2, Adam McCluskey1

    • 1 The University of Newcastle, Chemistry, Newcastle, Australia
    • 2 Calvary Mater Hospital, Medical Oncology, Newcastle, Australia
    • 3 Purdue University, Chemistry, West Lafayette, United States
    View abstract

    Combining C-H functionalisation and flow photochemical heterocyclic metamorphosis (FP-HM) for the synthesis of benzo[1,3]oxazepines

    Jasraj S. Babra, Andrew T. Russell, Christopher D. Smith, Yuxiong Zhang

    • Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK
    View abstract

    Multistep Continuous-Flow Processes for the Preparation of Heterocyclic Active Pharmaceutical Ingredients

    Romaric Gérardy, Jean-Christophe M. Monbaliu

    • Center for Integrated Technology and Organic Synthesis, Department of Chemistry, University of Liège, Liège, Belgium
    View abstract

    Flow Chemistry Approaches Applied to the Synthesis of Saturated Heterocycles

    Marcus Baumann, Ian R. Baxendale

    • Department of Chemistry, University of Durham, Durham, UK
    View abstract

    An efficient benzoxaborole one‐pot synthesis by SiliaCat DPP‐Pd heterogeneous catalysis using diboronic acid

    Kana kunihiro1, Laurence Dumais2, Guillaume Lafitte2, Emeric Varvier2, Loïc Tomas2, Craig Harris2

    • 1 Ecole Nationale Supérieure des Ingenieurs en Arts Chimiques et Technologiques, France
    • 2 Nestlé Skin Health, Galderma R&D, France
    View abstract

    Total Synthesis of Neomarchantin A: Key Bond Constructions Performed Using Continuous Flow Methods

    Émilie Morin, Michaël Raymond, Amaury Dubart, and Shawn K. Collins

    • Department of Chemistry and Centre for Green Chemistry and Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, Canada H3C 3J7
    View abstract

    In situ epoxide generation by dimethyldioxirane oxidation and the use of epichlorohydrin in the flow synthesis of a library of β-amino alcohols

    Peter J. Cossar, Jennifer R. Baker, Nicholas Cain, Adam McCluskey

    • Chemistry, The University of Newcastle, University Drive Callaghan, New South Wales 2308, Australia
    View abstract

    Safe Use of Hazardous Chemicals in Flow

    MT Rahman1, T Wirth2

    • 1 School of Chemistry and Chemical Engineering, Queen’s University Belfast, Belfast, UK
    • 2 School of Chemistry, Cardiff University, Cardiff, UK
    View abstract

    Photochemical Synthesis of Heterocycles: Merging Flow Processing and Metal-Catalyzed Visible Light Photoredox Transformations

    T Glasnov

    • Institute of Chemistry, University of Graz, Graz, Austria
    View abstract

    Flow Chemistry as a Drug Discovery Tool: A Medicinal Chemistry Perspective

    Andrew R. Bogdan1, Michael G. Organ2

    • 1 Discovery Chemistry and Technology, AbbVie Inc., North Chicago, USA
    • 2 Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada
    View abstract

    Copper mediated, heterogeneous, enantioselective intramolecular Buchner reactions of α-diazoketones using continuous flow processing

    DC Crowley, D Lynch, AR Maguire

    • School of Chemistry, Analytical and Biological Chemistry Research Facility, University College Cork, Cork T12 K8AF, Ireland
    • School of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork T12 K8AF, Ireland
    View abstract

    Functionalization of Heteroarenes Under Continuous Flow

    Joachim Demaerel, Vidmantas Bieliũnas, Wim M. De Borggraeve

    • Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Leuven, Belgium
    View abstract

    Photoredox Iridium–Nickel Dual-Catalyzed Decarboxylative Arylation Cross-Coupling: From Batch to Continuous Flow via Self-Optimizing Segmented Flow Reactor

    Hsiao-Wu Hsieh, Connor W. Coley, Lorenz M. Baumgartner, Klavs F. Jensen*‡, Richard I. Robinson*†

    • Global Discovery Chemistry − Chemical Technology Group, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    • Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    View abstract

    A combination of flow and batch mode processes for the efficient preparation of mGlu2/3 receptor negative allosteric modulators (NAMs)

    Raveendra Panickar Dhanya, Ananda Herath, Douglas J. Sheffler, Nicholas D.P. Cosford

    • Cancer Metabolism and Signaling Networks Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, USA
    View abstract

    On-demand synthesis of organozinc halides under continuous flow conditions

    Mateo Berton, Lena Huck, Jesús Alcázar

    • Lead Discovery, Janssen Research and Development, Janssen-Cilag, S.A., Toledo, Spain
    View abstract

    Generation of Diversity Sets with High sp3 Fraction Using the Photoredox Coupling of Organotrifluoroborates and Organosilicates with Heteroaryl/Aryl Bromides in Continuous Flow

    Kevin D Raynor, Gregory D May, Upul K. Bandarage, and Michael J. Boyd

    • Vertex Pharmaceuticals Inc., 50 Nothern Avenue, Boston, Massachusetts 02210, United States
    View abstract

    Iron-Catalyzed Batch/Continuous Flow C-H Functionalization Module for the Synthesis of Anticancer Peroxides

    Moreshwar Bhagwan Chaudhari, Suresh Moorthy, Sohan Patil, Girish Singh Bisht, Haneef Mohamed, Sudipta Basu, and Boopathy Gnanaprakasam

    • Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India
    View abstract

    5′-substituted nucleoside compounds

    Inventors: Guillermo S CORTEZ, Zahid Quyoom BONDAY

    • Assignee: Eli Lilly and Co
    View abstract

    Selective N-monomethylation of primary anilines with dimethyl carbonate in continuous flow

    Hyowon Seo, Anne-Catherine Bédard, Willie P. Chen, Robert W. Hicklin, Alexander Alabugin, Timothy F. Jamison

    • Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139, USA
    View abstract

    Continuous flow multistep synthesis of α-functionalized esters via lithium enolate intermediates

    Timo von Keutza,b, Franz J. Straussb, David Cantilloa,b, C. Oliver Kappea,b

    • a Center for Continuous Flow Synthesis and Processing (CC FLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria
    • b Institute of Chemistry, NAWI Graz, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria
    View abstract

    A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic

    Marcus Baumann, Ian R. Baxendale and Fabien Deplante

    • Department of Chemistry, University of Durham, South Road, Durham, Durham, DH1 3LE, UK
    View abstract

    Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification

    Serena Mostardaa, Daniela Passerib, Andrea Carottia,1, Bruno Cerraa, Carolina Collivab, Tiziana Benicchib, Antonio Macchiaruloa, Roberto Pellicciarib, Antimo Gioielloa

    • a Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1, 06123 Perugia, Italy
    • b TES Pharma, Corso Vannucci, 47, 06121 Perugia, Italy
    View abstract

    5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine derivatives useful as inhibitors of beta-secretase (BACE)

    Inventors: Andrés Avelino Trabanco-Suárez, Francisca Delgado-Jiménez, Juan Antonio Vega Ramiro, Gary John Tresadern, Henricus Jacobus Maria Gijsen, Daniel Oehlrich,

    • Assignee: Janssen Pharmaceutica NV Janssen Cilag SA
    View abstract

    Conjugated polymers via direct arylation polymerization in continuous flow: minimizing the cost and batch-to-batch variations for high-throughput energy conversion

    Nemal S. Gobalasingham1, Jon E. Carlé2, Frederik C. Krebs2, Barry C. Thompson1, Eva Bundgaard2, Martin Helgesen*,2

    • 1 Department of Chemistry and Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, California, 90089-1661
    • 2 DTU Energy, Technical University of Denmark, Roskilde, DK-4000, Denmark
    View abstract

    Recent advances of microfluidics technologies in the field of medicinal chemistry

    László Ürge*, Jesus Alcazar, Lena Huck, György Dormán

    • * DBH Group, Budapest, Hungary
    • Janssen Research and Development, Toledo, Spain
    • Innostudio Inc., Budapest, Hungary
    View abstract

    Sustainable flow synthesis of a versatile cyclopentenone building block

    Marcus Baumann, Ian R. Baxendale, Paolo Filipponi, Te Hu

    • Department of Chemistry, University of Durham, South Road, DH1 3LE Durham, U.K
    • Novartis Pharma AG, Fabrikstrasse 14, 4002 Basel, Switzerland
    View abstract

    Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives

    Inventors: Daniel Kopetzki, David Tyler McQuade, Peter H. Seeberger, Kerry Gilmore

    • Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften
    View abstract

    Auto-Tandem Catalysis: Pd(II)-Catalysed Dehydrogenation/Oxidative Heck of Cyclopentane-1,3-diones

    Claire J C Lamb, Bryan G Nderitu, Gemma McMurdo, John MTobin, Filipe Vilela, and Ai-Lan Lee

    • Institute of Chemical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, United Kingdom
    View abstract

    Exploring effects of intermittent light upon visible light promoted water oxidations

    Dominic Walsh*a, Pascaline Patureaua, Karen Robertsona, Shaun Reekstingb, Anneke Lubbenb, Salvador Eslavac, Mark T. Welleraa

    • a Department of Chemistry, University of Bath, Bath, BA2 7AY, UK. E-mail: [email protected]
    • b Chemical Characterization and Analysis Facility, University of Bath, Bath, BA2 7AY, UK
    • c Department of Chemical Engineering, University of Bath, BA2 7AY, UK
    View abstract

    Telescoped continuous flow generation of a library of highly substituted 3-thio-1,2,4-triazoles.

    Mariana C. F. C. B. Damiãoa, Renan Galavernaa, Alan P. Kozikowskib, James Eubanksc, Julio C. Pastrea

    • a Institute of Chemistry, University of Campinas - UNICAMP, PO Box 6154 - Zip Code 13083-970, Campinas, SP, Brazil
    • b StarWise Therapeutics LLC - University Research Park – Zip Code 53719-1235, Madison, Wisconsin, USA
    • c Division of Genetics and Development - Krembil Research Institute – Zip Code M5T 2S8, Toronto, Ontario, Canada
    View abstract

    Targeting a mirabegron precursor by BH3-mediated continuous flow reduction process

    Sonia De Angelisa, Claudia Carluccia, Modesto de Candiaa, Gabriele Rebuzzinib, Paolo Celestinib, Massimiliano Riscazzib, Renzo Luisia, Leonardo Degennaroa

    • a FLAME-Lab − Flow Chemistry and Microreactor Technology Laboratory, Department of Pharmacy — Drug Sciences, University of Bari “A. Moro” Via E. Orabona 4, Bari 70125, Italy
    • b COSMA S.p.A, Via Colleoni 15/17, Ciserano, BG 24040, Italy
    View abstract

    In Situ Preparation and Consumption of O-Mesitylsulfonylhydroxylamine (MSH) in Continuous Flow for the Amination of Pyridines

    Cara E. Brocklehurst*, Guido Koch, Stephanie Rothe-Pöllet, Luigi La Vecchia

    • Synthesis and Technologies, Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Klybeckstrasse 141, 4057 Basel, Switzerland
    View abstract

    Highly efficient oxidation of amines to aldehydes with flow-based biocatalysis

    Dr. Martina L. Contente1,2, Federica Dall'Oglio3, Dr. Lucia Tamborini3, Prof. Francesco Molinari4, Prof. Francesca Paradisi1,2

    • 1 School of Chemistry, University of Nottingham, Nottingham, UK
    • 2 UCD School of Chemistry, University College Dublin, Dublin, Ireland
    • 3 Department of Pharmaceutical Sciences, DISFARM, University of Milan, Milan, Italy
    • 4 Department of Food, Environmental and Nutritional Science, DeFENS, University of Milan, Milan, Italy
    View abstract

    Novel Polystyrene-Immobilized Chiral Amino Alcohols as Heterogeneous Ligands for the Enantioselective Arylation of Aldehydes in Batch and Continuous Flow Regime

    José AugustoForni, Luiz Fernando Toneto, Novaes, Renan Galaverna, Julio C.Pastre

    • Institute of Chemistry, University of Campinas – UNICAMP, PO Box 6154, 13083-970, Campinas, SP, Brazil
    View abstract

    An efficient and green pathway for continuous Friedel-Crafts acylation over α-Fe2O3 and CaCO3 nanoparticles prepared in the microreactors

    Zheng Fanga1, Wei Heb1, Tao Tub, Niuniu Lva, Chuanhong Qiua, Xin Lia, Ning Zhua, Li Wana, Kai Guoac

    • a College of Biotechnology and Pharmaceutical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China
    • b Department of Chemistry, Fudan University, No. 220 Handan Road, Shanghai, 200433, PR China
    • c State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China
    View abstract

    A nanoporous graphene analog for superfast heavy metal removal and continuous-flow visible-light photoredox catalysis

    Ran Xiaoa, John Michael Tobinb, Meiqin Zhaa, Yunlong Houa, Jun Hec, Filipe Vilela*b, Zhengtao Xu*a

    • a Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong
    • b School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK
    • c School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China
    View abstract

    A novel micro-flow system under microwave irradiation for continuous synthesis of 1, 4-dihydropyridines in the absence of solvents via Hantzsch reaction

    Wei Hea,b, Zheng Fangb, Kai Zhangb, Tao Tua, Niuniu Lvb, Chuanhong Qiub, Kai Guob,c

    • a Department of Chemistry, Fudan University, No. 220 Handan Road, Shanghai, 200433, PR China
    • b College of Biotechnology and Pharmaceutical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China
    • c State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China
    View abstract

    Methanolysis of epoxidized soybean oil in continuous flow conditions

    Vincenzo Pantonea, Amelita Grazia Laurensab, Cosimo Annesec, Francesco Fracassib, Caterina Fuscob, Angelo Naccib,c, Antonella Russoa, Lucia D’Accoltib,c

    • a Greenswitch s.r.l., Ferrandina MT, Italy
    • b Dipartimento di Chimica, Università di Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy
    • c ICCOM-CNR, SS Bari, Via E. Orabona 4, 70126 Bari, Italy
    View abstract

