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The following (non-exhaustive) list of papers shows peer-reviewed work that has been published using the Vapourtec R-Series and E-Series flow chemistry systems. As new work is continually published, please check here for updates.

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The Photochemical Mediated Ring Contraction of 4H-1,2,6-Thiadiazines To Afford 1,2,5-Thiadiazol-3(2H)-one 1-Oxides

Emmanouil Broumidis^a, Christopher G. Thomson^a, Brendan Gallagher^a, Lia Sotorríos^a, Kenneth G. McKendrick^a, Stuart A. Macgregor*^a, Martin J. Paterson^a, Janet E. Lovett^b, Gareth O. Lloyd^c, Georgina M. Rosair^a, Andreas S. Kalogirou^d,e, Panayiotis A. Koutentis*^e, and Filipe Vilela*^a,f

^aInstitute of Chemical Sciences, School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, United Kingdom

^bSUPA School of Physics and Astronomy and BSRC, University of St Andrews, St. Andrews, KY16 9SS, United Kingdom

^cJoseph Banks Laboratories, School of Chemistry, University of Lincoln, Brayford Pool, Lincoln LN6 7TS, United Kingdom

^dDepartment of Life Sciences, School of Sciences, European University Cyprus, 6 Diogenes Str., Engomi, P.O. Box 22006, 1516 Nicosia, Cyprus

^eDepartment of Chemistry, University of Cyprus, P.O. Box 20537, 1678 Nicosia Cyprus

^fContinuum Flow Lab, School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, United Kingdom

View abstract

Development of a Continuous Flow Baldwin Rearrangement Process and Its Comparison to Traditional Batch Mode

Arlene Bonner^a, Marcus Baumann^a

^aSchool of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland D04 N2E2

View abstract

Continuous Flow Oxidation of Alcohols Using TEMPO/NaOCl for the Selective and Scalable Synthesis of Aldehydes

Parth Naik^a, Jorge García-Lacuna^a, Patrick O’Neill^b, and Marcus Baumann^a

^aSchool of Chemistry, University College Dublin, Science Centre South, Belfield D04 N2E5, Ireland

^bPfizer Ireland, Ringaskiddy P43 X336, Ireland

View abstract

Development of Continuous Flow Processes to Access Pyrrolo[2,1-f][1,2,4]triazin-4-amine: An RSM for the Synthesis of Antiviral Drugs

Maksim Vasilev^a, Aravind S. Gangu^a, Praveen Gajula^a, Nathaniel D. Kaetzel^a, Vasudevan Natarajan^a, Bimbisar Desai^a, Gopal Sirasani^a, Bo Qu^a, and Chris H. Senanayake^a

^aTCG GreenChem, Inc., 701 Charles Ewing Boulevard, Ewing, New Jersey 08628, United States

View abstract

Late-Stage C(sp2)–C(sp3) Diversification via Nickel Oxidative Addition Complexes

Carlota Odena^1,3, María Lourdes Linares⁴, Nahury Castellanos-Blanco¹, Ryan T. McGuire¹, Jose Manuel Alonso⁴, Alejandro Diéguez⁵, Eric Tan⁵, Jesús Alcázar⁴, Peter Buijnsters⁵ Santiago Cañellas⁴ and Ruben Martin^1,2

¹Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Spain

²ICREA, Passeig Lluïs Companys 23, 08010 Barcelona, Spain

³Department de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, c/ Marcel·lí Domingo 1, 43007 Tarragona, Spain

⁴Janssen Research and Development, Janssen-Cilag, S. A. c/ Rio Jarama 75, 45007 Toledo, Spain

⁵Medicinal Chemistry, Janssen Pharmaceutica, N. V. B-2340 Beerse, Belgium

View abstract

Recent advances in photoredox catalytic transformations by using continuous-flow technology

Xin Yuan^a, Hai-Bin Fan^a, Jie Liu^a, Long-Zhou Qin^a, Jian Wang^a, Xiu Duan^a, Jiang-Kai Qiu^a,b, Kai Guo^a,b

^aCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, Jiangsu, China

^bState Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211800, Jiangsu, China

View abstract

Metal-Free Addition of Alkyl Bromides to Access 3,3-Disubstituted Quinoxalinones Enabled by Visible-Light Photoredox Catalysis

Jennie Liao^a, David N. Hunter^b, Ugochinyere Nancy Oloyede^b, Joseph W. McLaughlin^b, Cheng Wang^b, and Abdellatif El Marrouni^b

^aProcess Research & Development, MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

^bDiscovery Chemistry, MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

View abstract

Direct Arylation of Thiophenes in Continuous Flow

Alessandro Petronilli^a, Prof. Tommaso Carofiglio^a and Dr. Paolo Zardi^a,b

^aDepartment of Chemical Sciences, University of Padova, Via Francesco Marzolo 1, 35131 Padova, Italy

^bDepartment of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi 103, 41125 Modena, Italy

View abstract

Metal-free synthesis of selenoesters directly from carboxylic acids using bifunctional selenoureas under batch and continuous-flow conditions

Mouzma Mhate^a, Chandra Sekhara Mahanta^a, Devendra K. Dhaked^b, Velyutham Ravichandiran^a and Sharada Prasanna Swain^a

^aDepartment of Medicinal Chemistry and Centre for Marine Therapeutics (CMT), National Institute of Pharmaceutical Education and Research-Kolkata, 168, Maniktala Main Road, Kolkata 700054, India

^bDepartment of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research-Kolkata, 168, Maniktala Main Road, Kolkata 700054, India

View abstract

Continuous Flow Synthesis of Cycloparaphenylene Building‐Blocks on a Large Scale

Jan H. Griwatz^a,b, Mika L. Kessler^a, Hermann A. Wegner^a,b

^aInstitute of Organic Chemistry, Justus Liebig University Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany

^bCenter for Materials Research, Justus Liebig University Giessen, Heinrich-Buff-Ring 16, 35392 Giessen, Germany

View abstract

Continuous Flow Chemistry: A Novel Technology for the Synthesis of Marine Drugs

Laura F. Peña^a, Paula González-Andrés^a, Lucía G. Parte^a, Raúl Escribano^a, Javier Guerra^a, Asunción Barbero^a and Enol López^a

^aDepartment of Organic Chemistry, Campus Miguel Delibes, University of Valladolid, 47011 Valladolid, Spain

View abstract

Visible-Light-Mediated TiO2-Catalyzed Aerobic Dehydrogenation of N-Heterocycles in Batch and Flow

Junghoon Noh^a, Jun-Young Cho^a, Mincheol Park^b, and Boyoung Y. Park^a

^aDepartment of Fundamental Pharmaceutical Science, Kyung Hee University, Seoul 02447, South Korea

^bDepartment of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, South Korea

View abstract

Continuous flow synthesis of pyridinium salts accelerated by multi-objective Bayesian optimization with active learning

John H. Dunlap^ab, Jeffrey G. Ethier^ab, Amelia A. Putnam-Neeb ^ac, Sanjay Iyer^d, Shao-Xiong Lennon Luo^e, Haosheng Feng^e, Jose Antonio Garrido Torres^f, Abigail G. Doyle^g, Timothy M. Swager^e, Richard A. Vaia^a, Peter Mirau^a, Christopher A. Crouse^a and Luke A. Baldwin^a

^aMaterials and Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson AFB, OH 45433, USA.

^bUES, Inc., Dayton, OH 45431, USA

^cNational Research Council Research Associate, Air Force Research Laboratory, Wright-Patterson AFB, OH 45433, USA

^dDepartment of Chemistry, Purdue University, West Lafayette, IN 47907, USA

^eDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

^fDepartment of Chemistry, Princeton University, Princeton, NJ 08544, USA

^gDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA

View abstract

Liquid/liquid heterogeneous reaction monitoring: Insights into biphasic Suzuki-Miyaura cross-coupling

Yusuke Sato¹, Junliang Liu¹, Ikenna Edward Ndukwe², Maria Victoria Silva Elipe², Daniel J. Griffin³, James I. Murray^4,5, Jason E. Hein^1,5,6,7

¹Department of Chemistry, The University of British Columbia, Vancouver, BC V6T 1Z1, Canada

²Pivotal Attribute Sciences, Drug Substance Technologies, Amgen, Inc., Thousand Oaks, CA 91320, USA

³Pivotal and Commercial Synthetics, Drug Substance Technologies, Amgen, Inc., Cambridge, MA 02142, USA

⁴Pivotal and Commercial Synthetics, Drug Substance Technologies, Amgen, Inc., Thousand Oaks, CA 91320, USA

⁵Acceleration Consortium, University of Toronto, Toronto, ON, Canada

⁶Department of Chemistry, University of Bergen, Bergen, Norway

View abstract

Shining a Light on the Advances, Challenges and Realisation of Utilising Photoredox Catalysis in Pharmaceutical Development

Dr. Emily E. Callard-Langdon^a, Dr. Alan Steven^a, Dr. Rachel J. Kahan^a

^aCatSci Ltd, CBTC2, Capital Business Park, Wentloog, Cardiff, CF3 2PX UK

View abstract

Modular Photochemical Flow Synthesis of Structurally Diverse Benzyne and Triazine Precursors

Jorge García-Lacuna^a, Marcus Baumann^a

^aSchool of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Dublin, Ireland

View abstract

Research Activities at Faculty of Chemical Technology, Hanoi University of Industry – 20 Years of Growth and Development

Tuan Anh Nguyen^a, The Huu Nguyen^a, Van Dong Pham^a, Minh Tan Vu^a, Thi Mai Huong Pham^a

^aHanoi University of Industry, 298 Cau Dien Street, Bac Tu Liem District, Hanoi, 10000 Viet Nam

View abstract

Metabolite Changes of Perna canaliculus Following a Laboratory Marine Heatwave Exposure: Insights from Metabolomic Analyses

Awanis Azizan¹, Leonie Venter¹, Peet J. Jansen van Rensburg², Jessica A. Ericson³, Norman L. C. Ragg³ and Andrea C. Alfaro¹

¹Aquaculture Biotechnology Research Group, School of Science, Auckland University of Technology, Private Bag 92006, Auckland 1142, New Zealand

²Human Metabolomics, North-West University, Potchefstroom 2520, South Africa

¹Cawthron Institute, Private Bag 2, Nelson 7042, New Zealand

View abstract

Combining Tailored Ionic Liquids with Ti3C2Tx MXenes for an Enhanced Load-Carrying Capacity Under Boundary Lubrication

Philipp G. Grützmacher^a, Roman Neuhauser^a, Kristof Stagel^b, Katharina Bica-Schröder^b, Guido Boidi^c, Carsten Gachot^a, Andreas Rosenkranz^d

^aInstitute for Engineering Design and Product Development Research Unit Tribology E307-05, TU Wien, 1060 Vienna, Austria

^bInstitut für Angewandte Synthesechemie (IAS), Sustainable Organic Synthesis and Catalysis research group, TU Wien, 1060 Vienna, Austria

^cAC2T research GmbHViktor-Kaplan-Straße 2/C, 2700 Wiener Neustadt, Austria

^dDepartment of Chemical Engineering, Biotechnology and Materials (FCFM), Universidad de Chile, Santiago 8370448, Chile

View abstract

An all-in-one multipurpose robotic platform for the self-optimization, intensification and scale-up of photocatalysis in flow

Aidan Slattery^a,Zhenghui Wen^a, Pauline Tenblad^a, Diego Pintossi^a, Jesus Sanjose-Orduna^a, Tim den Hartog^{a, b, c}, Timothy Noel^a

^aFlow Chemistry Group, van ’t Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands

^bZuyd University of Applied Sciences, Nieuw Eyckholt 300, 6419 DJ Heerlen, The Netherlands

^cThe Netherlands Organisation for Applied Scientific Research (TNO), High Tech Campus 25, 5656AE Eindhoven, The Netherlands

View abstract

Multi-platform synthesis of ondansetron featuring process intensification in flow

Yoshio Hato^a,b, Timothy F. Jamison^a

^aDepartment of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA

^bShionogi Pharmaceutical Research Center, Shionogi & Co., Ltd., Toyonaka, Osaka 561-0825, Japan

View abstract

Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations

Liang Chang^a, Shun Wang^b, Qing An^b, Linxuan Liu^b, Hexiang Wang^b, Yubo Li^b, Kaixuan Feng^b and Zhiwei Zuo^b

^aSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China

^bState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

View abstract

Photo- and Electrochemical Cobalt Catalysed Hydrogen Atom Transfer for the Hydrofunctionalisation of Alkenes

Samikshan Jana¹, Victor Jose Mayerhofer¹, Christopher Teskey²

¹RWTH: Rheinisch-Westfalische Technische Hochschule Aachen, Institute of Organic Chemistry, GERMANY

²RWTH Aachen: Rheinisch-Westfalische Technische Hochschule Aachen, Institute of Organic Chemistry, Landoltweg 1, 52074, Aachen, GERMANY

View abstract

The α-alkylation of ketones in flow

Ella Cooper^a, Emma Alcock^a, Mark Power^a, Gerard McGlacken^a

^aSchool of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, T12 YN60 Cork, Ireland

View abstract

Continuous Flow Synthesis of Cyclobutenes Using LED Technology

Megan Smyth^a, Thomas S Moody^a,b, Scott Wharry^a, Marcus Baumann^c

^aBiocatalysis group, Almac Sciences Ltd, Craigavon, United Kingdom of Great Britain and Northern Ireland

^bManufacturing, Arran Chemical Company, Athlone, Ireland

^bChemistry, University of Durham, Durham, United Kingdom of Great Britain and Northern Ireland

View abstract

Accelerated Chemical Reaction Optimization Using Multi-Task Learning

Connor J. Taylor*^a,b, Kobi C. Felton^c, Daniel Wigh^b,c, Mohammed I. Jeraal^d, Rachel Grainger^a, Gianni Chessari^a, Christopher N. Johnson^a, and Alexei A. Lapkin*^b,c,d

^aAstex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge, CB4 0QA, United Kingdom

^bInnovation Centre in Digital Molecular Technologies, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom

^cDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, United Kingdom

^dCambridge Centre for Advanced Research and Education in Singapore Ltd., 1 Create Way, CREATE Tower #05-05, 138602, Singapore

View abstract

Efficient degassing and ppm-level oxygen monitoring flow chemistry system

Paulius Baronas^a, Jacob Lynge Elholm^a, Kasper Moth-Poulsen^a,b,c,d

^aThe Institute of Materials Science of Barcelona, ICMAB-CSIC, Bellaterra, 08193, Barcelona, Spain

^bCatalan Institution for Research & Advanced Studies, ICREA, Pg. Lluís Companys 23, 08010 Barcelona, Spain

^cDepartment of Chemical Engineering, Universitat Politècnica de Catalunya, EEBE, Eduard Maristany 10–14, 08019 Barcelona, Spain

^dChalmers University of Technology, Department of Chemistry and Chemical Engineering. SE-412 96 Gothenburg, Sweden

View abstract

Photo-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds

Antonella Ilenia Alfano^a, Sveva Pelliccia^a, Giacomo Rossino^b, Orazio Chianese^c, Vincenzo Summa^a, Simona Collina^b, and Margherita Brindisi^a

^aDepartment of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy

^bDepartment of Drug Sciences, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy

^cGenetic S.p.A., Via Canfora, 64, 84084 Fisciano (Salerno), Italy

View abstract

Boronic Acids and Their Derivatives as Continuous-Flow-Friendly Alkyl Radical Precursors

Monica Oliva^a, Viktoriia V. Chernobrovkina^b, Erik V. Van der Eycken^a,b, Upendra Kumar Sharma^a

^aLaboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, 3001 Leuven, Belgium

^bPeoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya street 6, 117198 Moscow, Russia

View abstract

Advances in continuous polymer analysis in flow with application towards biopolymers

Samuel B. H. Patterson^a, Raymond Wong^b, Graeme Barker^a & Filipe Vilela^a

^aSchool of Engineering and Physical Sciences, Institute of Chemical Sciences, Heriot Watt University, Edinburgh, EH14 4AS, UK

^bShimadzu Centre of Excellence, Milton Keynes, UK

View abstract

Continuous Flow-Facilitated CB2 Agonist Synthesis, Part 1: Azidation and [3 + 2] Cycloaddition

Peter Sagmeister^a,b, Michael Prieschl^a,b, Dainis Kaldre^c, Chethana Gadiyar^d, Christian Moessner^c, Joerg Sedelmeier^c, Jason D. Williams^a,b, and C. Oliver Kappe^a,b

^aCenter for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, AustriaM/li> ^bInstitute of Chemistry, NAWI Graz, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria

^cDepartment of Process Chemistry & Catalysis, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland

^dDepartment of Solid State Sciences, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland

View abstract

Continuous Flow-Facilitated CB2 Agonist Synthesis, Part 2: Cyclization, Chlorination, and Amination

Michael Prieschl^a,b, Peter Sagmeister^a,b, Christian Moessner^c, Joerg Sedelmeier^c, Jason D. Williams^a,b, and C. Oliver Kappe^a,b

^aCenter for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria

^bInstitute of Chemistry, NAWI Graz, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria

^cDepartment of Process Chemistry & Catalysis, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland

View abstract

Flow Electrochemistry for the N-Nitrosation of Secondary Amines

Rojan Ali^a, Dr. Rasool Babaahmadi^a, Dr. Matthew Didsbury^b, Dr. Rebecca Stephens^b, Prof. Rebecca L. Melen^a, Prof. Thomas Wirth^a

^aSchool of Chemistry, Cardiff University, Park Place, Main Building, Cardiff, CF10 3AT UK

^bBAE Systems, Glascoed, Usk, Monmouthshire, NP15 1XL UK

View abstract

Alkene reactions with superoxide radical anions in flow electrochemistry

Rojan Ali^a, Tuhin Patra^a and Thomas Wirth^a

^aSchool of Chemistry, Cardiff University, Park Place, Main Building, Cardiff CF10 3AT (UK)

View abstract

Antimicrobial Evaluation of New Pyrazoles, Indazoles and Pyrazolines Prepared in Continuous Flow Mode

Adam Burke¹, Mara Di Filippo¹, Silvia Spiccio¹, Anna Maria Schito², Debora Caviglia^2,3, Chiara Brullo³, Marcus Baumann¹

¹Science Centre South, School of Chemistry, University College Dublin, Dublin 4, Ireland

²Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, 16132 Genoa, Italy

³Section of Medicinal Chemistry, Department of Pharmacy (DIFAR), University of Genoa, 16132 Genoa, Italy

View abstract

Photochemical Synthesis of Pyrazolines from Tetrazoles in Flow

Adam Burke^a, Silvia Spiccio^a, Mara Di Filippo^a, Marcus Baumann^a

^aSchool of Chemistry, University College Dublin, Science Centre South, D04 N2E2, Dublin, Ireland

View abstract

Continuous Flow Inter- and Intramolecular Macrolactonization under High Dilution Conditions

Dashrat Vishambar Sutar^a, Neha Uttamrao Sarang^a, Akash Bandu Jamdade^a, Boopathy Gnanaprakasam^a

^aDepartment of Chemistry, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pashan, Pune 411008, India

View abstract

Visible-Light Photoredox-Catalyzed Giese Reaction of α-Silyl Ethers with Various Michael Acceptors

Young Woo Kang^a, Ran Hui Kim^a, Shafrizal Rasyid Atriardi^a, Sang Kook Woo^a

^aDepartment of Chemistry, University of Ulsan, 93 Daehak-Ro, Nam-Gu, Ulsan 44610, Korea

View abstract

Skeletal Editing Approach to Bridge-Functionalized Bicyclo[1.1.1]pentanes from Aza-Bicyclo[2.1.1]hexanes

Brandon A. Wright¹, Anastassia Matviitsuk², Michael J. Black¹, Pablo García-Reynaga², Luke E. Hanna², Aaron T. Herrmann², Michael K. Ameriks², Richmond Sarpong¹, Terry P. Lebold²

¹Department of Chemistry, University of California, Berkeley, California 94720, United States

²Janssen Research and Development, San Diego, California 92121, United States

View abstract

Visible-Light Photocatalysis Academic–Industrial Collaboration Retrospective: Shared Learning and Impact Analysis

Kevin P. Cole^a, James J. Douglas^a,b, Travis Hammerstad^b, Corey R. J. Stephenson^b

^aSynthetic Molecule Design and Development, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States

^bDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States

View abstract

Catalytic multi-step continuous-flow processes for scalable transformation of eugenol into potential fragrances

Fábio M.S. Rodrigues^a, Vitaliy Masliy^a, Madalena F.C. Silva^a, Alexandre P. Felgueiras^a, Rui M.B. Carrilho^a, Mariette M. Pereira^a

^aUniversity of Coimbra, Coimbra Chemistry Centre, Department of Chemistry, Rua Larga, 3004-535 Coimbra, Portugal

View abstract

Development and optimization of a continuous flow ester reduction with LiAlH4 in the synthesis of a key intermediate for a PI3Kδ inhibitor (CPL302415)

Stanisław Michałek^a,b, Anna M. Maj^a, Lidia Gurba-Bryśkiewicz^a, Wioleta Maruszak^a, Marcin Zagozda^a, Zbigniew Ochal^b, Krzysztof Dubiel^a, Maciej Wieczorek^a

^aCelon Pharma S.A., ul. Marymoncka 15, 05-152 Kazuń Nowy, Poland

^bFaculty of Chemistry, Warsaw University of Technology, ul. Noakowskiego 3, 00-664 Warsaw, Poland

View abstract

Lipase-Mediated Synthesis of Oleoyl Ethanolamide Starting from High-Oleic Sunflower Oil Soapstock

Elisabetta Brenna^a, Valeria De Fabritiis^a, Fabio Parmeggiani^a, Francesca Tentori^a, Davide Tessaro^a

^aDipartimento di Chimica, Materiali ed Ingegneria Chimica “Giulio Natta”, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milano, Italy

View abstract

Continuous-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds

Antonella Ilenia Alfano^a, Sveva Pelliccia^a, Giacomo Rossino^b, Orazio Chianese^c, Vincenzo Summa^a, Simona Collina^b, and Margherita Brindisi^a

^aDepartment of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131, Naples, Italy

^bDepartment of Drug Sciences, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy

^cGenetic S.p.A., Via Canfora, 64, 84084 Fisciano (Salerno), Italy

View abstract

Continuous Flow Synthesis of Substituted 3, 4-Propylenedioxythiophene Derivatives

Dattatray L. Tarange^a, Nagaraj Nayak^a, Anil Kumar^a

^aDepartment of Chemistry, Indian Institute of Technology-Bombay (IITB), Powai, Mumbai 400076, India

View abstract

Flow photochemistry — from microreactors to large-scale processing

Mengxue Zhang^a, Philippe Roth^a

^aCorning SAS, 7 bis avenue de Valvins, CS 70156 Samois sur Seine, 77215 Avon Cedex, France

View abstract

Continuous-flow photochemistry as an automated platform integrated with closed-loop AI/ML approaches

Brenda Pijper¹, Jesus Alcázar¹, Gabriela Oksdath-Mansilla², Fabricio Román Bisogno²

¹Discovery Chemistry, Janssen, Pharmaceutical Companies of Johnson and Johnson, Janssen-Cilag, S.A., Calle Río Jarama 75A, 45007 Toledo, Spain

²INFIQC-CONICET-UNC, Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, X5000HUA Córdoba, Argentina

View abstract

Laboratory Scale Continuous Flow Systems for the Enantioselective Phase Transfer Catalytic Synthesis of Quaternary Amino Acids

Milena Krstić¹, Sergio Rossi¹, Miguel Sanz², Alessandra Puglisi¹

¹Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy

²Taros Chemicals, GmbH & Co. KG Emil-Figge-Str 76a, 44227 Dortmund, Germany

View abstract

Continuous Flow Synthesis of Non-Symmetrical Ureas from CO2

Alexandre Labiche^a, Maylis Norlöff^a, Dr. Sophie Feuillastre^a, Dr. Frederic Taran^a, Dr. Davide Audisio^a

^aUniversité Paris Saclay, CEA, Département Médicaments et Technologies pour la Santé, SCBM, 91191 Gif-sur-Yvette, France

View abstract

Flow photochemical Giese reaction via silane-mediated activation of alkyl bromides

Fabiola Fanini^ab, Alberto Luridiana^a, Daniele Mazzarella^ac, Antonella Ilenia Alfano^ad, Perryvan der Heide^a, Juan A. Rincón^e, Pablo García-Losada^e, Carlos Mateos^e, Michael O. Frederick^f, Manuel Nuño^g, Timothy Noël^a

^aFlow Chemistry Group, Van ’t Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam Science Park 904, 1098 XH Amsterdam, The Netherlands

^bDepartment of Biomolecular Sciences, University of Urbino “Carlo Bo”, Piazza Rinascimento 6, I-61029 Urbino, Italy

^cDepartment of Chemical Sciences, University of Padova Institution, Via Francesco Marzolo, 1, 35131 Padova, Italy

^dDepartment of Pharmacy, Department of Excellence 2018-2022, School of Medicine and Surgery, University of Naples “Federico II”, Via D. Montesano 49, I-80131 Naples, Italy

^eCentro de Investigación Lilly S.A., Avda. de la Industria 30, Alcobendas-Madrid 28108, Spain

^fSmall Molecule Design and Development, Eli Lilly and Company, Indianapolis, IN 46285, United States

^gVapourtec Ltd. Park Farm Business Centre, Fornham St Genevieve, Bury St Edmunds, Suffolk IP28 6TS, United Kingdom

View abstract

Generation of 1,2-Difluorobenzene via a Photochemical Fluorodediazoniation Step in a Continuous Flow Mode

Kevin Simon^ab, Desiree Znidar^ab, Julien Boutet^c, Gérard Guillamot^c, Jean-Yves Lenoir^c, Doris Dallinger^ab, and C. Oliver Kappe^ab

^aCenter for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, Graz 8010, Austria

^bInstitute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, Graz 8010, Austria

^cSeqens SAS, 21 Chemin de la Sauvegarde, 21 Ecully Parc, Ecully 69130, France

View abstract

Continuous flow synthesis of phenyl glucosazone and its conversion to 2H-1,2,3-Triazole building blocks

Maria Molnar^a, Marcus Baumann^a

^aSchool of Chemistry, Science Centre South, University College Dublin, Dublin, D04 N2E2, Ireland

View abstract

Continuous Flow Epoxidation of Alkenes Using a Homogeneous Manganese Catalyst with Peracetic Acid

Ailbhe A. Ryan^abc, Seán D. Dempsey^abc, Megan Smyth^a, Karen Fahey^b, Thomas S. Moody^ab, Scott Wharry^a, Paul Dingwall^c, David W. Rooney^c, Jillian M. Thompson^c, Peter C. Knipe^c, and Mark J. Muldoon^c

^aAlmac Group, Craigavon BT63 5QD, United Kingdom

^bArran Chemical Company, Roscommon N37 DN24, Ireland

^cQueen’s University Belfast, Belfast BT9 5AG, United Kingdom

View abstract

The applications of organozinc reagents in continuous flow chemistry: Negishi coupling

Roop Varghese Rubert^a, Rony Rajan Paul^a

^aDepartment of Chemistry, CMS College Kottayam, Kottayam, Kerala, 686001, India

View abstract

Alternate end-game strategies towards Nirmatrelvir synthesis: Defining a continuous flow process for the preparation of an anti-COVID drug

Karuna Veeramani^a, Manish Shinde^a, Vishnuvardhana Vema Reddy Eda^b, Bala Chennaiah Darapaneni^b, Rama Mohan Hindupur^c, Srinivasa Rao Madarapu^c, Saikat Sen^b, Srinivas Oruganti^b

^a10X Chemical Process Automation Laboratory, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, Telangana, India

^bCentre for Process Research and Innovation, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, Telangana, India

^cAurigene Pharmaceutical Services Limited, JP Nagar Road, Miyapur, Hyderabad 500 049, Telangana, India

View abstract

Iron-catalyzed [4 + 2] annulation of amidines with α,β-unsaturated ketoxime acetates toward 2,4,6-trisubstituted pyrimidines

Qinghuan Wu^a, Luchao Li^a, Binyan Xu^a, Jie Sun^a, Dong Ji^b, Yuguang Li^b, Lei Shen^b, Zheng Fang^a, Jindian Duan^a, Beining Chen^c, Kai Guo^a

^aCollege of Biotechnology and Pharmaceutical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China

^bInstitute of Nanjing Advanced Biomaterials & Processing Equipment, Nanjing, 211299, China

^cDepartment of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK

View abstract

Visible-Light Photoredox Catalysis for the Synthesis of Fluorinated Aromatic Compounds

Tomasz Kliś^a

^aFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland

View abstract

Process intensification of dendritic fibrous nanospheres of silica (DFNS) via continuous flow: a scalable and sustainable alternative to the conventional batch synthesis

Karuna Veeramani^abc, Nagaraj Nayak^a, Neil R. Cameron^c, Anil Kumar^*a

^aDepartment of Chemistry, Indian Institute of Technology-Bombay (IITB), Powai, Mumbai-400076, India

^bIITB-Monash Research Academy, Indian Institute of Technology-Bombay (IITB), Powai, Mumbai-400076, India

^cIITB-Monash Research Academy, Indian Institute of Technology-Bombay (IITB), Powai, Mumbai-400076, India

View abstract

Continuous-flow Fe-zeolite-catalyzed temperature-directed synthesis of bioactive tetraketones and xanthenes using epoxides and cyclic-1,3-diketones via a Meinwald rearrangement

Shankhajit Mondal^a, Akanksha M. Pandey^a, Boopathy Gnanaprakasam^a

^aDepartment of Chemistry, Indian Institute of Science Education and Research (IISER) Pune, Dr. Homi Bhabha Road, Pune 411008, Maharashtra, India

View abstract

Development of an automated platform for C(sp3)-C(sp3) bond formation via XAT chemistry

Brenda Pijper^a, Irini Abdiaj^a, Daniele Leonori^b, Jesus Alcázar^a

^aJanssen Cilag SA, Discovery Chemistry, Jarama 75A, 45007 Toledo, SPAIN

^bRWTH Aachen, Institute of Organic Chemistry, GERMANY

View abstract

Photochemical Synthesis of Pyrazolines from Tetrazoles in Flow

Adam Burke^a, Silvia Spiccio^a, Mara Di Filippo^a, Marcus Baumann^b

^aChemistry, University College Dublin, Dublin, Ireland

^bChemistry, University of Durham, Durham, United Kingdom of Great Britain and Northern Ireland

View abstract

Continuous Process to Safely Manufacture an Aryldiazoacetate and Its Direct Use in a Dirhodium-Catalyzed Enantioselective Cyclopropanation

Stephen P. Lathrop^a, Laurie B. Mlinar^a, Onkar N. Manjrekar^a, Yong Zhou^a, Kaid C. Harper^a, Eric R. Sacia^a, Molly Higgins^a, Andrew R. Bogdan^b, Zhe Wang^a, Steven M. Richter^a, Wei Gong^c, Eric A. Voight^c, Jeremy Henle^a, Moiz Diwan^a, Jeffrey M. Kallemeyn^a, Jack C. Sharland^d, Bo Wei^d, and Huw M. L. Davies^d

^aProcess Research and Development, AbbVie Inc., North Chicago, Illinois 60064, United States

^bAdvanced Chemistry Technologies, AbbVie Inc., North Chicago, Illinois 60064, United States

^cDrug Discovery Science & Technology, AbbVie Inc., North Chicago, Illinois 60064, United States

^dDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States

View abstract

Multicompartment polymeric colloids from functional precursor Microgel: Synthesis in continuous process

^aDWI – Leibniz-Institute for Interactive Materials e.V, Forckenbeckstraße 50, 52074 Aachen, Germany

^bInstitute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 2, 52074 Aachen, Germany

^cAachen-Maastricht Institute for Biobased Materials (AMIBM), Maastricht University, Urmonderbaan 22, 6167 RD Geleen, The Netherlands

^dZuyd University of Applied Sciences, Nieuw Eyckholt 300, 6419 DJ Heerlen, The Netherlands

^eJülich Centre for Neutron Science (JCNS-1), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straβe, 52428 Jülich, Germany

^fCNRS, UMR 8232 – IPCM – Institut Parisien de Chimie Moléculaire – Polymer Chemistry Team, Sorbonne Université, 4 Pl. Jussieu, 75005 Paris, France

View abstract

TBADT-Mediated C-C Bond Formation Exploiting Aryl Aldehydes in a Photochemical Flow Reactor

Adam Cruise^a, Marcus Baumann^a

^aUniversity College Dublin, School Of Chemistry, Science Centre - South, Dublin 4 Belfield, IRELAND

View abstract

Synthesis of picramide using nitration and ammonolysis in continuous flow

Ankit Kumar Mittal^a, Gaurav Prakash^a, Pramod Pathak^a, Debabrata Maiti^a

^aIndian Institute of Technology Bombay, Chemistry, INDIA

View abstract

End-to-End Automated Synthesis of C(sp3)-Enriched Drug-like Molecules via Negishi Coupling and Novel, Automated Liquid–Liquid Extraction

Irini Abdiaj^a, Santiago Cañellas^a, Alejandro Dieguez^a, Maria Lourdes Linares^a, Brenda Pijper^a, Alberto Fontana^a, Raquel Rodriguez^a, Andres Trabanco^a, Eduardo Palao^a, Jesus Alcázar*^a

^aDiscovery Chemistry, Janssen Research and Development, Janssen-Cilag, S.A., C/ Jarama 75, E-45007Toledo, Spain

View abstract

Flow platform for the synthesis of benzodiazepines

Maria Ivanova^a, Thomas Poisson^a, Philippe Jubault^a, Julien Legros^a

^aNormandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA, 76000, Rouen, France

View abstract

Mimicking natural metabolisms: cell‐free flow preparation of dopamine

Silvia Donzella^a, Agostina Colacicco^a, Luca Nespoli^a, Dr. Martina L. Contente^a

^aDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria, 2, 20133 Milan, Italy

View abstract

Improving the Sustainability and Safety of Ursodeoxycholic Acid Synthesis in Continuous Flow Process with Water

Hahyeon Kim^a, Jonghyun Lee^b, Seung Jae Lee^c, Jeong Eun Oh^a, Soo Dong Kim^a, Yashwardhan R. Malpani^c, Ye-Jin Hwang^d

^aDepartment of Biomedical and Pharmaceutical Science, Kyung Hee University, 26 Kyughee-daero, Dongdaemun-gu, Seoul 02447, Republic of Korea

^bDepartment of Basic Pharmaceutical Science, College of Pharmacy, Kyung Hee University, 26 Kyughee-daero, Dongdaemun-gu, Seoul 02447, Republic of Korea

^cAPI Synthesis Team, Daewoong-Bio, 29-Jeyakdanji-ro, Hyangnam-eup, Hwaseung-si, Hyeonggi-do 18608, Republic of Korea

^dDepartment of Chemistry and Chemical Engineering, Education and Research Center for Smart energy and Materials, Inha University 100 Inha-ro, Michugol-gu, Incheon, Republic of Korea

View abstract

The design of experiments (DoE) in optimization of an aerobic flow Pd-catalyzed oxidation of alcohol towards an important aldehyde precursor in the synthesis of phosphatidylinositide 3-kinase inhibitor (CPL302415)

Stanisław Michałek^a,b, Lidia Gurba-Bryśkiewicz^a, Wioleta Maruszak^a, Marcin Zagozda^a, Anna M. Maj^a, Zbigniew Ochal^b, Krzysztof Dubiel^a, Maciej Wieczorek^a

^aCelon Pharma S.A., Ul. Marymoncka 15, 05-152 Kazuń Nowy, Poland

^bFaculty of Chemistry, Warsaw University of Technology, Ul. Noakowskiego 3, 00-664 Warsaw, Poland

View abstract

Exploring Visible Light for Carbon–Nitrogen and Carbon–Oxygen Bond Formation via Nickel Catalysis

Shengqing Zhu^a, Huan Li^a, Yingying LI^a, Zhonghou HUANG^a, Lingling Chu^a

^aState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Center for Advanced Low-Dimension Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China

View abstract

Consecutive photochemical reactions enabled by a dual flow reactor coil strategy

Ruairi Crawford^a, Mara Di Filippo^a, Duncan Guthrie^b, Marcus Baumann^a

^aSchool of Chemistry, Science Centre South, University College Dublin, D04 N2E2, Dublin, Ireland

^bVapourtec, Fornham St Genevieve, Bury St Edmunds, Suffolk, IP28 6TS, UKM

View abstract

Spheroplasts preparation boosts the catalytic potential of a squalene-hopene cyclase

Ana I. Benítez-Mateos^a, Andreas Schneider, Eimear Hegarty^a, Bernhard Hauer, Francesca Paradisi^a

^aDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012, Bern, Switzerland

^bInstitute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart-Vaihingen, Germany

View abstract

Membrane-based TBADT recovery as a strategy to increase the sustainability of continuous-flow photocatalytic HAT transformations

Zhenghui Wen^a, Diego Pintossi^a, Manuel Nuño^b, Timothy Noël^a

^aFlow Chemistry Group, Van ‘t Hoff Institute for Molecular Sciences, Faculty of Science, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands

^bVapourtec Ltd., Park Farm Business Centre, Fornham St Genevieve, Bury St Edmunds, Suffolk, IP28 6TS, UK

View abstract

Two-Step Continuous-Flow Synthesis of 6-Membered Cyclic Iodonium Salts via Anodic Oxidation

Julian Spils¹, Thomas Wirth², Boris J. Nachtsheim¹

¹Institute for Organic and Analytical Chemistry, University of Bremen, Leobener Straße 7, 28359 Bremen ²School of Chemistry, Cardiff University, Park Place, Main Building, Cardiff CF10 3AT (UK)

View abstract

Development of a flow process for an easy and fast access to 2-pyrone derivatives

Grazia Isa C. Righetti^a, Francesca Tentori^a, Elisabetta Brenna^a, Cristian Gambarotti^a

^aDepartment of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy

View abstract

Intraligand Charge Transfer Enables Visible-Light-Mediated Nickel-Catalyzed Cross-Coupling Reactions

Cristian Cavedon^a,b, Sebastian Gisbertz^a,b,Susanne Reischauer^a,b, Sarah Vogl^c, Eric Sperlich^d, John H. Burke^e, Rachel F. Wallick^e, Stefanie Schrottke^f, Wei-Hsin Hsu^a, Lucia Anghileri^a,b, Yannik Pfeifer^d, Noah Richter^a, Christian Teutloff^f, Henrike Müller-Werkmeister^d, Dario Cambié^a, Peter H. Seeberger^a,b, Josh Vura-Weis^e, Renske M. van der Veen^e,g, Arne Thomas^c, Bartholomäus Pieber^a

^aDepartment of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany

^bDepartment of Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195 Berlin, Germany

^cDepartment of Chemistry, Functional Materials, Technische Universität Berlin, Hardenbergstraße 40, 10623 Berlin, Germany

^dInstitute of Chemistry, University of Potsdam, Karl-Liebknecht-Strasse 24–25, 14476 Potsdam, Germany

^eDepartment of Chemistry, University of Illinois Urbana-Champaign, Urbana, Illinois, 61801 USA

^fDepartment of Physics, Freie Universität Berlin, Arnimallee 22, 14195 Berlin, Germany

^gHelmholtz Zentrum Berlin für Materialien und Energie GmbH, Hahn-Meitner-Platz 1, 14109 Berlin, Germany

View abstract

A practical flow synthesis of 1,2,3-triazoles

Dawid Drelinkiewicz^a, Richard J. Whitby^a

^aSchool of Chemistry, Faculty of Engineering and Physical Sciences, The University of Southampton, Southampton, UK

View abstract

A simple one-pot oxidation protocol for the synthesis of dehydrohedione from Hedione

James S. Sharley^a, Guido Gambacorta^a, Ana María Collado Pérez^b, Estela Espinos Ferri^b, Amadeo Fernandez Miranda^b, Isabelle Fernández Fernández^b, Jorge Sanchez Quesada^b, Ian R.Baxendale^a

^aDepartment of Chemistry, University of Durham, South Road, Durham, DH1 3LE, United Kingdom

^bInternational Flavours & Fragrances Inc., Avda Felipe Klein 2, 12580, Benicarló, Castellón, Spain

View abstract

Self-healing and polymer welding of soft and stiff epoxy thermosets via silanolates

Amelia A. Putnam-Neeb^a, Jordan M. Kaiser^a,b, Amber M. Hubbard^a, Dayton P. Street^a, Matthew B. Dickerson^a, Dhriti Nepal^a, Luke A. Baldwin^a

^aAir Force Research Laboratory, Wright Patterson Air Force Base, Dayton, OH, 45433, USA

^bUES, Inc, Dayton, OH, 45432, USA

View abstract

Multicomponent Direct Assembly of N-Heterospirocycles Facilitated by Visible-Light-Driven Photocatalysis

Oliver M. Griffiths^a, Steven V. Ley^a

^aYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.

View abstract

Scalable synthesis of favipiravir via conventional and continuous flow chemistry

Thanat Tiyasakulchai^a, Netnapa Charoensetakul^a, Thitiphong Khamkhenshorngphanuch^b, Chawanee Thongpanchanga^a, Onsiri Srikun^c, Yongyuth Yuthavong^a, Nitipol Srimongkolpithak^a

^aNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand

^bDepartment of General Education, Faculty of Science and Health Technology, Navamindradhiraj University, Bangkok, Thailand

^cGovernment Pharmaceutical Organization (GPO), Bangkok, Thailand

View abstract

Merging dual photoredox/cobalt catalysis and boronic acid (derivatives) activation for the Minisci reaction

Serena Pillitteri^a, Prabhat Ranjan^b, Gerardo M. Ojeda-Carralero^a,c, Laura Y. Vázquez Amaya^a, Javier E. Alfonso-Ramos^d, Erik V. Van der Eycken^a,e, Upendra K. Sharma^a

^aLaboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001 Leuven, Belgium

^bAachen Maastricht Institute for Biobased Materials (AMIBM), Maastricht University, Urmonderbaan 22, 6167 RD Geleen, The Netherlands

^cDepartment of General and Inorganic Chemistry, Faculty of Chemistry, University of Havana, Zapata y G, Havana 10400, Cuba

^dLaboratory of Computational and Theoretical Chemistry, Faculty of Chemistry, University of Havana, Zapata y G, Havana 10400, Cuba

^ePeoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya street 6, 117198 Moscow, Russia

View abstract

The Merger of Benzophenone HAT Photocatalysis and Silyl Radical-Induced XAT Enables Both Nickel-Catalyzed Cross-Electrophile Coupling and 1,2-Dicarbofunctionalization of Olefins

Alberto Luridiana^a, Daniele Mazzarella^a, Luca Capaldo^a, Juan A. Rincón^b, Pablo García-Losada^b, Carlos Mateos^b, Michael O. Frederick^c, Manuel Nuño^d, Wybren Jan Buma^e and Timothy Noël^a

^aFlow Chemistry Group, Van’t Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands

^bCentro de Investigación Lilly S.A., Avda. de la Industria 30, Alcobendas-Madrid 28108, Spain

^cSmall Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana 46285, United States

^dVapourtec Ltd. Park Farm Business Centre, Fornham St Genevieve, Bury St Edmunds, Suffolk IP28 6TS, U.K.

^eMolecular Photonics, Van’t Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands

View abstract

Taming photocatalysis in flow: easy and speedy preparation of α-aminoamide derivatives

Ricardo I. Rodríguez^a, Marina Sicignano^a, Montaña J. García^a, Rodrigo G. Enríquez^a, Silvia Cabrera^b,c, José Alemán^a,c,d

^aOrganic Chemistry Department, Science Faculty, Universidad Autónoma de Madrid, Madrid-28049, Spain

^bInorganic Chemistry Department, Science Faculty, Universidad Autónoma de Madrid, Madrid-28049, Spain

^cInstitute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, 28049 Madrid, Spain

^dCenter for Innovation in Advanced Chemistry (ORFEO-CINQA), Universidad Autónoma de Madrid, Spain

View abstract

Synthesis of CTA and DNAN using flow chemistry

Ankit Kumar Mittal^a, Gaurav Prakash^a, Pramod Pathak^a, Debabrata Maiti^a

^aIndian Institute of Technology Bombay, Department of Chemistry, Mumbai, INDIA

View abstract

Flow synthesis of photocatalytic semiconductor–metal hybrid nanocrystals

Tal Cohen^a,b, Nir Waiskopf^a,b, Adar Levi^a,b, David Stone^a,b, Sergei Remennik^b, Uri Banin^a,b

^aThe Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

^bThe Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

View abstract

Taylor-vortex membrane reactor for continuous gas-liquid reactions

Baldassarre Venezia^a, David C. Morris^b, Asterios Gavriilidis^a

^aDepartment of Chemical Engineering, University College London, Torrington Place, London, UK

^bAutichem Ltd, Unit 4, Gatewarth Industrial Estate Barnard Street Warrington WA5 1DD

View abstract

Statistical optimization modeling of organic dye photodegradation process using slag nanocomposite

Kingsley Safo^a, Hussien Noby^a,b, Mitsuhara Matatoshi^c, Hiroshi Naragino^c, Ahmed H. El-Shazly^a,d

^aDepartment of Chemical and Petrochemicals Engineering, Egypt-Japan University of Science and Technology, New Borg Al-Arab City, Alexandria, Egypt

^bMaterials Engineering and Design, Faculty of Energy Engineering, Aswan University, Aswan, Egypt

^cInterdisciplinary Graduate School of Engineering Sciences, Kyushu University, 6-1 Kasuga Kouen, Kasuga, Fukuoka, 816-8580, Japan

^dDepartment of Chemical Engineering, Faculty of Engineering, Alexandria University, Alexandria, Egypt

View abstract

4,7-Diarylbenzo[c][1,2,5]thiadiazoles as fluorophores and visible light organophotocatalysts

Dominic Taylor^a, Thomas Malcomson^b, Adilet Zhakeyev^c, Shengxian Cheng^d, Georgina M. Rosair^a, Jose Marques-Hueso^c, Zhengtao Xu^e, Martin J. Paterson^a, Scott J. Dalgarno^a, Filipe Vilela^a

^aInstitute of Chemical Sciences, School of Engineering and Physical Science, Heriot-Watt University, Riccarton, Edinburgh EH14 4AS, UK.

^bDepartment of Chemistry, Lancaster University, Lancaster, LA1 4YB, UK

^cInstitute of Sensors, Signals and Systems, School of Engineering and Physical Science, Heriot-Watt University, Riccarton, Edinburgh EH14 4AS, UK

^dDepartment of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong

^eInstitute of Materials Research and Engineering (IMRE), Agency of Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis, Singapore 138634

View abstract

Recent advances in chemical fixation of CO2 based on flow chemistry

Hui Luo^a, Jing Ren^a, Ying Sun^a, Yunlin Liu^b, Feng Zhou^a,c, Guoyue Shi^a, Jian Zhou^a,d

^aSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China

^bSchool of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou, 510006, China

^cInstitute of Eco-Chongming, Shanghai 202162, China

^dState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China

View abstract

Kinetics and hydrodynamics of Candida antartica lipase-catalyzed synthesis of glycerol dioleate (GDO) in a continuous flow packed-bed millireactor

Nurul Nadiah Abd Razak^a,b, Patrick Cognet^b, Yolande Pérès^b, Lai Ti Gew^a,e

^aDepartment of Biological Sciences, School of Medical and Life Sciences, Sunway University, Petaling Jaya, Selangor, 47500, Malaysia

^bLaboratoire de Génie Chimique, Université de Toulouse, CNRS, INPT, UPS, Toulouse, 31423, France

^cCentre for Carbon Dioxide Capture and Utilization (CCDCU), School of Engineering and Technology, Sunway University, Petaling Jaya, Selangor, 47500, Malaysia

^dDepartment of Engineering, Lancaster University, Lancaster, LA1 4YW, United Kingdom

^eSunway Materials Smart Science & Engineering (SMS2E) Cluster, Sunway University, Petaling Jaya, Selangor, 47500, Malaysia

View abstract

Microfluidic Asymmetrical Synthesis and Chiral Analysis

Konstantin A.Kochetkov^a, Nataliya A.Bystrova^a, Pavel A.Pavlov^b, Maxim S.Oshchepkov^b, Aleksandr S.Oshchepkov^c

^aNesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Moscow 119991, Russia

^bMendeleev University of Chemical Technology of Russia, Miusskaya pl. 9, Moscow 125047, Russia

^cMax Planck Institute for the Science of Light, Department of Physics, D-91058 Erlangen, Germany

View abstract

Evaluation of unexpected protecting group removal in solid-phase peptide synthesis: Quantified using continuous flow methods

Victoire Laude^a, Manuel Nuño^a, Roger C. Moses^a, Duncan Guthrie^a

^aVapourtec Ltd, Bury Saint Edmunds, UK

View abstract

Synthesis of Benzothiazinones from Benzoyl Thiocarbamates: Application to Clinical Candidates for Tuberculosis Treatment

William Connors^a, Ryan DeKorte^a, Simon C. C. Lucas^b, Ariamala Gopalsamy^b, Robert E Ziegler^a

^aAstraZeneca Pharmaceuticals LP, Medicinal Chemistry, United States

^bAstraZeneca Pharmaceuticals LP, Hit Discovery, United Kingdom

View abstract

Synthesis of new heterocyclic resveratrol analogues in milli- and microreactors: intensification of the Wittig reaction

Milena Mlakić^a, Lucija Rajič^a,b, Anabela Ljubić^b, Vitomir Vušak^b, Bruno Zelić^c,d, Martin Gojun^c, Ilijana Odak^e, Ivona Čule^e, Ivana Šagud^b, Anita Šalić^c, Irena Škorić^a

^aDepartment of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, HR-10 000, Zagreb, Croatia

^bPliva R&D, Teva Pharmaceutical Industries Ltd, Prilaz baruna Filipovića 29, HR-10 000, Zagreb, Croatia

^cDepartment of Reaction Engineering and Catalysis, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, HR-10 000, Zagreb, Croatia

^dDepartment of Packaging, Recycling and Environmental Protection, University North, Trg dr. Žarka Dolinara 1, HR-48 000, Koprivnica, Croatia

^eDepartment of Chemistry, Faculty of Science and Education, University of Mostar, Matice hrvatske bb, 88 000, Mostar, Bosnia and Herzegovina

View abstract

Multistep Continuous Flow Synthesis of Isolable NH2‐Sulfinamidines via Nucleophilic Addition to Transient Sulfurdiimide

Michael Andresini^a, Sebastien Carret^b, Leonardo Degennaro^a, Fulvio Ciriaco^a, Jean-François Poisson^b, Renzo Luisi^a

^aUniversity of Bari: Universita degli Studi di Bari Aldo Moro, Pharmacy - Drug Sciences, Via E. Orabona,4, 70125 Bari, ITALY

^bUniversite Grenoble Alpes, Chemistry, rue de la chimie, 38000 Grenoble, FRANCE

View abstract

A multi-step continuous flow synthesis of pomalidomide

Maria Ivanova^a, Julien Legros^a, Thomas Poisson^a,b, Philippe Jubault^a

^aNormandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA, 76000, Rouen, France

^bInstitut Universitaire de France, Paris, France

View abstract

Continuous Flow Preparation of Benzylic Sodium Organometallics

Johannes H. Harenberg^a, Dr. Rajasekar Reddy Annapureddy^a, Prof. Dr. Konstantin Karaghiosoff^a, Prof. Dr. Paul Knochel^a

^aDepartment Chemie, Ludwig-Maximilians-Universität München, Butenandtstraße 5–13, Haus F, 81377 München, Germany

View abstract

Flow Chemistry Opportunities for Drug Discovery

María Lourdes Linares^a, Enol López^b, Eduardo Palao^a, Jesús Alcázar^a

^aJanssen Research and Development, Janssen-Cilag, S.A., Discovery Chemistry, C/ Jarama, 75, 45007 Toledo Spain

^bUniversidad de Castilla-La Mancha, Facultad de Ciencias y Tecnologías Químicas, Av. Camilo José Cela, 14, 13005 Ciudad Real Spain

View abstract

Innovative Process Development of Pharmaceutical Intermediates Under Continuous-Flow System

Koji Machida^a, Hiroaki Yasukouchi^a

^aPharma & Supplemental Nutrition Solutions Vehicle, Kaneka Corporation, Pharma Business Division Research Group, 1-8 Miyamae-cho, Takasago-cho, Takasago, Hyogo, 676-8688 Japan

View abstract

Flow Chemistry in Medicinal Chemistry: Applications to Bcr – Abl Kinase Inhibitors

Paul Richardson^a

^aPfizer-La Jolla, Medicine Design, 10770 Science Center Drive, La Jolla, CA, 92121 USA

View abstract

Flow Chemistry at the Extremes: Turning Complex Reactions into Scalable Processes

Andrew R. Bogdan^a

^aAbbVie, Inc., Drug Discovery Science and Technology, 1 North Waukegan Rd, North Chicago, IL, 60064 USA

View abstract

Application of Continuous-Flow Processing in Multistep API and Drug Syntheses

Faith M. Akwi^a, Paul Watts^a

^aNelson Mandela University, Faculty of Science, Department of Chemistry, University Way, Port Elizabeth, 6031 South Africa

View abstract

Heterogeneous metallaphotoredox catalysis in a continuous-flow packed bed reactor

Wei-Hsin Hsu^a,b, Susanne Reischauer^a,b, Peter H Seeberger^a,b, Bartholomäus Pieber^a, Dario Cambié^a

^aMax Planck Institute of Colloids and Interfaces, Biomolecular Systems Department, Am Mühlenberg 1, 14476 Potsdam, Germany

^bFreie Universität Berlin, Institute for Chemistry and Biochemistry, Arnimallee 22, 14195 Berlin, Germany

View abstract

An Overview on the Production of Biodiesel Enabled by Continuous Flow Methodologies

Claudia Carlucci^a

^aCNR-Institute of Nanotechnology (CNR-NANOTEC), c/o Campus Ecotekne, Via Monteroni, 73100 Lecce, Italy

View abstract

Continuous flow synthesis of azobenzenes via Baeyer–Mills reaction

Jan H. Griwatz^a,b, Anne Kunz^a,b, Hermann A. Wegner^a,b

^aInstitute of Organic Chemistry, Justus Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany

^bCenter for Material Research (ZfM/LaMa), Justus Liebig University, Heinrich-Buff-Ring 16, 35392 Giessen, Germany

View abstract

Synthesis of 2,4,6-Trisubstituted Pyrimidines via Iron-Catalyzed Homocoupling of α,β-Unsaturated Ketoximes

Kai Guo^a, Gaochen Xu^a, Xuemei Wang^a, Chenglong Jia^a, Huan Yan^a, Sai Zhang^a, Qinghuan Wu^a, Ning Zhu^a, Zheng Fang^a, Jindian Duan^a

^aCollege of Biotechnology and Pharmaceutical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University,30 Puzhu Rd S., Nanjing 211816, China

View abstract

Continuous Processing of Concentrated Organolithiums in Flow Using Static and Dynamic Spinning Disc Reactor Technologies

Ulrich Wietelmann^a, Johannes Klösener^a, Peter Rittmeyer^a, Stefan Schnippering^a, Henk Bats^b, Wouter Stam^b

^aAlbemarle Germany GmbH, Industrial Park Hoechst, D-65926 Frankfurt am Main, Germany

^bFlowid, Achtseweg Zuid 157C, NL-5651 GW Eindhoven, The Netherlands

View abstract

Process Intensive Synthesis of Propofol Enabled by Continuous Flow Chemistry

Laurent Vinet^a, Lorenzo Di Marco^a, Vanessa Kairouz^a, André B. Charette^a

^aCentre in Green Chemistry and Catalysis, Center for Continuous Flow Synthesis, Department of Chemistry, Université de Montréal, 1375, av. Thérèse Lavoie-Roux, Montréal, Québec H2V 0B3, Canada

View abstract

Immobilized Eosin Y for the photocatalytic oxidation of tetrahydroisoquinolines in flow

Fabian Herbrik^a,b, Sergio Rossi^a, Miguel Sanz^b, Alessandra Puglisi^a, Maurizio Benaglia^a

^aDipartimento di Chimica, Università degli Studi di Milano, Via Camillo Golgi 19, 20133 Milano, Italy

^bTaros Chemicals GmbH & Co. KG, Emil-Figge-Strasse 76A, 44227 Dortmund, Germany

View abstract

Sn-Catalyzed Criegee-Type Rearrangement of Peroxyoxindoles Enabled by Catalytic Dual Activation of Esters and Peroxides

Moreshwar B. Chaudhari^a, Krishna Jayan^a, Boopathy Gnanaprakasam^a

^aDepartment of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India

View abstract

The Ugly Duckling Metamorphosis: The Ammonia/Formaldehyde Couple Made Possible in Ugi Reactions.

Thaissa Pasquali F. Rosalba^a, Samia Sayegh A. Kas^a, Ana Beatriz S. Sampaio^a, Dr. Carlos Eduardo M. Salvador^a, Dr. Carlos Kleber Z. Andrade^a

^aInstituto de Química, Laboratório de Química Metodológica e Orgânica Sintética (LaQMOS), Universidade de Brasília, Campus Universitário, Asa Norte, 70904-970 Brasília, Brasil

View abstract

Continuous-Flow Hofmann Rearrangement Using Trichloroisocyanuric Acid for the Preparation of 2-Benzoxazolinone

Guido Gambacorta^a, Ian R. Baxendale^a

^a Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, U.K.

View abstract

Boosting the Productivity of H2-Driven Biocatalysis in a Commercial Hydrogenation Flow Reactor Using H2 From Water Electrolysis

Barnabas Poznansky^a, Sarah E. Cleary^a, Lisa A. Thompson^a, Holly A. Reeve^a, Kylie A. Vincent*^a

^aInorganic Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom

View abstract

Continuous flow heterogeneous catalytic reductive aminations under aqueous micellar conditions enabled by an oscillatory plug flow reactor

Michaela Wernik^a,b, Gellért Sipos^c,d, Balázs Buchholcz^e, Ferenc Darvas^c,d, Zoltán Novák^f, Sándor B. Ötvös^a,b, C. Oliver Kappe^a,b

^aInstitute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz, Austria

^bCenter for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, A-8010 Graz, Austria

^cThalesNano Inc., Záhony u. 7, 1031 Budapest, Hungary

^dComInnex Inc., Záhony u. 7, 1031 Budapest, Hungary

^eInnostudio Inc., Záhony u. 7, 1031 Budapest, Hungary

^fELTE “Lendület” Catalysis and Organic Synthesis Research Group, Faculty of Science, Institute of Chemistry, Eötvös Loránd University, Pázmány Péter stny. 1/a, 1117 Budapest, Hungary

View abstract

Continuous flow processing of bismuth-photocatalyzed atom transfer radical addition reactions using an oscillatory flow reactor

Pauline Bianchi^a, Jason D. Williams^a,b, C. Oliver Kappe^a,b

^aInstitute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010 Graz, Austria

^bCenter for Continuous Flow Synthesis and Processing (CC FLOW), Research Center Pharmaceutical Engineering (RCPE), Inffeldgasse 13, 8010 Graz, Austria

View abstract

Automated Chemical Solid-Phase Synthesis of Glycans

Xiaona Li^a, You Yang^a

^aShanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237 China

View abstract

Cutting edge of diphenyl phosphorazidate (DPPA) as a synthetic reagent–A fifty-year odyssey

Takayuki Shioiri^a, Kotaro Ishihara^a, Masato Matsugi^a

^aFaculty of Agriculture, Meijo University, Shiogamaguchi, Tempaku, Nagoya 468-8502, Japan

View abstract

Cobalt-electrocatalytic HAT for functionalization of unsaturated C–C bonds

Samer Gnaim^a, Adriano Bauer^a, Hai-Jun Zhang^a, Longrui Chen^a, Cara Gannett^b, Christian A. Malapit^c, David E. Hill^d, David Vogt^c, Tianhua Tang^c, Ryan A. Daley^a, Wei Hao^a, Rui Zeng^b, Mathilde Quertenmont^e, Wesley D. Beck^c, Elya Kandahari^d, Julien C. Vantourout^a, Pierre-Georges Echeverria^e, Hector D. Abruna^b, Donna G. Blackmond^a, Shelley D. Minteer^c, Sarah E. Reisman^d, Matthew S. Sigman^c & Phil S. Baran^a

^aDepartment of Chemistry, The Scripps Research Institute (TSRI), La Jolla, CA, USA

^bDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA

^cDepartment of Chemistry, University of Utah, Salt Lake City, UT, USA

^dThe Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA

^eMinakem Recherche, Beuvry-la-Forêt, France

View abstract

Total Synthesis of Phytotoxic Radulanin A Facilitated by the Photochemical Ring Expansion of a 2,2-Dimethylchromene in Flow

Bruce Lockett-Walters^a, Simon Thuillier^a,b, Emmanuel Baudouin^b, Bastien Nay*^a

^aLaboratoire de Synthèse Organique, Ecole Polytechnique, CNRS, Institut Polytechnique de Paris, 91128 Palaiseau, France

^bInstitut de Biologie Paris-Seine (IBPS), Laboratoire de Biologie du Développement, Sorbonne Université, CNRS, UMR7622, F-75005 Paris, France

View abstract

Practical Ferrioxalate Actinometry for the Determination of Photon Fluxes in Production-Oriented Photoflow Reactors

Bavo Vandekerckhove^a, Nicola Piens^b, Bert Metten^b, Christian V. Stevens^a, Thomas S. A. Heugebaert*^a

^aSynBioC Research Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium

^bAjinomoto Bio-Pharma Services, Cooppallaan 91, 9230 Wetteren, Belgium

View abstract

Continuous Flow Technology as an Enabler for Innovative Transformations Exploiting Carbenes, Nitrenes, and Benzynes

Kian Donnelly^a, Marcus Baumann^a

^aSchool of Chemistry, Science Centre South, University College Dublin, D04 N2E2 Dublin, Ireland

View abstract

Online reaction monitoring with fast and flow-compatible diffusion NMR spectroscopy

Achille Marchand^a, Rituraj Mishra^a, Aurélie Bernard^a, Jean-Nicolas Dumez^a

^aUniversité,CNRS, CEISAM UMR6230,F-44000 Nantes, France

View abstract

Analytical Tools Integrated in Continuous-Flow Reactors: Which One for What?