    Visible-light-induced trifluoromethylation of highly functionalized arenes and heteroarenes in continuous flow

    Irini Abdiaja, Cecilia Bottecchiab, Jesus Alcazar*a, Timothy Noёl*b

    • a Janssen Research & Development, Jarama 75A, 45007 Toledo, Spain
    • b Department of Chemical Engineering and Chemistry, Micro Flow Chemistry & Process Technology, Eindhoven University of Technology, Den Dolech 2, 5612 AZ Eindhoven, The Netherlands
    View abstract

    Continuous preparation and use of dibromoformaldoxime as a reactive intermediate for the synthesis of 3- bromoisoxazolines

    Claudio Battilocchioa*, Francesco Bosicaa, Sam M. Rowea, Bruna L. Abreua, Edouard Godineaub*, Matthias Lehmannb, Steven V. Leya

    • a Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
    • b Syngenta Crop Protection AG, Crop Protection Research, Schaffhauserstrasse 101, CH-4332 Stein, Switzerland
    View abstract

    Treatment of alcohols

    Inventors: Thomas Mark Douglas, Andrew John Hogben, David John Law, John Glenn Sunley, Thomas Giles Parsons

    • Assignee: Technip E&C Ltd
    View abstract

    Chemoenzymatic synthesis in flow reactors: a rapid and convenient preparation of captopril

    Dr. Valerio De Vitis1, Dr. Federica Dall'Oglio1, Dr. Andrea Pinto2, Prof. Carlo De Micheli2, Prof. Francesco Molinari1, Prof. Paola Conti2, Dr. Diego Romano1, Dr. Lucia Tamborini2

    • 1 Department of Food Environmental and Nutritional Science, University of Milan, Milan, Italy
    • 2 Department of Pharmaceutical Sciences, University of Milan, Milan, Italy
    View abstract

    Preparation of polyfunctional diorgano-magnesium and – zinc reagents using in situ trapping halogen-lithium exchange of highly functionalized (hetero)aryl halides in continuous flow

    Marthe Ketels, Maximilian Andreas Ganiek, Niels Weidmann, Paul Knochel

    • LMU München, Department of Chemistry, München, Germany
    View abstract

    Flow assisted synthesis: a key fragment of SR 142948A

    Matthew Oliver Kitching, Olivia E Dixon, Marcus Baumann, Ian Richard Baxendale

    • University of Durham, Chemistry, Durham, UK
    View abstract

    Singlet oxygen oxidations in homogeneous continuous flow using a gas–liquid membrane reactor

    Antonia Kouridaki, Kevin Huvaere

    • EcoSynth NV, Industrielaan 12, 9800 Deinze, Belgium
    View abstract

    A convenient, mild and green synthesis of NH-sulfoximines in flow reactors

    Leonardo Degennaro1, Arianna Tota1, Sonia De Angelis1, Michael Andresini1, Cosimo Cardellicchio2, Maria Annunziata Capozzi1, Giuseppe Romanazzi3, Renzo Luisi1

    • 1 University of Bari, Department of Pharmacy - Drug Sciences, Bari, Italy
    • 2 CNR ICCOM, Department of Chemistry, Bari, Italy
    • 3 Politecnico di Bari, DICATECh, Bari, Italy
    View abstract

    A continuous flow method for the desulfurization of substituted thioimidazoles applied to the synthesis of new etomidate derivatives

    Marcus Baumann, Ian R Baxendale

    • Durham University, Department of Chemistry, Durham, UK
    View abstract

    High throughput photo-oxidations in a packed bed reactor system

    Caleb J. Kong, Daniel Fisher, Bimbisar K. Desai,. Yuan Yang, Saeed Ahmad, Katherine Belecki, B. Frank Gupton

    • Department of Chemistry and Department of Chemical and Life Science Engineering, Virginia Commonwealth University, 601 W. Main St. Richmond, VA 23220, USA
    View abstract

    Phase separation macrocyclization in a complex pharmaceutical setting: application toward the synthesis of vaniprevir

    Eric Godin, Anne-Catherine Bédard, Michael Raymond, Shawn K. Collins*

    • Département de Chimie, Centre for Green Chemistry and Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, H3C 3J7 Canada
    View abstract

    Method for the synthesis of N-(phosphonomethyl)glycine

    Inventors: Sebastian Burck, Frederic Bruyneel, Patrick Notte

    • Assignee: Monsanto Technology LLC
    View abstract

    Isoquinoline derivatives

    Inventors: Simona M. Ceccarelli, Ravi Jagasia, Roland Jakob-Roetne, Rainer E. Martin, Juergen Wichmann

    • Assignee: Hoffmann La Roche Inc
    View abstract

    Removal of nitrogen-containing impurities form alcohol compositions

    Inventors:, Thomas Mark Douglas, Nakul Thakar

    • Assignee: Technip E&C Ltd
    View abstract

    Substituted 1,6-naphthyridines

    Inventors:, Simona M. Ceccarelli, Ravi Jagasia, Roland Jakob-Roetne, Rainer E. Martin, Jens-Uwe Peters, Juergen Wichmann

    • Assignee: Hoffmann La Roche Inc
    View abstract

    Process for the preparation of efavirenz and devices suitable therefore

    Inventors, Camille A. Correia, Kerry Gilmore, David Tyler McQuade, Peter H. Seeberger

    • Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften
    View abstract

    RAFT polymers

    Inventors:, John Chiefari, Christian Hornung, Almar Postma, Simon Saubern

    • Assignee: Commonwealth Scientific and Industrial Research Organization CSIRO
    View abstract

    Method for preparing caprolactam by using a microreactor under lewis acid catalysis

    Inventors:, Kai Guo, Xin Li, Zheng Fang, Kai Zhang, Qi Yu, Pingkai Ouyang

    • Assignee: Nanjing Tech University
    View abstract

    Grignard reagents on a tab: direct magnesium insertion under flow conditions

    Lena Huck†,‡, Antonio de la Hoz, Angel Díaz-Ortiz, Jesus Alcázar

    • Janssen Research and Development, Janssen-Cilag, S.A., C/Jarama 75, 45007 Toledo, Spain
    • Facultad de Ciencias Químicas, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain
    View abstract

    Co-production of HMF and gluconic acid from sucrose by chemo-enzymatic method

    Hongli Wu, Ting Huang, Fei Cao, Qiaogen Zou, Ping Wei, Pingkai Ouyang

    • College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816 PR China
    View abstract

    The Application of a Continuous Grignard Reaction in the Preparation of Fluconazole

    Sudha Korwar, Somi Amir, Perrer N. Tosso, Bimbisar K. Desai, Caleb J. Kong, Swara Fadnis, Nakul S. Telang, Saeed Ahmad, Thomas D. Roper, B. Frank Gupton*

    • Department of Chemistry and Department of Chemical and Life Science, Engineering, Virginia Commonwealth University, 601 W. Main St., R ichmond, VA 23220, USA
    View abstract

    Efficient synthesis of 5-(chloromethyl) furfural (CMF) from high fructose corn syrup (HFCS) using continuous flow processing

    T. M. Kohla, B. Bizeta, P. Kevana, C. Sellwooda, J. Tsanaktsidisa, C. H. Hornunga

    • a CSIRO Manufacturing Flagship, Bag 10, Clayton South, Australia
    View abstract

    Barbier continuous flow preparation and reactions of carbamoyllithiums for nucleophilic amidation

    Maximilian Andreas Ganiek, Matthias Richard Becker, Guillaume Berionni, Hendrik Zipse, Paul Knochel

    • LMU München, Department of Chemistry, München, Germany
    View abstract

    Polymer-supported photosensitizers for oxidative organic transformations in flow and under visible light irradiation

    John M. Tobin, Timothy J. D. McCabe, Andrew W. Prentice, Sarah Holzer, Gareth O. Lloyd, Martin J. Paterson, Valeria Arrighi, Peter A. G. Cormack, Filipe Vilela

    • School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS Scotland, United Kingdom
    • WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow, G1 1XL Scotland, United Kingdom
    View abstract

    Direct valorisation of waste cocoa butter triglycerides via catalytic epoxidation, ring-opening and polymerisation

    Dorota D Plazaa, Vinzent Strobelb, Parminder Kaur KS Heerb, Andrew B Sellarsd, Seng-Soi Hoongd, Andrew J Clarkd, Alexei A Lapkinb

    • a School of Engineering, University of Warwick, Coventry, UK
    • b Department of Chemical Engineering and Biotechnology, University of Cambridge, UK
    • c Aachener Verfahrenstechnik – Process Systems Engineering, RWTH Aachen University, Aachen, Germany
    • d Department of Chemistry, University of Warwick, Coventry, UK
    View abstract

    Hydrogen sulfide chemistry in continuous flow: Efficient synthesis of 2-oxopropanethioamide

    David Cantillo1,2, Phillip A. Inglesby3, Alistair Boyd3, Oliver Kappe1,2

    • 1 Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010 Graz, Austria
    • 2 Research Center Pharmaceutical Engineering (RCPE), Inffeldgasse 13, 8010 Graz, Austria
    • 3 AstraZeneca, Silk Road Business Park, Macclesfield, SK10 2NA, United Kingdom
    View abstract

    Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic

    Chinmay A. Shukla1,2, Amol A. Kulkarni1,2

    • 1 Academy of Scientific and Innovative Research (AcSIR), CSIR-National Chemical Laboratory (NCL) Campus, Pune 411008, India
    • 2 Chem. Eng. & Proc. Dev. Div., CSIR-National Chemical Laboratory, Dr. Homi Bhaba Road, Pashan, Pune 411008, India
    View abstract

    Utilizing on‐and off‐line monitoring tools to follow a kinetic resolution step during flow synthesis

    Kathleen A. Farley, Usa Reilly, Dennis P. Anderson, Brian P. Boscoe, Mark W. Bundesmann, David A. Foley, Manjinder S. Lall, Chao Li, Matthew R. Reese, Jiangli Yan

    • Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT, United States
    View abstract

    Flow Synthesis of Cyclobutanones via [2+2] Cycloaddition of Keteneiminium Salts and Ethylene Gas

    Claudio Battilocchioa, Grazia Iannuccia, Shiyi Wanga, Edouard Godineaub, Amandine Kriegerb, Alain De Mesmaekerb, Steven V Ley*a

    • a Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, UK
    • b Syngenta Crop Protection AG, Crop Protection Research, Schaffhauserstrasse 101, CH-4332, Switzerland
    View abstract

    Continuous Flow α-Arylation of N,N-Dialkylhydrazones under Visible-Light Photoredox Catalysis

    Juan A. Vega, José Manuel Alonso, Gabriela Méndez, Myriam Ciordia, Francisca Delgado, Andrés A. Trabanco

    • Neuroscience Medicinal Chemistry, Janssen Research & Development, Jarama 75A, 45007 Toledo, Spain
    View abstract

    Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes

    Swapna S. Mohapatraa,b, Zoe E. Wilsona, Sujit Royb, Steven V. Leya

    • a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
    • b Organometallics & Catalysis Laboratory, School of Basic Sciences, Indian Institute of Technology, Bhubaneswar 751013, India
    View abstract

    Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction

    Ananda Herath, Nicholas D. P. Cosford

    • Cancer Metabolism & Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    View abstract

    Preparation of Forced Gradient Copolymers Using Tube-in-Tube Continuous Flow Reactors

    Simon Saubern, Xuan Nguyen, Van Nguyen, James Gardiner, John Tsanaktsidis, John Chiefari

    • CSIRO Manufacturing, Clayton, VIC, Australia
    View abstract

    A Continuous Flow Synthesis and Derivatization of 1,2,4-Thiadiazoles

    Marcus Baumann, Ian R. Baxendale

    • Department of Chemistry, University of Durham, South Road, DH1 3LE Durham, United Kingdom.
    View abstract

    Self-Optimisation and Model-Based Design of Experiments for Developing a C–H Activation Flow Process

    Alexander Echtermeyer1,2, Yehia Amar2, Jacek Zakrzewski2, Alexei Lapkin2

    • 1 Aachener Verfahrenstechnik – Process Systems Engineering, RWTH Aachen University, Aachen, Germany
    • 2 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom
    View abstract

    Diels–Alder reactions of myrcene using intensified continuous-flow reactors

    Christian H. Hornung, Miguel Á. Álvarez-Diéguez, Thomas M. Kohl and John Tsanaktsidis

    • CSIRO Manufacturing, Bag 10, Clayton South, Victoria 3169, Australia
    View abstract

    Active Site-Mapping of Xylan-Deconstructing Enzymes with Arabinoxylan Oligosaccharides Produced by Automated Glycan Assembly

    Deborah Senf, Colin Ruprecht, Goswinus de Kruijff, Sebastian Simonetti, Frank Schuhmacher, Peter Seeberger, Fabian Pfrengle

    • Max-Planck-Institute of Colloids and Interfaces, Biomolecular Systems, Potsdam, Germany
    View abstract

    Mixed-Linkage Glucan Oligosaccharides Produced by Automated Glycan Assembly Serve as Tools to Determine the Substrate Specificity of Lichenase

    Pietro Dallabernardina, Frank Schuhmacher, Peter H Seeberger, Fabian Pfrengle

    • Max-Planck-Institute of Colloids and Interfaces, Biomolecular Systems, Potsdam, Germany
    View abstract

    Improving the throughput of batch photochemical reactions using flow: Dual photoredox and nickel catalysis in flow for C(sp2) C(sp3) cross-coupling

    Irini Abdiaj, Jesús Alcázar

    • Janssen Research and Development, Janssen-Cilag, S.A., C/Jarama 75, 45007 Toledo, Spain
    View abstract

    Synthesis of Cycloalkyl Substituted 7-Azaindoles via Photoredox Nickel Dual Catalytic Cross-Coupling in Batch and Continuous Flow

    Natalie Palaychuk, Travis J. DeLano, Michael J. Boyd, Jeremy Green, and Upul K. Bandarage

    • Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, Massachusetts 02210, United States
    View abstract