Mireia Rodriguez-Zubiri^a, François-Xavier Felpin^a

^aNantes Université, CNRS, CEISAM, UMR 6230, F-44000 Nantes, France

View abstract

Development of a palladium-catalyzed decarboxylative arene cross-coupling of pyrrole derivatives in a flow reactor

Cindy Buonomano^a,b, Michael Holtz-Mulholland^a,b, Sydney Sullivan^a,b, Pat Forgione^a,b

^aDepartment of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke O, Montréal, QC, H4B 1R6, Canada

^bCentre in Green Chemistry and Catalysis, Montréal, QC, H3C 3J7, Canada

View abstract

Continuous synthesis of benzaldehyde by ozonolysis of styrene in a micro-packed bed reactor

Fengyan Lou^a,b,c, Qiang Cao^a, Chenghao Zhang^a, Ning Ai^c, Qining Wang^b, Jisong Zhang^a

^aThe State Key Lab of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, 100084, Beijing, China

^bCollege of Chemical Engineering, Zhejiang University of Technology, 310014, Hangzhou, Zhejiang, China

^cCollege of Biological, Chemical Science and Engineering, Jiaxing University, 314001, Jiaxing, Zhejiang, China

View abstract

α-Amino Radical Halogen Atom Transfer Agents for Metallaphotoredox Catalyzed Cross-Electrophile Couplings of Distinct Organic Halides

Xianhai Tian^a, Jaspreet Kaur^a, Shahboz Yakubov^a, Joshua P. Barham^a

^aInstitute of Organic Chemistry, University of Regensburg Universitätsstr. 31, 93053 Regensburg (Germany)

View abstract

Enzymatic continuous-flow preparation of nature-inspired phenolic esters as antiradical and antimicrobial agents

Francesca Annunziata^a, Martina L.Contente^b, Valentina Anzi^a, Silvia Donzella^b, Paola Conti^a, Francesco Molinari^b, Piera Anna Martino^c, Gabriele Meroni^c, Valerio Massimo Sora^c, Lucia Tamborini^a, Andrea Pinto^b

^aDepartment of Pharmaceutical Sciences (DISFARM), University of Milan, via Mangiagalli 25, 20133 Milan, Italy

^bDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, Italy

^cDepartment of Biomedical, Surgical and Dental Sciences (DSBCO), One Health Unit, University of Milan, via Pascal 36, 20133 Milan, Italy

View abstract

Integration of Liquid–Liquid Biphasic Flow Alkylation and Continuous Crystallization Using Taylor Vortex Flow Reactors

Masahiro Hosoya^a, Masashi Tanaka^a, Atsushi Manaka^a, Shogo Nishijima^a, Naoki Tsuno^a

^a API R&D Laboratory, CMC R&D Division, Shionogi and Company Ltd., 1-3, Kuise Terajima 2-chome, Amagasaki, Hyogo 660-0813, Japan

View abstract

Cutting edge of diphenyl phosphorazidate (DPPA) as a synthetic reagent – A fifty-year odyssey

Takayuki Shioiri^a, Kotaro Ishihara^a, and Masato Matsugi^a

^aFaculty of Agriculture, Meijo University, Shiogamaguchi, Tempaku, Nagoya 468- 8502, Japan

View abstract

Total synthesis of phytotoxic radulanin A facilitated by the photochemical ring expansion of a 2,2-dimethylchromene in flow

Bruce Lockett-Walters¹, Simon Thuillier^1,2, Emmanuel Baudouin², Bastien Nay*¹

¹Laboratoire de Synthèse Organique, Ecole Polytechnique, CNRS, Institut Polytechnique de Paris, 91128 Palaiseau, France

²Sorbonne Université, CNRS, Institut de Biologie Paris-Seine (IBPS), Laboratoire de Biologie du Développement, UMR7622, F-75005, Paris, France

View abstract

An environmentally benign and high-rate Appel type reaction

Nicolas Mattias Del Rio Fuenzalida^a, Eirin Alme^a, Frida Johanne Lundevall^a, Hans-René Bjørsvik^a

^aDepartment of Chemistry, University of Bergen, Allégaten 41, 5007 Bergen, Norway

View abstract

Selective Photochemical Continuous Flow Benzylic Monochlorination

Robbie Radjagobalou^a, Miguel Imbratta^b, Julie Bergraser^b, Marion Gaudeau^b, Gildas Lyvinec^b, Dominique Delbrayelle^b, Olivier Jentzer^b, Jérémy Roudin^a, Benjamin Laroche^a, Stéphanie Ognier^a, Michael Tatoulian^a, Janine Cossy^a, Pierre-Georges Echeverria^b

^aParis FLOW Tech − PSL, ENSCP, 11 rue Pierre et Marie Curie, Paris 75005, France

^bMinakem Recherche, 145 Chemin des Lilas, Beuvry-La-Forêt 59310, France

View abstract

Continuous flow process for preparing budesonide

Manjinder Singh Phull^a,b, Surender Singh Jadav^c,d, Chander Singh Bohara^b, Rambabu Gundla^a, Prathama S Mainkar^c,d

^aDepartment of Chemistry, School of Science, GITAM (Deemed to Be University), Hyderabad, Telangana, 502329, India

^bCipla Limited Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai, 400013, India

^cDepartment of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India

^dAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

View abstract

Chemical Recycling of Polystyrene to Valuable Chemicals via Selective Acid-Catalyzed Aerobic Oxidation under Visible Light

Zhiliang Huang^a, Muralidharan Shanmugam^b, Zhao Liu^c, Adam Brookfield^b, Elliot L. Bennett^a, Renpeng Guan^a, David E. Vega Herrera^a, Jose A. Lopez-Sanchez^a, Anna G. Slater^a, Eric J. L. McInnes^b, Xiaotian Qi*^c, Jianliang Xiao^a

^aDepartment of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K.

^bDepartment of Chemistry and Photon Science Institute, The University of Manchester, Manchester M13 9PL, U.K.

^cEngineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China

View abstract

Sustainable Synthesis of Noroxymorphone via a Key Electrochemical N-Demethylation Step

Florian Sommer^a,b, Roman Gerber Aeschbacher^c, Urs Thurnheer^c, C. Oliver Kappe^a,b, David Cantillo^a,b

^aInstitute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010, Graz, Austria

^bCenter for Continuous Flow Synthesis and Processing (CCFLOW), Research Center, Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria.

^bAZAD Pharma AG, Durachweg 15, CH-8200 Schaffhausen, Switzerland

View abstract

Photocatalytic Approach to α,α-Difluoroalkyl Alcohols

Georgii Kachkovskyi^a, Marcin Cieślak^a, Piotr Graczyk^a, Przemysław Zawadzki^a, Justyna Kalinowska-Tłuścik^b, Mateusz Werłos^a,b

^aSelvita SA., Bobrzyńskiego 14, 30-348 Kraków, Poland

^bFaculty of Chemistry Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland

View abstract

Spheroplasts preparation boosts the catalytic potential of a terpene cyclase

Ana I. Benítez-Mateos¹, Andreas Schneider², Eimear Hegarty¹, Bernhard Hauer², Francesca Paradisi¹

¹ Department of Chemistry, Biochemistry and Pharmaceutical Sciences. University of Bern Freiestrasse 3, 3012 Bern (Switzerland)

²Institute of Biochemistry and Technical Biochemistry, University of Stuttgart Allmandring 31, 70569 Stuttgart-Vaihingen (Germany)

View abstract

Scale-Up of Diazonium Salts and Azides in a Three-Step Continuous Flow Sequence

Hansjoerg Lehmann^a, Thomas Ruppen^a, Thomas Knoepfel^a

^aGlobal Discovery Chemistry, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland

View abstract

Quantitative and convenient real-time reaction monitoring using stopped-flow benchtop NMR

Tristan Maschmeyer^a, Lars P. E. Yunker^a, Jason E. Hein^a

^aDepartment of Chemistry, The University of British Columbia, Vancouver, BC V6T 1Z1, Canada

View abstract

Amino Alcohols as Potential Antibiotic and Antifungal Leads

Jennifer R. Baker¹, Peter J. Cossar¹, Mark A. T. Blaskovich², Alysha G. Elliott², Johannes Zuegg², Matthew A. Cooper², Peter J. Lewis^3,4, Adam McCluskey¹

¹Chemistry, School of Environmental & Life Sciences, The University of Newcastle, University Drive Callaghan, Newcastle, NSW 2308, Australia

²Community for Open Antimicrobial Drug Discovery, Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia

³Biology, School of Environmental & Life Sciences, The University of Newcastle, University Drive Callaghan, Newcastle, NSW 2308, Australia

⁴Molecular Horizons, School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia

View abstract

Continuous-Flow Synthesis of Alkyl Zinc Sulfinates for the Direct Photofunctionalization of Heterocycles

José Luis Nova-Fernández^a,b, Montaña J. García^a, Leonardo Mollari^a, Gustavo Pascual-Coca^b, Silvia Cabrera^c,d,e, José Alemána^d,e

^aOrganic Chemistry Department, M1, Universidad Autónoma de Madrid, 28049, Madrid, Spain.

^bSynthelia Organics Labs, C/ Faraday, 7, Labs 2.05 and 0.03, Parque Científico de Madrid, 28049, Madrid, Spain.

^cInorganic Chemistry Department, M7, Universidad Autónoma de Madrid, 28049, Madrid, Spain.

^dInstitute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, 28049, Madrid, Spain.

^eCenter for Innovation in Advanced Chemistry (ORFEO-CINQA), Universidad Autónoma de Madrid.

View abstract

Continuous flow Meerwein–Ponndorf–Verley reduction of HMF and furfural using basic zirconium carbonate

Henrique Magri Marçon^a, Julio Cezar Pastre^a

^aInstitute of Chemistry, University of Campinas – UNICAMP, PO Box 6154, Zip Code 13083-970, Campinas, SP, Brazil

View abstract

“Green Is the Color”: An Update on Ecofriendly Aspects of Organoselenium Chemistry

Juliano B. Azeredo¹, Filipe Penteado², Vanessa Nascimento³, Luca Sancineto⁴, Antonio L. Braga⁵, Eder João Lenardao², Claudio Santi⁴

¹Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pampa, Uruguaiana, Uruguaiana 97501-970, RS, Brazil

²Laboratório de Síntese Orgânica Limpa-LaSOL-CCQFA, Universidade Federal de Pelotas-UFPel, P.O. Box 354, Pelotas 96010-900, RS, Brazil

³Laboratório SupraSelen, Departamento de Química Orgânica, Instituto de Química, Campus do Valonguinho, Universidade Federal Fluminense, Niteroi 24020-150, RJ, Brazil

⁴Group of Catalysis Synthesis and Organic Green Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06100 Perugia, Italy

⁵Departamento de Química, Universidade Federal de Santa Catarina—UFSC, Florianopolis 88040-900, SC, Brazil

View abstract

An electrochemical γ-C–H arylation of amines in continuous flow

José A.Forni^a, Milena L.Czyz^a, David W.Lupton^b, Anastasios Polyzos^a,c

^aSchool of Chemistry, The University of Melbourne, Parkville 3010, Victoria, Australia

^bSchool of Chemistry, Monash University, Clayton 3800, Victoria, Australia

^cCSIRO Manufacturing, Research Way, Clayton VIC 3168, Australia

View abstract

Chip-Scale Solar-Thermal-Electrical Power Generation

Zhihang Wang¹, Zhenhua Wu², Zhiyu Hu², Jessica Orrego-Hernandez¹, Erzhen Mu³, Zhao-Yang Zhang⁴, Martyn Jevric¹, Yang Liu², Xuecheng Fu⁵, Fengdan Wang⁵, Tao Li⁴, Kasper Moth-Poulsen¹

¹Chalmers University of Technology - Department of Chemistry and Chemical Engineering

²Shanghai Jiao Tong University (SJTU) - National Key Laboratory of Science and Technology on Micro/Nano Fabrication

³Henan Polytechnic University - School of Materials Science and Engineering

⁴Shanghai Jiao Tong University (SJTU) - Shanghai Key Laboratory of Electrical Insulation and Thermal Aging

⁵Shanghai Jiao Tong University (SJTU) - Center for Advanced Electronic, Materials and Devices (AEMD)

View abstract

A continuous-flow protocol for photoredox-catalyzed multicomponent Petasis reaction

Monica Oliva¹, Frederick Martens¹, Erik V.Van der Eycken^1,2, Upendra Kumar Sharma¹

¹Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium

²Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya street 6, Moscow 117198, Russia

View abstract

Continuous-Flow Preparation of Benzotropolones: Combined Batch and Flow Synthesis of Epigenetic Modulators of the (JmjC)-Containing Domain

Dr. José A. Souto^a

^aDepartamento de Química Orgánica, Facultade de Química, Centro de Investigacións Biomédicas (CINBIO) and IIS Galicia Sur., Universidade de Vigo, 36310 Vigo, Spain

View abstract

Continuous flow synthesis of Celecoxib from 2-bromo-3,3,3-trifluoropropene

Maria Ivanova¹, Julien Legros¹, Thomas Poisson^1,2, Philippe Jubault¹

¹INSA Rouen, CNRS, UNIROUEN, COBRA, Normandie Univ, 76000 Rouen, France

²Institut Universitaire de France, 1 Rue Descartes, 75231 Paris, France

View abstract

Scalable Synthesis of Norbornadienes via in situ Cracking of Dicyclopentadiene Using Continuous Flow Chemistry

Jessica Orrego-Hernández^[a], Helen Hölzel^[a], Maria Quant^[a], Zhihang Wang^[a], KasperMoth-Poulsen^[a]

^[a]Departmentof Chemistry and Chemical Engineering, Chalmers University of Technology, Kemigården4, 412 96 Gothenburg, Sweden

View abstract

Photoredox Iridium–Nickel Dual Catalyzed Cross-Electrophile Coupling: From a Batch to a Continuous Stirred-Tank Reactor via an Automated Segmented Flow Reactor

Rohit Duvadie^a, Alexander Pomberger^b, Yiming Mo^b, Erhan I. Altinoglu^c, Hsiao-Wu Hsieh^a, Kakasaheb Y. Nandiwale^a, Victor L. Schultz^b, Klavs F. Jensen^b, Richard I. Robinson^a

^aGlobal Discovery Chemistry, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

^bDepartment of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

^cChemical and Pharmaceutical Profiling, Novartis Global Drug Development, 700 Main Street South, Cambridge, Massachusetts 02139, United States

View abstract

Optimizing the Performance of the Meso-Scale Continuous-Flow Photoreactor for Efficient Photocatalytic CO2 Reduction with Water Over Pt/TiO2/RGO Composites

Samar Nabil^a, Elsayed A. Shalaby^a, Marwa F. Elkady^b,c, Yoshihisa Matsushita^d, Ahmed H. El-Shazly^b,e

^aDepartment of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria, 21526, Egypt

^bChemical and Petrochemicals Engineering Department, Egypt-Japan University of Science and Technology, Alexandria, 21934, Egypt

^cFabrication Technology Department, Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications, Alexandria, Egypt

^dEgypt-Japan University of Science and Technology, 179 New Borg El‐Arab, Alexandria, 21934, Egypt

^eChemical Engineering Department, Faculty of Engineering, Alexandria University, Alexandria, 21544, Egypt

View abstract

From Platform to Knowledge Graph: Evolution of Laboratory Automation

Jiaru Bai^a, Liwei Cao^a, Sebastian Mosbach^a,b, Jethro Akroyd^a,b

^aDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, United Kingdom

^bCambridge Centre for Advanced Research and Education in Singapore (CARES), CREATE Tower #05-05, 1 Create Way, 138602 Singapore

^cCambridge Centre for Advanced Research and Education in Singapore (CARES), CREATE Tower #05-05, 1 Create Way, 138602 Singapore

^dThe Alan Turing Institute, London NW1 2DB, United Kingdom

View abstract

Continuous flow technology-a tool for safer oxidation chemistry

Li Wan^a, Meifen Jiang^a, Dang Cheng^a, Minjie Liu^a, Fener Chen^*ab

^aEngineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China

^bShanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China

View abstract

Continuous Flow Synthesis of a Blocked Polyisocyanate: Process Intensification, Reaction Monitoring Via In-Line FTIR Analysis, and Comparative Life Cycle Assessment

Gabriel Glotz^a,b, Katharina Waniek^a,c, Josef-Peter Schöggl^c, David Cantillo^a,b, Clemens Stueckler^d, Anton Arztd^{,
Andreas Gollner^d,
Rudolf Schipfer^d,
Rupert J. Baumgartner^c,
C. Oliver Kappe^a,b}

^aInstitute of Chemistry, NAWI Graz, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria

^bCenter for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria

^cChristian Doppler Laboratory for Sustainable Product Management, Institute of Systems Sciences, Innovation and Sustainability Research, University of Graz, Merangasse 18/I, 8010 Graz, Austria

^dAllnex Austria GmbH, Bundesstrasse 175, 8402 Werndorf, Austria

View abstract

Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

Cloudius R. Sagandira^a, Sinazo Nqeketo^a, Kanyisile Mhlana^a, Thembela Sonti^a, Sibongiseni Gaqa^a, Paul Watts^*a

^aNelson Mandela University, University Way, Port Elizabeth, South Africa

View abstract

Flow-Assisted Synthesis of Alkyl Citrate Natural Products

Nikolai Piers Rossouw^a, Mark A. Rizzacasa*^a, Anastasios Polyzos*^a,b

^aSchool of Chemistry, The University of Melbourne, Parkville 3010, Victoria, Australia

^bCSIRO Manufacturing, Research Way, Clayton 3168, Victoria, Australia

View abstract

Continuous Flow Acylation of (Hetero)aryllithiums with Polyfunctional N,N-Dimethylamides and Tetramethylurea in Toluene

Dimitrije Djukanovic^a, Benjamin Heinz^a, Dr. Francesca Mandrelli^b, Dr. Serena Mostarda^b, Dr. Paolo Filipponi^b, Dr. Benjamin Martin^b, Prof. Dr. Paul Knochel^a, , ^aDepartment Chemie, Ludwig-Maximilians-Universität München, Butenandtstraße 5–13, Haus F, 81377 Munich, Germany, ^bNovartis Pharma AG, Chemical Development Fabrikstraße, 4002 Basel, Switzerland
View abstract

In Situ Investigation of Multicomponent MOF Crystallization during Rapid Continuous Flow Synthesis

Brandon He^a,b, Lauren K. Macreadie^c,d, James Gardiner^b, Shane G. Telfer^d, Matthew R. Hill*^a,b

^aDepartment of Chemical Engineering, Monash University, Clayton, VIC 3800, Australia

^bCSIRO Private Bag 10, Clayton South, VIC 3169, Australia

^c,School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia

^dMacDiarmid Institute for Advanced Materials and Nanotechnology Institute of Fundamental Sciences, Massey University, Palmerston North 4442, New Zealand

View abstract

Automated Synthesis of Chondroitin Sulfate Oligosaccharides

Chien-Fu Liang^a, Heung Sik Hahm^a,b, Narayana Murthy Sabbavarapu, Peter H. Seeberger

^aDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany

^bDepartment of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany

View abstract

Biocatalyzed Synthesis of Vanillamides and Evaluation of Their Antimicrobial Activity

Cecilia Pinna¹, Piera Anna Martino², Gabriele Meroni², Valerio Massimo Sora², Lucia Tamborini³, Sabrina Dallavalle¹, Martina L. Contente*¹, Andrea Pinto¹

¹Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, Italy

²Department of Biomedical, Surgical and Dental Sciences (DSBCO), One Health Unit, University of Milan, via Pascal 36, 20133 Milan, Italy

³Department of Pharmaceutical Sciences (DISFARM), University of Milan, via Mangiagalli 25, 20133 Milan, Italy

View abstract

Multi-gram preparation of cinnamoyl tryptamines as skin whitening agents through a chemo-enzymatic flow process

David Roura Padrosa^a, Martina L. Contente^b

^aDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland

^bDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133, Milan, Italy

View abstract

Flow Chemistry as an Enabling Technology for Synthetic Organic Chemistry

Nicholas E. Leadbeater

Department of Chemistry, University of Connecticut, Storrs, USA

View abstract

Synthesis and chemical reactions of thieno[3,2-c]quinolines from arylamine derivatives, part (V): a review

Ameen A. Abu-Hashem^{a, b}, A. B. A. El-Gazzar^a, Ahmed A. M. Abdelgawad^{b, c}, Moustafa A. Gouda^{d, e}

^aPhotochemistry Department (Heterocyclic Unit), National Research Centre, Dokki, Giza, Egypt

^bChemistry Department, Faculty of Science, Jazan University, Jazan, Saudi Arabia

^cMedicinal and Aromatic Plants Department, Desert Research Center, Cairo, Egypt

^dDepartment of Chemistry, Faculty of Science and Arts, Taibah University, Ulla, Medina, Saudi Arabia

^eDepartment of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt

View abstract

From Platform to Knowledge Graph: Evolution of Laboratory Automation

Jiaru Bai¹, Liwei Cao¹, Sebastian Mosbach^{1, 2}, Jethro Akroyd^{1, 2}, Alexei A. Lapkin^{1, 2}, Markus Kraft^{1, 2, 3, 4}

¹Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge, CB3 0AS, United Kingdom

²CARES, Cambridge Centre for Advanced, Research and Education in Singapore, 1 Create Way, CREATE Tower, #05-05, Singapore, 138602

³School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459

⁴The Alan Turing Institute, London, NW1 2DB, United Kingdom

View abstract

Dimeric cyclobutane formation under continuous flow conditions using organophotoredox catalysed [2+2]-cycloaddition

Helena F. Grantham^a, Marc C. Kimber^a

^aSchool of Science, Department of Chemistry, Loughborough University, LE11 3TU, UK

View abstract

Synthesis of 2H-Indazoles via the Cadogan Reaction in Batch and Flow Mode

Matilda Duffy^a, Mara Di Filippo^a, Marcus Baumann^a

^aUniversity College Dublin, School of Chemistry, Science Centre South, Dublin D04 N2E5, Ireland

View abstract

DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Charles E. Mowbray*¹, Stéphanie Braillard¹, Paul A. Glossop², Gavin A. Whitlock², Robert T. Jacobs³, Jason Speake³, Bharathi Pandi³, Bakela Nare³, Louis Maes⁴, Vanessa Yardley⁵, Yvonne Freund⁶, Richard J. Wall⁷, Sandra Carvalho⁷, Davide Bello⁷, Magali Van den Kerkhof⁴, Guy Caljon⁴, Ian H. Gilbert⁷, Victoriano Corpas-Lopez⁷, Iva Lukac⁷, Stephen Patterson⁷, Fabio Zuccotto⁷, Susan Wyllie*⁷

¹Drugs for Neglected Diseases initiative (DNDi), 15 Chemin Louis-Dunant, 1202 Geneva, Switzerland

²Sandexis Medicinal Chemistry Ltd, Innovation House, Discovery Park, Ramsgate Road, Sandwich, Kent CT13 9ND, U.K.

³Scynexis, 3501 C Tricenter Boulevard, Durham, North Carolina 27713, United States

⁴Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium

⁵Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, U.K.

⁶Anacor Pharmaceuticals, 1020 East Meadow Circle, Palo Alto, California 94303, United States

⁷Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.

View abstract

SBA15-Supported Nano-ruthenium Catalyst for the Oxidative Cleavage of Alkenes to Aldehydes under Flow Conditions

Alessandro Di Michele^a, Stefano Giovagnoli^b, Paolo Filipponi^b, Francesco Venturoni^b, Antimo Gioiello^b

^aDepartment of Physics and Geology, University of Perugia, Via A. Pascoli 1, 06123 Perugia, Italy

^bDepartment of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06122 Perugia, Italy

View abstract

Iron-catalyzed synthesis of pyridines from α,β-unsaturated ketoxime acetates and N-acetyl enamides

Gaochen Xu¹, Huan Yan¹, Sai Zhang¹, Qinghuan Wu¹, Jindian Duan¹, Kai Guo¹

¹College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China

View abstract

Photoredox Iridium–Nickel Dual Catalyzed Cross-Electrophile Coupling: From a Batch to a Continuous Stirred-Tank Reactor via an Automated Segmented Flow Reactor

Rohit Duvadie¹, Alexander Pomberger¹, Yiming Mo¹, Erhan I. Altinoglu², Hsiao-Wu Hsieh³, Kakasaheb Y. Nandiwale¹, Victor L. Schultz¹, Klavs F. Jensen*¹, Richard I. Robinson³

¹Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

²Chemical and Pharmaceutical Profiling, Novartis Global Drug Development, 700 Main Street South, Cambridge, Massachusetts 02139, United States

³Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

View abstract

Method for preparing epoxidized trans-1, 4-polyisoprene by using micro-reaction device

Inventor: 乔凯, 张锴, 李玉光, 何伟, 郭凯

Assignee: Nanjing Advanced Biomaterials And Process Equipment Research Institute Co ltd

View abstract

Lithium aluminum hydride in flow: overcoming exotherms, solids, and gas evolution en route to chemoselective reductions

Aliakbar Mohammadzadeh^a, Sepideh Sharif^a, Volodymyr Semeniuchenko^a, Norman Townsend^b, Andrew D. Corbett^b, Michael G. Organ^a

^aFlow Chemistry Core Facility, Centre for Catalysis Research and Innovation (CCRI)Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, K1N 6N5, Canada

^bToronto Research Chemicals, a Subsidiary of LGC, 20 Martin Ross Avenue, Toronto, ON, M3J 2K8, Canada

View abstract

Synthesis of 7-Chloroquinoline Derivatives Using Mixed Lithium-Magnesium Reagents

Valter E. Murie^a, Paula V. Nicolino^a, Thiago dos Santos^a, Guido Gambacorta^b, Rodolfo H. V. Nishimura^a, Icaro S. Perovani^c, Luciana C. Furtado^d, Leticia V. Costa-Lotufo^d, Anderson Moraes de Oliveira^c, Ricardo Vessecchi^c, Ian R. Baxendale^b, Giuliano C. Clososki^{b, c}

^aDepartamento de Ciências BioMoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café S/N, Ribeirão Preto 14040-903, Brazil

^bDepartment of Chemistry, Durham University, South Road, Durham DH1 3LE, United Kingdom

^cDepartamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14040-901, Brazil

^dDepartamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Prof. Lineu Prestes 1524, São Paulo 05508-900, Brazil

View abstract

Photocatalytic Hydroaminoalkylation of Styrenes with Unprotected Primary Alkylamines

Hannah E. Askey^a, James D. Grayson^a, Joshua D. Tibbetts^a, Jacob C. Turner-Dore^a, Jake M. Holmes^a, Gabriele Kociok-Kohn^b, Gail L. Wrigley^c, Alexander J. Cresswell^a

^aDepartment of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, U.K.

^bMaterials and Chemical Characterisation Facility (MC), University of Bath, Claverton Down, Bath BA2 7AY, U.K.

^cOncology R&D, Research & Early Development, AstraZeneca, Darwin Building, 310, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.

View abstract

Photocatalysis in the Life Science Industry

Lisa Candish^a, Karl D. Collins^b, Gemma C. Cook^c, James J. Douglas^d, Adrián Gómez-Suárez^e, Anais Jolit^f, Sebastian Keess^f

^aDrug Discovery Sciences, Pharmaceuticals, Bayer AG, 42113 Wuppertal, Germany

^bBayer Foundation, Public Affairs, Science and Sustainability, Bayer AG, 51368 Leverkusen, Germany

^cDiscovery High-Throughput Chemistry, Medicinal Science and Technology, GlaxoSmithKline, Stevenage SG1 2NY, U.K.

^dEarly Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield SK10 2NA, U.K.