    Acridinium-Based Photocatalysts: A Sustainable Option in Photoredox Catalysis

    Amruta Joshi-Pangu, François Lévesque, Hudson G. Roth, Steven F. Oliver, Louis-Charles Campeau, David Nicewicz, Daniel A. DiRocco

    • Process Research & Development, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, United States
    • Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, United States
    View abstract

    Halogenation of organic compounds using continuous flow and microreactor technology

    David Cantilloab, C. Oliver Kappe*ab

    • a Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, Graz, Austria
    • b Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria
    View abstract

    Application of the Photoredox Coupling of Trifluoroborates and Aryl Bromides to Analog Generation Using Continuous Flow

    Travis J. DeLano, Upul K. Bandarage, Natalie Palaychuk, Jeremy Green, and Michael J. Boyd

    • Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, Massachusetts 02210, United States
    View abstract

    Design and Development of Pd-catalyzed Aerobic N-Demethylation Strategies for the Synthesis of Noroxymorphone in Continuous Flow Mode

    Bernhard Gutmanna,b, David Cantilloa,b, Ulrich Weiglc, D Phillip Coxd, C. Oliver Kappea,b

    • a,b Institute of Chemistry, University of Graz, Nawi Graz, Heinrichstrasse 28, 8010 Graz, Austria and Research Center Pharmaceutical Engineering (RCPE), Inffeldgasse 13, 8010 Graz, Austria
    • c Cilag AG, Hochstrasse 201, 8200 Schaffhausen, Switzerland
    • d Noramco Inc., 503 Carr Road, Suite 200, Wilmington, DE 19809, USA
    View abstract

    γ-Glutamyl-dipeptides: Easy tools to rapidly probe the stereoelectronic properties of the ionotropic glutamate receptor binding pocket

    Lucia Tamborinia, Veronica Nicosiaa, Paola Contia, Federica Dall'Oglioa, Carlo De Michelia, Birgitte Nielsenb, Anders A. Jensenb, Darryl S. Pickeringb, Andrea Pintoa

    • a Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
    • b Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen OE, Denmark
    View abstract

    Expedited access to thieno[3,2-c]quinolin-4(5H)-ones and benzo[h]-1,6-naphthyridin-5(6H)-ones via a continuous flow photocyclization method

    Y. Fanga, G. K. Tranmer*ab

    • * Corresponding author
    • a College of Pharmacy, Faculty of Health Science, University of Manitoba, Winnipeg, Canada
    • b Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, Canada
    View abstract

    A benchtop NMR spectrometer as a tool for monitoring mesoscale continuous-flow organic synthesis: equipment interface and assessment in four organic transformations

    Cynthia M. Archambaulta, Nicholas E. Leadbeater*a

    • * Corresponding author
    • a Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, USA
    View abstract

    BODIPY-based conjugated microporous polymers as reusable heterogeneous photosensitisers in a photochemical flow reactor

    J. M. Tobina, J. Liub, H. Hayesa, M. Demleitnera, D. Ellisa, V. Arrighia, Z. Xu*b, F. Vilela*a

    • * Corresponding author
    • a School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK
    • b Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, China
    View abstract

    Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

    L. Hucka,b, M. Bertona, A. de la Hozb, A. Díaz-Ortizb, J. Alcázar*a

    • * Corresponding author
    • a Janssen Research and Development, Janssen-Cilag, S.A., C/ Jarama 75, Toledo, Spain
    • b Facultad de Ciencias Químicas, Universidad de Castilla-La Mancha, Ciudad Real, Spain
    View abstract

    Visible light activation of Boronic Esters enables efficient photoredox C(sp2)–C(sp3) cross-couplings in flow

    Fabio Limaa, Dr. Mikhail A. Kabeshova, Dr. Duc N. Trana, Dr. Claudio Battilocchioa, Dr. Joerg Sedelmeierb, Dr. Gottfried Sedelmeierb, Dr. Berthold Schenkelb, S. V. Ley*a

    • * Corresponding author
    • a Department of Chemistry, University of Cambridge, Cambridge, UK
    • b Novartis Pharma AG, Basel, Switzerland
    View abstract

    Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform

    D. E. Fitzpatricka, S. V. Ley*a

    • * Corresponding author
    • a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    View abstract

    Triphenylphosphine-grafted, RAFT-synthesised, porous monoliths as catalysts for Michael addition in flow synthesis

    Kristine J. Barlowa, Victor Bernabeua, Xiaojuan Haoa, Timothy C. Hughesa, Oliver E. Hutta, Anastasios Polyzosa,b, Kathleen A. Turnera, Graeme Moada

    • a CSIRO Manufacturing Flagship, Bag 10, Clayton South, Victoria 3169, Australia
    • b University of Melbourne, School of Chemistry, Parkville, Victoria 3010, Australia
    View abstract

    Ethyl Lithiodiazoacetate: Extremely unstable intermediate handled efficiently in flow

    Simon T. R. Müllera, Tobias Hokampa, Svenja Ehrmanna, Paul Hellierb, Thomas Wirtha

    • a Cardiff University School of Chemistry Cardiff UK
    • b Parc Industriel de la Chartreuse Pierre Fabre Médicament Castres CEDEX France
    View abstract

    A facile hybrid ‘flow and batch’ access to substituted 3,4-dihydro-2H-benzo[b][1,4]oxazinones

    Andrew J. S. Lina, Cecilia C. Russella, Jennifer R. Bakera, Shelby L. Fraileyab, Jennette A. Sakoffc, Adam McCluskey*a

    • * Corresponding authors
    • a Chemistry, Centre for Chemical Biology, School of Environmental & Life Sciences, University of Newcastle, University Drive, Callaghan, Australia
    • b Chemical Engineering, Trine University, Angola, 46703 USA
    • c Department of Medical Oncology, Calvary Mater Newcastle Hospital, Waratah, Australia
    View abstract

    Continuous flow biocatalysis: production and in-line purification of amines by immobilised transaminase from Halomonas elongata

    Matteo Planchestainera, Martina Letizia Contenteab, Jennifer Cassidya, Francesco Molinarib, Lucia Tamborini*c, Francesca Paradisi*ad

    • * Corresponding authors
    • a UCD School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland
    • b Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli studi di Milano, Via Mangiagalli 25, Milan, Italy
    • c Department of Pharmaceutical Sciences (DISFARM), Università degli studi di Milano, Via Mangiagalli 25, Milan, Italy
    • d School of Chemistry, University of Nottingham, University Park, Nottingham, UK
    View abstract

    Method and device for the synthesis of artemisinin

    Inventors:, Peter H. Seeberger, Daniel Kopetzki, Francois Lévesque

    • Assignee:
    • Max-Planck-Gesellschaft zur Forderung der Wissenschaften
    View abstract

    A laboratory-scale continuous flow chlorine generator for organic synthesis

    Franz J. Straussa, David Cantillo*ab, Javier Guerrac, C. Oliver Kappe*ab

    • * Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, Graz, Austria
    • a Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria
    • b Crystal Pharma, Gadea Pharmaceutical Group, A Division of AMRI, Parque Tecnológico de Boecillo, Valladolid, Spain
    View abstract

    Continuous processing and efficient in situ reaction monitoring of a hypervalent iodine (III) mediated cyclopropanation using benchtop NMR spectroscopy

    Batool Ahmed-Omera, Eric Sliwinskia, John Paul Cerrotib, Steven V Leya

    • aDepartment of chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    • bMagritek GmbH, Gebäude VO (Building VO), Triwo Technopark Aachen, Philipsstrasse 8, 52068 Aachen, Germany
    View abstract

    Aryl amination using ligand-free Ni(II) salts and photoredox catalysis

    Emily B. Corcoran1, Michael T. Pirnot2, Shishi Lin3, Spencer D. Dreher3, Daniel A. DiRocco3, Ian W. Davies3, Stephen L. Buchwald2,*, David W. C. MacMillan1,*

    • 1 Merck Center for Catalysis at Princeton University, Princeton, NJ 08544, USA
    • 2 Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    • 3 Department of Process Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
    View abstract

    Catalytic Chan–Lam coupling using a ‘tube-in-tube’ reactor to deliver molecular oxygen as an oxidant

    Carl J. Mallia1, Paul M. Burton2, Alexander M. R. Smith2, Gary C. Walter2, Ian R. Baxendale1

    • 1 Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, United Kingdom
    • 2 Syngenta CP R&D Chemistry, Jealott’s Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, United Kingdom
    View abstract

    An approach to the synthesis of 4-aryl and 5-aryl substituted thiazole-2(3H)-thiones employing flow processing

    Monaem Baltia, Shelli A. Millerb, Mohamed Lotfi Efrita, Nicholas E. Leadbeater*b

    • * Corresponding authors
    • a Université Tunis El Manar, Laboratory of Organic Synthesis and Heterocyclic Chemistry, Faculty of Science of Tunis, Department of Chemistry, 1060 Tunis, Tunisia
    • b Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, USA
    View abstract

    Flow carbonylation of sterically hindered ortho-subsituted iodoarenes

    Carl J. Mallia1, Gary C. Walter2, Ian R. Baxendale1

    • 1 Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, United Kingdom
    • 2 Syngenta CP R&D Chemistry, Jealott’s Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, United Kingdom
    View abstract

    Exploring flow procedures for diazonium formation

    Te Hu, Ian R. Baxendale and Marcus Baumann

    • Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK
    View abstract

    Catalytic macrocyclization strategies using continuous flow: formal total synthesis of ivorenolide A

    Mylène de Léséleuc, Eric Godin, Shawn Parisien-Collette, Alexandre Levesque, and Shawn K. Collins

    • University of Montréal, Department of Chemistry, Montréal, Canada
    View abstract

    Delivering enhanced efficiency in the synthesis of α-diazosulfoxides by exploiting the process control enabled in flow

    Patrick G. McCaw1, Benjamin J. Deadman1, Anita R. Maguire1,2, Stuart G. Collins1

    • 1 Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork, Ireland
    • 2 Department of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork, Ireland
    View abstract

    The generation of a library of bromodomain-containing protein modulators expedited by continuous flow synthesis

    Paolo Filipponi and Ian R. Baxendale*

    • * Department of Chemistry, University of Durham South Road, Durham, DH1 3LE, United Kingdom
    View abstract

    An efficient etherification of Ginkgol biloba extracts with fewer side effects in a micro-flow system

    Yin-Lin Qina, Wei Hea, Mei Sub, Zheng Fangc, Ping-Kai Ouyanga, Kai Guoa,d

    • a College of Biotechnology and Pharmaceutical Engineering, Nanjing Technology University, Nanjing 210009, China
    • b Jiangsu Carephar Pharmaceutical Co., Ltd., Nanjing 210014, China
    • c School of Pharmaceutical, Nanjing Technology University, Nanjing 210009, China
    • d State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Technology University, Nanjing 211816, China
    View abstract

    Continuous-flow synthesis and derivatization of aziridines through palladium-catalyzed C(sp3)−H activation

    Jacek Zakrzewski1, Adam P. Smalley2, Dr. Mikhail A. Kabeshov2, Prof. Matthew J. Gaunt2, Prof. Alexei A. Lapkin1

    • 1 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
    • 2 Chemistry Department, University of Cambridge, Cambridge, UK
    View abstract

    Metal-free borylation of electron-rich aryl(pseudo)halides under continuous-flow photolytic conditions

    Kai Chena, Man Sing Cheungb, Zhenyang Lin*b, Pengfei Li*a

    • a Center for Organic Chemistry, Frontier Institute of Science and Technology (FIST) and Frontier Institute of Chemistry, Xi'an Jiaotong University, 99 Yanxiang Road, Xi'an, China
    • b Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, China
    View abstract

    Difluorocarbene addition to alkenes and alkynes in continuous flow

    Pauline Rullière, Patrick Cyr, André B. Charette*

    • Université de Montréal, Centre in Green Chemistry and Catalysis, Department of Chemistry, Faculty of Arts and Science, P.O. Box 6128, Station Downtown, Québec, Canada H3C 3J7
    View abstract

    A simple setup for transfer hydrogenations in flow chemistry

    Matthew Hutchings, Thomas Wirth*

    • School of Chemistry, Cardiff University, Cardiff CF10 3AT, UK
    View abstract

    A scalable and operationally simple radical trifluoromethylation

    Joel W. Beatty1, James J. Douglas1,2, Kevin P. Cole2, Corey R. J. Stephenson1

    • 1 Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    • 2 Small Molecule Design and Development, Lilly Research Laboratoires, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    View abstract

    Photoactive and metal-free polyamide-based polymers for water and wastewater treatment under visible light irradiation

    Junjie Shena, Roman Steinbacha, John Tobina, Mayumi Mouro Nakataa, Matthew Bowerb, Martin McCoustraa, Helen Bridlea, Valeria Arrighia, Filipe Vilelaa

    • a School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, United Kingdom
    • b Drinking Water Quality Regulator for Scotland, Edinburgh, EH6 6WW, United Kingdom
    View abstract

    Biodiesel synthesis using integrated acid and base catalysis in continuous flow

    Mousa Asadia, Joel F. Hoopera, David W. Luptona

    • aSchool of Chemistry, Monash University, Clayton 3800, Victoria, Australia
    View abstract

    Fine chemical syntheses under flow using SiliaCat catalysts

    Rosaria Ciriminna a, Valerica Pandarus b, François Béland *b, Mario Pagliaro *a

    • * Corresponding authors a Istituto per lo Studio dei Materiali Nanostrutturati, CNR, via U. La Malfa 153, 90146 Palermo, Italy
    • b SiliCycle, 2500, Parc-Technologique Blvd, Québec, G1P 4S6 Canada
    View abstract

    Continuous-flow synthesis of 2H-azirines and their diastereoselective transformation to aziridines

    Marcus Baumann *, Ian R. Baxendale

    • Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK
    View abstract

    Continuous flow magnesiation or zincation of acrylonitriles, acrylates, and nitroolefins. Application to the synthesis of butenolides

    Maximilian A. Ganiek, Matthias R. Becker, Marthe Ketels, Paul Knochel *

    • Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich, Germany
    View abstract

    Continuous flow photo-initiated RAFT polymerisation using a tubular photochemical reactor

    James Gardiner a, Christian H. Hornung a, John Tsanaktsidis a, Duncan Guthrie b

    • a CSIRO Manufacturing, Bag 10, Clayton South, Victoria 3169, Australia
    • b Vapourtec Ltd, Park Farm Business Centre, Bury St Edmunds IP28 6TS, United Kingdom
    View abstract

    Continuous-flow photochemistry: a need for chemical engineering

    Karine Loubière a,b, Michael Oelgemöller c, Tristan Aillet a,b, Odile Dechy-Cabaret a,d, Laurent Prat a,b

    • a CNRS, Laboratoire de Génie Chimique (LGC UMR 5503), 4 allée Emile Monso, BP 84234, 31432 Toulouse, France
    • b Université de Toulouse, INPT, ENSIACET, F-31432 Toulouse, France
    • c James Cook University, College of Science, Technology and Engineering, Townsville, Queensland 4811, Australia
    • d CNRS, Laboratoire de Chimie de Coordination (LCC UPR 8241), 205 route de Narbonne, BP 44099, F-31077 Toulouse, France
    View abstract

    Efficient metal-free photochemical borylation of aryl halides under batch and continuous-flow conditions

    Kai Chen, Shuai Zhang, Pei He, Pengfei Li *

    • Center for Organic Chemistry, Frontier Institute of Science and Technology (FIST), Xi'an Jiaotong University, 99 Yanxiang Road, Xi'an, Shaanxi 710054, China
    View abstract

    Continuous flow photochemistry as an enabling synthetic technology: synthesis of substituted-6(5H)-phenanthridinones for use as poly(ADP-ribose) polymerase inhibitors

    Y. Fang a, G. K. Tranmer *a,b

    • * Corresponding authors a College of Pharmacy, Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
    • b Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, Canada
    View abstract

    Controlled generation and use of CO in flow

    Steffen V. F. Hansen a,b, Zoe E. Wilson a, Trond Ulven *b, Steven V. Ley *a

    • a Department of Chemistry, University of Cambridge Lensfield Road, Cambridge, CB2 1EW, UK
    • b Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
    View abstract

    The solid copper-mediated C-N cross-coupling of phenylboronic acids under continuous flow conditions

    Jennifer Bao a, Geoffrey K. Tranmer a,b

    • a College of Pharmacy, Faculty of Health Science, University of Manitoba, Winnipeg, MB R3E 0T5, Canada
    • b Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
    View abstract

    Visible-light photoredox catalysis using a macromolecular ruthenium complex: reactivity and recovery by size-exclusion nanofiltration in continuous flow

    Javier Guerra ab, David Cantillo a, C. Oliver Kappe *a, Antonio Macchiarulo a, Antimo Gioiello *a

    • a Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz, Austria
    • b Crystal Pharma, Gadea Pharmaceutical Group, a division of AMRI, Parque Tecnológico de Boecillo, Valladolid, 47151, Spain
    View abstract

    Integrating multicomponent flow synthesis and computational approaches for the generation of a tetrahydroquinoline compound based library

    Bruno Cerra a, Serena Mostarda a, Chiara Custodi a, Antonio Macchiarulo a, Antimo Gioiello *a

    • a Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, I-06122 Perugia, Italy
    View abstract

    The expanding utility of continuous flow hydrogenation

    Peter J. Cossar a, Lacey Hizartzidis a, Michela I. Simone a, Adam McCluskey *a, Christopher P. Gordon *b

    • * Corresponding authors a Centre for Chemical Biology, Chemistry Building, School of Environmental and Life Science, The University of Newcastle, University Drive, Callaghan, Australia
    • b Nanoscale Organisation and Dynamics Group, School of Science and Health, University of Western Sydney, Locked Bag, Penrith, Australia
    View abstract

    Highly efficient and safe procedure for the synthesis of aryl 1,2,3-triazoles from aromatic amine in a continuous flow reactor

    Federica Stazi a, Damiano Cancogni a, Lucilla Turco b, Pieter Westerduin a, Sergio Bacchi a

    • a GlaxoSmithKline Spa, Chemical Development Department, Synthetic Chemistry, Via Fleming 4, 37135 Verona, Italy
    • b GlaxoSmithKline Spa, Analytical Chemistry, Via Fleming 4, 37135 Verona, Italy
    View abstract

    Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor

    Keiji Nakayama,a, Duncan L. Browne,b, Ian R. Baxendale,b,1, Steven V. Ley,*a

    • a Process Technology Research Laboratories, Pharmaceutical Technology Division, Daiichi Sankyo, Shinomiya, Hiratsuka, Kanagawa, 254-0014, Japan
    • b Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
    View abstract

    The Changing Face of Organic Synthesis

    Ley, Steven V., Baxendale, Ian R.

    • CHIMIA International Journal for Chemistry, Volume 62, Number 3, March 2008, pp. 162-168(7)
    View abstract

    Continuous Heterogeneously Catalyzed Oxidation of Benzyl Alcohol in a Ceramic Membrane Packed- Bed Reactor

    Achilleas Constantinou†¶, Gaowei Wu, Albert Corredera, Peter Ellis, Donald Bethell§, Graham J. Hutchings, Simon Kuhn, Asterios Gavriilidis*†

    • Department of Chemical Engineering, University College London, Torrington Place, London, WC1E 7JE, United Kingdom
    • Division of Chemical and Petroleum Engineering, School of Engineering, London South Bank University, London, SE1 0AA, United Kingdom
    • Johnson Matthey, Blounts Court Road, Reading, RG4 9NH, United Kingdom
    • § Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, United Kingdom
    • School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, United Kingdom
    • Department of Chemical Engineering, KU Leuven, W. de Croylaan 46, 3001 Leuven, Belgium
    View abstract

    Continuous flow Buchwald–Hartwig amination of a pharmaceutical intermediate

    Polina Yaseneva a, Paul Hodgson a, Jacek Zakrzewski a, Sebastian Falß b, Rebecca E. Meadows c, Alexei A. Lapkin * a

    •   a Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK. E-mail: [email protected] Fax: +44 (0)1223 334796
    • INVITE GmbH, Chempark Leverkusen, 51373 Leverkusen, Germany
    • Pharmaceutical Development, AstraZeneca, Silk Road Business Park, Macclesfield SK10 2NA, UK
    View abstract

    Thermolysis of 1,3-dioxin-4-ones: fast generation of kinetic data using in-line analysis under flow

    Thomas Duranda, Cyril Henrya, David Boliena, David C. Harrowvena, Sally Bloodwortha, Xavier Franckb, Richard J. Whitby* a

    • a Chemistry, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, UK
    • b Normandie Université, COBRA, UMR 6014 & FR 3038, Université de Rouen, INSA Rouen, CNRS, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex, France
    View abstract

    Continuous photochemistry: the flow synthesis of ibuprofen via a photo-Favorskii rearrangement

    M. Baumanna, Ian R. Baxendale* a

    • a Department of Chemistry, University of Durham, South Road, Durham, UK
    View abstract

    Automated glycan assembly of xyloglucan oligosaccharides

    Pietro Dallabernardinaa b, Frank Schuhmachera b, Peter H. Seebergera b, Fabian Pfrengle* a b

    • a Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany
    • b Freie Universität Berlin, Institute of Chemistry and Biochemistry, Arnimallee 22, 14195 Berlin, Germany
    View abstract

    Dynamic flow synthesis of porous organic cages

    Michael E. Briggsa, Anna G. Slatera, Neil Lunta, Shan Jianga, Marc A. Littlea, Rebecca L. Greenawaya, Tom Hasella, Claudio Battilocchiob, Steven V. Leyb, Andrew I. Cooper* a

    • a Department of Chemistry and Centre for Materials Discovery, University of Liverpool, Crown Street, Liverpool, UK
    • b Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
    View abstract

    An integrated flow and microwave approach to a broad spectrum protein kinase inhibitor

    Cecilia Russella, Andrew J. S. Lina, Peter Hainsb, Michela I. Simonea, Phillip J. Robinsonb, Adam McCluskey* a

    • A Centre for Chemical Biology, Chemistry, School of Environmental and Life Science, The University of Newcastle, University Drive, Callaghan, Australia
    • B Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, Australia
    View abstract

    A Flow-based Synthesis of Telmisartan

    Alex Martin, Ali Siamaki, Katherine Belecki, B. Gupton

    • Department of Chemistry and Department of Chemical and Life Science Engineering Virginia Commonwealth University 601 W. Main St. Richmond Virginia 23284 United States
    View abstract

    The Preparation of Ethyl Levulinate Facilitated by Flow Processing: The Catalyzed and Uncatalyzed Esterification of Levulinic Acid

    Meghan P. Negus1, Andrew C. Mansfield2, Nicholas E. Leadbeater1

    • 1 Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269, United States
    • 2 Vapourtec Ltd., Park Farm Business Centre, Bury St. Edmunds IP28 6TS, United Kingdom
    • 3 Department of Community Medicine and Health Care, University of Connecticut Health Center, The Exchange, 263 Farmington Ave, Farmington, CT 06030, United States
    View abstract

    Photodecarboxylations in an advanced meso-scale continuous flow photoreactor

    Sam Josland1, Saira Mumtaz2, Michael Oelgemöller2 *

    • 1 University of Southampton, Department of Chemistry, University Road, Southampton, SO17 1BJ, United Kingdom
    • 2 James Cook University, College of Science, Technology and Engineering, Townsville, QLD 4811, Australia
    View abstract

    Efficient Continuous-Flow Synthesis of Macrocyclic Triazoles

    Anne-Catherine Bédard, Jeffrey Santandrea, Shawn K. Collins

    • Department of Chemistry and Centre for Green Chemistry and Catalysis, University of Montreal
    View abstract

    Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing

    Thomas M. Kohl *, Christian H. Hornung, John Tsanaktsidis

    • CSIRO Manufacturing Flagship, Bag 10, Clayton South, Victoria 3169, Australia
    View abstract

    A Short Multi-step Flow Synthesis of a Potential Spirocyclic Fragrance Component

    Ian R. Baxendale*

    • Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK
    View abstract

    Flow Synthesis of 2-Methylpyridines via α-Methylation

    Camille Manansala1, Geoffrey K. Tranmer1 2 *

    • 1 College of Pharmacy, Faculty of Health Science, University of Manitoba, Winnipeg, MB R3E 0T6, Canada
    • 2 Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
    View abstract

    The development of a short route to the API ropinirole hydrochloride

    Zeshan Yousufa, Andrew K. Richardsb, Andrew N. Dwyerc, Bruno Linclaua, David C. Harrowven* a

    • a Chemistry, University of Southampton, Highfield, Southampton, UK
    • b GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, UK
    • c Formally at GlaxoSmithKline Innovation and Sustainable Manufacturing COE, Worthing, UK
    View abstract

    Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform

    Bimbisar Desai, Karen Dixon, Elizabeth Farrant, Qixing Feng, Karl R. Gibson, Willem P. van Hoorn, James Mills, Trevor Morgan, David M. Parry, Manoj K. Ramjee, Christopher Nicholas Selway, Gary J. Tarver, Gavin Whitlock, Adrian G. Wright

    • Cyclofluidic Ltd.
    View abstract

    Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

    Ashley R. Longstreet1, Suzanne M. Opalka1, Brian S. Campbell1, B. Frank Gupton2, Tyler McQuade1

    • 1 Department of Chemistry and Biochemistry, Florida State University, United States
    • 1 Department of Chemistry, Virginia Commonwealth University, United States
    View abstract

    Efficient synthesis of panaxadiol derivatives using continuous-flow microreactor and evaluation of anti-tumor activity

    Yan Wua,1, Wei-Qi Chenb,1, Yu-Qing Zhaoc, Hu-Ri Piaoa

    • aKey Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy, China
    • bDepartment of Chemistry, Fudan University, Shanghai, China
    • cSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
    View abstract

    Continuous Reductions and Reductive Aminations Using Solid Sodium borohydride

    Kerry Gilmore, Stella Vukelic, D. Tyler McQuade†§, Beate Koksch, Peter H. Seeberger*†‡

    • Max Planck Institute of Colloids and Interfaces, Germany
    • Institute of Chemistry and Biochemistry, Freie Universität Berlin, Germany
    • § Department of Chemistry and Biochemistry, Florida State University, United States
    View abstract

    Photodecarboxylative Benzylations of N-Methoxyphthalimide under Batch and Continuous-Flow Conditions

    Hossein Mohammadkhani Pordanjani A B, Christian Faderl A C, Jun Wang A, Cherie A. Motti D, Peter C. Junk A, Michael Oelgemöller A E

    • A James Cook University, College of Science, Technology and Engineering, Townsville, Qld 4811, Australia.
    • B Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 6517838683, Iran.
    • C Institut für Organische Chemie, Universität Regensburg, Universitätsstr. 31, D-93053 Regensburg, Germany.
    • D Australian Institute of Marine Science (AIMS), Biomolecular Analysis Facility, Townsville, Qld 4810, Australia.
    • E Corresponding author. Email: [email protected]
    View abstract

    Chemical Assembly Systems: Layered Control for Divergent, Continuous, Multistep Syntheses of Active Pharmaceutical Ingredients

    Dr. Diego Ghislieri, Dr. Kerry Gilmore, Prof. Dr. Peter H. Seeberger*

    • Department of Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Universität Berlin, Germany
    View abstract

    Light-Induced C-H Arylation of (Hetero)arenes by In Situ Generated Diazo Anhydrides

    Dr. David Cantillo1, Dr. Carlos Mateos2, Dr. Juan A. Rincon2, Dr. Oscar de Frutos2 *, Prof. Dr. C. Oliver Kappe1 *

    • 1 Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010 Graz (Austria)
    • 2 Centro de Investigación Lilly S. A. Avda. de la Industria 30, 28108 Alcobendas-Madrid (Spain)
    View abstract

    Continuous flow polymerisation process

    Inventors:, John Chiefari, Christian Hornung, Simon Saubern

    • Assignee: Commonwealth Scientific and Industrial Research Organization CSIRO
    View abstract