^eOrganic Chemistry, Bergische Universität Wuppertal, 42119 Wuppertal, Germany

^fMedicinal Chemistry Department, Neuroscience Discovery Research, AbbVie Deutschland GmbH & Co. KG, 67061 Ludwigshafen, Germany

View abstract

Continuous slurry plug flow Fe/ppm Pd nanoparticle-catalyzed Suzuki–Miyaura couplings in water utilizing novel solid handling equipment

Alex B. Wood^a, Scott Plummer^b, Richard I. Robinson^b, Marie Smith^c, Jim Chang^c, Fabrice Gallou^d, Bruce H. Lipshutz^a

^aDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA

^bGlobal Discovery Chemistry – Chemistry Technology Group, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA

^cGenomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Dr., San Diego, CA 92121, USA

^dNovartis Pharma AH, CH-4057 Basel, Switzerland

View abstract

Photoredox-Catalyzed Multicomponent Petasis Reaction in Batch and Continuous Flow with Alkyl Boronic Acids

Monica Oliva¹, Prabhat Ranjan¹, Serena Pillitteri¹, Guglielmo Attilio Coppola¹, Monica Messina¹, Erik V. Van der Eycken^1,2, Upendra Kumar Sharma¹

¹Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven B-3001, Belgium

²Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya street 6, Moscow RU-117198, Russia

View abstract

Photoredox-Catalyzed Dehydrogenative Csp3–Csp2 Cross-Coupling of Alkylarenes to Aldehydes in Flow

Oliver M. Griffiths^a, Henrique A. Esteves^a, Yiding Chen^a, Karin Sowa^a,b, Oliver S. May^a, Peter Morse^c, David C. Blakemore^c, Steven V. Ley*^a

^aYusuf Hamied Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, U.K.

^bDepartment of Chemistry, University of Münster, 48149 Münster, Germany

^cMedicine Design, Pfizer, Inc., Groton, Connecticut 06340, United States

View abstract

Drug Discovery Automation and Library Synthesis in Flow

Paul Richardson¹, Irini Abdiaj²

¹Pfizer Medicine Design, Pfizer, La Jolla, USA

²Janssen Research and Development, Toledo, Spain

View abstract

Homogeneous Catalytic C(sp3 )–H Functionalization of Gaseous Alkanes

Antonio Pulcinella^a, Daniele Mazzarella^a, Timothy Noël^a

^aFlow Chemistry Group, Van ’t Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam

View abstract

Telescoped Lithiation, C-Arylation and Methoxylation in Flow-Batch Hybrid toward the Synthesis of Canagliflozin

Dominik Polterauer^a,b, Jason D. Williams^a,b, Christopher A.Hone^a,b, C. Oliver Kappe^a,b

^aCenter for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering (RCPE), Inffeldgasse 13, A-8010 Graz, Austria

^bInstitute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz, Austria

View abstract

A small footprint oxycodone generator based on continuous flow technology and real-time analytics

Florian Sommer^a,b, David Cantillo^a,b, C. Oliver Kappe^a,b

^aInstitute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010, Graz, Austria

^bCenter for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010, Graz, Austria

View abstract

Unlocking the Accessibility of Alkyl Radicals from Boronic Acids through Solvent-Assisted Organophotoredox Activation

Prabhat Ranjan^a, Serena Pillitteri^a, Guglielmo Coppola^a, Monica Oliva^a, Erik V. Van der Eycken^a,b, Upendra K. Sharma^a

^aLaboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001 Leuven, Belgium

^bPeoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya Street 6, 117198 Moscow, Russia

View abstract

Organic–inorganic hybrid electro-optic material with Disperse Red 1 chromophore fabricated by flow chemistry

Yoonseok Ko^a, Minsang Kim^a, Changho Noh^a, Mi-Jeong Kim^a, Keechang Lee^a, Jongback Kim^b, Sung Dug Kim^a, Sang Soo Jee^a

^aPolymer Research Lab, Samsung Advanced Institutes of Technology (SAIT), Samsung Electronics, Suwon-si, Gyeonggi-do, Korea

^bAnalytical Engineering Group, Samsung Advanced Institutes of Technology (SAIT), Samsung Electronics, Suwon-si, Gyeonggi-do, Korea

View abstract

Technological Innovations in Photochemistry for Organic Synthesis: Flow Chemistry, High-Throughput Experimentation, Scale-up, and Photoelectrochemistry

Laura Buglioni^a,b, Fabian Raymenants^a, Aidan Slattery^a, Stefan D. A. Zondag^a, Timothy Noël^a

^aFlow Chemistry Group, van ’t Hoff Institute for Molecular Sciences (HIMS), Universiteit van Amsterdam (UvA), Science Park 904, 1098 XH, Amsterdam, The Netherlands

^bMicro Flow Chemistry and Synthetic Methodology, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld, Bldg 14—Helix, 5600 MB, Eindhoven, The Netherlands

View abstract

Pyrrolidine and bicycloheteroaryl containing oga inhibitor compounds

Inventor: José Manuel Bartolomé-Nebreda, Andrés Avelino TRABANCO-SUÁREZ, Ana Isabel De Lucas Olivares, Sergio-Alvar Alonso-De Diego

Assignee: Janssen Pharmaceutica Nv

View abstract

Flow chemistry synthesis of isocyanates

Inventors: Michael D. BurkartThien An PHUNG HAI

Assignee: The Regents Of The University Of California

View abstract

Cyclodextrin

Inventors: Tammy Savage, Stephen Wicks, John Mitchell

Assignee: CURADEV PHARMA PRIVATE Ltd

View abstract

Compounds and compositions as inhibitors of endosomal toll-like receptors

Inventors: Phillip Alper, Jonathan DEANE, Songchun Jiang, Tao Jiang, Thomas Knoepfel, Pierre-Yves Michellys, Daniel Mutnick, Wei Pei, Peter SYKA, Guobao Zhang, Yi Zhang

Assignee: Novartis AG, Novartis Institutes for BioMedical Research Inc

View abstract

High-Yielding Flow Synthesis of a Macrocyclic Molecular Hinge

Christopher D. Jones^a, Laurence J. Kershaw Cook^a, David Marquez-Gamez^a, Konstantin V. Luzyanin^a, Jonathan W. Steed^b, Anna G. Slater^a

^aDepartment of Chemistry and Materials Innovation Factory, University of Liverpool, Crown Street, Liverpool L69 7ZD, U.K.

^bDepartment of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.

View abstract

Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1-Oxa-8-azaspiro [4.5] decan-3-amine

Jeffrey T. Kohrt^a, Peter H. Dorff^a, Michael Burns^b, Chewah Lee^b, Steven V. O’Neil^b, Robert J. Maguire^b, Rajesh Kumar^b, Melissa Wagenaar^b, Loren Price^a, Manjinder S. Lall^a

^aMedicine Design, Pfizer Inc., 445 Eastern Point Road, Groton, Connecticut 06340, United States

^bChemical Research and Development, Pfizer Inc., 445 Eastern Point Road, Groton, Connecticut 06340, United States

View abstract

Scalable Synthesis of Norbornadienes via in situ Cracking of Dicyclopentadiene using Continuous Flow Chemistry

Jessica Orrego-Hernández^a, Helen Hölzel^a, Maria Quant^a, Zhihang Wang^a, Kasper Moth-Poulsen^a

^aChalmers University of Technology: Chalmers tekniska hogskola, Chemistry, Sweden

View abstract

Delineating a green, catalyst free synthesis of a popular nutraceutical methylsulfonylmethane (MSM) in continuous flow

Chinmay A. Shukla^a, Bantu Udaykumar^a, Y. Saisivanarayana^a, Arsh Ismaili^a, T Haripriya^a, Manish M. Shinde^b, Srinivasan Neti^c, Maheshkumar Uppada^a, Vishnuvardhana Eda^c, Saikat Sen^c, Srinivas Oruganti^a,b,c

^a10X Chemical Process Automation Laboratory, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India

^bFlow Chemistry Technology Hub, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India

^cCentre for Process Research and Innovation, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India

View abstract

Evaluation of a Continuous-Flow Photo-Bromination Using N-Bromosuccinimide for Use in Chemical Manufacture

Matthew Waterford^a, Simon Saubern^a, Christian H. Hornung^a

^aCSIRO Manufacturing, Bag 10, Clayton South, Vic. 3169, Australia.

View abstract

Scalability of photochemical reactions in continuous flow mode

Kian Donnelly^a, Marcus Baumann^a

^aSchool of Chemistry, Science Centre South, University College Dublin, D04 N2E2, Dublin, Ireland

View abstract

Synthesis of Enantiopure Unnatural Amino Acids by Metallaphotoredox Catalysis

Tomer M. Faraggi^a, Caroline Rouget-Virbel^a, Juan A. Rincón^b, Mario Barberis^b, Carlos Mateos^b, Susana García-Cerrada^b, Javier Agejas^b, Oscar de Frutos^b, David W. C. MacMillan^a

^aMerck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States

^bCentro de Investigación Eli Lilly, S. A. Avda de la Industria 30, Alcobendas-Madrid 28108, Spain

View abstract

Biocatalyzed Flow Oxidation of Tyrosol to Hydroxytyrosol and Efficient Production of Their Acetate Esters

Francesca Annunziata¹, Martina L. Contente², Cecilia Pinna², Lucia Tamborini¹, Andrea Pinto²

¹Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy

²Department of Food, Environmental and Nutritional Sciences, University of Milan, Via Celoria 2, 20133 Milan, Italy

View abstract

Supporting-Electrolyte-Free Anodic Oxidation of Oxamic Acids into Isocyanates: An Expedient Way to Access Ureas, Carbamates, and Thiocarbamates

Alessia Petti^a, Corentin Fagnan^a, Carlo G. W. van Melis^a, Nour Tanbouza^b, Anthony D. Garcia^a, Andrea Mastrodonato^a, Matthew C. Leech^a, Iain C. A. Goodall^a, Adrian P. Dobbs^a, Thierry Ollevier^b, Kevin Lam*^a

^aSchool of Science, University of Greenwich, Chatham Maritime, Chatham, Kent ME4 4TB, U.K.

^bDépartement de Chimie, Université Laval, 1045 avenue de la Médecine, Québec, QC G1V 0A6, Canada

View abstract

Application of reactor engineering concepts in continuous flow chemistry: a review

Nicole C. Neyt^a, Darren L. Riley^*a

^aFaculty of Natural and Agricultural Sciences, Department of Chemistry, University of Pretoria, South Africa

View abstract

In situ sensors for flow reactors – a review

Jun Li^a, Helena Šimek^b, David Ilioae^c, Nicole Jung^b, Stefan Bräse^b, Hans Zappe^c, Roland Dittmeyer^a, Bradley P. Ladewig^*a

^aInstitute for Micro Process Engineering (IMVT), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, Germany

^bInstitute of Biological and Chemical Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, Germany

^cGisela and Erwin Sick Laboratory for Micro-optics, Department of Microsystems Engineering, University of Freiburg, Germany

View abstract

Mechanism and kinetics of the aerobic oxidation of benzyl alcohol to benzaldehyde catalyzed by cobalt porphyrin in a membrane microchannel reactor

Qi Han^a, Xian-Tai Zhou^a, Xiao-Qi He^d, Hong-Bing Ji^{b, c}

^aFine Chemical Industry Research Institute, School of Chemical Engineering and Technology, Sun Yat-sen University, Zhuhai 519082, China

^bFine Chemical Industry Research Institute, School of Chemistry, Sun Yat -sen University, Guangzhou 510275, China

^cSchool of Chemical Engineering, Guangdong University of Petrochemical Technology, Maoming 525000, China

^dHuizhou Research Institute, Sun Yat-sen University, Huizhou 516081, China

View abstract

Expanding the Tool Kit of Automated Flow Synthesis: Development of In-line Flash Chromatography Purification

Christopher G. Thomson^a, Colin Banks^b, Mark Allen^c, Graeme Barker^{a, d}, Christopher R. Coxon^a, Ai-Lan Lee*^a, Filipe Vilela*^{a, d}

^aInstitute of Chemical Sciences, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, Scotland EH14 4AS, United Kingdom

^bCheshire Sciences (UK) Limited, Kao Hockham Building, Edinburgh Way, Harlow, Essex, England CM20 2NQ, United Kingdom

^cAdvion (UK) Limited, Kao Hockham Building, Edinburgh Way, Harlow, Essex, England CM20 2NQ, United Kingdom

^dContinuum Flow Lab, Heriot-Watt University, Edinburgh, Scotland EH14 4AS, United Kingdom

View abstract

The integration of catalyst design and process intensification in the efficient synthesis of 5-hydroxymethyl-2-furancarboxylic acid from fructose

Wei He^a1, Congcong Zhang^b1, Wenyan Zhang^a, YuchenZhu^c, Zheng Fang^a, Lili Zhao^b, Kai Guo^{a, d}

^aCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, PR China

^bInstitute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China

^cSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China

^dState Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 210009, PR China

View abstract

(Trifluoromethylselenyl)methylchalcogenyl as Emerging Fluorinated Groups: Synthesis under Photoredox Catalysis and Determination of the Lipophilicity

Kevin Grollier^[a], Arnaud De Zordo-Banliat^[b], Flavien Bourdreux^[b], Bruce Pegot^[b], Guillaume Dagousset^[b], Emmanuel Magnier^*[b], Thierry Billard*^{[a, c]}

^[a]Institute of Chemistry and Biochemistry (ICBMS, UMR CNRS 5246) Univ Lyon, Universite Lyon 1, CNRS,CPE, INSA43 Bd du 11 novembre 1918, 69622 Villeurbanne (France)

^[b]InstitutLavoisierdeVersailles (UMR CNRS 8180)Universit Paris-Saclay,UVSQ,CNRS78035 Versailles (France)

^[c]CERMEP-In vivo imaging59 Bd Pinel, 69677 Lyon (France)

View abstract

«Quick, convenient, and clean»: Advancing education in green chemistry and nanocatalysis using sol-gel catalysts under flow

Antonino Scurria^a, Mario Pagliaro^a, Rosaria Ciriminna^a

^aIstituto per lo Studio dei Materiali Nanostrutturati, CNR, via U. La Malfa 153, 90146 Palermo, Italy

View abstract

Scale-Up and Optimization of a Continuous Flow Carboxylation of N-Boc-4,4-difluoropiperidine Using s-BuLi in THF

Jean-Paul Kestemont^a, James R. Frost^b, Jérôme Jacq^a, Patrick Pasau^a, Frédéric Perl^a, Julien Brown^b, Matthieu Tissot*^a

^aUCB Biopharma SPRL, Avenue de l’industrie, 1420 Braine l’Alleud, Belgium

^bUCB, 216 Bath Road, Slough SL1 3WE, United Kingdom

View abstract

Exploration of continuous-flow benchtop NMR acquisition parameters and considerations for reaction monitoring

Tristan Maschmeyer^a, Paloma L. Prieto^a, Shad Grunert^a, Jason E. Hein^a

^aDepartment of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada

View abstract

Amino alcohol acrylonitriles as broad spectrum and tumour selective cytotoxic agents

Jennifer R. Baker^a, Cecilia C. Russell^a, Jayne Gilbert^b, Adam McCluskey^a, Jennette A. Sakoff^b

^aChemistry, School of Environmental & Life Sciences, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia

^bExperimental Therapeutics Group, Department of Medical Oncology, Calvary Mater Newcastle Hospital, Edith Street, Waratah, NSW 2298, Australia

View abstract

Ozone-Mediated Amine Oxidation and Beyond: A Solvent Free, Flow-Chemistry Approach

Eric A. Skrotzki^a, Jaya Kishore Vandavasi^a, Stephen G. Newman^a

^aCentre for Catalysis Research and Innovation, Department of Chemistry and Biomolecular Sciences, University of Ottawa, 10 Marie-Curie, Ottawa, Ontario K1N 6N5, Canada.

View abstract

A sustainable and scalable multicomponent continuous flow process to access fused imidazoheterocycle pharmacophores

Blake J. M. Baker^{a, b}, William J. Kerr^*b, David M. Lindsay^b, Vipul kumar K. Patel^a, Darren L. Poole^a

^aGlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK

^bDepartment of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, UK

View abstract

Reproducible and rapid synthesis of a conjugated polymer by Stille polycondensation in flow: Effects of reaction parameters on molecular weight

Woojin Shin^{a, 1}, Wonyoung Ko^{a, 1}, Seung-Hwan Jin^a, Taeshik Earmme^b, Ye-Jin Hwang^a

^aDepartment of Chemistry and Chemical Engineering, Education and Research Center for Smart Energy and Materials, Inha University, 100 Inha-ro, Michuhol-gu, Incheon, Republic of Korea

^bDepartment of Chemical Engineering, Hongik University, 94 Wausan-ro, Mapo-gu, Seoul 04066, Republic of Korea

View abstract

Innovation in delivering synthetically challenging bicyclic arginase inhibitors to enhance immunotherapy

Derun Li^a, Hongjun Zhang^a, Thomas W. Lyons^a, Theodore A. Martinot^a, Abdelghani Achab^a, Min lu^a, Lisa M. Nogle^a, Spencer McMinn^a, Matthew J. Mitcheltree^a, Matthew Childers^a, Qinglin Pu^a, Symon Gathiaka^a, Anand Palani^a, Kalyan Chakravarthy^a, Amy D. DeCastro^a, Jennifer O'Neil^a, Roshi Afshar^a, Nicole C. Walsh^a, Peter W. Fan^a, Mangeng Cheng^a, Richard Miller^a, Amy Doty^a, Rachel Palte^a, Hai-Young Kim^a, Josep Saurí^a, Adam Beard^a, Christopher Brynczka^a and Christian Fischer^a

^aMerck Research Laboratory, Boston, MA.

View abstract

A revised 1D equivalent model for the determination of incident photon flux density in a continuous-flow LED-driven spiral-shaped microreactor using the actinometry method with Reinecke’s salt

Robbie Radjagobalou^a, Victoria Dias Da Silva Freitas^a, Jean-François Blanco^a, Fabrice Gros^b, Jérémy Dauchet^b, Jean-François Cornet^b, Karine Loubiere^a

^aLaboratoire de Génie Chimique (LGC), Université de Toulouse, CNRS, INPT, UPS, 4 allée Emile Monso, CS 84234, 31 432, Toulouse, France

^bUniversité Clermont Auvergne, Clermont Auvergne INP, CNRS, Institut Pascal, F-63000, Clermont-Ferrand, France

View abstract

Interrupted Curtius Rearrangements of Quaternary Proline Derivatives: A Flow Route to Acyclic Ketones and Unsaturated Pyrrolidines

Marcus Baumann^a, Thomas S. Moody^{b, c}, Megan Smyth^b, Scott Wharry^b

^aSchool of Chemistry, University College Dublin, Science Centre South, Belfield D04 N2E2, Ireland

^bDepartment of Technology, Almac Sciences, 20 Seagoe Industrial Estate, Craigavon BT63 5QD, United Kingdom

^cArran Chemical Company, Roscommon N37 DN24, Ireland

View abstract

Flow electrochemistry: a safe tool for fluorine chemistry

Bethan Winterson^a, Tim Rennigholtz^a, Thomas Wirth^a

^aSchool of Chemistry, Cardiff University, Park Place, Main Building, Cardiff, Cymru/Wales, UK

View abstract

Flow Electrosynthesis of Sulfoxides, Sulfones, and Sulfoximines without Supporting Electrolytes

Nasser Amri¹ and Thomas Wirth¹

¹School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, United Kingdom

View abstract

Discrete Ti−O−Ti Complexes: Visible-Light-Activated, Homogeneous Alternative to TiO2 Photosensitisers

Kira Behm^a, Dr. Eszter Fazekas^a, Prof. Martin J. Paterson^a, Dr. Filipe Vilela^a, Dr. Ruaraidh D. McIntosh^a

^aInstitute of Chemical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS UK

View abstract

Stereospecific amination of mesylated cyclobutanol in continuous flow

Matthieu Tissot^a, Jérôme Jacq^a, Patrick Pasau^a

UCB Biopharma SPRL, Avenue de l’industrie, 1420 Braine l’Alleud, Belgium^a

View abstract

Chemo-enzymatic oxidative cleavage of isosafrole for the synthesis of piperonal

Francesca Tentori^*a, Elisabetta Brenna^*a, Chiara Ferrari^a, Francesco G. Gatti^a, Maria Chiara Ghezzi^a, Fabio Parmeggiani^a

^aDipartimento di Chimica, Materiali ed Ingegneria Chimica “Giulio Natta”, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milano, Italy.

View abstract

Radical alpha-Trifluoromethoxylation of Ketones by Means of Organic Photoredox Catalysis

Thibaut Duhail^[a]†, Tommaso Bortolato^[b]†, Javier Mateos^[b], Elsa Anselmi^[a,c], Benson Jelier^[d], Antonio Togni^[d], Emmanuel Magnier^[a], Guillaume Dagousset^[a], Luca Dell’Amico^[b]

^[a] Université Paris-Saclay, UVSQ, CNRS, UMR 8180, Institut Lavoisier de Versailles, 78035 Versailles Cedex (France)

^[b]Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131, Padova (Italy)

^[c] Université de Tours, Faculté des Sciences et Techniques, 37200 Tours (France)

^[d]Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zurich, Vladimir-Prelog-Weg 2, 8093 Zurich (Switzerland)

View abstract

Rapid Optimization of Photoredox Reactions for Continuous-Flow Systems Using Microscale Batch Technology

María González-Esguevillas^a, David F. Fernández^a, Juan A. Rincón^b, Mario Barberis^b, Oscar de Frutos^b, Carlos Mateos^b, Susana García-Cerrada^b, Javier Agejas^b, David W. C. MacMillan*^a

^aMerck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States

^bCentro de Investigación Eli Lilly, S. A., Avda. de la Industria 30, 28108 Alcobendas, Madrid, Spain

View abstract

Microfluidic synthesis of CsPbBr3/Cs4PbBr6 nanocrystals for inkjet printing of mini-LEDs

Zhen Bao^a,1, Jian-Wen Luo^b,1, Yu-Sin Wang^c, Ting-Chou Hu^c, Sung-Yu Tsai^c, Yi-Ting Tsai^d, Huang-Chia Wang^d, Fu-Hsin Chen^d, Yu-Chun Lee^d, Tzong-Liang Tsai^d, Ren-Jei Chung^b, Ru-Shi Liu^a,e

^aDepartment of Chemistry, National Taiwan University, Taipei 106, Taiwan

^bDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan

^cChina Glaze Co., Ltd., Hsinchu 310, Taiwan

^dLextar Electronics Corporation, Hsinchu 300, Taiwan

^eAdvanced Research Center of Green Materials Science and Technology, National Taiwan University, Taipei 106, Taiwan

View abstract

Modular allylation of C(sp3)−H bonds by combining decatungstate photocatalysis and HWE olefination in flow

Luca Capaldo¹, Stefano Bonciolini¹, Antonio Pulcinella¹, Manuel Nuño², Timothy Noël¹

¹ Flow Chemistry Group, van ’t Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands

²Vapourtec Ltd., Park Farm Business Centre, Fornham St Genevieve, Bury St Edmunds, Suffolk IP28 6TS, United Kingdom

View abstract

Decatungstate-mediated C(sp3 )‒H Heteroarylation via Radical Polar Crossover in Batch and Flow

Ting Wan^a, Luca Capaldo^a, Gabriele Laudadio^a, Alexander V. Nyuchev^b, Juan A. Rincón^c, Pablo García-Losada^c, Carlos Mateos^c, Michael O. Frederick^d, Manuel Nuño^e, Timothy Noël*^a

^aFlow Chemistry Group, Van ’t Hoff Institute for Molecular Sciences(HIMS), University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands

^bDepartment of Organic Chemistry, Lobachevsky State University of Nizhny Novgorod Gagarina Avenue 23, 603950, Nizhny Novgorod, Russia

^cCentro de Investigación Lilly S.A. Avda. de la Industria 30, Alcobendas-Madrid 28108, Spain.

^dSmall Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.

^eVapourtec Ltd., Park Farm Business Centre, Fornham St Genevieve, Bury St Edmunds, Suffolk IP28 6TS, United Kingdom.

View abstract

Highly Permeable Fluorinated Polymer Nanocomposites for Plasmonic Hydrogen Sensing

Ida Östergren¹, Amir Masoud Pourrahimi¹, Iwan Darmadi², Robson da Silva¹, Alicja Stolaś¹, Sarah Lerch¹, Barbara Berke², Manuel Guizar-Sicairos³, Marianne Liebi², Giacomo Foli⁴, Vincenzo Palermo^4,5, Matteo Minelli⁶, Kasper Moth-Poulsen¹, Christoph Langhammer², and Christian Müller¹

¹Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Göteborg 412 96, Sweden

²Department of Physics, Chalmers University of Technology, Göteborg 412 96, Sweden

³Paul Scherrer Institut, Villigen PSI 5232, Switzerland

⁴Institute of Organic Synthesis and Photoreactivity, National Research Council, Bologna 40129, Italy

⁵Department of Industrial and Materials Science, Chalmers University of Technology, Göteborg 412 96, Sweden

⁶Department of Civil, Chemical, Environmental and Materials Engineering, Alma Mater Studiorum—University of Bologna, Bologna 40131, Italy

View abstract

Efficient Amino Donor Recycling in Amination Reactions: Development of a New Alanine Dehydrogenase in Continuous Flow and Dialysis Membrane Reactors

David Roura Padrosa¹, Zoya Nisar², Francesca Paradisi^1,2

¹Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland

²School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK

View abstract

Iron-catalyzed [4 + 2] annulation of α,β-unsaturated ketoxime acetates with enaminones toward functionalized pyridines

Jindian Duan, Gaochen Xu, Binsen Rong, Huan Yan, Sai Zhang, Qinghuan Wu, Ning Zhu, Kai Guo

College of Biotechnology and Pharmaceutical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China

View abstract

Enzyme-electrochemical continuous flow cascades synthesis of substituted benzimidazoles

Ting-Ting Shi^a,b, Shu-Zhan Wang^a, Zhao Yang^c, Yilin Wang^a, Chengkou Liu^a, Wei He^*a, Zheng Fang^*a,d, Kai Guoa^d

^aCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, P. R. China.

^bDepartment of Chemistry, Bengbu Medical College, 233030, P. R. China.

^cSchool of Engineering, China Pharmaceutical University, No.639 Longmian Avenue, Nanjing 211198, China

^dState Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, P. R. China.