    Two-Stage Flow Synthesis of Coumarin via O-Acetylation of Salicylaldehyde

    Xin Li1, Anbang Chen1, Yangzhi Zhou1, Lingling Huang2, Zheng Fang2, Haifeng Gan1, Kai Guo1

    • 1 College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
    • 2 School of Pharmaceutical Sciences, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
    • 3 State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
    View abstract

    Flow Alkylation of Thiols, Phenols, and Amines Using a Heterogenous Base in a Packed-Bed Reactor

    Alastair Baker1, Michael Graz2, Robert Saunders2, Gareth J. S. Evans2, Ilaria Pitotti1 Thomas Wirth1

    • 1 School of Chemistry, Cardiff University, Park Place, Main Building, Cardiff CF10 3AT, UK
    • 2 Neem Biotech, Willowbrook Technical Units, Llandogo Road, St. Mellons, Cardiff CF3 0EF, UK
    View abstract

    An efficient continuous flow process for the synthesis of a non-conventional mixture of fructooligosaccharides

    Paolo Zambellia, Lucia Tamborinib, Samuele Cazzamallib, Andrea Pintob, Stefania Ariolia, Silvia Balzarettia, Francisco J. Plouc, Lucia Fernandez-Arrojoc, Francesco Molinaria, Paola Contib, Diego Romanoa

    • a Department of Food Environmental and Nutritional Science (DeFENS), University of Milan, Via Mangiagalli, 20133 Milan, Italy
    • b Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
    • c Instituto de Catálisis y Petroleoquímica, CSIC, 28049 Madrid, Spain
    View abstract

    A practical deca-gram scale ring expansion of (R)-(−)-carvone to (R)-(+)-3-methyl-6-isopropenyl- cyclohept-3-enone-1

    Leandro de C. Alvesa, André L. Desideráa, Kleber T. de Oliveiraa, Sean Newtonb, Steven V. Ley* b, Timothy J. Brocksom* a

    • a Departamento de Química, Universidade Federal de São Carlos, P.O. Box 676, São Carlos – SP, Brazil
    • b Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
    View abstract

    Factors Influencing the Regioselectivity of the Oxidation of Asymmetric Secondary Amines with Singlet Oxygen

    Dr. Dmitry B. Ushakov 1 †, Matthew B. Plutschack 1 †, Dr. Kerry Gilmore 1 *, Prof. Dr. Peter H. Seeberger 1

    • 1 Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany)
    View abstract

    Electroactive and Photoactive Poly[Isoindigo-alt-EDOT] Synthesized Using Direct (Hetero)Arylation Polymerization in Batch and in Continuous Flow

    François Grenier , Badrou Réda Aïch † ‡, Yu-Ying Lai §, Maxime Guérette , Andrew B. Holmes §, Ye Tao , Wallace W. H. Wong * §, Mario Leclerc * †

    • Département de Chimie, Université Laval, Québec City, Qc G1V 0A6, Canada
    • Information and Communications Technologies Portfolio, National Research Council of Canada, Ottawa, ON K1A 0R6, Canada
    • § School of Chemistry, Bio21 Institute, the University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia
    View abstract

    A Concise Flow Synthesis of Efavirenz

    Dr. Camille A. Correia1, Dr. Kerry Gilmore1, Prof. Dr. D. Tyler McQuade3, Prof. Dr. Peter H. Seeberger1 2 *

    • 1 Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany)
    • 2 Institute for Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195 Berlin (Germany)
    • 3 Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306 (USA)
    View abstract

    Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines

    Marcus Baumann 1, Antonio M. Rodriguez Garcia 1 2, Ian R. Baxendale * 1

    • 1 Department of Chemistry, Durham University, South Road, Durham, UK
    • 2 Universidad de Castilla-La Mancha, Departamento de Química Orgánica, Facultad de Ciencias y Tecnologías Químicas, Avd. Camilo José Cela, 10, 13071 Ciudad Real, Spain
    View abstract

    Development of a flow method for the hydroboration/oxidation of olefins

    José A. Souto* 1 2, Robert A. Stockman3, Steven V. Ley1

    • 1 Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    • 2 Departamento de Química Orgánica, Universidade de Vigo, Vigo, Spain
    • 3 School of Chemistry, University of Nottingham, Nottingham, UK
    View abstract

    Making Ends Meet: Flow Synthesis as the Answer to Reproducible High-Performance Conjugated Polymers on the Scale that Roll-to-Roll Processing Demands

    Martin Helgesen, Jon E. Carlé, Gisele A. dos Reis Benatto, Roar R. Søndergaard, Mikkel Jørgensen, Eva Bundgaard, Frederik C. Krebs

    • Department of Energy Conversion and Storage, Technical University of Denmark, Roskilde, Denmark
    View abstract

    Reevaluation of the 2-nitrobenzyl protecting group for nitrogen containing compounds: an application of flow photochemistry

    Chloe I. Wendell, Michael J. Boyd

    • Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA, United States
    View abstract

    Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent

    Catherine J. Smith, Christopher D. Smith, Nikzad Nikbin, Steven V. Ley, Ian R. Baxendale

    • Innovative Technology Centre, Cambridge, UK
    View abstract

    Generation and Trapping of Ketenes in Flow

    Cyril Henry1, David Bolien1, Bogdan Ibanescu1, Sally Bloodworth1, David C. Harrowven1, Xunli Zhang2, Andy Craven3, Helen F. Sneddon3, Richard J. Whitby1 *

    • 1 Chemistry, University of Southampton, Southampton, HANTS, SO17 1BJ, UK,
    • 2 Bioengineering Group, Faculty of Engineering and the Environment, University of Southampton, Southampton, HANTS, SO17 1BJ, UK
    • 3 GlaxoSmithKline R&D Ltd., Medicines Research Centre, Gunnels Wood Road, Stevenage, HERTS, SG1 2NY, UK
    View abstract

    A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions

    Maria Victoria Rojo* 1, Lucie Guetzoyan1, Ian. R. Baxendale1 2

    • 1 Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
    • 2 Department of Chemistry, University of Durham, South Road, Durham, UK
    View abstract

    C(sp³)–H functionalisation of N-aryl tetrahydroisoquinolines via an iron-catalysed aerobic nitro-Mannich reaction and continuous flow processing

    Martin Brzozowski, Jose A. Forni, G. Paul Savage and Anastasios Polyzos*

    • CSIRO Manufacturing Flagship, Bayview Avenue, Clayton, Australia
    View abstract

    Facilitating Biomimetic Syntheses of Borrerine Derived Alkaloids by Means of Flow-Chemical Methods

    Sonja B. KamptmannA, Steven V. Ley

    • A Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    View abstract

    The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

    Steffen Glöckner, Duc N. Tran, Richard J. Ingham, Sabine Fenner, Zoe E. Wilson, Claudio Battilocchio, Steven V. Ley*

    • Department of Chemistry, University of Cambridge, Cambridge, UK
    View abstract

    Development of a Grignard-Type Reaction for Manufacturing in a Continuous-Flow Reactor

    Fabrice G. J. Odille†§, Anna Stenemyr†§, Fritiof Pontén*‡

    • Pharmaceutical Development R&D, Chemical Science, AstraZeneca, SE-151 85 Södertälje, Sweden
    • Innovative Medicines, Cardiovascular and Metabolic Diseases, Medicinal Chemistry, AstraZeneca R&D, Sweden
    • § SP Process Development, Forskargatan, Sweden
    View abstract

    Regioselective Synthesis of 3-Aminoimidazo[1,2-a]-pyrimidines under Continuous Flow Conditions

    Ashlie J. E. Butler, Mark J. Thompson, Patrick J. Maydom, James A. Newby, Kai Guo, Harry Adams, Beining Chen*

    • Department of Chemistry, University of Sheffield, Sheffield, U.K.
    View abstract

    Microwave irradiation and flow chemistry for a straightforward synthesis of piano-stool iron complexes

    Anastassiya Pagnoux-Ozherelyevaa, David Bolienb, Sylvain Gaillarda, Flavie Peudrua, Jean-François Lohiera, Richard J. Whitbyb, Jean-Luc Renauda

    • aNormandie University, University of Caen Basse Normandie, Laboratoire de Chimie Moléculaire et Thioorganique, CNRS, Caen, France
    • bChemistry, University of Southampton, Southampton, UK
    View abstract

    Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs–Knorr reaction optimization

    Serena Mostardaa, Paolo Filipponia, Roccaldo Sardellaa, Francesco Venturonia, Benedetto Natalinia, Roberto Pellicciariab, Antimo Gioiello*a

    • aLaboratory of Medicinal and Advanced Synthetic Chemistry (Lab MASC), Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy
    • bTES Pharma S.r.l., Corciano, Italy
    View abstract

    A General Continuous Flow Method for Palladium Catalysed Carbonylation Reactions Using Single and Multiple Tube-in-Tube Gas-Liquid Microreactors

    Ulrike Gross1, Peter Koos1, Matthew O'Brien1,2,*, Anastasios Polyzos1,3, Steven V. Ley1

    • 1Whiffen Laboratory, Department of Chemistry, University of Cambridge, Cambridge, UK
    • 2School of Physical and Geographical Sciences, Keele University, Staffordshire, UK
    • 3CSIRO, Materials Science and Engineering, Clayton South, Australia
    View abstract

    Consecutive Oxygen-based Oxidations Convert Amines to a-Cyanoepoxides

    Dmitry B. Ushakova, Kerry Gilmore*a, Peter H. Seeberger*a,b

    • aMax Planck Institute of Colloids and Interfaces, Potsdam, Germany
    • bInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany
    View abstract

    Synthesis of a Carprofen Analogue Using a Continuous Flow UV-Reactor

    Antoine Caron, Augusto C. Hernandez-Perez, Shawn K. Collins*

    • Department of Chemistry and Centre for Green Chemistry and Catalysis, Université de Montréal, Québec, Canada.
    View abstract

    Flow Chemistry Meets Advanced Functional Materials

    Dr. Rebecca M. Myers, Daniel E. Fitzpatrick, Dr. Richard M. Turner, Prof. Steven V. Ley*

    • Department of Chemistry, University of Cambridge, Cambridge, UK
    View abstract

    Continuous Synthesis of Artemisinin-Derived Medicines

    Kerry Gilmorea, Daniel Kopetzkia, Ju Weon Leeb, Zoltan Horvathb, D. Tyler McQuadea, Andreas Seidel-Morgensternb,c, Peter H. Seebergera,d

    • aMax-Planck-Institute of Colloids and Interfaces, Department of Biomolecular Systems, Germany
    • bMax-Planck-Institute for Dynamics of Complex Technical Systems, Germany
    • cOtto-von-Guericke-University, Chair for Chemical Process Technology, Germany
    • dFreie Universität Berlin, Institute of Chemistry and Biochemistry, Berlin, Germany
    View abstract

    A Continuous-Flow Approach to 3,3,3-Trifluoromethylpropenes: Bringing Together Grignard Addition, Peterson Elimination, Inline Extraction, and Solvent Switching

    Trevor A. Hamlin, Gillian M. L. Lazarus, Christopher B. Kelly, Nicholas E. Leadbeater*†‡

    • Department of Chemistry, University of Connecticut, United States
    • Department of Community Medicine & Health Care, University of Connecticut Health Center, United States
    View abstract

    Heterogenization of Pd–NHC complexes onto a silica support and their application in Suzuki–Miyaura coupling under batch and continuous flow conditions

    Alberto Martíneza, Jamin L. Krinskya, Itziar Peñafiela, Sergio Castillónb, Konstantin Loponov, Alexei Lapkinc, Cyril Godard*a, Carmen Claver*a

    • aDepartment of Physical and Inorganic Chemistry, Universitat Rovira i Virgili, Tarragona, Spain
    • bDepartment of Analytical and Organic Chemistry, Universitat Rovira i Virgili, Tarragona, Spain
    • cDepartment of Chemical Engineering and Biotechnology, University of Cambridge, , Cambridge, UK
    View abstract

    Glycosylation with N-acetyl glycosamine donors using catalytic iron(III) triflate: from microwave batch chemistry to a scalable continuous-flow process

    Amandine Xolina, Arnaud Stévenina, Mathieu Pucheaultb, Stéphanie Norsikiana, François-Didier Boyer*ac, Jean-Marie Beau*ad

    • aCentre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France
    • bInstitut des Sciences Moléculaires, CNRS-Université de Bordeaux, Talence, France
    • cInstitut Jean-Pierre Bourgin, UMR1318 INRA-AgroParisTech, Versailles, France
    • dUniversité Paris-Sud and CNRS, Laboratoire de Synthèse de Biomolécules, Institut de Chimie Moléculaire et des Matériaux, Orsay, France
    View abstract

    Multistep Flow Synthesis of 5-Amino-2-aryl-2H-[1,2,3]-triazole-4-carbonitriles

    YDr. Jérôme Jacq, Dr. Patrick Pasau*

    • UCB Biopharma, Avenue de l'Industrie, 1420 Braine l'Alleud (Belgium)
    View abstract

    Versatile, High Quality and Scalable Continuous Flow Production of Metal-Organic Frameworks

    Marta Rubio-Martinez, Michael P. Batten, Anastasios Polyzos, Keri-Constanti Carey, James I. Mardel, Kok-Seng Lim, Matthew R. Hill

    • CSIRO Materials Science and Engineering, Australia
    View abstract

    Continuous Flow Magnesiation of Functionalized Heterocycles and Acrylates with TMPMgCl·LiCl

    Dr. Trine P. Petersen, Matthias R. Becker, Prof. Dr. Paul Knochel*

    • Ludwig-Maximilians-Universität München, Department Chemie, München, Germany
    View abstract

    Continuous Synthesis of Organozinc Halides Coupled to Negishi Reactions

    Nerea Alonso2,3, L. Zane Miller1, Juan de M. Muñoz2, Jesus Alcázar2,*, D. Tyler McQuade1,*

    • 1Department of Chemistry and Biochemistry, Florida State University, USA
    • 2Janssen Research and Development, Janssen-Cilag, Toledo, Spain
    • 3Facultad de Química, Universidad de Castilla-La Mancha, Spain
    View abstract

    Continuous Flow Synthesis of Thieno[2,3-c]isoquinolin-5(4H)-one Scaffold: A Valuable Source of PARP-1 Inhibitors

    Paolo Filipponi, Carmine Ostacolo, Ettore Novellino, Roberto Pellicciari†§, Antimo Gioiello*†

    • Dipartimento di Scienze Farmaceutiche, Università di Perugia, Via del Liceo 1, I-06123 Perugia, Italy
    • Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Napoli, Italy §TES Pharma S.r.l., Corciano (Perugia), Italy
    View abstract

    First Example of a Continuous-Flow Carbonylation Reaction Using Aryl Formates as CO Precursors

    Nerea Alonso1,3, Juan de Muñoz1, Brecht Egle2, Johannes L. Vrijdag2, Wim M. De Borggraeve2, Antonio de la Hoz3, Angel Díaz-Ortiz3, Jesús Alcázar1

    • 1Janssen Research and Development, Janssen-Cilag Department of Medicinal Chemistry S.A., Toledo, Spain
    • 2Molecular Design and Synthesis University of Leuven, Department of Chemistry, Heverlee Belgium
    • 3Universidad de Castilla-La Mancha Facultad de Ciencias y Tecnologías Químicas Real, Spain
    View abstract

    Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

    Richard J. Ingham1, Claudio Battilocchio1, Joel M. Hawkins2, Steven V. Ley1

    • 1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK
    • 2 Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA
    View abstract

    Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure–Activity Relationship Data of ?-Secretase (BACE1) Inhibitors

    Dr. Michael Werner1,*, Christoph Kuratli1, Dr. Rainer E. Martin1,*, Dr. Remo Hochstrasser1, David Wechsler1, Dr. Thilo Enderle1, Dr. Alexander I. Alanine1, Prof. Dr. Horst Vogel2

    • 1 Medicinal Chemistry, Small Molecule Research, Pharma Research & Early Development (pRED), F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel (Switzerland)
    • 2 Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology of Lausanne (EPFL), Station 6, 1015 Lausanne (Switzerland)
    View abstract

    Sequential flow process for the controlled polymerisation and thermolysis of RAFT-synthesised polymers

    CH Hornung, A Postma, S Saubern, J Chiefari

    • CSIRO Materials Science and Engineering, Victoria, Australia
    View abstract

    Robust and reusable supported palladium catalysts for cross-coupling reactions in flow

    William R. Reynoldsab, Pawel Plucinskibc, Christopher G. Frost*ab

    •   * Corresponding authors
    • a Centre for Sustainable Chemical Technologies, University of Bath, Claverton Down, Bath, UK
    • b Department of Chemistry, University of Bath, Claverton Down, Bath, UK
    • c Department of Chemical Engineering, University of Bath, Claverton Down, Bath, UK
    View abstract

    Continuous-Flow Oxidative Cyanation of Primary and Secondary Amines Using Singlet Oxygen

    Dmitry B. Ushakov, Kerry Gilmore, Daniel Kopetzki, D. Tyler McQuade, Peter H. Seeberger

    • 1Department für Biomolekulare Systeme, Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Potsdam, Germany
    • 2Institut für Chemie und Biochemie, Freie Universität Berlin, Berlin, Germany
    • 3Department of Chemistry and Biochemistry, Florida State University, Tallahassee, USA
    View abstract

    Flow synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe

    Matthew B. Plutschack1,2, D. Tyler McQuade1,2, Giulio Valenti2, Peter H. Seeberger2

    •   1Department of Chemistry and Biochemistry, Florida State University, USA
    • 2Max Planck Institute of Colloids and Interfaces, Germany
    View abstract

    The Fit For Purpose Development of S1P1 Receptor Agonist GSK2263167 Using a Robinson Annulation and Saegusa Oxidation to Access an Advanced Phenol Intermediate

    Robert M. Harris, Benjamin I. Andrews, Stacy Clark, Jason W. B. Cooke, John C. S. Gray, Stephanie Q. Q. Ng

    • Chemical Development, GlaxoSmithKline Research and Development Ltd., UK
    View abstract

    Flow-Based, Cerium Oxide Enhanced, Low-Level Palladium Sonogashira and Heck Coupling Reactions by Perovskite Catalysts

    Claudio Battilocchio1, Benjamin N. Bhawal1, Rajeev Chorghade1, Benjamin J. Deadman1, Joel M. Hawkins2, Steven V. Ley1

    • 1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, UK
    • 2 Pfizer Worldwide Research & Development, Groton, USA
    View abstract

    Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions

    Trevor A. Hamlin, Nicholas E. Leadbeater

    • Department of Chemistry, University of Connecticut, USA
    View abstract

    Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z)-Tamoxifen

    Philip R D Murray, Duncan L Browne, Julio C Pastre, Chris Butters, Duncan Guthrie, Steven V Ley

    • Department of Chemistry, University of Cambridge, UK Instituto de Química, University of Campinas, Brazil Vapourtec Ltd, UK
    View abstract

    Biotransformation with whole microbial systems in a continuous flow reactor: resolution of (RS)-flurbiprofen using Aspergillus oryzae by direct esterification with ethanol in organic solvent

    Lucia Tamborinia, Diego Romanob, Andrea Pintoa, Martina Contentea, Maria C. Iannuzzia, Paola Contia, Francesco Molinarib

    • a Dipartimento di Scienze Farmaceutiche, Universitá degli Studi di Milano, Italy
    • b Dipartimento di Scienze per gli Alimenti, la Nutrizione e l'Ambiente (DEFENS), Universitá degli Studi di Milano, Italy
    View abstract

    Porous, functional, poly(styrene-co-divinylbenzene) monoliths by RAFT polymerization

    Kristine J. Barlow (née Tan), Xiaojuan Hao, Timothy C. Hughes, Oliver E. Hutt, Anastasios Polyzos, Kathleen A. Turner, Graeme Moad

    • Commonwealth Scientific and Industrial Research Organisation (CSIRO), Materials Science & Engineering, Australia
    View abstract

    The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow

    Kimberley A. Roper1, Malcolm B. Berry2, Steven V. Ley1

    • 1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, Cambridge, U.K.
    • 2 GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
    View abstract

    Continuous Flow Synthesis of Coumarin

    Anbang Chen1, Xin Li1, Yangzhi Zhou1, Lingling Huang2, Zheng Fang2, Haifeng Gan1, Kai Guo1

    • 1 College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology 2 School of Pharmceutical Sciences, Nanjing University of Technology
    View abstract

    Synthesis of All Four Stereoisomers of 3-(tert-Butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid

    Bettina Bakonyi, Markus Furegati*‡, Christian Kramer§, Luigi La Vecchia, Flavio Ossola

    • Doetsch Grether AG, Falkensteinerstrasse 37, 4132 Muttenz, Switzerland
    • Preparations Laboratories, Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Klybeckstrasse 141, 4057 Basel,Switzerland
    • § Institute of General, Inorganic and Theoretical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria
    View abstract

    The rapid generation of isothiocyanates in flow

    Marcus Baumann, Ian R. Baxendale

    • Department of Chemistry, University of Durham, U.K.
    View abstract

    Continuous synthesis of pyridocarbazoles and initial photophysical and bioprobe characterization

    D. Tyler McQuade*ab, Alexander G. O'Briena, Markus Dörrc, Rajathees Rajaratnamc, Ursula Eisoldd, Bopanna Monnandaa, Tomoya Nobutaa, Hans-Gerd Löhmannsröbend, Eric Meggersc, Peter H. Seebergerae

    • a Department for Biomolecular Systems, Max Planck Institute for Colloids and Interfaces
    • b Department of bChemistry and Biochemistry, Florida State University
    • c Fachbereich Chemie, Philipps-Universität Marburg
    • d Potsdam Institut für Chemie
    • e Freie Universität Berlin
    View abstract

    Microwave heating and conventionally-heated continuous-flow processing as tools for performing cleaner palladium-catalyzed decarboxylative couplings using oxygen as the oxidant – a proof of principle study

    Nicholas E. Leadbeater1, DiAndra M. Rudzinski1

    • 1 Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269, USA
    View abstract

    Hypervalent iodine/TEMPO-mediated oxidation in flow systems: a fast and efficient protocol for alcohol oxidation

    Nida Ambreen, Ravi Kumar, Thomas Wirth

    • Innovative Technology Centre, Cardiff University, School of Chemistry, Park Place, Cardiff, UK
    View abstract

    First Example of Alkyl-Aryl Negishi Cross-Coupling in Flow: Mild, Efficient and Clean Introduction of Functionalized Alkyl Groups

    Brecht Egle2, Juan de Muñoz1, Nerea Alonso1, Wim M. De Borggraeve2, Antonio de la Hoz3, Angel Díaz-Ortiz3, Jesús Alcázar1

    • 1Janssen Research and Development Department of Medicinal Chemistry Janssen-Cilag, Toledo Spain
    • 2Department of Chemistry, Molecular Design and Synthesis University of Leuven, Heverlee Belgium
    • 3Universidad de Castilla-La Mancha Facultad de Ciencias y Tecnologías Químicas, Spain
    View abstract

    Controlled synthesis of poly(3-hexylthiophene) in continuous flow

    Helga Seyler, Jegadesan Subbiah, David J. Jones, Andrew B. Holmes, Wallace W. H. Wong*

    • School of Chemistry, Bio21 Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia
    • *Corresponding author
    View abstract

    Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhibitors: Application to Drug Discovery

    Werngard Czechtizky, Jurgen Dedio, Bimbisar Desai, Karen Dixon, Elizabeth Farrant, Qixing Feng Trevor Morgen, David M Parry, Manoj K. Ramjee, Christopher N. Selway, Thorsten Schmidt, Gary J. Tarver, Adrian G. Wright

    • Sanofi-Aventis, Frankfurt, Germany. Cyclofluidic Ltd., U.K.
    View abstract

    Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis

    D. Tyler McQuade1 3, Peter H. Seeberger1 2

    • 1 Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces
    • 2 Institute for Chemistry and Biochemistry, Freie Universität Berlin,
    • 3 Department of Chemistry and Biochemistry, Florida State University
    View abstract

    Continuous flow macrocyclization at high concentrations: synthesis of macrocyclic lipids

    Anne-Catherine Bédard, Sophie Régnie, Shawn K. Collins

    • Département de Chimie, Centre for Green Chemistry, Catalysis, Université de Montréal, Montréal, Canada
    View abstract

    Continuous Synthesis and Use of N-Heterocyclic Carbene Copper(I) Complexes from Insoluble Cu2O

    Suzanne M. Opalka1, Jin Kyoon Park3, Ashley R. Longstreet2, D. Tyler McQuade2

    • 1Department of Chemistry and Biochemistry, Florida State University, USA
    • 2Department of Chemistry and Chemical Biology, Cornell University, USA
    • 3Department of Chemistry and Chemical Institute for Functional Materials, Pusan National University, Korea
    View abstract

    Ozonolysis of some complex organic substrates in flow

    M. D. Roydhouse1, W. B. Motherwell1, A. Constantinou2, A. Gavriilidis2, R. Wheeler3, K. Down3, I. Campbell3

    • 1Dept of Chemistry, University College London, UK
    • 2Dept of Chemical Engineering, University College London, UK
    • 3GSK, Stevenage, UK
    View abstract

    Synthesis of Carbohydrate-Functionalised Sequence-Defined Oligo(amidoamine)s by Photochemical ThiolEne Coupling in a Continuous Flow Reactor

    Felix Wojcik1,2, Alexander G. O'Brien1,2, Sebastian Götze1,2, Peter H. Seeberger1,2, Laura Hartmann1,2

    • 1Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam (Germany)
    • 2Institute for Chemistry and Biochemistry, Freie Universität Berlin, Berlin (Germany)
    View abstract

    Continuous-flow generation of diazoesters and their direct use in S-H and P-H insertion reactions: synthesis of a-sulfanyl, a-sulfonyl and a-phosphono carboxylates

    Hannah E. Bartrum1, David C. Blakemore2, Christopher J. Moody1, Christopher J. Hayes1

    • 1School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
    • 2Pfizer Neusentis, The Portway Building, Granta Park, Cambridge, CB21 6GS, UK
    View abstract

    Synthesis of RAFT Block Copolymers in a Multi-Stage Continuous Flow Process Inside a Tubular Reactor

    Christian H. Hornung, Xuan Nguyen, Stella Kyi, John Chiefari, Simon Saubern

    • CSIRO Materials Science & Engineering, Victoria, Australia.
    View abstract

    An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

    Mark D Hopkin, Ian Baxendale, Steven.V.Ley

    • Dept of Chemistry, University of Cambridge, UK
    View abstract

    A Multi-Step Continuous Flow Process for the N-Demethylation of Alkaloids

    Yuji Nakano1, G. Paul Savage1, Simon Saubern1, Peter J. Scammells2, Anastasios Polyzos1

    • 1 CSIRO Materials Science and Engineering, Victoria, Australia.
    • 2 Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria, Australia.
    View abstract

    A Two-Stage Continuous-Flow Synthesis of Spirooxazine Photochromic Dyes

    Mark York123, Adriana Edenharter1

    • 1CSIRO Materials Science and Engineering, Clayton, Vic. 3169, Australia.
    • 2Cooperative Research Centre for Polymers, Notting Hill, Vic. 3168, Australia.
    • 3Advanced Polymerik Pty Ltd, Notting Hill, Vic. 3168, Australia.
    View abstract

    Continuous Flow Synthesis of Organic Electronic Materials : Case Studies in Methodology Translation and Scale-up

    Helga Seyler1, Stefan Haid2, Tae-Hyuk Kwon1, David J. Jones1, Peter Bäuerle2, Andrew B. Holmes1, Wallace W. H. Wong1*

    • 1Bio21 Institute, University of Melbourne, Australia.
    • 2Institute of Organic Chemistry II and Advanced Materials, University of Ulm, Germany.
    View abstract