View abstract

A Practical Transferring Method from Batch to Flow Synthesis of Dipeptides via Acid Chloride Assisted by Simulation of the Reaction Rate

Masahiro Hosoya, *Go Shiino, Naoki Tsuno

API R&D Laboratory, CMC R&D Division, Shionogi and Co., Ltd., 1-3, Kuise Terajima 2-chome, Amagasaki, Hyogo 660-0813, Japan

View abstract

Synthesis of the Lipophilic Amine Tail of Abediterol Enabled by Multiphase Flow Transformations

Jorge García-Lacuna¹, Tobias Fleiß^1,2, Rachel Munday³, Kevin Leslie³, Anne O’Kearney-McMullan³, Christopher A. Hone*^1,2, C. Oliver Kappe*^1,2

¹Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz, Austria

²Center for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria

³Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, United Kingdom

View abstract

The CO2 photoconversion over reduced graphene oxide based on Ag/TiO2 photocatalyst in an advanced meso-scale continuous-flow photochemical reactor

Samar Nabil¹, Ahmed S. Hammad², Haitham M. El-Bery³, Elsayed A. Shalaby¹, Ahmed H. El-Shazly^4,5

¹Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria, 21526, Egypt

²Chemical Engineering Department, Faculty of Engineering, Port Said University, Port Said, Egypt

³Advanced Functional Materials Laboratory, Chemistry Department, Faculty of Science, Assiut University, Assiut, 71515, Egypt

⁴Chemical and Petrochemicals Engineering Department, Egypt-Japan University of Science and Technology, Alexandria, 21934, Egypt

⁵Chemical Engineering Department, Faculty of Engineering, Alexandria University, Alexandria, 21544, Egypt

View abstract

Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicity

Hsien-Ya Lin^1,2,7, Chia-Yu Chen^1,2,7, Ting-Chien Lin^1,2,7, Lun-Fu Yeh1, Wei-Che Hsieh¹, Shijay Gao¹, Pierre-Alain Burnouf³, Bing-Mae Chen³, Tung-Ju Hsieh¹, Punsaldulam Dashnyam¹, Yen-Hsi Kuo¹, Zhijay Tu¹, Steve R. Roffler^3,4, Chun-Hung Lin^1,2,5,6

¹Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

²Department of Chemistry, National Taiwan University, Taipei, Taiwan

³Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

⁴Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

⁵Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan

⁶The Genomics Research Center, Academia Sinica, Taipei, Taiwan

⁷These authors contributed equally

View abstract

Enantio-Complementary Continuous-Flow Synthesis of 2-Aminobutane Using Covalently Immobilized Transaminases

Christian M. Heckmann^a, Beatriz Dominguez^b, Francesca Paradisi^a,c

^aSchool of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom

^bJohnson Matthey, 28 Cambridge Science Park, Milton Road, Cambridge, CB4 0FP, United Kingdom

^cDept. of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012, Bern, Switzerland

View abstract

A Machine Learning‐Enabled Autonomous Flow Chemistry Platform for Process Optimization of Multiple Reaction Metrics

Dr. Mohammed I. Jeraal^a, Dr. Simon Sung^a, Prof. Alexei A. Lapkin^a,b

^aCambridge Centre for Advanced Research and Education in Singapore Ltd., 1 Create Way, CREATE Tower #05-05, 138602 Singapore

^bDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, CB3 0AS UK

View abstract

Enzymatic esterification of lauric acid to give monolaurin in a microreactor

Shanshan Miao, Xin Li

College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, P.R. China

View abstract

A continuous flow synthesis of [1.1.1]propellane and bicyclo[1.1.1]pentane derivatives

Kian Donnelly, Marcus Baumann

School of Chemistry, University College Dublin, Science Centre South, Belfield, Ireland

View abstract

A Process for Making Brominating Agents in Flow

Inventors:, Dermaut, Wim (Mortsel, BE), Cappuyns, Bart (Mortsel, BE), Moens, Matthias (Mortsel, BE), Stevens, Christian (Mortsel, BE)

Assignee:

AGFA NV

UNIVERSITEIT GENT

View abstract

Dimethyl Fumarate: Heterogeneous Catalysis for the Development of an Innovative Flow Synthesis

Fabiana Dedè¹, Oreste Piccolo², Daniele Vigo¹

¹Cambrex Profarmaco Milano S.r.l., via Curiel 34, 20067 Milan, Paullo, Italy

²Studio di Consulenza scientifica, via Bornò 5, 23896 Lecco, Sirtori, Italy

View abstract

Flow Biocatalysis 101: design, development and applications

Ana I. Benítez-Mateos, Martina Letizia Contente, David Roura Padrosa, Francesca Paradisi

Department of Chemistry and Biochemistry University of Bern, Freiestrasse 3, Bern (Switzerland)

View abstract

Coupling biocatalysis with high-energy flow reactions for the synthesis of carbamates and β-amino acid derivatives

Alexander Leslie¹, Thomas S. Moody^2,3, Megan Smyth², Scott Wharry², Marcus Baumann¹

¹School of Chemistry, University College Dublin, D04 N2E2, Ireland

²Almac Group Ltd., Craigavon BT63 5QD, United Kingdom

³Arran Chemical Company, Athlone, Co. Roscommon N37 DN24, Ireland

View abstract

Development of a Continuous Photochemical Benzyne-Forming Process

Cormac Bracken^a, Andrei S. Batsanov^b, Marcus Baumann^a

^aSchool of Chemistry, University College Dublin, Science Centre South, D04 N2E2, Dublin, Ireland

^bDepartment of Chemistry, University of Durham, South Road, DH1 3LE, Durham, UK

View abstract

Photocatalytic (Het)arylation of C(sp3)–H Bonds with Carbon Nitride

Saikat Das^a, Kathiravan Murugesan^a, Gonzalo J. Villegas Rodríguez^a, Jaspreet Kaur^a, Joshua. P. Barham^a, Aleksandr Savateev^b, Markus Antonietti^b, Burkhard König^a

^aFakultät für Chemie und Pharmazie, Universität Regensburg, 93040 Regensburg, Germany

^bDepartment of Colloid Chemistry, Max-Planck Institute of Colloids and Interfaces, Research Campus Golm, 14424 Potsdam, Germany

View abstract

The rise of continuous flow biocatalysis – fundamentals, very recent developments and future perspectives

Piera De Santis^a, Lars-Erik Meyer^a, Selin Kara^a

^aAarhus University, Department of Engineering, Biological and Chemical Engineering Section, Biocatalysis and Bioprocessing Group, Gustav Wieds Vej 10, DK 8000 Aarhus, Denmark

View abstract

Corymbia citriodora: A Valuable Resource from Australian Flora for the Production of Fragrances, Repellents, and Bioactive Compounds

Tyler Goodine^a, Michael Oelgemöller^a,b

^aJames Cook University, College of Science and Engineering, 1 James Cook Drive, 4811 Townsville, Queensland, Australia

^bGhent University, Department of Organic and Macromolecular Chemistry, Krijgslaan 281 S4, 9000 Gent, Belgium

View abstract

Combining Radial and Continuous Flow Synthesis to Optimize and Scale-up the Production of Medicines

Mara Guidi^a,b, Sooyeon Moon^a,b, Lucia Anghileri^a,b, Dario Cambié^a, Peter H. Seeberger*^a,b, Kerry Gilmore*^a,c

^aDepartment of Biomolecular Systems Max Planck Institute of Colloids and Interfaces Am Mühlenberg 1, 14476 Potsdam (Germany)

^bDepartment of Chemistry and Biochemistry Freie Universität Berlin Arnimallee 22, 14195 Berlin (Germany)

^cUniversity of Connecticut, Storrs, CT 06269 (United States)

View abstract

Additive manufacturing of intricate and inherently photocatalytic flow reactor components

Adilet Zhakeyev^a,b, Mary C.Jones^b, Christopher G.Thomson^b, John M.Tobin^c, Huizhi Wang^d, Filipe Vilela^b, Jin Xuan^a

^aDepartment of Chemical Engineering, Loughborough University, Loughborough, LE11 3TU, UK

^bSchool of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK

^cSchool of Chemistry, The University of Edinburgh, Edinburgh, EH9 3FJ, UK

^dDepartment of Mechanical Engineering, Imperial College London, Exhibition Road, South Kensington Campus, London, SW7 2AZ, UK

View abstract

Continuous Flow Synthesis and Antimicrobial Evaluation of NHC* Silver Carboxylate Derivatives of SBC3 in vitro and in vivo

Cillian O’Beirne^†a, Magdalena E. Piatek^b, Jen Fossen^c, Helge Müller-Bunz^a, David R. Andes^c, Kevin Kavanagh^b, Siddappa A. Patil^d, Marcus Baumann^a, Matthias Tacke^†a

^aSchool of Chemistry, University College Dublin, Belfield, Stillorgan, Dublin 4, Republic of Ireland

^bSSPC Pharma Research Centre, Department of Biology, Maynooth University, Maynooth, W23F2H6, Co. Kildare, Republic of Ireland

^cJ. Fossen, Prof. D. R. Andes, Department of Medicine, 600 Highland Avenue, University of Wisconsin, Madison, USA

^dCentre for Nano and Material Sciences, Jain University, Bangalore, Karnataka, India

View abstract

γ-Amino phosphonates via the photocatalytic α-C–H alkylation of primary amines

James D. Grayson, Alexander J. Cresswell

Department of Chemistry, University of Bath, 1 South, Claverton Down, Bath, BA2 7AY, UK

View abstract

Development and Proof of Concept for a Large-Scale Photoredox Additive-Free Minisci Reaction

Mark A. Graham*^a, Gary Noonan*^a, Janette H. Cherryman^a, Miguel Gonzalez^b, Lucinda V. Jackson^a, Kevin Leslie^a, Zhi-qing Liu^b, David McKinney^a, Rachel H. Munday^a, Chris D. Parsons^c, David T. E. Whittaker^c, En-xuan Zhang^b, Jun-wang Zhang^b

^aChemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield SK10 2NA, U.K.

^bAsymchem Laboratories (Tianjin) Co. Ltd., TEDA, Tianjin 300457, P. R. China

^cEarly Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield SK10 2NA, U.K.

View abstract

Achieving selectivity in porphyrin bromination through a DoE-driven optimization under continuous flow conditions

Paolo Zardi, Michele Maggini, Tommaso Carofiglio

Dipartimento di Scienze Chimiche, Università degli Studi di Padova, Via Marzolo 1, 35131, Padova, Italy

View abstract

A scalable continuous photochemical process for the generation of aminopropylsulfones

Stefano Bonciolini^a, Mara Di Filippo^a, Marcus Baumann^a

^aSchool of Chemistry, University College Dublin, Science Centre South, Belfield, Ireland

View abstract

Recent Advances in Continuous-Flow Reactions Using Metal-Free Homogeneous Catalysts

Naoto Sugisawa^1,2, Hiroyuki Nakamura^>1, Shinichiro Fuse³

¹Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8503, Japan

²School of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan

³Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya 464-8601, Japan

View abstract

Continuous Flow Photo-RAFT and Light-PISA

Jian Wang^a,c, Xin Hu^b,c, Ning Zhu^a,c, Kai Guo^c

^aCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu 211800, China

^bCollege of Materials Science and Engineering, Nanjing Tech University, Nanjing, Jiangsu 211800, China

^cState Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, Jiangsu 211800, China

View abstract

Tandem Continuous Flow Curtius Rearrangement and Subsequent Enzyme-Mediated Impurity Tagging

Marcus Baumann¹, Alexander Leslie¹, Thomas S. Moody^{2, 3}, Megan Smyth*², Scott Wharry²

¹School of Chemistry, Science Centre, University College Dublin, South Belfield, Dublin 4, Ireland

²Almac Group Ltd., 20 Seagoe Industrial Estate, Craigavon BT63 5QD, United Kingdom

³Arran Chemical Company, Unit 1 Monksland Industrial Estate, Athlone, Co. Roscommon N37 DN24, Ireland

View abstract

An open source toolkit for 3D printed fluidics

Adam J. N. Price¹, Andrew J. Capel², Robert J. Lee¹, Patrick Pradel³, Steven D. R. Christie¹

¹School of Science, Loughborough University, Loughborough LE11 3TU, UK

²School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK

³Design School, Loughborough University, Loughborough LE11 3TU, UK

View abstract

Bicyclic Quinazolinone Derivatives

Inventors:, Hert, Jerome (Basel, CH), Hunziker, Daniel (Basel, CH), Kuratli, Christoph (Basel, CH), Martin, Rainer E. (Basel, CH), Mattei, Patrizio (Basel, CH), Satz, Alexander Lee (Basel, CH)

Assignee: Hoffmann-La Roche Inc. (Little Falls, NJ, US)

View abstract

Characterization of reaction enthalpy and kinetics in a microscale flow platform.

Agnieszka Ladosz, Christina Kuhnle, Klavs F Jensen

Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA

View abstract

Photochemical Flow Oximation of Alkanes

Oliver M. Griffiths^{a, b}, Michele Ruggeri^a, Ian R. Baxendale∗^a

^aDepartment of Chemistry, University of Durham, South Road, Durham, Durham, DH1 3LE, UK

^bDepartment of Chemistry, Cambridge University, South Road, Cambridge, Cambridgeshire, CB2 1EW, UK

View abstract

Development of a packed-bed flow process for the production scale hydrogenation of 7-oxo-lithocholic acid to ursodeoxycholic acid

Seung Jae Lee^{1, 2}, Yashwardhan R. Malpani², Il Won Kim¹

¹Department of Chemical Engineering, Soongsil University, 369 Sangdo-ro, Dongjak-gu 06978 Seoul, Republic of Korea

²API Synthesis Team, Daewoong-Bio, 29-Jeyakdanji-ro, Hyangnam-eup, Hwaseung-si, Gyeonggi-do 18608, Republic of Korea

View abstract

A Vilsmeier Chloroformylation by Continuous Flow Chemistry

Manuel Carrera¹, Laurens De Coen¹, Michelle Coppens², Wim Dermaut², Christian V. Stevens²

¹Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Campus Coupure, Coupure Links 653, Gent B-9000, Belgium

²Agfa-Gevaert NV, Septestraat 27, Mortsel B-2640, Belgium

View abstract

Exploration of continuous flow benchtop NMR acquisition parameters and considerations for reaction monitoring

Tristan Maschmeyer, Paloma L. Prieto, Shad Grunert Jason E. Hein

Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada

View abstract

Predicting performance of photochemical transformations for scaling up in different platforms by combining high-throughput experimentation with computational modeling

Melda Sezen-Edmonds^1,‡,*, Jose E. Tabora1^‡, Benjamin M. Cohen¹, Serge Zaretsky¹, Eric M. Simmons¹, Trevor C. Sherwood², Antonio Ramirez¹

¹Chemical Process Development, Bristol Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States

²Discovery Chemistry, Bristol Myers Squibb, Lawrenceville, New Jersey 08543, United States

^‡These authors contributed equally to this work.

View abstract

Application of a Dual Catalytic Nickel/Iridium-Based Photoredox Reaction to Synthesize 2-Alkyl-N-Arylindoles in a Continuous Flow

Jasmin C. Wilson, Michael J. Boyd, Simon Giroux, Upul K. Bandarage*

Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, Massachusetts 02210, United States

View abstract

Convenient Continuous Flow Synthesis of N-Methyl Secondary Amines from Alkyl Mesylates and Epoxides

Gary Mathieu, Heena Patel, Hélène Lebel

Department of Chemistry and Center in Green Chemistry and Catalysis (CGCC), Université de Montréal, P.O. Box 6128, Station, Downtown, Montréal, QC H3C 3J7, Canada

View abstract

Synthesis of metal-organic frameworks (MOFs) and its application in food packaging: A critical review

P.S.Sharanyakanth, R.Mahendran

Centre of Excellence in Nonthermal Processing, Indian Institute of Food Processing Technology (IIFPT), Pudukkottai Road, Thanjavur, India

View abstract

Flow chemistry as a tool to access novel chemical space for drug discovery

Enol López^a, María Lourdes Linares^b, Jesús Alcázar^b

^aFacultad de Ciencias y Tecnologías Químicas, Universidad de Castilla-La Mancha, Av. Camilo José Cela, 14, Ciudad Real, 13005, Spain

^bJanssen Research & Development, Janssen-Cilag, S.A., Jarama, 75A, Toledo, 45007, Spain

View abstract

Continuous flow synthesis of lipophilic cations derived from benzoic acid as new cytotoxic chemical entities in human head and neck carcinoma cell lines

Mabel Catalán,‡^a, Vicente Castro-Castillo,‡§^b, Javier Gajardo-de la Fuente^b, Jocelyn Aguilera^c, Jorge Ferreira^a, Ricardo Ramires-Fernandez^d, Ivonne Olmedo^e, Alfredo Molina-Berríos^c, Charlotte Palominos^a, Marcelo Valencia^a, Marta Domínguez^f, José A. Souto*^f, José A. Jara*^c

^*Corresponding authors

^aClinical and Molecular Pharmacology Program, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Universidad de Chile, Santiago, Chile

^bDepartment of Organic and Physical Chemistry, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile, Santos Dumont 964, Santiago 8380494, Chile

^cInstitute for Research in Dental Sciences (ICOD), Faculty of Dentistry, Universidad de Chile, Santiago, Chile

^dDentistry School, Universidad Mayor, Santiago 8340585, Chile

^ePhysiopathology Program, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile

^fDepartamento de Química Orgánica, Facultad de Química, CINBIO and IIS Galicia Sur, Universidade de Vigo, Vigo, Spain

View abstract

Antibody Conjugation Method

Inventor: Spedaliere, Christopher J. (Allentown, PA, US)

Assignee: FUJIREBIO DIAGNOSTICS, INC. (MALVERN, PA, US)

View abstract

Novel Applications of α-Diazocarbonyl Compounds and Enabling Technologies in Stereoselective Synthesis

Micol Santi

PhD Thesis, May 2020, Cardiff University

View abstract

Efficient Chemo-Enzymatic Flow Synthesis of High Value Amides and Esters

Francesca Annunziata¹, Martina Letizia Contente², Daniele Betti¹, Cecilia Pinna¹, Francesco Molinari³, Lucia Tamborini^1*, Andrea Pinto³

¹Department of Pharmaceutical Sciences (DISFARM), University of Milan, via Mangiagalli 25, 20133 Milan, Italy

²School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK

³ Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, Italy

View abstract

Continuous Flow Synthesis of Quinolines via a Scalable Tandem Photoisomerization-Cyclization Process

Mara Di Filippo, Marcus Baumann

School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin D04 N2E2, Ireland

View abstract

Toward Secure Supply of Remdesivir via a 2-Pot Triazine Synthesis: Supply Centered Synthesis

Dinesh J. Paymode^a, Flavio S. P. Cardoso^a, Joshua D. Sieber^a, John W. Tomlin^a, Daniel W. Cook^b, Justina Burns^b, Rodger W. Stringham^b, B. Frank Gupton^a, David Snead^a, Toolika Agrawal^a

^aChemical Development, Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond VA, 23298-0100

^bAnalytical Development, Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond VA, 23298-0100

View abstract

Process of Manufacturing Polyols

Inventors: Raghuraman, Arjun (Pearland, TX, US) Heath, William H. (Lake Jackson, TX, US), Mukhopadhyay, Sukrit (Midland, MI, US), Spinney, Heather A. (Midland, MI, US), Wilson, David R. (Midland, MI, US), Gies, Anthony P. (Lake Jackson, TX, US), Paradkar, Manjiri R. (Lake Jackson, TX, US), Notestein, Justin M. (Evanston, IL, US), Nguyen, Sonbinh T. (Evanston, IL, US)

Assignees:

Dow Global Technologies LLC (Midland, MI, US)

Northwestern University (Evanston, IL, US)

View abstract

Accelerating gas–liquid chemical reactions in flow

Suyong Han^a, Marjan Alsadat Kashfipour^a, Mahdi Ramezani^a, Milad Abolhasani^*a

^aDepartment of Chemical and Biomolecular Engineering, North Carolina State University, 911 Partners Way, Raleigh, NC, USA

View abstract

Manganese-Catalyzed Synthesis of Quaternary Peroxides: Application in Catalytic Deperoxidation and Rearrangement Reactions

Akash S. Ubale, Moreshwar B. Chaudhari, Moseen A. Shaikh, Boopathy Gnanaprakasam*

Department of Chemistry, Indian Institute of Science Education and Research, Pune-411008, India.

View abstract

Chemoenzymatic Synthesis of Arabinomannane (AM) Glycoconjugates as Potential Vaccines for Tuberculosis

Zhihao Li^a, Teodora Bavaro^b, Sara Tengattini^b, Roberta Bernardini^c, Maurizio Mattei^c,d, Francesca Annunziata^e, Richard B. Cole^a, Changping Zheng^a, Matthieu Sollogoub^a, Lucia Tamborini^e, Marco Terreni^b, Yongmin Zhang^a

^aSorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire, UMR 8232, 4 Place Jussieu, 75005 Paris, France.

^bDrug Sciences Department, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.

^cItaly Centro Servizi Interdipartimentale – STA, University of Rome “Tor Vergata”, Rome, Italy.

^dDept. of Biology, University of Rome “Tor Vergata”, Rome, Italy.

^eDepartment of Pharmaceutical Sciences, University of Milan, via Mangiagalli 25, 20133 Milan, Italy.

View abstract

Automation of Synthesis in Medicinal Chemistry: Progress and Challenges

Elizabeth Farrant*

New Path Molecular Research Ltd, Building 580, Babraham Research Campus, Cambridge CB22 3AT, UK.

View abstract

Practical Considerations and Examples in Adapting Amidations to Continuous Flow Processing in Early Development

Bryan Li*, Gerald A. Weisenburger, J. Christopher McWilliams

Chemical Research & Development, Pharmaceutical Science Small Molecules Division, Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States

View abstract

Two Colour Photoflow Chemistry for Macromolecular Design

Matthias Van De Walle, Kevin De Bruycker, James P. Blinco, Christopher Barner-Kowollik

Centre for Materials Science, School of Chemistry and Physics, Queensland University of Technology (QUT)2 George St., Brisbane, QLD 4000 (Australia)

View abstract

Photocatalytic α‐Tertiary Amine Synthesis via C−H Alkylation of Unmasked Primary Amines

Alison S. H. Ryder¹ William B. Cunningham², George Ballantyne², Tom Mules², Anna G. Kinsella², Jacob Turner-Dore², Catherine M. Alder³, Lee J. Edwards³, Blandine S. J. McKay³, Matthew N. Grayson², Alexander J. Cresswell²

¹Centre for Sustainable Chemical Technologies, University of Bath 1 South, Claverton Down, Bath, BA2 7AY (UK)

²Department of Chemistry, University of Bath 1 South, Claverton Down, Bath, BA2 7AY (UK) E-Mail: [email protected]

³Medicines Design, GSK Medicines Research Centre Gunnels Wood Rd, Stevenage, SG1 2NY (UK)

View abstract

Lewis Acid Polymerization Catalyst

Inventors: Raghuraman, Arjun (Pearland, TX, US), Heath, William H. (Lake Jackson, TX, US), Mukhopadhyay, Sukrit (Midland, MI, US), Spinney, Heather A. (Midland, MI, US), Wilson, David R. (Midland, MI, US)

Assignee: Dow Global Technologies LLC (Midland, MI, US)

View abstract

Automated Glycan Assembly of Plant Cell Wall Oligosaccharides

Fabian Pfrengle

Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany

View abstract

Process of Manufacturing Surfactants and Lubricants

Raghuraman, Arjun (Pearland, TX, US), Heath, William H. (Lake Jackson, TX, US), Hook, Bruce D. (Lake Jackson, TX, US), Yu, Wanglin (Pearland, TX, US), Mukhopadhyay, Sukrit (Midland, MI, US), Spinney, Heather A. (Midland, MI, US), Wilson, David R. (Midland, MI, US), Notestein, Justin M. (Evanston, IL, US), Nguyen, Sonbinh T. (Evanston, IL, US)

Dow Global Technologies LLC (Midland, MI, US)

Northwestern University (Evanston, IL, US)

View abstract

Preparation of Diorganomagnesium Reagents by Halogen–Lithium Exchange of Functionalized Heteroaryl Halides and Subsequent in situ Trapping with MgCl2·LiCl in Continuous Flow

Rodolfo Hideki Vicente Nishimura^a, Niels Weidmann^b, Paul Knochel^∗b

^aColegiado de Ciências Farmacêuticas, Universidade Federal do Vale do São Francisco, Avenue José de Sá Maniçoba, Petrolina, 56304-205 Petrolina, Brazil

^bLudwig-Maximilians-Universität München, Department Chemie, Butenandtstraße 5–13, 81377 München, Germany

View abstract

C(sp3)–H functionalizations of light hydrocarbons using decatungstate photocatalysis in flow

Gabriele Laudadio^1*, Yuchao Deng^1,2,3,*, Klaas van der Wal¹, Davide Ravelli⁴, Manuel Nuño⁵, Maurizio Fagnoni⁴, Duncan Guthrie⁵, Yuhan Sun^2,3, Timothy Noël^1,†

¹Micro Flow Chemistry and Synthetic Methodology, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Eindhoven, Netherlands.

²School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, P. R. China.

³Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, P. R. China.

⁴PhotoGreen Lab, Department of Chemistry, University of Pavia, Pavia 27100, Italy.

⁵Vapourtec, Fornham St Genevieve, Bury St Edmunds, Suffolk IP28 6TS, UK.

^†Corresponding author. Email: [email protected]

^*These authors contributed equally to this work.

View abstract

Disposable cartridge concept for the on-demand synthesis of turbo Grignards, Knochel–Hauser amides, and magnesium alkoxides

Mateo Berton¹, Kevin Sheehan², Andrea Adamo², D. Tyler McQuade¹

¹Department of Chemical and Life Sciences Engineering, Virginia Commonwealth University, Biotech Eight, 737 N. 5th St., Box 980100, Richmond, VA 23219, USA

²Zaiput Flow Technologies, 300 2nd Avenue, Waltham, MA 02451, USA

View abstract

Flow Chemistry System for Carbohydrate Analysis by Rapid Labeling of Saccharides after Glycan Hydrolysis

Wei-Ting Hung¹, Yi-Ting Chen¹, Chung-Hsuan Chen¹, Yuan Chuan Lee², Jim-Min Fang^{1, 3}, Wen-Bin Yang¹

¹The Genomics Research Center, Academia Sinica, Taipei

²Department of Biology, Johns Hopkins University, Baltimore, MD, USA

³Department of Chemistry, National Taiwan University, Taipei

View abstract

Continuous-Flow Approach for the Multi-Gram Scale Synthesis of C2-Alkyl- or β-Amino Functionalized 1,3-Dicarbonyl Derivatives and Ondansetron Drug Using 1,3-Dicarbonyls

Nirmala Mohant, Krishna Nair, Dasharath Vishambar Sutar, Boopathy Gnanaprakasam*

Department of Chemistry, Indian Institute of Science Education and Research (IISER) Pune, Dr. Homi Bhabha Road, Pune 411008, Maharashtra, (India).

View abstract

Preparation of Mono- and Diisocyanates in Flow from Renewable Carboxylic Acids

Michael D. Burkar¹, Thien An Phung Hai¹, Laurent J. S. De Backer², Nicholas D. P. Cosford²

¹Department of Chemistry and Biochemistry and The California Center for Algae Biotechnology, University of California, San Diego, La Jolla, California 92093-0358, United States

²Cancer Metabolism & Signaling Networks Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States

View abstract

Accelerating Electrochemical Synthesis through Automated Flow: Efficient Synthesis of Chalcogenophosphites

Nasser Amri, Thomas Wirth*

School of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, UK

View abstract

Rearrangement of 3-Hydroxyazetidines into 2-Oxazolines

Ian R. Baxendale¹, Michele Ruggeri¹, Amanda W. Dombrowski², Stevan W. Djuric³

¹Department of Chemistry, University of Durham, Durham DH1 3LE, United Kingdom

² Discovery Chemistry and Technology AbbVie Inc., North Chicago, Illinois 60064, United States

³Discovery Chemistry and Technology Consulting LLC, New Bern, North Carolina 28562, United States

View abstract

Selective DIBAL‑H Monoreduction of a Diester Using Continuous Flow Chemistry: From Benchtop to Kilo Lab

Nick Uhlig¹, Andrew Martins¹, Detian Gao²

¹Process Development, Gilead Alberta ULC,Edmonton, Alberta T6S 1A1, Canada

²Commercial API Process Optimization, Gilead Alberta ULC, Edmonton, Alberta T6S 1A1, Canada

View abstract

Flow Reactor Synthesis of Bio-Based Polyol from Soybean Oil for the Production of Rigid Polyurethane Foam

Kai Guo¹, Zheng Fang², Wei He², Peng Kang³, Jingying Hao⁴, Hao Wu², Yuchen Zhu⁵

¹College of Biotechnology and Pharmaceutical Engineering and State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, China

²College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China

³SINOPEC Beijing Research Institute of Chemical Industry, Beijing 100013, China

⁴The Research Institute of SINOPEC Co., Ltd, Tianjin Branch, Tianjin 10000, China

⁵School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China

View abstract

Bicyclic quinazolinone derivatives

Inventors: Jerome HertDaniel, HunzikerChristoph Kuratli, Rainer E. Martin, Patrizio Mattei, Alexander Lee Satz

Assignee: Hoffmann La Roche Inc

View abstract

Ir/Ni Photoredox Dual Catalysis with Heterogeneous Base Enabled by an Oscillatory Plug Flow Photoreactor

Wouter Debrouwer,^a*, Wim Kimpe^a, Ruben Dangreau,^a, Kevin Huvaere,^a, Hannes P.L. Gemoets,^b, Milad Mottaghi,^c, Simon Kuhn,^c, Koen Van Aken^ab

^aEcoSynth, Industrielaan 12, 9800 Deinze, Belgium

^bCreaflow, Industrielaan 12, 9800 Deinze, Belgium

^c Department of Chemical Engineering, KU Leuven, Celestijnenlaan 200F, 3001, Leuven, Belgium

View abstract

Visible Light Mediated N-Desulfonylation of N-Heterocycles using a Heteroleptic Copper (I) Complex as a Photocatalyst

Cameron J. Hunter, Michael J. Boyd, Gregory D. May, Robert Fimognari*

Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, Massachusetts 02210, United States

View abstract

A Flow Process Built upon a Batch Foundation—Preparation of a Key Amino Alcohol Intermediate via Multistage Continuous Synthesis

John Jin Lim,^*,†, Kenneth Arrington,^*,†, Anna L. Dunn,^†, David C. Leitch,^‡,†, Ian Andrews,^†, Neil R. Curtis,^§, Mark J. Hughes,^§, Daniel R. Tray,^§, Charles E. Wade,^§, Matthew P. Whiting,^§, Charles Goss,^∥, Yangmu Chloe Liu,^§, Brian M. Roesch^§

^†Chemical Development, API Chemistry, GlaxoSmithKline, Upper Providence, Pennsylvania 19426, United States

^‡Department of Chemistry, University of Victoria, Victoria, BC V8P 5C2, Canada

^§Chemical Development, API Chemistry, GlaxoSmithKline, Stevenage SG1 2NY, U.K.

^∥Chemical Development, Product and Process Engineering, GlaxoSmithKline, Upper Providence, Pennsylvania 19426, United States

View abstract

Streamlined Synthesis of Fluoroquinolones

Gupton, Frank B. (Midlothian, VA, US) Tosso, Perrer N. (Glen Allen, VA, US)

VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, VA, US)

View abstract

Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry en Route to the Synthesis of Remdesivir

Tiago Vieira^1*, Andrew C. Stevens^1*, Andrei Chtchemelinine², Detian Gao¹, Pavel Badalov¹, Lars Heumann²

¹Gilead Alberta ULC, 1021 Hayter Road, Edmonton, Alberta T6S 1A1, Canada

²Gilead Sciences, Inc. 333 Lakeside Drive, Foster City, California 94404, United States

View abstract

A Metallaphotoredox Method for the Expansion of Benzyl SAR on Electron-Deficient Amines

Meghan D. Shea, Umar Faruk Mansoor, Brett A. Hopkins*

Discovery Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States

View abstract

Tropylium-promoted prenylation reactions of phenols in continuous flow

Klaus Omoregbee^1,2, Kevin N. H. Luc¹, An H. Dinh¹, Thanh Vinh Nguyen¹

¹School of Chemistry, University of New South Wales, Sydney, Australia

²Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin, Berlin, Germany

View abstract

Continuous-Flow Accelerated Sulfation of Heparan Sulfate Intermediates

Saurabh Anand, Sandhya Mardhekar, Rakesh Raigawali, Nirmala Mohanta, Prashant Jain, Chethan D. Shanthamurthy, Boopathy Gnanaprakasam*, Raghavendra Kikkeri*

Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411 008, India

View abstract

Electrochemistry in continuous systems

Thomas P. Nicholls, Christiane Schotten, Charlotte E. Willans

School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK

View abstract

Continuous Flow Aminolysis of RAFT Polymers Using Multistep Processing and Inline Analysis

Christian H. Hornung*, Karin von Känel, Ivan Martinez-Botella, Maria Espiritu, Xuan Nguyen, Almar Postma, Simon Saubern, John Chiefari, San H. Thang

CSIRO Manufacturing Flagship, Bag 33, Clayton South, Victoria 3169, Australia

View abstract

Making electrochemistry easily accessible to the synthetic chemist

Christiane Schotten^*a, Thomas P. Nicholls^a, Richard A. Bourne^b, Nikil Kapur^c, Bao N. Nguyen^a, Charlotte E. Willans^*a

^aSchool of Chemistry, University of Leeds, Leeds LS2 9JT, UK.

^bSchool of Chemical and Process Engineering, University of Leeds, Leeds LS2 9JT, UK

^cSchool of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK

View abstract

Scale-up and Optimization of a Continuous Flow Synthesis of an α-Thio-β-chloroacrylamide

Olga C. Dennehy¹, Denis Lynch¹, Stuart G. Collins^1*, Anita R. Maguire^2*, Humphrey A. Moynihan^1*

¹School of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork T12 K8AF, Ireland.

²School of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork T12 K8AF, Ireland

View abstract

Automated Glycan Assembly in a Variable-Bed Flow Reactor Provides Insights into Oligosaccharide–Resin Interactions

Eric T. Sletten¹, José Danglad-Flores¹, Manuel Nuño², Duncan Guthrie², Peter H. Seeberger¹

¹Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany

²Vapourtec, Ltd., Park Farm Business Centre, Fornham St. Genevieve, Bury St. Edmunds, Suffolk IP28 6TS, United Kingdom

View abstract

Photocatalytic α‐Tertiary Amine Synthesis via C–H Alkylation of Unmasked Primary Amines

Alison S. H. Ryder^a, William B. Cunningham^b, George Ballantyne^b, Tom Mules^b, Anna G. Kinsella^b, Jacob Turner-Dore^b, Catherine M. Alder^c, Lee J. Edwards^c, Blandine S. J. McKay^c, Matthew N. Grayson^b, Alexander J. Cresswell^b*

^aCentre for Sustainable Chemical Technologies, 1 South, University of Bath, Claverton Down, Bath, BA2 7AY (UK)

^bDepartment of Chemistry, 1 South, University of Bath, Claverton Down, Bath, BA2 7AY (UK)

^cMedicines Design, GSK Medicines Research Centre, Gunnels Wood Rd, Stevenage, SG1 2NY (UK)

View abstract

Dynamic Crystallization Pathways of Polymorphic Pharmaceuticals Revealed in Segmented Flow with Inline Powder XRD

Mark Alan Levenstein^{1, 2}, Lois E Wayment^{3, 4, 5}, C. Daniel Scott^{3, 6}, Ruth A Lunt^{3, 4}, Pierre-Baptiste Flandrin³, Sarah Day⁵, Chiu Tang⁵, Chick C. Wilson³, Fiona C. Meldrum², Nikil Kapur¹, Karen Robertson³

¹School of Mechanical Engineering, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK

²School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK

³Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK

⁴CMAC Future Manufacturing Hub, University of Bath, Claverton Down, Bath BA2 7AY, UK

⁵Diamond Light Source, Harwell Campus, Didcot, Oxfordshire OX11 0DE, UK

⁶Centre for Sustainable Chemical Technologies, University of Bath, Claverton Down, Bath BA2 7AY, UK

View abstract

Management of the Heat of Reaction under Continuous Flow Conditions Using In-Line Monitoring Technologies

Masahiro Hosoya, Shogo Nishijima, Noriyuki Kurose

API R&D Laboratory, CMC R&D Division, Shionogi and Co., Ltd., 1-3, Kuise Terajima 2-chome, Amagasaki, Hyogo 660-0813, Japan

View abstract

Improving Efficiency by Using Continuous Flow to Enable Cycles: Pseudo-Catalysis, Catalysis and Kinetics

Ryan Sullivan, Ottawa, Canada

Thesis submitted to the University of Ottawa, 2020

View abstract

Production of Metal-Organic Frameworks

Rubio Martinez, Marta (Clayton South, AU), Hill, Matthew Roland (Clayton South, AU), Batten, Michael (Clayton South, AU), Lim, Kok Seng (Clayton South, AU), Polyzos, Anastasios (Clayton South, AU), Barton, Timothy Raymond (Clayton South, AU), Hadley, Trevor Deon (Clayton South, AU), Monch, Andreas Alexander (Clayton South, AU)

Commonwealth Scientific and Industrial Research Organisation, Acton (AU)

View abstract

Continuous-Flow Synthesis of Tramadol from Cyclohexanone

Timothy M. Monos^a, Jonathan N. Jaworski^a, John C. Stephens^{b, c}, Timothy F. Jamison*^a

^aDepartment of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA

^bDepartment of Chemistry, Maynooth University, Maynooth, Co. Kildare, Ireland

^cThe Kathleen Lonsdale Institute of Human Health Research, Maynooth University, Maynooth, Co. Kildare, Ireland

View abstract

Photon Equivalents as a Parameter for Scaling Photoredox Reactions in Flow: Translation of Photocatalytic C−N Cross‐Coupling from Lab Scale to Multikilogram Scale

Emily B. Corcoran^*a, Jonathan P. McMullen^*b, François Lévesque^b, Michael K. Wismer^c, John R. Naber^b

^aProcess Research & Development, Merck & Co., Inc., Boston, MA 02115 (USA)

^bProcess Research & Development, Merck & Co., Inc., Rahway, NJ 07065 (USA)

^cScientific Engineering & Design, Merck & Co., Inc., Kenilworth, NJ 07033 (USA)

View abstract

Rapid, Heterogeneous Biocatalytic Hydrogenation and Deuteration in a Continuous Flow Reactor

Lisa A. Thompson^a, Jack S. Rowbotham^a, Jake H. Nicholson^a, Miguel A Ramirez^a, Ceren Zor^b, Holly A. Reeve^a, Nicole Grobert^b, Kylie A. Vincent^a*

^aDepartment of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford, OX1 3QR, UK

^bDepartment of Materials, University of Oxford, Parks Road, Oxford, OX1 3PH, UK

View abstract

A Continuous Flow Sulfuryl Chloride Based Reaction – Synthesis of a Key Intermediate in a New Route Toward Emtricitabine and Lamivudine

Juliana M. de Souza, Mateo Berton, David R. Snead*, D. Tyler McQuade

Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, 23284-3068, USA.

View abstract

Automated Electrochemical Selenenylations

Nasser Amri, Thomas Wirth

School of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, UK

View abstract

Automated radial synthesis of organic molecules

Sourav Chatterjee¹, Mara Guidi^{1, 2}, Peter H. Seeberger^{1, 2}, Kerry Gilmore¹

¹Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

²Freie Universität Berlin, Institute of Chemistry and Biochemistry, Berlin, Germany

View abstract

An Enzymatic Flow-Based Preparative Route to Vidarabine

Lucia Tamborini¹*, Clelia Previtali¹, Francesca Annunziata¹, Teodora Bavaro², Marco Terreni², Enrica Calleri², Francesca Rinaldi², Andrea Pinto³, Giovanna Speranza⁴, Daniela Ubiali²*, Paola Conti¹

¹Department of Pharmaceutical Sciences, University of Milan, via Mangiagalli 25, 20133 Milano, Italy

²Department of Drug Sciences, University of Pavia, viale Taramelli 12, 27100 Pavia, Italy

³Department of Food, Environmental and Nutritional Sciences, University of Milan, via Celoria 2, 20133 Milano, Italy

⁴Department of Chemistry, University of Milan, via Golgi 19, 20133 Milano, Italy

View abstract

Preparation of 5-Hydroxymethylfurfural from High Fructose Corn Syrup Using Organic Weak Acid in Situ as Catalyst

Changqu Lin, Hongli Wu, Junyi Wang, Jinsha Huang, Fei Cao*, Wei Zhuang*, Yanyu Lu, Jiao Chen, Honghua Jia, Pingkai Ouyang

College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, P. R. China

View abstract

Amino Alcohol Acrylonitriles as Activators of the Aryl hydrocarbon Receptor Pathway, An Unexpected MTT Phenotypic Screening Outcome

Jennifer Baker ¹, Cecilia C Russel ¹, Jayne Gilbert ², Jennette Sakoff ², Adam McCluskey ¹

¹ The University of Newcastle, Chemistry, University Drive, Callaghan, 2308 Newcastle, AUSTRALIA

² Calvary Mater Hospital, Medical Oncology, Eidith Street, Waratah, 2298 Newcastle, AUSTRALIA

View abstract

Continuous flow aminolysis under high temperature and pressure

Bryan Li¹, Scott Bader^{1, 2}, Steve M. Guinness¹, Sally Gut Ruggeri¹, Cheryl M. Hayward¹, Steve Hoagland¹, John Lucas^{1, 3}, Ruizhi Li¹, David Limburg¹, J. Christopher McWilliams¹, Jeffrey Raggo¹, John Van Alsten^{1, 4}

¹Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT, 06340, USA

²Celgene Corporation, 556 Morris Ave, Summit, NJ, USA

³Rhodes Technologies, 498 Washington Street, Coventry, RI, USA

⁴Nitto Denko Avecia Inc, 155 Fortune Blvd., Milford, MA, USA

View abstract

Continuous Flow Photochemistry for the Preparation of Bioactive Molecules

Mara Di Filippo, Cormac Bracken, Marcus Baumann*

School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland

View abstract

Development of a Continuous Flow Photoisomerization Reaction Converting Isoxazoles into Diverse Oxazole Products

Cormac Bracken, Marcus Baumann*

School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland

View abstract

Continuous-Flow Biocatalytic Process for the Synthesis of the Best Stereoisomers of the Commercial Fragrances Leather Cyclohexanol (4-Isopropylcyclohexanol) and Woody Acetate (4-(Tert-Butyl)Cyclohexyl Acetate)

Francesca Tentori ^1,†, Elisabetta Brenna ^1,2,*, Michele Crotti ¹, Giuseppe Pedrocchi-Fantoni ², Maria Chiara Ghezzi ¹, and Davide Tessaro ¹

¹ Dipartimento di Chimica, Materiali ed Ingegneria Chimica “Giulio Natta”, Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy

² Istituto di Scienze e Tecnologie Chimiche – CNR, Via Mancinelli 7, 20131 Milano, Italy

View abstract

Visible Light-Mediated (Hetero)aryl Amination Using Ni(II) Salts and Photoredox Catalysis in Flow: A Synthesis of Tetracaine

Boyoung Y. Park, Michael T. Pirnot andStephen L. Buchwald*

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

View abstract

In-Line Purification: A Key Component to Facilitate Drug Synthesis and Process Development in Medicinal Chemistry

Nopphon Weeranoppanant^{1, 2}, Andrea Adamo³

¹Department of Chemical Engineering, Faculty of Engineering, Burapha University, 169 Longhard Bangsaen Road, Muang, Chonburi 02131, Thailand

²School of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Wangchan Valley 555 Moo 1 Payupnai, Wangchan, Rayong 21210 Thailand

³Zaiput Flow Technologies, 300 Second Avenue, Waltham, Massachusetts 02451, United States

View abstract

Preparation of HMF from High Fructose Corn Syrup Using Organic Weak Acid in situ as Catalyst

Changqu Lin, Hongli Wu, Junyi Wang, Jinsha Huang, Fei Cao*, Wei Zhuang*, Yanyu Lu, Jiao Chen, Honghua Jia, Pingkai Ouyang

College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing, 211816 (P. R. China)

View abstract

Continuous flow aminolysis under high temperature and pressure

Bryan Li, Scott Bader, Steve M. Guinness, Sally Gut Ruggeri, Cheryl M. Hayward, Steve Hoagland, John Lucas, Ruizhi Li, David Limburg, J. Christopher McWilliams, Jeffrey Raggon, John Van Alsten

Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT, 06340, USA

View abstract

Amino Alcohol Acrylonitriles as Activators of the Aryl hydrocarbon Receptor Pathway, An Unexpected MTT Phenotypic Screening Outcome

Jennifer Baker^a, Cecilia C Russel^a, Jayne Gilbert^b, Jennette Sakoff*^b, Adam McCluskey*^a

^aChemistry, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia

^bExperimental Therapeutics Group, Department of Medical Oncology, Calvary Mater Hospital, Edith Street, Waratah NSW 2298, Australia

View abstract

Development of a Continuous Flow Photoisomerization Reaction Converting Isoxazoles into Diverse Oxazole Products

Cormac Bracken, Marcus Baumann

School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland

View abstract

Visible Light-Mediated (Hetero)aryl Amination Using Ni(II) Salts and Photoredox Catalysis in Flow: A Synthesis of Tetracaine

Boyoung Y. Park, Michael T. Pirnot, Stephen L. Buchwald*

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

View abstract

Use of Immobilized Amine Transaminase from Vibrio fluvialis under Flow Conditions for the Synthesis of (S)‐1‐(5‐Fluoropyrimidin‐2‐yl)‐ethanamine

Riccardo Semproli ^[a], Gianmarco Vaccaro ^[a],[b], Erica E. Ferrandi ^[c], Marta Vanoni ^[c], Teodora Bavaro ^[a], Giorgio Marrubini ^[a], Francesca Annunziata ^[b], Paola Conti ^[b], Giovanna Speranza ^[d], Daniela Monti ^[*c], Lucia Tamborini ^[*b], Daniela Ubiali ^[*a]

^[a] R. Semproli, G. Vaccaro, Dr. G. Marrubini, Dr. T. Bavaro, Prof. D. Ubiali, Department of Drug Sciences, University of Pavia, Viale Taramelli 12, I-27100 Pavia, Italy

^[b] G. Vaccaro, F. Annunziata, Prof. P. Conti, Prof. L. Tamborini, Department of Pharmaceutical Sciences, University of Milano, Via Mangiagalli 25, I-20133 Milano, Italy

^[c] Dr. E. E. Ferrandi, M. Vanoni, Dr. D. Monti, Istituto di Scienze e Tecnologie Chimiche "Giulio Natta" (SCITEC) – CNR, Via Bianco 9, I-20131 Milano, Italy

^[d] Prof. G. Speranza, Department of Chemistry, University of Milano, Via Golgi 19, I-20133 Milano, Italy

View abstract

Continuous Flow Enables Metallaphotoredox Catalysis in a Medicinal Chemistry Setting: Accelerated Optimization and Library Execution of a Reductive Coupling between Benzylic Chlorides and Aryl Bromides

Zachary G. Brill, Casey B. Ritts, Umar Faruk Mansoor, Nunzio Sciammetta

Department of Discovery Chemistry, MRL, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115 USA

View abstract

Continuous Flow Synthesis of Methyl Oximino Acetoacetate: Accessing Greener Purification Methods with Inline Liquid-Liquid Extraction and Membrane Separation Technology

René Lebl^{1, 2}, Trevor Murray³, Andrea Adamo³, David Cantillo^{1, 2}, C. Oliver Kappe^{1, 2}

¹Center for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria

²Institute of Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria

³Zaiput Flow Technologies, 300 2nd Avenue, Waltham, Massachusetts 02451, United States

View abstract

Cellulose fast pyrolysis for platform chemicals: assessment of potential targets and suitable reactor technology

Anurag Parihar, Sankar Bhattacharya

Department of Chemical Engineering, Monash University, Clayton, VIC, Australia

View abstract

Continuous and green microflow synthesis of azobenzene compounds catalyzed by consecutively prepared tetrahedron CuBr

Hong Qin^a,1, Chengkou Liu^a,1, Niuniu Lva², Wei He^a, Jingjing Meng^a, Zheng Fang^a, Kai Guo^a,b

^a College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30 Puzhu South Road, Nanjing, China

^b State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China

View abstract

Safe and Scalable Continuous Flow Azidophenylselenylation of Galactal to Prepare Galactosamine Building Blocks

Mónica Guberman^a,b, Bartholomäus Pieber^a, Peter H. Seeberger^a,b

^aDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany

^bDepartment of Chemistry and Biochemistry, Freie Universitat Berlin, Arnimalle 22, 14195 Berlin, Germany

View abstract

A practical method for continuous production of sp3-rich compounds from (hetero)aryl halides and redox-active esters

Eiichi Watanabe^a, Yiding Chen^b, Oliver May^b, Steven V. Ley^*b

^aNew Path Molecular Ltd. Building 580, Babraham Research Campus, Cambridge (UK)

^bDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge (UK)

View abstract

Metal‐Free Visible‐Light‐Mediated Hydrotrifluoromethylation of Unactivated Alkenes and Alkynes in Continuous Flow

Anne‐Laure Barthelemy Guillaume Dagousset Emmanuel Magnier

View abstract

A new formulation for symbolic regression to identify physico-chemical laws from experimental data

Pascal Neumann^ab, Liwei Cao ^bc, Danilo Russo^b, Vassilios S. Vassiliadis^b, Alexei A.Lapkin^bc

^a Aachener Verfahrenstchnik – Process Systems Engineering, RWTH Aachen University, Aachen, Germany

^b Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK

^c Cambridge Centre for Advanced Research and Education in Singapore, CARES Ltd., 1 CREATE Way, CREATE Tower #05-05, 138602 Singapore, Singapore

View abstract

Real-Time Monitoring of Solid-Phase Peptide Synthesis Using a Variable Bed Flow Reactor

Eric T. Sletten^a, Manuel Nuno^b, Duncan Guthrie^b, Peter Seeberger^a,c

^aDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany

^bVapourtec Ltd, Park Farm Business Centre, Fornham St Genevieve, Bury St Edmunds, Suffolk IP28 6TS, U.K

^cDepartment of Chemistry and Biochemistry, Freie Universität Berlin, Arnimalle 22, 14195, Berlin, Germany

View abstract

Electroorganic Synthesis under Flow Conditions

Mohamed Elsherbini, Thomas Wirth

School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, United Kingdom

View abstract

Lilly Research Award Program (LRAP): A Successful Academia–Industry Partnership Model in the Context of Flow Chemistry for Drug Discovery

Mateos, Carlos
View abstract

In situ non-invasive Raman spectroscopic characterisation of succinic acid polymorphism during segmented flow crystallisation

Anuradha R. Pallipurath^a, Pierre-Baptiste Flandrin^a, Lois E. Wayment^{a, b, c}, Chick C. Wilson^{a, b}, Karen Robertson^a

^aDepartment of Chemistry, University of Bath, Claverton Down, BA2 7AY, UK

^bCMAC Future Manufacturing Hub, University of Bath, Claverton Down, Bath BA2 7AY, UK

^c.Diamond Light Source, Harwell Campus, Didcot, Oxfordshire OX11 0DE, UK

View abstract

Trypanosomes inhibitors

Inventors: Maude Giroud, Wolfgang Haap, Bernd Kuhn, Rainer E. Martin

Assignee: Hoffmann La Roche Inc

View abstract

Microfluidic synthesis of fatty acid esters: Integration of dynamic combinatorial chemistry and scale effect

Wei He ^a,1, Yuan Gao ^a,1, Guiqin Zhu ^a, Hao Wu ^a, Zheng Fang ^a, Kai Guo ^a,b

^a College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, PR China

^b State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 210009, PR China

View abstract

MnO2@Fe3O4 Magnetic Nanoparticles as Efficient and Recyclable Heterogeneous Catalyst for Benzylic sp3 C−H Oxidation

Akanksha M. Pandey^a, Dr. Sandip G. Agalave^a, Dr. Chathakudath P. Vinod^b, Dr. Boopathy Gnanaprakasam^a

^aDepartment of Chemistry, Indian Institute of Science Education and Research, Pune-, 411008 India

^bCSIR-NCL Catalysis and Inorganic Chemistry Division, Pune, India

View abstract

Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction

Sonia De Angelis^{1, 2}, Paolo Celestini³, Rosa Purgatorio¹, Leonardo Degennaro^{1, 2}, Gabriele Rebuzzini³, Renzo Luisi^{1, 2}, Claudia Carlucci^{1, 2}

¹Department of Pharmacy - Drug Sciences, University of Bari "A. Moro" Via E. Orabona 4, Bari, Italy

²Flow Chemistry and Microreactor Technology FLAME-Lab, Bari, Italy

³COSMA S.p.A, Ciserano Italy

View abstract

Photochemical flow synthesis of 3‐hydroxyazetidines

Michele Ruggeri¹, Amanda Worthy Dombrowski², Stevan W. Djuric², Ian Richard Baxendale¹

¹University of Durham, Department of Chemistry, South Road, DH1 3LE Durham, UNITED KINGDOM

²AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064 Chicago, UNITED STATES

View abstract

Flow nanoprecipitation of size-controlled D-leucine nanoparticles for spray-drying formulations

Bruno Cerra, Gabriele Mosca, Maurizio Ricci, Aurélie Schoubben and Antimo Gioiello

Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, I-06122 Perugia, Italy

View abstract

Visible‐Light‐Mediated Cross‐Couplings and C–H Activation via Dual Photoredox/Transition‐Metal Catalysis in Continuous‐Flow Processes

Soo Dong Kim, Jonghyun Lee, Nam-Jung Kim, Boyoung Park

Kyung Hee University, Department of Pharmacy, Kyungheedaero 26, 02447 Seoul, Republic of Korea

View abstract

A flow platform for degradation-free CuAAC bioconjugation

Marine Z. C. Hatit¹, Linus F. Reichenbach¹, John M. Tobin², Filipe Vilela², Glenn A. Burley¹, Allan J. B. Watson³

¹Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, UK

²Chemical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK

³School of Chemistry, University of St Andrews, North Haugh, St Andrews

View abstract

Batch Versus Flow Lithiation‐Substitution of 1,3,4‐Oxadiazoles: Exploitation of Unstable Intermediates Using Flow Chemistry

Jeff Y. F. Wong, John M. Tobin, Filipe Vilela, Graeme Barker

Institute of Chemical Sciences, Heriot-Watt University, Edinburgh EH11 4AS, Scotland, UK

View abstract

A Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow

Yiding Chen^†, Oliver May^†, David C. Blakemore^‡, and Steven V. Ley^†*

^† Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.

^†‡ Medicine Design, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States

View abstract

Heumann Indole Flow Chemistry Process

Cynthia Crifar, Fenja Leena Dücker, Sacha Nguyen Thanh, Vanessa Kairouz, William D. Lubell

Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montreal, Quebec H3C 3J7, Canada

View abstract

Integrated plug flow synthesis and crystallisation of pyrazinamide

C. Daniel Scott^a, Ricardo Labes^b, Martin Depardieu^c, Claudio Battilocchio^b, Matthew G. Davidson^a, Steven V. Ley^b, Chick C. Wilson^ad, and Karen Robertson^*c

^a Centre for Sustainable Chemical Technologies, Department of Chemistry, University of Bath, UK

^b Department of Chemistry, University of Cambridge, UK

^c Department of Chemistry, University of Bath, UK

^d EPSRC Future Continuous Manufacturing and Advanced Crystallisation Research Hub, University of Bath, UK

View abstract

Conjugated porous polymers for photocatalytic applications

Y. L. Wong^a, J. M. Tobin^b, Z. Xu^a, F. Vilela^*b

^aDepartment of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong

^bSchool of Engineering and Physical Sciences, Heriot Watt University, Edinburgh, UK

View abstract

In-Flow Flash Nanoprecipitation of Size-Controlled D-Leucine Nanoparticles for Spray-Drying Formulations

Bruno Cerra^a, Gabriele Mosca^a, Maurizio Ricci^a, Aurélie Schoubben^a, Antimo Gioiello^a

^aDepartment of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, I-06122 Perugia, Italy.

View abstract

The Role of Single-Atom Catalysis in Potentially Disruptive Technologies

Mario Pagliaro

Instituto per lo Studio dei Materiali Nanostrutturati, CNR, Palermo, Italy

View abstract

A Simple and Efficient Flow Preparation of Pyocyanin a Virulence Factor of Pseudomonas aeruginosa

Frederik B. Mortzfeld^a,b, Jörg Pietruszka^b, Ian R. Baxendale*^a

^aDepartment of Chemistry, University of Durham, South Road, Durham, Durham, DH1 3LE, UK

^bInstitut für Bioorganische Chemie, Heinrich‐Heine‐Universität Düsseldorf im Forschungszentrum Jülich, 52425, Jülich, Deutschland

View abstract

Electrophilic Bromination in Flow: A Safe and Sustainable Alternative to the Use of Molecular Bromine in Batch

Reinout Van Kerrebroeck, Pieter Naert, Thomas S. A. Heugebaert, Matthias D'hooghe, Christian V. Stevens*

SynBioC research Group, Department of Green Chemistry and Technology, Ghent University, Coupure Links 653, 9000 Ghent, Belgium

View abstract

Microfluidic process intensification for synthesis and formulation in the pharmaceutical industry

Aliaa I. Shallan^a,b,*, Craig Priest^a,c

^aFuture Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia

^bFaculty of Pharmacy, Helwan University, Cairo, 11795, Egypt

^cSchool of Engineering, University of South Australia, Mawson Lakes, SA, 5095, Australia

View abstract

Continuous Flow Chemo-Enzymatic Baeyer–Villiger Oxidation with Superactive and Extra-Stable Enzyme/Carbon Nanotube Catalyst: An Efficient Upgrade from Batch to Flow

Anna Szelwicka^a, Przemysław Zawadzki^b, Magdalena Sitko^a, Sławomir Boncel^c, Wojciech Czardybon^b, Anna Chrobok^*a

^aDepartment of Chemical Organic Technology and Petrochemistry, Silesian University of Technology, Krzywoustego 4, 44-100 Gliwice, Poland

^bSelvita S.A., Bobrzynskiego 14, 30-348 Cracow, Poland

^cDepartment of Organic Chemistry, Bioorganic Chemistry, and Biotechnology, Silesian University of Technology, Krzywoustego 4, 44-100 Gliwice, Poland

View abstract

Synthetic Route Design of AZD4635, an A2AR Antagonist

Mairi M. Littleson ^*†, Andrew D. Campbell ^†, Adam Clarke ^†, Mark Dow ^†, Gareth Ensor ^†, Matthew C. Evans ^†, Adam Herring ^†,Bethany A. Jackson ^†, Lucinda V. Jackson ^†, Staffan Karlsson ^‡, David J. Klauber ^†, Danny H. Legg ^§, Kevin W. Leslie ^†, Štefan Moravcí̌k ^‡, Chris D. Parsons ^§, Thomas O. Ronson ^†, Rebecca E. Meadows ^†

^† Chemical Development, Pharmaceutical Technology and Development, AstraZeneca, Macclesfield Campus, SK10 2NA, Macclesfield, U.K.

^‡ Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, SE-431 83 Mölndal, Sweden

^§ Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Macclesfield Campus, SK10 2NA, Macclesfield, U.K.

View abstract

Continuous flow knitting of a triptycene hypercrosslinked polymer

Cher Hon Lau ^*a, Tian-dan Lu ^b, Shi-Peng Sun ^b, Xianfeng Chen ^a, Mariolino Carta ^c, Daniel M. Dawson ^d

^a School of Engineering, The University of Edinburgh, Robert Stevenson Road,Edinburgh EH9 3FB, UK

^b State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech. University, Nanjing 210009, China

^c Department of Chemistry, College of Science, Swansea University, Grove Building, Singleton Park, Swansea SA2 8PP, UK

^d School of Chemistry, EaStCHEM and Centre of Magnetic Resonance, University of St. Andrews, KY16 9ST, UK

View abstract

Transaminase‐catalyzed continuous synthesis of biogenic aldehydes

Martina L. Contente ^a, Francesca Paradisi ^*a,b

^a School of Chemistry, University of Nottingham, University Park, Nottingham, NG7, 2RD, United Kingdom

^b Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern

View abstract

Optimisation by Design of Experiment of Benzimidazol-2-One Synthesis under Flow Conditions

Serena Mostarda^1,2, Tugçe Gür Maz³, Alessandro Piccinno¹, Bruno Cerra¹, Erden Banoglu³

¹Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy

²Current affiliation: Novartis Pharma AG, CH-4002 Basel, Switzerland

³Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Etiler, 06560 Ankara, Turkey

View abstract

A Novel and Efficient Continuous-Flow Route To Prepare Trifluoromethylated N‑Fused Heterocycles for Drug Discovery and Pharmaceutical Manufacturing

Lara Amini-Rentsch^1,2, Ennio Vanoli², Sylvia Richard-Bildstein¹, Roger Marti², Gianvito Vilé¹

¹ Idorsia Pharmaceuticals Ltd., Chemistry Technologies & Lead Discovery, Department of Drug Discovery Chemistry, Hegenheimermattweg 91, CH-4123 Allschwil, Switzerland

² University of Applied Sciences Western Switzerland (HES-SO), Haute Ecole d’Ingénierie et d’Architecture de Fribourg, Institute of Chemical Technology, 80 boulevard de Pérolles, CH-1700 Fribourg, Switzerland

View abstract

A robust and scalable continuous flow process for glycerol carbonate

Seger Van Mileghem^a,b, Wim M. De Borggraeve^b, Ian R. Baxendale^a

^aUniversity of Durham, Department of Chemistry, South Road, DH1 3LE Durham, UK

^bKU Leuven, Division of Molecular Design and Synthesis, Department of Chemistry, Celestijnenlaan 200F, 3001 Heverlee, Belgium

View abstract

Flow Hydrodediazoniation of Aromatic Heterocycles

Liesa Röder¹, Alexander J. Nicholls², Ian R. Baxendale²

¹ Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany

² Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK

View abstract

Continuous-Flow Electrochemical Generator of Hypervalent Iodine Reagents: Synthetic Applications

Dr Mohamed Elsherbini, Bethan Winterson, Haifa Alharbi, Ana A. Folgueiras-Amador, Clina Gnot, Thomas Wirth

School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT UK

View abstract

Definitive screening designs for multistep kinetic models in flow

Christopher A. Hone^a, Alistair Boyd^b, Anne O’Kearney-McMullan^b, Richard A. Bourne^a*, Frans L. Muller^a*

^a Institute of Process Research and Development (iPRD), School of Chemistry and School of Chemical and Process Engineering, University of Leeds, LS2 9JT, UK

^b Global Development, AstraZeneca, Macclesfield, Cheshire, UK, SK10 2NA, UK

View abstract

Visible light‐promoted Fe‐catalyzed Csp2‐Csp3 Kumada cross‐coupling in flow

Xiao-Jing Wei^a, Irini Abdiaj^b, Carlo Sambiagio^a, Chenfei Li^c, Eli Zysman-Colman^c, Jesús Alcázar^b, Timothy Noël^a

^a Department of Chemical Engineering and Chemistry Micro Flow Chemistry and Synthetic Methodology Eindhoven University of Technology Den Dolech 2, 5612 AZ Eindhoven (The Netherlands)

^b Discovery Sciences, Janssen Research and Development Jannsen-Cilag, S.A. Jarama 75A, 45007 Toledo (Spain)

^c Organic Semiconductor Center, EaStCHEM School of ChemistryUniversity of St Andrews, St Andrews, Fife, KY16 9ST (UK).