    Preparation of Arene Chromium Tricarbonyl Complexes Using Continuous-Flow Processing: (n6-C6H5CH3)Cr(CO)3 as an example

    Christopher (Xiang) Lee1, Elizabeth A. Pedrick1, Nicholas E. Leadbeater1

    • 1Department of Chemistry, University of Connecticut, USA
    • 2Department of Community Medicine and Health Care, University of Connecticut Health Center, USA
    View abstract

    Visible Light-Initiated Preparation of Functionalized Polystyrene Monoliths for Flow Chemistry

    Farhan R. Bou-Hamdan1, Kathleen Krüger1, Klaus Tauer1, Tyler McQuade1,3 , Peter H. Seeberger 1,2

    • 1Max Planck Institute of Colloids and Interfaces Potsdam, Germany.
    • 2Institute of Chemistry and Biochemistry, Freie Universität Berlin , Germany.
    • 3Department of Chemistry and Biochemistry, Florida State University, USA.
    View abstract

    Integrated Continuous Processing and Flow Characterization of RAFT Polymerization in Tubular Flow Reactors

    Christian H. Hornung, Xuan Nguyen, Geoff Dumsday, Simon Saubern*

    • CSIRO Materials Science and Engineering, Victoria. Australia
    View abstract

    Synthesis of an H3 Antagonist via Sequential One-Pot Additions of a Magnesium Ate Complex and an Amine to a 1,4-Ketoester followed by Carbonyl-Directed Fluoride Addition

    Joel M. Hawkins, Pascal Dubé, Mark T. Maloney, Lulin Wei. Marcus Ewing, Stephen M. Chesnut, Joshua R. Denette, Brett M. Lillie, Rajappa Vaidyanathan

    • Pharmaceutical Sciences, Pfizer Inc., Groton, USA
    View abstract

    A “Catch-React-Release” Method for the Flow Synthesis of 2-Aminopyrimidines and Preparation of the Imatinib Base

    Richard J. Ingham, Elena Riva, Nikzad Nikbin, Ian R. Baxendale, Steven V. Ley*

    • Innovative Technology Centre, University of Cambridge, U.K.
    View abstract

    Sustainable and efficient methodology for CLA synthesis and identification

    Andres Moreno, Maria Moreno, Maria Victoria Gómez, Cristina Cebrian, Pilar Prieto, Antonio de la Hoz

    • Departamento de Química Inorgánica, , Universidad de Castilla-La Mancha, Ciudad Real, Spain.
    View abstract

    A Continuous Flow Process for the Radical Induced End Group Removal of RAFT Polymers

    Christian H. Hornung, Almar Postma, Simon Saubern, John Chiefari

    • CSIRO Materials Science & Engineering, Victoria Australia
    View abstract

    Continuous Synthesis and Purification by Direct Coupling of a Flow Reactor with Simulated Moving-Bed Chromatography

    Alexander G. O’Brien1, Zoltán Horváth3, François Lévesque1, Ju Weon Lee3, Andreas Seidel-Morgenstern3, Peter H. Seeberger1,2

    • 1Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Potsdam, Germany
    • 2Freie Universität Berlin, Germany
    • 3Max-Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany
    View abstract

    Asymmetric Homogeneous Hydrogenation in Flow using a Tube-in-Tube Reactor

    Sean Newton1, Steven V. Ley1, Eva Casas Arcé2, Damian M. Grainger2

    • 1Department of Chemistry, University of Cambridge, U.K.
    • 2Johnson Matthey Catalysis and Chiral Technology, Cambridge, U.K.
    View abstract

    Continuous Flow Synthesis of Secondary Amides by Tandem Azidation- Amidation of Anilines

    Christian Spiteri, John E. Moses*

    • School of Chemistry, University of Nottingham, UK
    View abstract

    Continuous Flow Hydrogenation Using an On-Demand Gas Delivery Reactor

    Michael A. Mercadante, Christopher B. Kelly, Christopher (Xiang) Lee, Nicholas E. Leadbeater*

    • Department of Chemistry, University of Connecticut, USA
    View abstract

    Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts

    Francesco Venturoni, Antimo Gioiello, Roccaldo Sardella, Benedetto Natalini, Roberto Pellicciari

    • Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy
    View abstract

    Phase-Transfer Catalysis under Continuous Flow Conditions: An Alternative Approach to the Biphasic Liquid/Liquid O-Alkylation of Phenols

    Daniele De Zani2, Matteo Colombo1

    • 1NiKem Research 20021 via Zambeletti 25 Milan Baranzate Italy
    • 2Erregierre, San Paolo D'Argon Bergamo Italy
    View abstract

    An efficient method for the lipase-catalysed resolution and in-line purification of racemic flurbiprofen in a continuous-flow reactor

    Lucia Tamborini1, Diego Romano2, Andrea Pinto1, Arianna Bertolani1,2, Francesco Molinari2, Paola Conti1

    • 1Dipartimento di Scienze Farmaceutiche ‘Pietro Pratesi’, Universitá degli Studi di Milano, Italy
    • 2Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, Universitá degli Studi di Milano, Italy
    View abstract

    Development of a Continuous Flow Scale-Up Approach of Reflux Inhibitor AZD6906

    Tomas Gustafsson, Henrik Sörensen, Fritiof Pontén*

    • Medicinal Chemistry, AstraZeneca R&D Mölndal, Sweden
    View abstract

    Soluble Polymer-Supported Flow Synthesis: A Green Process for the Preparation of Heterocycles

    Nicolò Prosa, Raphaël Turgis, Riccardo Piccardi, Marie-Christine Scherrmann

    • Institut de Chimie Moléculaire et des Matériaux d'Orsay, Université Paris-Sud, France
    View abstract

    Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands

    Claudio Battilocchio1,3, Marcus Baumann1, Ian R. Baxendale1, Mariangela Biava3, Matthew O. Kitching1, Steven V. Ley1, Rainer E. Martin*2, Stephan A. Ohnmacht2, Nicholas D. C. Tappin1

    • 1Department of Chemistry, University of Cambridge, UK
    • 2F. Hoffmann-La Roche Ltd., Pharmaceuticals Division, Basel, Switzerland
    • 3Department of Pharmaceutical Chemistry and Technology, Sapienza University of Rome, Italy
    View abstract

    Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

    François Lévesque1, Peter H. Seeberger1,2

    • 1Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Germany
    • 2Institute for Chemistry and Biochemistry, Freie Universität Berlin, Germany
    View abstract

    The Continuous-Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas Permeable Membrane Reactor

    Anastasios Polyzos, Matthew O’Brien, Trine P. Petersen, Ian R. Baxendale, Steven V. Ley

    • Innovative Technology Centre, Department of Chemistry, University of Cambridge
    View abstract

    Continuous proline catalysis via leaching of solid proline

    Suzanne M. Opalka1, Ashley R. Longstreet2, D. Tyler McQuade2

    • 1Department of Chemistry and Chemical Biology, Cornell University, USA
    • 2Department of Chemistry and Biochemistry, Florida State University,USA
    View abstract

    The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

    Kimberley A. Roper1, Heiko Lange1, Anastasios Polyzos1, Malcolm B. Berry2, Ian R. Baxendale1, Steven V. Ley1

    • 1Innovative Technology Centre, University of Cambridge
    • 2GlaxoSmithKline, Stevenage, UK
    View abstract

    Application of Flow Chemistry to the Selective Reduction of Esters to Aldehydes

    Juan de M. Muñoz1, Jesús Alcázar1, Antonio de la Hoz2, Angel Díaz-Ortiz2

    • 1Janssen, Toledo, Spain
    • 2Facultad de Ciencias Químicas, Universidad de Castilla-La Mancha, Spain
    View abstract

    Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels-Alder Reaction under Superheated Continuous Flow Conditions

    Rainer E. Martin1, Falk Morawitz1, Christoph Kuratli1, André M. Alker2, Alexander I. Alanine1

    • 1Chemistry Technology and Innovation, F. Hoffmann-La Roche Ltd, Basel, Switzerland
    • 2Biostructure Section, F. Hoffmann-La Roche Ltd,Basel, Switzerland
    View abstract

    Continuous Preparation of Arylmagnesium Reagents in Flow with Inline IR Monitoring

    Tobias Brodmann1, Peter Koos1, Albrecht Metzger1, Paul Knochel*2, Steven V. Ley*1

    • 1Department of Chemistry, University of Cambridge, U.K.
    • 2Department of Chemistry, Ludwig Maximilians-Universität München, Germany
    View abstract

    Lead Diversification 2: Application to P38, gMTP and lead compounds

    M. Abid Masood1, Marc Bazin2, Mark E. Bunnage1, Andrew Calabrese3, Mark Cox1, Sally-Ann Fancy1, Elizabeth Farrant1, David W. Pearce1, Manuel Perez1, Laure Hitzel1, Torren Peakman1

    • 1Worldwide Medicinal Chemistry, Pfizer, UK
    • 2Hepatochem, Cambridge, MA, USA
    • 3Celgene San Diego, USA
    View abstract

    New Insights into Cyclobutenone Rearrangements: A Total Synthesis of the Natural ROS-Generating Anti-Cancer Agent Cribrostatin 6

    Mubina Mohamed1, Théo P. Gonçalves1, Prof. Richard J. Whitby1, Dr. Helen F. Sneddon2, Prof. David C. Harrowven1

    • 1 Chemistry, University of Southampton, UK
    • 2 GlaxoSmithKline Medicines Research Centre, UK
    View abstract

    New Insights into Cyclobutenone Rearrangements: A Total Synthesis of the Natural ROS-Generating Anti-Cancer Agent Cribrostatin (ROS=reactive-oxygen species)

    Mubina Mohamed1, Théo P. Gonçalves1, Richard J. Whitby1, Helen F. Sneddon2, David C. Harrowven1

    • 1Dept of Chemistry, University of Southampton, UK
    • 2GSK Medicines Research Centre, Stevenage, UK
    View abstract

    A continuous-flow synthesis of annulated and polysubstituted furans from the reaction of ketones and a-haloketones

    Mark York

    • CSIRO Materials Science and Engineering, Australia
    • Cooperative Research Centre for Polymers, Notting Hill, Australia
    View abstract

    The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact

    Trine P. Petersen1,2,3, Anastasios Polyzos1,4, Matthew O’Brien1, Trond Ulven2, Ian R. Baxendale1, Steven V. Ley1

    • 1Whiffen Laboratory, University of Cambridge, UK
    • 2Department of Physics and Chemistry, University of Southern Denmark
    • 3Discovery Chemistry and DMPK, H. Lundbeck A/S,Denmark
    • 4CSIRO, Materials Science and Engineering, Australia
    View abstract

    Continuous flow synthesis of conjugated polymers

    Helga Seyler, David J. Jones, Andrew B. Holmes, Wallace W. H. Wong

    • Bio21 Institute, University of Melbourne, Australia
    View abstract

    Suzuki-Miyaura Cross-Coupling of Heteroaryl Halides and Arylboronic Acids in Continuous Flow

    Timothy Noël, Andrew J. Musacchio

    • Department of Chemistry, MIT, USA
    View abstract

    Nitrile Oxide 1,3-Dipolar Cycloaddition by Dehydration of Nitromethane Derivatives Under Continuous Flow Conditions

    Malte Brasholz, Simon Saubern*, G. Paul Savage

    • CSIRO Materials Science and Engineering, Victoria, Australia.
    View abstract

    Continuous-flow, palladium-catalysed alkoxycarbonylation reactions using a prototype reactor in which it is possible to load gas and heat simultaneously

    Michael A. Mercadante, Nicholas E. Leadbeater

    • Department of Chemistry, University of Connecticut, USA
    View abstract

    Continuous flow photolysis of aryl azides: Preparation of 3H-azepinones

    Farhan R. Bou-Hamdan, François Lévesque, Alexander G. O'Brien, Peter H. Seeberger

    • Max Planck Institute of Colloids and Interfaces, Berlin, Germany
    View abstract

    Teflon AF-2400 mediated gas–liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

    Peter Koos, Ulrike Gross, Anastasios Polyzos, Matthew O'Brien, Ian Baxendale, Steven V. Ley

    • Innovative Technology Centre, University of Cambridge, UK
    View abstract

    Rapid Access to α-Alkoxy and α-Amino Acid Derivatives through Safe Continuous-Flow Generation of Diazoesters

    Hannah E. Bartrum1, David C. Blakemore2, Christopher J. Moody1, Christopher J. Hayes1, 1School of Chemistry, University of Nottingham, UK, 2Pfizer Global Research and Development, Sandwich, UK

    View abstract

    Ozonolysis in Flow Using Capillary Reactors

    M. D. Roydhouse1, A. Ghaini2, A. Constantinou, A. Cantu-Perez2, W. B. Motherwell1, A. Gavriilidis2

    • 1 Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ
    • 2 Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE
    View abstract

    An Integrated Flow and Batch-Based Approach for the Synthesis of O-Methyl Siphonazole

    Marcus Baumann, Ian R. Baxendale, Malte Brasholz, John J. Hayward, Steven V. Ley, Nikzad Nikbin

    • Innovative Technology Centre, Cambridge, UK
    View abstract

    Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods

    Marcus Baumann1, Ian R. Baxendale1, Steven V. Ley1, Christoph Kuratli2, Rainer E. Martin2, Josef Schneider2

    • 1Innovative Technology Centre, University of Cambridge, U.K.
    • 2F. Hoffmann-La Roche Ltd., Basel, Switzerland
    View abstract

    Nitration Chemistry in Continuous Flow using Fuming Nitric Acid in a Commercially Available Flow Reactor

    Cara E. Brocklehurst, Hansjoerg Lehmann, Luigi La Vecchia

    • Global Discovery Chemistry, Novartis, Basel, Switzerland
    View abstract

    Synthesis of (+)-Dumetorine and Congeners by Using Flow Chemistry Technologies

    Elena Riva2, Anna Rencurosi1, Stefania Gagliardi1, Daniele Passarella2, Marisa Martinelli1*

    • 1NiKem Research S.r.l., Milan, Italy
    • 2Università degli Studi di Milano,Milan, Italy
    View abstract

    Continuous flow synthesis of fullerene derivatives

    Helga Seyler, Wallace Wing Ho Wong, Dave Jones, Andrew B. Holmes

    • University Of Melbourne, Australia
    View abstract

    Preparation of fluoxetine by multiple flow processing steps

    Batoul Ahmed-Omer, Adam J. Sanderson

    • Eli Lilly and Co. Ltd.
    • Lilly Research Centre, UK.
    View abstract

    Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith

    Heiko Lange, Matthew J. Capener, Alexander X. Jones, Catherine J. Smith, Nikzad Nikbin, Ian R. Baxendale, Steven V. Ley*

    • Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
    View abstract

    Highly efficient dehydration of carbohydrates to 5-(chloromethyl)furfural (CMF), 5-(hydroxymethyl)furfural (HMF) and levulinic acid by biphasic continuous flow processing

    Malte Brasholz, Karin von Känel, Christian H. Hornung, Simon Saubern, John Tsanaktsidis

    • CSIRO Materials Science & Engineering, Victoria , Australia
    View abstract

    A General, One-Step Synthesis of Substituted Indazoles using a Flow Reactor

    Rob C. Wheeler, Emma Baxter, Ian B. Campbell, Simon J. F. Macdonald

    • GlaxoSmithKline, Stevenage, UK
    View abstract

    Controlled RAFT Polymerization in a Continuous Flow Microreactor

    Christian H. Hornung, Carlos Guerrero-Sanchez, Malte Brasholz, Simon Saubern, John Chiefari, Graeme Moad, Ezio Rizzardo, San H. Thang

    • CSIRO Materials Science & Engineering, Victoria, Australia
    View abstract

    Diastereoselective Chain-Elongation Reactions Using Microreactors for Applications in Complex Molecule Assembly

    Catherine F. Carter1, Heiko Lange1, Daiki Sakai2, Ian R. Baxendale1, Steven V. Ley1

    • 1Innovative Technology Centre, University of Cambridge, UK, CB2 1EW, UK
    • 2Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan
    View abstract

    Decarboxylative biaryl synthesis in a continuous flow reactor

    1Paul P. Lange, 1Lukas J. Gooßen, 2Philip Podmore, 2Toby Underwood, 2Nunzio Sciammetta

    • 1Technische Universität Kaiserslautern, Germany
    • 2Pfizer Global R&D, Sandwich, UK
    View abstract

    A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

    Catherine J. Smith, Nikzad Nikbin, Steven V. Ley, Heiko Lange, Ian R. Baxendale

    • Innovative Technology Centre, Cambridge, UK
    View abstract

    A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing

    Heiko Lange1, Catherine F. Carter1, Mark D. Hopkin1, Adrian Burke2, Jon G. Goode2, Ian R. Baxendale1, Steven V. Ley1

    • 1Innovative Technology Centre, University of Cambridge, UK
    • 2Mettler-Toledo AutoChem UK
    View abstract

    One-Flow, Multistep Synthesis of Nucleosides by Brønsted Acid-Catalyzed Glycosylation

    Adam Sniady, Matthew W. Bedore, Timothy F. Jamison

    • Novartis Institutes for Biomedical Research Inc., Cambridge, USA MIT, Cambridge, USA
    View abstract

    Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates

    Alexander G. O'Brien, François Lévesque, Peter H. Seeberger

    • Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
    View abstract

    Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor

    Laetitia J. Martin1, Andreas L. Marzinzik1, Steven V. Ley2, Ian R. Baxendale2

    • 1Novartis Institute for BioMedical Research, Basel, Switzerland
    • 2Innovative Technology Centre, Department of Chemistry, University of Cambridge
    View abstract

    Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing

    Yun Zhang1, Timothy F. Jamison2, Sejal Patel1, Nello Mainolfi1, 1Novartis Institutes for Biomedical Research Inc., Cambridge, USA, 2MIT, Cambridge, USA

    View abstract

    Synthesis of β-Keto Esters In-Flow and Rapid Access to Substituted Pyrimidines

    Hannah E. Bartrum1, David C. Blakemore2, Christopher J. Moody1, Christopher J. Hayes1

    • 1School of Chemistry, University of Nottingham, UK
    • 2Pfizer Global Research and Development, Sandwich, UK
    View abstract

    Synthesis of 3-Aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole Derivatives: A Comparison between Conventional, Microwave-Assisted and Flow-Based Methodologies

    Sabrina Castellano1, Lucia Tamborini2, Monica Viviano1, Andrea Pinto2, Gianluca Sbardella1, Paola Conti2

    • 1Dipartimento di Scienze Farmaceutiche, Universit degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Italy
    • 2Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universit degli Studi di Milano , Italy
    View abstract

    Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor

    Laia Malet-Sanz, Julia Madrzak, Steven V.Ley, Ian R.Baxendale

    • Innovative Technology Centre, University of Cambridge
    View abstract

    A Gram-Scale Batch and Flow Total Synthesis of Perhydrohistrionicotoxin

    Dr. Malte Brasholz1, Dr. James M. Macdonald1, Dr. Simon Saubern1, Dr. John H. Ryan1, Prof. Dr. Andrew B. Holmes1,2

    • 1CSIRO Molecular and Health Technologies, Victoria, Australia
    • 2School of Chemistry, Bio 21 Institute, University of Melbourne, Victoria, Australia
    View abstract

    A Continuous Flow Process Using a Sequence of Microreactors with In-line IR Analysis for the Preparation of N,N-Diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a Potent and Highly Selective δ-Opioid Receptor Agonist

    Zizheng Qian, Ian R. Baxendale, Steven V. Ley

    • Innovative Technology Centre, University of Cambridge
    View abstract

    Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor

    Marcus Baumann, Ian R. Baxendale, Andreas Kirschning, Steven V. Ley*, Jens Wegner

    • Department of Chemistry, University of Cambridge
    View abstract

    KMnO4-Mediated Oxidation as a Continuous Flow Process

    Jorg Sedelmeier, Steven V. Ley, Ian R. Baxendale, Marcus Baumann

    • Innovative Technology Centre, University of Cambridge
    View abstract

    Flow synthesis of tricyclic spiropiperidines as building blocks for the histrionicotoxin family of alkaloids

    Malte Brasholz1, Brian A. Johnson2, James M. Macdonald1, Anastasios Polyzos1, John Tsanaktsidis1, Simon Saubern1, Andrew B. Holmes1,2, John H. Ryan1

    • 1CSIRO Molecular and Health Technologies, Victoria, Australia
    • 2School of Chemistry, Bio 21 Institute, University of Melbourne, Victoria, Australia
    View abstract

    Effect of phase transfer chemistry, segmented fluid flow, and sonication on the synthesis of cinnamic esters

    Mauro Riccaboni, Elena La Porta, Andrea Martorana, Roberta Attanasio

    • Department of Medicinal Chemistry, NiKem Research Srl, Milan, Italy
    View abstract

    Continuous Flow Palladium(II)-Catalyzed Oxidative Heck Reactions with Arylboronic Acids

    Luke R. Odell1, Jonas Lindh1, Tomas Gustafsson2, Mats Larhed1*

    • 1Organic Pharmaceutical Chemistry, Department of MedChem, Uppsala University, Sweden
    • 2AstraZeneca R&D Mölndal, Sweden
    View abstract

    A flow-based synthesis of Imatinib: the API of Gleevec

    Mark D. Hopkin, Ian R. Baxendale, Steven V. Ley

    • Innovative Technology Centre, Department of Chemistry, University of Cambridge
    View abstract

    Reaction of Grignard reagents with carbonyl compounds under continuous flow conditions

    E. Riva1, S. Gagliardi2, M. Martinelli2, D. Passarella1, D. Vigo2, A. Rencurosi2

    • 1Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Milano, Italy
    • 2NiKem Research S.r.l., , Milan, Italy
    View abstract

    The application of flow microreactors to the preparation of a family of casein kinase I inhibitors

    Francesco Venturoni, Nikzad Nikbin, Steven V. Ley, Ian R. Baxendale

    • Innovative Technology Centre, Department of Chemistry, University of Cambridge
    View abstract

    A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT1B> Antagonist

    Zizheng Qian, Ian R. Baxendale, Steven V. Ley

    • Innovative Technology Centre, Department of Chemistry, University of Cambridge
    View abstract

    ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

    Catherine F. Carter1, Heiko Lange1, Steven V. Ley1, Ian R. Baxendale1, Brian Wittkamp2, Jon G. Goode3, Nigel L. Gaunt3

    • 1Innovative Technology Centre, Department of Chemistry, University of Cambridge
    • 2Mettler-Toledo AutoChem, USA
    • 3Mettler-Toledo AutoChem, UK
    View abstract

    A highly efficient flow reactor process for the synthesis of N-Boc-3,4-dehydro-l-proline methyl ester

    Lucia Tamborini, Paola Conti, Andrea Pinto, Carlo De Micheli

    • Dipartimento di Scienze Farmaceutiche ‘Pietro Pratesi’,
    • Università degli Studi di Milano, Italy
    View abstract

    [3+2] Dipolar cycloadditions of an unstabilised azomethine ylide under continuous flow conditions

    Mark Grafton, Andrew C. Mansfield, M. Jonathan

    • Pfizer Global Research and Development, Sandwich, UK
    View abstract

    Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of YneOnes and Their Use in Heterocycle Synthesis

    Ian R. Baxendale1, Søren C. Schou2, Jörg Sedelmeier1, Steven V. Ley1

    • 1ITC, Department of Chemistry, University of Cambridge
    • 2LEO Pharma, Medicinal Chemistry Research, Denmark
    View abstract

    A safe and reliable procedure for the iododeamination of aromatic and heteroaromatic amines in a continuous flow reactor

    Laia Malet-Sanz, Julia Madrzak, Rhian S. Holvey, Toby Underwood

    • Research Chemistry, Pfizer Global Research and Development, Sandwich, UK
    View abstract

    Development of fluorination methods using continuous-flow microreactors

    Marcus Baumann, Ian R. Baxendale, Laetitia J. Martin, Steven V. Ley

    • Innovative Technology Centre, Cambridge, UK
    View abstract

    Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles

    Ian R. Baxendale1, Steven V. Ley1, Andrew C. Mansfield2, Christopher D. Smith1

    • 1ITC, Department of Chemistry, University of Cambridge,
    • 2Pfizer Global R&D Research Centre, Sandwich, (UK)
    View abstract

    Efficient Continuous Flow Synthesis of Hydroxamic Acids and Suberoylanilide Hydroxamic Acid Preparation

    E. Riva1, S. Gagliardi2, Caterina Mazzoni2, M. Martinelli2, D. Passarella1, D. Vigo2, A. Rencurosi2

    • 1Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Italy
    • 2NiKem Research S.r.l., Milan, Italy
    View abstract

    A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor

    Ian R. Baxendale, Steven V. Ley, Christopher D. Smith, Lucia Tamborini, Ana-Florina Voica

    • Innovative Technology Centre, Cambridge, UK
    View abstract

    The Use of Diethylaminosulfur Trifluoride (DAST) for Fluorination in a Continuous-Flow Microreactor

    Baumann, Marcus, Baxendale, Ian R., Ley, Steven V.

    • Innovative Technology Centre, Cambridge, UK
    View abstract

    A modular flow reactor for performing Curtius rearrangements as a continuous flow process

    Marcus Baumann1, Ian R. Baxendale1, Steven V. Ley1, Nikzad Nikbin1, Christopher D. Smith1, Jason P. Tierney2

    • 1Innovative Technology Centre, Department of Chemistry, University of Cambridge
    • 2Neurology Lead Discovery Chemistry, GlaxoSmithKline R and D, Harlow, UK
    View abstract

    Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions

    Marcus Baumann, Ian R. Baxendale, Steven V. Ley, Nikzad Nikbin, Christopher D. Smith

    • Innovative Technology Centre, Cambridge, UK
    View abstract

    A Microcapillary Flow Disc Reactor for Organic Synthesis

    Christian H. Hornung1, Malcolm R. Mackley2, Ian R. Baxendale1, Steven V. Ley1

    • 1Department of Chemistry, University of Cambridge
    • 2Department of Chemical Engineering, University of Cambridge
    View abstract

    Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

    Christopher D. Smith, Ian Baxendale, Geoffrey Tranmer, Marcus Baumann, Stephen Smith, Russell Lewthwaite, Steven V. Ley

    • Department of Chemistry, University of Cambridge, UK
    View abstract

    [3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor

    Christopher D. Smith1, Ian R. Baxendale1, Steve Lanners1, John J. Hayward1, Steven V. Ley1, Stephen C. Smith2

    • 1Innovative Technology Centre, University of Cambridge, UK
    • 2Syngenta, Jealots Hill International Research Centre, UK
    View abstract

    Continuous Flow Ligand-Free Heck Reactions Using Monolithic Pd [0] Nanoparticles

    Nikzad Nikbin, Mark Ladlow, Steven V. Ley

    • Department of Chemistry, University of Cambridge, UK
    View abstract

    Fully Automated Flow-Through Synthesis of Secondary Sulfonamides in a Binary Reactor System

    Charlotte M. Griffiths-Jones, Mark D. Hopkin, Daniel Jönsson, Steven V. Ley, David J. Tapolczay, Emma Vickerstaffe, Mark Ladlow

    • GlaxoSmithKline Cambridge Technology Centre, Cambridge
    View abstract

    Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles

    Marcus Baumann, Ian R. Baxendale, Steven V. Ley, Christoper D. Smith, Geoffrey K. Tranmer

    • Innovative Technology Center, University of Cambridge
    View abstract

    A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

    Ian R. Baxendale, Steven V. Ley, Christopher D. Smith, Geoffrey K. Tranmer

    • Innovative Technology Centre, Cambridge, UK
    View abstract

    A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly

    Ian R. Baxendale, Jon Deeley, Charlotte M. Griffiths-Jones, Steven V. Ley, Steen Saaby, Geoffrey K. Tranmer

    • Innovative Technology Centre, University of Cambridge
    View abstract

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