View abstract

Experimental Methods in Chemical Engineering: Micro‐Reactors

Arturo Macchi ^a, Patrick Plouffe ^a, Gregory S. Patience ^b, Dominique M. Roberge ^c

^a Centre for Catalysis Research and Innovation, Department of Chemical and Biological Engineering, University of Ottawa, Ottawa, ON, K1N 6N5 Canada

^b Department of Chemical Engineering ‐ Ecole Polytechnique de Montreal, QC, H3C 3A7 Canada

^c Chemical Manufacturing Technologies, Lonza AG, CH‐, 3930 Visp, Switzerland

View abstract

Continuous Flow Synthesis of Highly Substituted Tetrahydrofurans

Patrick Hoffmeyer, Christoph Schneider

Institute of Organic Chemistry, University of Leipzig, Johannisallee 29, D, ‐04103 Leipzig Germany

View abstract

Peroxidation of 2-oxindole and barbituric acid derivatives under batch and continuous flow using an eco-friendly ethyl acetate solvent

Moreshwar B. Chaudhari ^a, Nirmala Mohanta ^a, Akanksha M. Pandey ^a, Madhusoodhanan Vandana ^b, Krishanpal Karmodiya ^b, Boopathy Gnanaprakasam*^a

^a Department of Chemistry, Indian Institute of Science Education and Research (IISER) Pune, Dr. Homi Bhabha Road, Pune 411008, India

^b Department of Biology, Indian Institute of Science Education and Research (IISER) Pune, Dr. Homi Bhabha Road, Pune 411008, India

View abstract

Rapid and Multigram Synthesis of Vinylogous Esters under Continuous Flow: An Access to Transetherification and Reverse Reaction of Vinylogous Esters

Nirmala Mohanta, Moreshwar B. Chaudhari, Naveen Kumar Digrawal, Boopathy Gnanaprakasam*

Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India

View abstract

Continuous manufacturing – the Green Chemistry promise?

Luke Rogers and Klavs F. Jensen

Department of Chemical Engineering, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139-4307, USA

View abstract

Practical and regioselective amination of arenes using alkyl amines

Alessandro Ruffoni ¹, Fabio Juliá ¹, Thomas D. Svejstrup ¹, Alastair J. McMillan ¹, James J. Douglas ², Daniele Leonori ¹

¹ School of Chemistry, University of Manchester, Manchester, UK.

² Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit,AstraZeneca, Macclesfield, UK

View abstract

The Influence of Residence Time Distribution on Continuous-Flow Polymerization

Marcus H. Reis, Travis P. Varner, Frank A. Leibfarth

Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

View abstract

Additive manufacturing of photoactive polymers for visible light harvesting

Adilet Zhakeyev^ac, John Tobin^a, Huizhi Wang^b, Filipe Vilela^a, Jin Xuan^ac

^a School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK

^b Department of Mechanical Engineering, Imperial College London, Exhibition Road, South Kensington Campus, London, SW7 2AZ, UK

^c Department of Chemical Engineering, Loughborough University, Loughborough, UK

View abstract

Modeling and Design of a Flow-Microreactor-Based Process for Synthesizing Ionic Liquids

Yuichi Nakahara ^*†⊥, Bert Metten ^‡, Osamu Tonomura ^§⊥, Aiichiro Nagaki ^∥⊥, Shinji Hasebe ^§⊥, Jun-ichi Yoshida ^⊥#, Francesco Molinari ¹

^† New Frontiers Research Group, Frontier Research Laboratories, Institute For Innovation, Ajinomoto Co., Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki, Kanagawa 210-8681, Japan

^‡ Ajinomoto Bio Pharma Services, Cooppallaan 91, B-9230 Wetteren, Belgium

^§ Department of Chemical Engineering, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan

^∥ Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan

^⊥ Micro Chemical Production Study Consortium in Kyoto University, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan

^# National Institute of Technology, Suzuka College, Shiroko-cho, Suzuka, Mie 510-0294, Japan

View abstract

Synthesis of a Renewable Macrocyclic Musk: Evaluation of Batch, Microwave, and Continuous Flow Strategies

Émilie Morin ^§, Johann Sosoe ^§, Michaël Raymond ^§, Benjamin Amorelli ^†*, Richard M. Boden ^†, Shawn K. Collins ^*§

^§ Department of Chemistry and Centre for Green Chemistry and Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, Canada H3C 3J7

^† Research & Development, International Flavors & Fragrances Inc., 1515 State Route 36, Union Beach, New Jersey, 07735, United States

View abstract

Bioprocess Intensification Using Flow Reactors: Stereoselective Oxidation of Achiral 1,3-diols with Immobilized Acetobacter Aceti

Valerio De Vitis ¹, Federica Dall’Oglio ², Francesca Tentori ³, Martina Letizia Contente ⁴, Elisabetta Brenna ³, Lucia Tamborini ², Francesco Molinari ¹

¹ Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, Via Celoria 2, 20133 Milan, Italy

² Department of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy

³ Dipartimento di Chimica, Materiali ed Ingegneria Chimica “Giulio Natta” Politecnico di Milano, Via Mancinelli 7, I-20131 Milan, Italy

⁴ School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK

View abstract

Reversible chemoselective transetherification of vinylogous esters using Fe-catalyst under additive free conditions

Nenavath Parvathalu, Sandip G. Agalave, Nirmala Mohanta and Boopathy Gnanaprakasam

Department of Chemistry, Indian Institute of Science Education and Research, Pune-411008, India

View abstract

Investigation of a Weak Temperature–Rate Relationship in the Carbamoylation of a Barbituric Acid Pharmaceutical Intermediate

Alexander G. O’Brien ^*†, Yangmu Chloe Liu ^*†, Mark J. Hughes ^‡, John Jin Lim ^†, Neil S. Hodnett ^‡, Nicholas Falco^†

^† GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States

^‡ GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom

View abstract

Protection‐Group‐Free Synthesis of Sequence‐Defined Macromolecules via Precision λ‐Orthogonal Photochemistry

Waldemar Konrad^1,2, Christian Fengler^1,2, Sarrah Putwa¹, Christopher Barner-Kowollik^1,2

¹Macromolecular Architectures, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology (KIT), Engesserstr. 18, 76131 Karlsruhe, Germany

²School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology (QUT), 2 George Street, QLD, 4000 Brisbane, Australia

View abstract

Decarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)phthalimides, an Organic Photocatalyst, and Visible Light

Trevor C. Sherwood^*†, Hai-Yun Xiao^*†, Roshan G. Bhaskar^†, Eric M. Simmons^‡, Serge Zaretsky^‡, Martin P. Rauch^§, Robert R. Knowles^§, T. G. Murali Dhar^†

^† Research and Development, Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States

^‡ Chemical and Synthetic Development, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States

^§Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States

View abstract

Flow Electrochemical Cyclizations via Amidyl Radicals: Easy Access to Cyclic Ureas

Nisar Ahmed^a,b*, Aggeliki Vgenopoulou^a

^a School of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, UK

^b School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK

View abstract

Efficient Flow Electrochemical Alkoxylation of Pyrrolidine-1-Carbaldehyde

Nasser Amri^a, Ryan A. Skilton^b, Duncan Guthrie^b, Thomas Wirth^*a

^a School of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, UK

^b Vapourtec Ltd., 21 Park Farm Business Centre, Bury St Edmunds, IP28 6TS, UK

View abstract

Overcoming Water Insolubility in Flow: Enantioselective Hydrolysis of Naproxen Ester

David Roura Padrosa¹, Valerio De Vitis², Martina Letizia Contente^1*, Francesco Molinari², Francesca Paradisi^1*

¹ School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK

² Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli studi di Milano, Via Mongiagalli 25, 20133 Milan, Italy;

View abstract

A solid-supported arylboronic acid catalyst for direct amidation

Yihao Du^a,, Thomas Barber^a,, Sol Ee Lim^a,, Henry S. Rzepa^b,, Ian R. Baxendale^*a,, Andrew Whiting^*a,

^a Centre for Sustainable Chemical Processes, Department of Chemistry, Durham University, Science Laboratories, South Road, Durham, UK

^a Department of Chemistry, Imperial College, South Kensington Campus, London, UK

View abstract

Visible Light‐Promoted Beckmann Rearrangements: Separating Sequential Photochemical and Thermal Phenomena in a Continuous Flow Reactor

Yuesu Chen, David Cantillo, C. Oliver Kappe

Karl-Franzens-Universitat Graz, Institute of Chemistry, 8010 Graz, AUSTRIA

View abstract

A Consolidated and Continuous Synthesis of Ciprofloxacin from a Vinylogous Cyclopropyl Amide

N. Perrer Tosso, Bimbisar K. Desai, Eliseu De Oliveira, Juekun Wen, John Tomlin, and B. Frank Gupton*

Department of Chemistry and Department of Chemical and Life Science Engineering, Virginia Commonwealth University, 601 West Main Street, Richmond, Virginia 23220, United States

View abstract

Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry

Andrew R Bogdan, Amanda W Dombrowski

Discovery Chemistry and Technologies, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States

View abstract

Towards a Scalable Synthesis of 2‐Oxabicyclo[2.2.0]hex‐5‐en‐3‐one Using Flow Photochemistry

Jason D. Williams^a,b, Yuma Otake^a, Guilhem Coussanes^c, Iakovos Saridakisc^c, Nuno Maulidec^c, C. Oliver Kappea^a,b

^a Center for Continuous Flow Synthesis and Processing (CC FLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria

^b Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010 Graz, Austria

^c Institute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090 Vienna, Austria

View abstract

Continuous flow processing as a tool for the generation of terpene-derived monomer libraries

Renan Galaverna^a, Lucas P. Fernandes^a, Duncan L. Browne^b, Julio C. Pastre^a

^a Institute of Chemistry, University of Campinas – UNICAMP, Campinas, Brazil

^b School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK

View abstract

Rapid Photochemical Reaction Studies under Continuous-flow Conditions in the Vapourtec UV-150 Reactor-A Technical Note

Richard Hunter^a, Sam Josland^a, Joseph Moore^b, Duncan Guthrie^b, Mark J. Robertson^a, Michael Oelgemöller^a

^a College of Science and Engineering, James Cook University, Townsville, QLD 4911, Australia

^b Vapourtec Ltd, Park Farm Business Centre, Fornham St Genevieve, Bury St Edmunds, Suffolk, IP28 6TS, UK

View abstract

Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines

Rachel Grainger^*a, Tom D. Heightman^a, Steven V. Ley^b, Fabio Lima^b,c, Christopher N. Johnson^*a

^a Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge, UK

^b Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK

^c Novartis Pharma AG, Novartis Campus, 4002 Basel, Switzerland

View abstract

Enhanced mixing of biphasic liquid-liquid systems for the synthesis of gem-dihalocyclopropanes using packed bed reactors

T von Keutz^1,2, D Cantillo^1,2, CO Kappe^1,2

¹ Center for Continuous Flow Synthesis and Processing (CCFLOW) Research Center Pharmaceutical Engineering GmbH (RCPE) Graz, Austria

² Institute of Chemistry, NAWI Graz, University of Graz, Graz, Austria

View abstract

Deprotection of N-Boc Groups Under Continuous Flow High Temperature Conditions

Bryan Li, Ruizhi Li, Peter Dorff, James Christopher McWilliams, Robert M Guinn, Steven M. Guinness, Lu Han, Ke Wang, Shu Yu

Medicinal Science, Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States

View abstract

A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light

Kaid C. Harper, Eric G. Moschetta, Shailendra V. Bordawekar, Steven J. Wittenberger

Process Research and Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States

View abstract

De novo design of organic photocatalysts: bithiophene derivatives for the visible‐light induced C‐H functionalization of heteroarenes

Cecilia Bottecchia¹, Raul Martin², Irini Abdiaj³, Ettore Crovini⁴, Jesus Alcazar³, Jesus Jorduna, Maria Blesa, Jose Carrillo³, Pilar Prieto, Timothy Noel¹

¹ TU Eindhoven, Netherlands

² Universidad de Castilla-La Mancha Facultad de Ciencias y Tecnologias Quimicas de Ciudad Real, Spain

³ Janssen Research and Development, Spain

⁴ University of Saint Andrews School of Chemistry, United Kingdom

View abstract

Integrating reactive distillation with continuous flow processing

Marcus Baumann

School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland

View abstract

Enabling tools for continuous-flow biphasic liquid–liquid reaction

Nopphon Weeranoppanant ^a

^a Department of Chemical Engineering, Faculty of Engineering, Burapha University, 169 Longhard Bangsaen, Saensook, Muang, Thailand

View abstract

High-Throughput Template-Free Continuous Flow Synthesis of Polyaniline Nanofibers

Rekha Singh^†#, Karuna Veeramani^†‡#, Rishab Bajpai^†, Anil Kumar^*†‡§

^† Department of Chemistry, ^‡ IITB-Monash Research Academy,^§ National Centre for Excellence in Technologies for Internal Security (NCETIS), Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India

View abstract

A Continuous Flow Strategy for the Facile Synthesis and Elaboration of Semi‐Saturated Heterobicyclic Fragments

Nicola Luise, Eleanor Wyatt, Gary Tarver, Paul Graham Wyatt

University of Dundee, School of Life Sciences, DD1 5EH Dundee, UNITED KINGDOM

View abstract

Continuous Flow Chlorination of Alkenyl Iodides Promoted by Copper Tubing

Antoine Nitelet^a, Vanessa Kairouz^b, Hélène Lebel^b, André B. Charette^b, Gwilherm Evano^a

^a Laboratoire de Chimie Organique, Service de Chimie et Physico, Chimie Organiques, Université libre de Bruxelles (ULB), Avenue F. D. Roosevelt 50, CP160/06, 1050 Brussels, Belgium

^b Centre in Green Chemistry and Catalysis, Faculty of Arts and Sciences, Department of Chemistry, Université de Montréal, P.O. Box 6128, Station Downtown, Montréal, Québec, H3C 3J7, Canada

View abstract

Continuous flow palladium-catalyzed trifluoromethylthiolation of C-H bonds

Alexanne Bouchard ¹, Vanessa Kairouz ¹, Maxime Manneveau ², Heng-Ying Xiong ², Tatiana Besset ²

¹ Department of Chemistry and Continuous Flow Synthesis Laboratory, Université de Montréal, Montréal, Canada

² INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), Normandie Université, Rouen, France

View abstract

Continuous preparation for rifampicin

Xin Li ¹, Zhuang Liu ¹, Zheng Fang ¹, Hao Qi ¹, Siyu Huang ¹, Shanshan Miao ¹, Kai Guo ^1,2

¹ College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China

² State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, China

View abstract

Using Carbon Dioxide as a Building Block in Continuous Flow Synthesis

Hyowon Seo, Long V. Nguyen, Timothy F. Jamison

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts

View abstract

Chemoselective Synthesis of Amines from Ammonium Hydroxide and Hydroxylamine in Continuous Flow

Clément Audubert, Alexanne Bouchard, Gary Mathieu, Hélène Lebel

Department of Chemistry and Centre in Green Chemistry and Catalysis (CGCC), Université de Montréal, P.O. Box 6128, Station Downtown, Montréal, QC H3C 3J7, Canada

View abstract

Enantiospecific cyclization of methyl N-(tert-butoxycarbonyl)-N-(3-chloropropyl)-D-alaninate to 2-methylproline derivative via ‘memory of chirality’ in flow

Gianvito Vilé ¹, Gunther Schmidt ², Sylvia Richard-Bildstein ¹, Stefan Abele ²,

¹ Drug Discovery Chemistry, Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland

² Chemical Development, Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland

View abstract

Mg-Catalyzed OPPenauer Oxidation—Application to the Flow Synthesis of a Natural Pheromone

Virginie Liautard, Mélodie Birepinte, Camille Bettoli, Mathieu Pucheault

Institut des Sciences Moléculaires (ISM), UMR 5255 CNRS—Université de Bordeaux, 351 Cours de la Libération, 33405 Talence CEDEX, France

View abstract

Dehydration of an Insoluble Urea Byproduct Enables the Condensation of DCC and Malonic Acid in Flow

Alexander G. O’Brien, Eric M. Ricci, Michel Journet

GlaxoSmithKline, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States

View abstract

Self-Sufficient Flow-Biocatalysis by Coimmobilization of Pyridoxal 5′-Phosphate and ω-Transaminases onto Porous Carriers

Ana I. Benítez-Mateos ^†, Martina L. Contente ^§, Susana Velasco-Lozano ^⊥, Francesca Paradisi ^*§, Fernando López-Gallego ^*⊥‡

^† Heterogeneous Biocatalysis Laboratory, CICbiomaGUNE, Paseo Miramón 182, Edificio empresarial C”, 20014 San Sebastián, Spain

^§ School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K

^⊥ Heterogeneous biocatalysis laboratory, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH−CSIC), University of Zaragoza, C/Pedro Cerbuna 12, 50009 Zaragoza, Spain

^‡ ARAID, Aragon I+D foundation, Zaragoza, Spain

View abstract

A Convergent Continuous Multistep Process for the Preparation of C4-Oxime-Substituted Thiazoles

Edouard Godineau ^*†, Claudio Battilocchio ^†‡, Matthias Lehmann ^†, Steven V. Ley ^†, Ricardo Labes ^‡, Letitia Birnoschi ^‡, Srinivas Subramanian ^§, C.S Prasanna ^§, Amol Gorde ^§, Mahesh Kalbagh ^§, Vivek Khade ^§, Anton Scherrer ^†, Anthony C. O’Sullivan ^†

^† Syngenta Crop Protection, Process Research, Schaffhauserstrasse 101, CH-4332, Switzerland

^‡ Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, UK

^§ Syngenta Research and Technology Centre, Santa Monica Works, Corlim, Goa India, 403110

View abstract

Additive Free Fe-Catalyzed Conversion of Nitro to Aldehyde under Continuous Flow Module

Sandip G. Agalave, Moreshwar B. Chaudhari, Girish Singh Bisht, Boopathy Gnanaprakasam*

Department of Chemistry, Indian Institute of Science Education and Research Pune-411008, India

View abstract

Recent Advances in Photodecarboxylations Involving Phthalimides

Saira Mumtaz, Mark J. Robertson, Michael Oelgemöller

James Cook University, College of Science and Engineering, Townsville, Qld 4811, Australia.

View abstract

C–H functionalisation of aldehydes using light generated, non-stabilised diazo compounds in flow

Paul Dingwall ^a, Andreas Greb ^a, Lorène N. S. Crespin ^a, Ricardo Labes ^a, Biagia Musio ^a, Jian-Siang Poh ^a, Patrick Pasau ^b, David C. Blakemore ^c, Steven V. Ley ^*a

^a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

^b UCB Biopharma SPRL, Chemical Research R5, Chemin du Foriest 1420, Braine-L’Alleud, Belgium

^c Medicine Design, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, USA

View abstract

Catalytic Static Mixers for the Continuous Flow Hydrogenation of a Key Intermediate of Linezolid (Zyvox)

James Gardiner ^a*, Xuan Nguyen ^a, Charlotte Genet ^a, Mike D. Horne ^b, Christian Hornung ^a, John Tsanaktsidis ^a

^a CSIRO Manufacturing Flagship, Bayview Avenue, Clayton, Australia

^b CSIRO Mineral Resources, Bayview Avenue, Clayton, VIC 3169, Australia

View abstract

Photoinduced Palladium Negishi Cross-Coupling Through Visible Light Absorption of Palladium-Organozinc complexes

Irini Abdiaj ^a, Lena Huck ^a,b, José Miguel Mateo ^b, Antonio de la Hoz ^b, M. Victoria Gomez ^c, Angel Díaz-Ortiz ^b, Jesús Alcázar ^a

^a Lead Discovery, Janssen Research and Development, Janssen-Cilag, S.A., Jarama 75A, 45007 Toledo, Spain

^b Facultad de Ciencias y Tecnologías Químicas, Universidad de Castilla-La Mancha, Av. Camilo José Cela 10, 13071 Ciudad Real, Spain

^c Instituto Regional de Investigación Científica Aplicada, Universidad de Castilla-La Mancha, Av. Camilo José Cela, sn, 13071 Ciudad Real, Spain

View abstract

Three-Component Assembly of Multiply Substituted Homoallylic Alcohols and Amines Using a Flow Chemistry Photoreactor

Yiding Chen ^†, David Blakemore ^‡, Patrick Pasau ^§, Steven V. Ley ^†

^† Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.

^‡ Medicine Design, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States

^§ UCB Biopharma SPRL, Chemical Research R5, Chemin du Foriest, 1420 Braine-L’Alleud, Belgium

View abstract

Mild Homologation of Esters via Continuous Flow Chloroacetate Claisen Reactions

Maximilian A. Ganiek, Maria V. Ivanova, Benjamin Martin*, Paul Knochel*

Department of Chemistry, Ludwig-Maximilians-Universität Munich, Butenandtstr. 5 – 13, 81377 Munich, Germany

View abstract

Regioselective Chlorination of Quinoline Derivatives via Fluorine Mediation in a Microfluidic Reactor

Hao Qi, Xin Li, Zhuang Liu, Shan‐Shan Miao, Prof. Zheng Fang, Lin Chen, Zheng Fang, Prof. Kai Guo

College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, China

View abstract

Molecular machines

Inventors: Colin Scott, Carol HARTLEY, Charlotte Williams, Quentin CHURCHES, Judith SCOBLE, Nicholas Turner, Nigel French

Assignee: Commonwealth Scientific and Industrial Research Organization CSIRO

View abstract

Continuous flow synthesis of a carbon-based molecular cage macrocycle via a three-fold homocoupling reaction

Melanie Kitchin^ab, Kristina Konstas^a, Christopher J. Sumby^b, Milena L. Czyz^a, Peter Valente^b, Matthew R. Hill^*ab, Anastasios Polyzos^*ac, Christian J. Doonan^*ab

^* Corresponding authors

^a CSIRO Manufacturing Flagship, Bayview Avenue, Clayton, Australia

^b Centre for Advanced Nanomaterials and the School of Physical Sciences, The University of Adelaide, Adelaide, Australia

View abstract

Flow-based biocatalysis: Application to peracetylated arabinofuranosyl-1,5-arabinofuranose synthesis

Teodora Bavaro^a, Andrea Pinto^b, Federica Dall’Oglio^c, María J. Hernáiz^d, Carlo F. Morelli^e, Paolo Zambelli^b, Carlo De Micheli^c, Paola Conti^c, Lucia Tamborini^c, Marco Terreni^a

^a Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy

^b Department of Food Environmental and Nutritional Science (DeFENS), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy

^c Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy

^d Department of Pharmaceutical and Organic Chemistry, Faculty of Pharmacy, Complutense University of Madrid, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain

^e Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milan, Italy

View abstract

Continuous Flow Photochemical Benzylic Bromination of a Key Intermediate in the Synthesis of a 2‐Oxazolidinone

Yuesu Chen^{a, b}, Oscar de Frutos^c, Carlos Mateos^c, Juan A. Rincon^c, David Cantillo^{*a, b}, C. Oliver Kappe^{*a, b}

^a Center for Continuous Flow Synthesis and Processing (CC FLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz (Austria)

^b Institute of Chemistry, University of Graz, Heinrichstrasse 28, 8010, Graz (Austria)

^c Centro de Investigacin Lilly S. A. Avda. de la Industria 30, 28108 Alcobendas-Madrid (Spain)

View abstract

Native Chemical Ligation–Photodesulfurization in Flow

Timothy S. Chisholm, Daniel Clayton, Luke J. Dowman, Jessica Sayers, Richard J. Payne

School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia

View abstract

Continuous flow biocatalysis

Joshua Britton, Sudpta Majumdar, Gregory A. Weiss

Department of Chemistry, Molecular Biology and Biochemistry, University of California, Irvine, USA

View abstract

Reductive aminations using a 3D printed supported metal(0) catalyst system

Charlotte Genet¹, Xuan Nguyen¹, Bita Bayatsarmadi², Mike D. Horne², James Gardiner¹, Christian H. Hornung¹

¹ CSIRO Manufacturing, Clayton, South Australia

² CSIRO Minerals Resources, Clayton, South Australia

View abstract

Flow Synthesis of Coumalic Acid and its Derivatization

Laura K. Smith and Ian R. Baxendale

Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK.

View abstract

Production of metal-organic frameworks

Inventors:, Marta RUBIO MARTINEZ, Matthew Roland Hill, Michael Batten, Kok Seng Lim, Anastasios POLYZOS, Timothy Raymond Barton, Trevor Deon HADLEY, Andreas Alexander MONCH

Assignee: Commonwealth Scientific and Industrial Research Organization CSIRO

View abstract

Combining CH functionalisation and flow photochemical heterocyclic metamorphosis (FP-HM) for the synthesis of benzo [1, 3] oxazepines

Jasraj S. Babra, Andrew T. Russell, Christopher D. Smith, Yuxiong Zhang

Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK

View abstract

Studies toward the scaling of gas‐liquid photocycloadditions

Dr. Emily B. Corcoran, Dr. François Lévesque, Dr. Jonathan P. McMullen, Dr. John R. Naber

Department of Process Research and Development, Merck Sharp & Dohme Corp., Rahway, USA

View abstract

Photooxygenation in an advanced led-driven flow reactor module: Experimental investigations and modelling

Robbie Radjagobalou^ab, Jean-François Blanco^a, Odile Dechy-Cabaret^b, Michael Oelgemöller^c, Karine Loubière^a

^a Laboratoire de Génie Chimique LGC, Université de Toulouse, CNRS, Toulouse, France

^b Laboratoire de Chimie de Coordination LCC, CNRS, Toulouse, France

^c James Cook University, College of Science and Engineering, Townsville, Queensland 4811, Australia

View abstract

P‐121: Successive and scalable synthesis of highly stable Cs4PbBr6 perovskite microcrystal by microfluidic system and their application in backlight display

Hung-Chia Wang¹, Zhen Bao¹, Ru-Shi Liu^1,2

¹ Department of Chemistry, National Taiwan University, Taipei, Taiwan

² Department of Mechanical Engineering and Graduate Institute of Manufacturing Technology, National Taipei University of Technology, Taipei, Taiwan

View abstract

Self-sustaining closed-loop multienzyme-mediated conversion of amines into alcohols in continuous reactions

Martina L. Contente, Francesca Paradisi

School of Chemistry, University of Nottingham, Nottingham, United Kingdom

View abstract

Dichlorophenylacrylonitriles as AhR Ligands displaying selective breast cancer cytotoxicity in vitro

Jennifer R Baker¹, Jayne Gilbert², Stefan Paula³, Xiao Zhu³, Jennette A Sakoff², Adam McCluskey¹

¹ The University of Newcastle, Chemistry, Newcastle, Australia

² Calvary Mater Hospital, Medical Oncology, Newcastle, Australia

³ Purdue University, Chemistry, West Lafayette, United States

View abstract

Combining C-H functionalisation and flow photochemical heterocyclic metamorphosis (FP-HM) for the synthesis of benzo[1,3]oxazepines

Jasraj S. Babra, Andrew T. Russell, Christopher D. Smith, Yuxiong Zhang

Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK

View abstract

Multistep Continuous-Flow Processes for the Preparation of Heterocyclic Active Pharmaceutical Ingredients

Romaric Gérardy, Jean-Christophe M. Monbaliu

Center for Integrated Technology and Organic Synthesis, Department of Chemistry, University of Liège, Liège, Belgium

View abstract

Flow Chemistry Approaches Applied to the Synthesis of Saturated Heterocycles

Marcus Baumann, Ian R. Baxendale

Department of Chemistry, University of Durham, Durham, UK

View abstract

An efficient benzoxaborole one‐pot synthesis by SiliaCat DPP‐Pd heterogeneous catalysis using diboronic acid

Kana kunihiro¹, Laurence Dumais², Guillaume Lafitte², Emeric Varvier², Loïc Tomas², Craig Harris²

¹ Ecole Nationale Supérieure des Ingenieurs en Arts Chimiques et Technologiques, France

² Nestlé Skin Health, Galderma R&D, France

View abstract

Total Synthesis of Neomarchantin A: Key Bond Constructions Performed Using Continuous Flow Methods

Émilie Morin, Michaël Raymond, Amaury Dubart, and Shawn K. Collins

Department of Chemistry and Centre for Green Chemistry and Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, Canada H3C 3J7

View abstract

In situ epoxide generation by dimethyldioxirane oxidation and the use of epichlorohydrin in the flow synthesis of a library of β-amino alcohols

Peter J. Cossar, Jennifer R. Baker, Nicholas Cain, Adam McCluskey

Chemistry, The University of Newcastle, University Drive Callaghan, New South Wales 2308, Australia

View abstract

Safe Use of Hazardous Chemicals in Flow

MT Rahman¹, T Wirth²

¹ School of Chemistry and Chemical Engineering, Queen’s University Belfast, Belfast, UK

² School of Chemistry, Cardiff University, Cardiff, UK

View abstract

Photochemical Synthesis of Heterocycles: Merging Flow Processing and Metal-Catalyzed Visible Light Photoredox Transformations

T Glasnov

Institute of Chemistry, University of Graz, Graz, Austria

View abstract

Flow Chemistry as a Drug Discovery Tool: A Medicinal Chemistry Perspective

Andrew R. Bogdan¹, Michael G. Organ²

¹ Discovery Chemistry and Technology, AbbVie Inc., North Chicago, USA

² Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada

View abstract

Copper mediated, heterogeneous, enantioselective intramolecular Buchner reactions of α-diazoketones using continuous flow processing

DC Crowley^†, D Lynch^†, AR Maguire^‡

^† School of Chemistry, Analytical and Biological Chemistry Research Facility, University College Cork, Cork T12 K8AF, Ireland

^‡ School of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork T12 K8AF, Ireland

View abstract

Functionalization of Heteroarenes Under Continuous Flow

Joachim Demaerel, Vidmantas Bieliũnas, Wim M. De Borggraeve

Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Leuven, Belgium

View abstract

Photoredox Iridium–Nickel Dual-Catalyzed Decarboxylative Arylation Cross-Coupling: From Batch to Continuous Flow via Self-Optimizing Segmented Flow Reactor

Hsiao-Wu Hsieh^†, Connor W. Coley^‡, Lorenz M. Baumgartner^‡, Klavs F. Jensen^*‡, Richard I. Robinson^*†

^† Global Discovery Chemistry − Chemical Technology Group, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

^‡ Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

View abstract

A combination of flow and batch mode processes for the efficient preparation of mGlu2/3 receptor negative allosteric modulators (NAMs)

Raveendra Panickar Dhanya, Ananda Herath, Douglas J. Sheffler, Nicholas D.P. Cosford

Cancer Metabolism and Signaling Networks Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, USA

View abstract

On-demand synthesis of organozinc halides under continuous flow conditions

Mateo Berton, Lena Huck, Jesús Alcázar

Lead Discovery, Janssen Research and Development, Janssen-Cilag, S.A., Toledo, Spain

View abstract

Generation of Diversity Sets with High sp3 Fraction Using the Photoredox Coupling of Organotrifluoroborates and Organosilicates with Heteroaryl/Aryl Bromides in Continuous Flow

Kevin D Raynor, Gregory D May, Upul K. Bandarage, and Michael J. Boyd

Vertex Pharmaceuticals Inc., 50 Nothern Avenue, Boston, Massachusetts 02210, United States

View abstract

Iron-Catalyzed Batch/Continuous Flow C-H Functionalization Module for the Synthesis of Anticancer Peroxides

Moreshwar Bhagwan Chaudhari, Suresh Moorthy, Sohan Patil, Girish Singh Bisht, Haneef Mohamed, Sudipta Basu, and Boopathy Gnanaprakasam

Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India

View abstract

5′-substituted nucleoside compounds

Inventors: Guillermo S CORTEZ, Zahid Quyoom BONDAY

Assignee: Eli Lilly and Co

View abstract

Selective N-monomethylation of primary anilines with dimethyl carbonate in continuous flow

Hyowon Seo, Anne-Catherine Bédard, Willie P. Chen, Robert W. Hicklin, Alexander Alabugin, Timothy F. Jamison

Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139, USA

View abstract

Continuous flow multistep synthesis of α-functionalized esters via lithium enolate intermediates

Timo von Keutz^a,b, Franz J. Strauss^b, David Cantillo^a,b, C. Oliver Kappe^a,b

^a Center for Continuous Flow Synthesis and Processing (CC FLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria

^b Institute of Chemistry, NAWI Graz, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria

View abstract

A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic

Marcus Baumann, Ian R. Baxendale and Fabien Deplante

Department of Chemistry, University of Durham, South Road, Durham, Durham, DH1 3LE, UK

View abstract

Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification

Serena Mostarda^a, Daniela Passeri^b, Andrea Carotti^a,1, Bruno Cerra^a, Carolina Colliva^b, Tiziana Benicchi^b, Antonio Macchiarulo^a, Roberto Pellicciari^b, Antimo Gioiello^a

^a Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1, 06123 Perugia, Italy

^b TES Pharma, Corso Vannucci, 47, 06121 Perugia, Italy

View abstract

5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine derivatives useful as inhibitors of beta-secretase (BACE)

Inventors: Andrés Avelino Trabanco-Suárez, Francisca Delgado-Jiménez, Juan Antonio Vega Ramiro, Gary John Tresadern, Henricus Jacobus Maria Gijsen, Daniel Oehlrich,

Assignee: Janssen Pharmaceutica NV Janssen Cilag SA

View abstract

Conjugated polymers via direct arylation polymerization in continuous flow: minimizing the cost and batch-to-batch variations for high-throughput energy conversion

Nemal S. Gobalasingham¹, Jon E. Carlé², Frederik C. Krebs², Barry C. Thompson¹, Eva Bundgaard², Martin Helgesen^*,2

¹ Department of Chemistry and Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, California, 90089-1661

² DTU Energy, Technical University of Denmark, Roskilde, DK-4000, Denmark

View abstract

Recent advances of microfluidics technologies in the field of medicinal chemistry

László Ürge^*, Jesus Alcazar^†, Lena Huck^†, György Dormán^‡

^* DBH Group, Budapest, Hungary

^† Janssen Research and Development, Toledo, Spain

^‡ Innostudio Inc., Budapest, Hungary

View abstract

Sustainable flow synthesis of a versatile cyclopentenone building block

Marcus Baumann^†, Ian R. Baxendale^†, Paolo Filipponi^‡, Te Hu^†

^† Department of Chemistry, University of Durham, South Road, DH1 3LE Durham, U.K

^‡ Novartis Pharma AG, Fabrikstrasse 14, 4002 Basel, Switzerland

View abstract

Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives

Inventors: Daniel Kopetzki, David Tyler McQuade, Peter H. Seeberger, Kerry Gilmore

Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften

View abstract

Auto-Tandem Catalysis: Pd(II)-Catalysed Dehydrogenation/Oxidative Heck of Cyclopentane-1,3-diones

Claire J C Lamb, Bryan G Nderitu, Gemma McMurdo, John MTobin, Filipe Vilela, and Ai-Lan Lee

Institute of Chemical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, United Kingdom

View abstract

Exploring effects of intermittent light upon visible light promoted water oxidations

Dominic Walsh^*a, Pascaline Patureau^a, Karen Robertson^a, Shaun Reeksting^b, Anneke Lubben^b, Salvador Eslava^c, Mark T. Wellera^a

^a Department of Chemistry, University of Bath, Bath, BA2 7AY, UK. E-mail: [email protected]

^b Chemical Characterization and Analysis Facility, University of Bath, Bath, BA2 7AY, UK

^c Department of Chemical Engineering, University of Bath, BA2 7AY, UK

View abstract

Telescoped continuous flow generation of a library of highly substituted 3-thio-1,2,4-triazoles.

Mariana C. F. C. B. Damião^a, Renan Galaverna^a, Alan P. Kozikowski^b, James Eubanks^c, Julio C. Pastre^a

^a Institute of Chemistry, University of Campinas - UNICAMP, PO Box 6154 - Zip Code 13083-970, Campinas, SP, Brazil

^b StarWise Therapeutics LLC - University Research Park – Zip Code 53719-1235, Madison, Wisconsin, USA

^c Division of Genetics and Development - Krembil Research Institute – Zip Code M5T 2S8, Toronto, Ontario, Canada

View abstract

Targeting a mirabegron precursor by BH3-mediated continuous flow reduction process

Sonia De Angelis^a, Claudia Carlucci^a, Modesto de Candia^a, Gabriele Rebuzzini^b, Paolo Celestini^b, Massimiliano Riscazzi^b, Renzo Luisi^a, Leonardo Degennaro^a

^a FLAME-Lab − Flow Chemistry and Microreactor Technology Laboratory, Department of Pharmacy — Drug Sciences, University of Bari “A. Moro” Via E. Orabona 4, Bari 70125, Italy

^b COSMA S.p.A, Via Colleoni 15/17, Ciserano, BG 24040, Italy

View abstract

In Situ Preparation and Consumption of O-Mesitylsulfonylhydroxylamine (MSH) in Continuous Flow for the Amination of Pyridines

Cara E. Brocklehurst*, Guido Koch, Stephanie Rothe-Pöllet, Luigi La Vecchia

Synthesis and Technologies, Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Klybeckstrasse 141, 4057 Basel, Switzerland

View abstract

Highly efficient oxidation of amines to aldehydes with flow-based biocatalysis

Dr. Martina L. Contente^1,2, Federica Dall'Oglio³, Dr. Lucia Tamborini³, Prof. Francesco Molinari⁴, Prof. Francesca Paradisi^1,2

¹ School of Chemistry, University of Nottingham, Nottingham, UK

² UCD School of Chemistry, University College Dublin, Dublin, Ireland

³ Department of Pharmaceutical Sciences, DISFARM, University of Milan, Milan, Italy

⁴ Department of Food, Environmental and Nutritional Science, DeFENS, University of Milan, Milan, Italy

View abstract

Novel Polystyrene-Immobilized Chiral Amino Alcohols as Heterogeneous Ligands for the Enantioselective Arylation of Aldehydes in Batch and Continuous Flow Regime

José AugustoForni, Luiz Fernando Toneto, Novaes, Renan Galaverna, Julio C.Pastre

Institute of Chemistry, University of Campinas – UNICAMP, PO Box 6154, 13083-970, Campinas, SP, Brazil

View abstract

An efficient and green pathway for continuous Friedel-Crafts acylation over α-Fe2O3 and CaCO3 nanoparticles prepared in the microreactors

Zheng Fang^a1, Wei He^b1, Tao Tu^b, Niuniu Lv^a, Chuanhong Qiu^a, Xin Li^a, Ning Zhu^a, Li Wan^a, Kai Guo^ac

^a College of Biotechnology and Pharmaceutical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China

^b Department of Chemistry, Fudan University, No. 220 Handan Road, Shanghai, 200433, PR China

^c State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China

View abstract

A nanoporous graphene analog for superfast heavy metal removal and continuous-flow visible-light photoredox catalysis

Ran Xiao^a, John Michael Tobin^b, Meiqin Zha^a, Yunlong Hou^a, Jun He^c, Filipe Vilela^*b, Zhengtao Xu^*a

^a Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong

^b School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK

^c School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China

View abstract

A novel micro-flow system under microwave irradiation for continuous synthesis of 1, 4-dihydropyridines in the absence of solvents via Hantzsch reaction

Wei He^a,b, Zheng Fang^b, Kai Zhang^b, Tao Tu^a, Niuniu Lv^b, Chuanhong Qiu^b, Kai Guo^b,c

^a Department of Chemistry, Fudan University, No. 220 Handan Road, Shanghai, 200433, PR China

^b College of Biotechnology and Pharmaceutical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China

^c State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China

View abstract

Methanolysis of epoxidized soybean oil in continuous flow conditions

Vincenzo Pantone^a, Amelita Grazia Laurensa^b, Cosimo Annese^c, Francesco Fracassi^b, Caterina Fusco^b, Angelo Nacci^b,c, Antonella Russo^a, Lucia D’Accolti^b,c

^a Greenswitch s.r.l., Ferrandina MT, Italy

^b Dipartimento di Chimica, Università di Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy

^c ICCOM-CNR, SS Bari, Via E. Orabona 4, 70126 Bari, Italy

View abstract

Visible-light-induced trifluoromethylation of highly functionalized arenes and heteroarenes in continuous flow

Irini Abdiaj^a, Cecilia Bottecchia^b, Jesus Alcazar^*a, Timothy Noёl^*b

^a Janssen Research & Development, Jarama 75A, 45007 Toledo, Spain

^b Department of Chemical Engineering and Chemistry, Micro Flow Chemistry & Process Technology, Eindhoven University of Technology, Den Dolech 2, 5612 AZ Eindhoven, The Netherlands

View abstract

Continuous preparation and use of dibromoformaldoxime as a reactive intermediate for the synthesis of 3- bromoisoxazolines

Claudio Battilocchio^a*, Francesco Bosica^a, Sam M. Rowe^a, Bruna L. Abreu^a, Edouard Godineau^b*, Matthias Lehmann^b, Steven V. Ley^a

^a Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.

^b Syngenta Crop Protection AG, Crop Protection Research, Schaffhauserstrasse 101, CH-4332 Stein, Switzerland

View abstract

Treatment of alcohols

Inventors: Thomas Mark Douglas, Andrew John Hogben, David John Law, John Glenn Sunley, Thomas Giles Parsons

Assignee: Technip E&C Ltd

View abstract

Chemoenzymatic synthesis in flow reactors: a rapid and convenient preparation of captopril

Dr. Valerio De Vitis¹, Dr. Federica Dall'Oglio¹, Dr. Andrea Pinto², Prof. Carlo De Micheli², Prof. Francesco Molinari¹, Prof. Paola Conti², Dr. Diego Romano¹, Dr. Lucia Tamborini²

¹ Department of Food Environmental and Nutritional Science, University of Milan, Milan, Italy

² Department of Pharmaceutical Sciences, University of Milan, Milan, Italy

View abstract

Preparation of polyfunctional diorgano-magnesium and – zinc reagents using in situ trapping halogen-lithium exchange of highly functionalized (hetero)aryl halides in continuous flow

Marthe Ketels, Maximilian Andreas Ganiek, Niels Weidmann, Paul Knochel

LMU München, Department of Chemistry, München, Germany

View abstract

Flow assisted synthesis: a key fragment of SR 142948A

Matthew Oliver Kitching, Olivia E Dixon, Marcus Baumann, Ian Richard Baxendale

University of Durham, Chemistry, Durham, UK

View abstract

Singlet oxygen oxidations in homogeneous continuous flow using a gas–liquid membrane reactor

Antonia Kouridaki, Kevin Huvaere

EcoSynth NV, Industrielaan 12, 9800 Deinze, Belgium

View abstract

A convenient, mild and green synthesis of NH-sulfoximines in flow reactors

Leonardo Degennaro¹, Arianna Tota¹, Sonia De Angelis¹, Michael Andresini¹, Cosimo Cardellicchio², Maria Annunziata Capozzi¹, Giuseppe Romanazzi³, Renzo Luisi¹

¹ University of Bari, Department of Pharmacy - Drug Sciences, Bari, Italy

² CNR ICCOM, Department of Chemistry, Bari, Italy

³ Politecnico di Bari, DICATECh, Bari, Italy

View abstract

A continuous flow method for the desulfurization of substituted thioimidazoles applied to the synthesis of new etomidate derivatives

Marcus Baumann, Ian R Baxendale

Durham University, Department of Chemistry, Durham, UK

View abstract

High throughput photo-oxidations in a packed bed reactor system

Caleb J. Kong, Daniel Fisher, Bimbisar K. Desai,. Yuan Yang, Saeed Ahmad, Katherine Belecki, B. Frank Gupton

Department of Chemistry and Department of Chemical and Life Science Engineering, Virginia Commonwealth University, 601 W. Main St. Richmond, VA 23220, USA

View abstract

Phase separation macrocyclization in a complex pharmaceutical setting: application toward the synthesis of vaniprevir

Eric Godin, Anne-Catherine Bédard, Michael Raymond, Shawn K. Collins*

Département de Chimie, Centre for Green Chemistry and Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, H3C 3J7 Canada

View abstract

Method for the synthesis of N-(phosphonomethyl)glycine

Inventors: Sebastian Burck, Frederic Bruyneel, Patrick Notte

Assignee: Monsanto Technology LLC

View abstract

Isoquinoline derivatives

Inventors: Simona M. Ceccarelli, Ravi Jagasia, Roland Jakob-Roetne, Rainer E. Martin, Juergen Wichmann

Assignee: Hoffmann La Roche Inc

View abstract

Removal of nitrogen-containing impurities form alcohol compositions

Inventors:, Thomas Mark Douglas, Nakul Thakar

Assignee: Technip E&C Ltd

View abstract

Substituted 1,6-naphthyridines

Inventors:, Simona M. Ceccarelli, Ravi Jagasia, Roland Jakob-Roetne, Rainer E. Martin, Jens-Uwe Peters, Juergen Wichmann

Assignee: Hoffmann La Roche Inc

View abstract

Process for the preparation of efavirenz and devices suitable therefore

Inventors, Camille A. Correia, Kerry Gilmore, David Tyler McQuade, Peter H. Seeberger

Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften

View abstract

RAFT polymers

Inventors:, John Chiefari, Christian Hornung, Almar Postma, Simon Saubern

Assignee: Commonwealth Scientific and Industrial Research Organization CSIRO

View abstract

Method for preparing caprolactam by using a microreactor under lewis acid catalysis

Inventors:, Kai Guo, Xin Li, Zheng Fang, Kai Zhang, Qi Yu, Pingkai Ouyang

Assignee: Nanjing Tech University

View abstract

Grignard reagents on a tab: direct magnesium insertion under flow conditions

Lena Huck^†,‡, Antonio de la Hoz^‡, Angel Díaz-Ortiz^‡, Jesus Alcázar^†

^† Janssen Research and Development, Janssen-Cilag, S.A., C/Jarama 75, 45007 Toledo, Spain

^‡ Facultad de Ciencias Químicas, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain

View abstract

Co-production of HMF and gluconic acid from sucrose by chemo-enzymatic method

Hongli Wu, Ting Huang, Fei Cao, Qiaogen Zou, Ping Wei, Pingkai Ouyang

College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816 PR China

View abstract

The Application of a Continuous Grignard Reaction in the Preparation of Fluconazole

Sudha Korwar, Somi Amir, Perrer N. Tosso, Bimbisar K. Desai, Caleb J. Kong, Swara Fadnis, Nakul S. Telang, Saeed Ahmad, Thomas D. Roper, B. Frank Gupton*

Department of Chemistry and Department of Chemical and Life Science, Engineering, Virginia Commonwealth University, 601 W. Main St., R ichmond, VA 23220, USA

View abstract

Efficient synthesis of 5-(chloromethyl) furfural (CMF) from high fructose corn syrup (HFCS) using continuous flow processing

T. M. Kohl^a, B. Bizet^a, P. Kevan^a, C. Sellwood^a, J. Tsanaktsidis^a, C. H. Hornung^a

^a CSIRO Manufacturing Flagship, Bag 10, Clayton South, Australia

View abstract

Barbier continuous flow preparation and reactions of carbamoyllithiums for nucleophilic amidation

Maximilian Andreas Ganiek, Matthias Richard Becker, Guillaume Berionni, Hendrik Zipse, Paul Knochel

LMU München, Department of Chemistry, München, Germany

View abstract

Polymer-supported photosensitizers for oxidative organic transformations in flow and under visible light irradiation

John M. Tobin^†, Timothy J. D. McCabe^‡, Andrew W. Prentice^†, Sarah Holzer^†, Gareth O. Lloyd^†, Martin J. Paterson^†, Valeria Arrighi^†, Peter A. G. Cormack^‡, Filipe Vilela^†

^† School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS Scotland, United Kingdom

^‡ WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow, G1 1XL Scotland, United Kingdom

View abstract

Direct valorisation of waste cocoa butter triglycerides via catalytic epoxidation, ring-opening and polymerisation

Dorota D Plaza^a, Vinzent Strobel^b, Parminder Kaur KS Heer^b, Andrew B Sellars^d, Seng-Soi Hoong^d, Andrew J Clark^d, Alexei A Lapkin^b

^a School of Engineering, University of Warwick, Coventry, UK

^b Department of Chemical Engineering and Biotechnology, University of Cambridge, UK

^c Aachener Verfahrenstechnik – Process Systems Engineering, RWTH Aachen University, Aachen, Germany

^d Department of Chemistry, University of Warwick, Coventry, UK

View abstract

Hydrogen sulfide chemistry in continuous flow: Efficient synthesis of 2-oxopropanethioamide

David Cantillo^1,2, Phillip A. Inglesby³, Alistair Boyd³, Oliver Kappe^1,2

¹ Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010 Graz, Austria

² Research Center Pharmaceutical Engineering (RCPE), Inffeldgasse 13, 8010 Graz, Austria

³ AstraZeneca, Silk Road Business Park, Macclesfield, SK10 2NA, United Kingdom

View abstract

Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic

Chinmay A. Shukla^1,2, Amol A. Kulkarni^1,2

¹ Academy of Scientific and Innovative Research (AcSIR), CSIR-National Chemical Laboratory (NCL) Campus, Pune 411008, India

² Chem. Eng. & Proc. Dev. Div., CSIR-National Chemical Laboratory, Dr. Homi Bhaba Road, Pashan, Pune 411008, India

View abstract

Utilizing on‐and off‐line monitoring tools to follow a kinetic resolution step during flow synthesis

Kathleen A. Farley, Usa Reilly, Dennis P. Anderson, Brian P. Boscoe, Mark W. Bundesmann, David A. Foley, Manjinder S. Lall, Chao Li, Matthew R. Reese, Jiangli Yan

Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT, United States

View abstract

Flow Synthesis of Cyclobutanones via [2+2] Cycloaddition of Keteneiminium Salts and Ethylene Gas

Claudio Battilocchio^a, Grazia Iannucci^a, Shiyi Wang^a, Edouard Godineau^b, Amandine Krieger^b, Alain De Mesmaeker^b, Steven V Ley^*a

^a Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, UK

^b Syngenta Crop Protection AG, Crop Protection Research, Schaffhauserstrasse 101, CH-4332, Switzerland

View abstract

Continuous Flow α-Arylation of N,N-Dialkylhydrazones under Visible-Light Photoredox Catalysis

Juan A. Vega, José Manuel Alonso, Gabriela Méndez, Myriam Ciordia, Francisca Delgado, Andrés A. Trabanco

Neuroscience Medicinal Chemistry, Janssen Research & Development, Jarama 75A, 45007 Toledo, Spain

View abstract

Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes

Swapna S. Mohapatra^a,b, Zoe E. Wilson^a, Sujit Roy^b, Steven V. Ley^a

^a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK

^b Organometallics & Catalysis Laboratory, School of Basic Sciences, Indian Institute of Technology, Bhubaneswar 751013, India

View abstract

Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction

Ananda Herath, Nicholas D. P. Cosford

Cancer Metabolism & Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA

View abstract

Preparation of Forced Gradient Copolymers Using Tube-in-Tube Continuous Flow Reactors

Simon Saubern, Xuan Nguyen, Van Nguyen, James Gardiner, John Tsanaktsidis, John Chiefari

CSIRO Manufacturing, Clayton, VIC, Australia

View abstract

A Continuous Flow Synthesis and Derivatization of 1,2,4-Thiadiazoles

Marcus Baumann, Ian R. Baxendale

Department of Chemistry, University of Durham, South Road, DH1 3LE Durham, United Kingdom.

View abstract

Self-Optimisation and Model-Based Design of Experiments for Developing a C–H Activation Flow Process

Alexander Echtermeyer^1,2, Yehia Amar², Jacek Zakrzewski², Alexei Lapkin²

¹ Aachener Verfahrenstechnik – Process Systems Engineering, RWTH Aachen University, Aachen, Germany

² Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom

View abstract

Diels–Alder reactions of myrcene using intensified continuous-flow reactors

Christian H. Hornung, Miguel Á. Álvarez-Diéguez, Thomas M. Kohl and John Tsanaktsidis

CSIRO Manufacturing, Bag 10, Clayton South, Victoria 3169, Australia

View abstract

Active Site-Mapping of Xylan-Deconstructing Enzymes with Arabinoxylan Oligosaccharides Produced by Automated Glycan Assembly

Deborah Senf, Colin Ruprecht, Goswinus de Kruijff, Sebastian Simonetti, Frank Schuhmacher, Peter Seeberger, Fabian Pfrengle

Max-Planck-Institute of Colloids and Interfaces, Biomolecular Systems, Potsdam, Germany

View abstract

Mixed-Linkage Glucan Oligosaccharides Produced by Automated Glycan Assembly Serve as Tools to Determine the Substrate Specificity of Lichenase

Pietro Dallabernardina, Frank Schuhmacher, Peter H Seeberger, Fabian Pfrengle

Max-Planck-Institute of Colloids and Interfaces, Biomolecular Systems, Potsdam, Germany

View abstract

Improving the throughput of batch photochemical reactions using flow: Dual photoredox and nickel catalysis in flow for C(sp2) C(sp3) cross-coupling

Irini Abdiaj, Jesús Alcázar

Janssen Research and Development, Janssen-Cilag, S.A., C/Jarama 75, 45007 Toledo, Spain

View abstract

Synthesis of Cycloalkyl Substituted 7-Azaindoles via Photoredox Nickel Dual Catalytic Cross-Coupling in Batch and Continuous Flow

Natalie Palaychuk, Travis J. DeLano, Michael J. Boyd, Jeremy Green, and Upul K. Bandarage

Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, Massachusetts 02210, United States

View abstract

Acridinium-Based Photocatalysts: A Sustainable Option in Photoredox Catalysis

Amruta Joshi-Pangu^†, François Lévesque^†, Hudson G. Roth^‡, Steven F. Oliver^†, Louis-Charles Campeau^†, David Nicewicz^‡, Daniel A. DiRocco^†

^† Process Research & Development, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, United States

^‡ Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, United States

View abstract

Halogenation of organic compounds using continuous flow and microreactor technology

David Cantillo^ab, C. Oliver Kappe^*ab

^a Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, Graz, Austria

^b Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria

View abstract

Application of the Photoredox Coupling of Trifluoroborates and Aryl Bromides to Analog Generation Using Continuous Flow

Travis J. DeLano, Upul K. Bandarage, Natalie Palaychuk, Jeremy Green, and Michael J. Boyd

Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, Massachusetts 02210, United States

View abstract

Design and Development of Pd-catalyzed Aerobic N-Demethylation Strategies for the Synthesis of Noroxymorphone in Continuous Flow Mode

Bernhard Gutmann^a,b, David Cantillo^a,b, Ulrich Weigl^c, D Phillip Cox^d, C. Oliver Kappe^a,b

^a,b Institute of Chemistry, University of Graz, Nawi Graz, Heinrichstrasse 28, 8010 Graz, Austria and Research Center Pharmaceutical Engineering (RCPE), Inffeldgasse 13, 8010 Graz, Austria

^c Cilag AG, Hochstrasse 201, 8200 Schaffhausen, Switzerland

^d Noramco Inc., 503 Carr Road, Suite 200, Wilmington, DE 19809, USA

View abstract

γ-Glutamyl-dipeptides: Easy tools to rapidly probe the stereoelectronic properties of the ionotropic glutamate receptor binding pocket

Lucia Tamborini^a, Veronica Nicosia^a, Paola Conti^a, Federica Dall'Oglio^a, Carlo De Micheli^a, Birgitte Nielsen^b, Anders A. Jensen^b, Darryl S. Pickering^b, Andrea Pinto^a

^a Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy

^b Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen OE, Denmark

View abstract

Expedited access to thieno[3,2-c]quinolin-4(5H)-ones and benzo[h]-1,6-naphthyridin-5(6H)-ones via a continuous flow photocyclization method

Y. Fang^a, G. K. Tranmer^*ab

^* Corresponding author

^a College of Pharmacy, Faculty of Health Science, University of Manitoba, Winnipeg, Canada

^b Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, Canada

View abstract

A benchtop NMR spectrometer as a tool for monitoring mesoscale continuous-flow organic synthesis: equipment interface and assessment in four organic transformations

Cynthia M. Archambault^a, Nicholas E. Leadbeater^*a

^* Corresponding author

^a Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, USA

View abstract

BODIPY-based conjugated microporous polymers as reusable heterogeneous photosensitisers in a photochemical flow reactor

J. M. Tobin^a, J. Liu^b, H. Hayes^a, M. Demleitner^a, D. Ellis^a, V. Arrighi^a, Z. Xu^*b, F. Vilela^*a

^* Corresponding author

^a School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK

^b Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, China

View abstract

Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

L. Huck^a,b, M. Berton^a, A. de la Hoz^b, A. Díaz-Ortiz^b, J. Alcázar^*a

^* Corresponding author

^a Janssen Research and Development, Janssen-Cilag, S.A., C/ Jarama 75, Toledo, Spain

^b Facultad de Ciencias Químicas, Universidad de Castilla-La Mancha, Ciudad Real, Spain

View abstract

Visible light activation of Boronic Esters enables efficient photoredox C(sp2)–C(sp3) cross-couplings in flow

Fabio Lima^a, Dr. Mikhail A. Kabeshov^a, Dr. Duc N. Tran^a, Dr. Claudio Battilocchio^a, Dr. Joerg Sedelmeier^b, Dr. Gottfried Sedelmeier^b, Dr. Berthold Schenkel^b, S. V. Ley^*a

^* Corresponding author

^a Department of Chemistry, University of Cambridge, Cambridge, UK

^b Novartis Pharma AG, Basel, Switzerland

View abstract

Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform

D. E. Fitzpatrick^a, S. V. Ley^*a

^* Corresponding author

^a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK

View abstract

Triphenylphosphine-grafted, RAFT-synthesised, porous monoliths as catalysts for Michael addition in flow synthesis

Kristine J. Barlow^a, Victor Bernabeu^a, Xiaojuan Hao^a, Timothy C. Hughes^a, Oliver E. Hutt^a, Anastasios Polyzos^a,b, Kathleen A. Turner^a, Graeme Moad^a

^a CSIRO Manufacturing Flagship, Bag 10, Clayton South, Victoria 3169, Australia

^b University of Melbourne, School of Chemistry, Parkville, Victoria 3010, Australia

View abstract

Ethyl Lithiodiazoacetate: Extremely unstable intermediate handled efficiently in flow

Simon T. R. Müller^a, Tobias Hokamp^a, Svenja Ehrmann^a, Paul Hellier^b, Thomas Wirth^a

^a Cardiff University School of Chemistry Cardiff UK

^b Parc Industriel de la Chartreuse Pierre Fabre Médicament Castres CEDEX France

View abstract

A facile hybrid ‘flow and batch’ access to substituted 3,4-dihydro-2H-benzo[b][1,4]oxazinones

Andrew J. S. Lin^a, Cecilia C. Russell^a, Jennifer R. Baker^a, Shelby L. Frailey^ab, Jennette A. Sakoff^c, Adam McCluskey^*a

^* Corresponding authors

^a Chemistry, Centre for Chemical Biology, School of Environmental & Life Sciences, University of Newcastle, University Drive, Callaghan, Australia

^b Chemical Engineering, Trine University, Angola, 46703 USA

^c Department of Medical Oncology, Calvary Mater Newcastle Hospital, Waratah, Australia

View abstract

Continuous flow biocatalysis: production and in-line purification of amines by immobilised transaminase from Halomonas elongata

Matteo Planchestainer^a, Martina Letizia Contente^ab, Jennifer Cassidy^a, Francesco Molinari^b, Lucia Tamborini^*c, Francesca Paradisi^*ad

^* Corresponding authors

^a UCD School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland

^b Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli studi di Milano, Via Mangiagalli 25, Milan, Italy

^c Department of Pharmaceutical Sciences (DISFARM), Università degli studi di Milano, Via Mangiagalli 25, Milan, Italy

^d School of Chemistry, University of Nottingham, University Park, Nottingham, UK

View abstract

Method and device for the synthesis of artemisinin

Inventors:, Peter H. Seeberger, Daniel Kopetzki, Francois Lévesque

Assignee:

Max-Planck-Gesellschaft zur Forderung der Wissenschaften

View abstract

A laboratory-scale continuous flow chlorine generator for organic synthesis

Franz J. Strauss^a, David Cantillo^*ab, Javier Guerra^c, C. Oliver Kappe^*ab

^* Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, Graz, Austria

^a Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria

^b Crystal Pharma, Gadea Pharmaceutical Group, A Division of AMRI, Parque Tecnológico de Boecillo, Valladolid, Spain

View abstract

Continuous processing and efficient in situ reaction monitoring of a hypervalent iodine (III) mediated cyclopropanation using benchtop NMR spectroscopy

Batool Ahmed-Omer^a, Eric Sliwinski^a, John Paul Cerroti^b, Steven V Ley^a

^aDepartment of chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK

^bMagritek GmbH, Gebäude VO (Building VO), Triwo Technopark Aachen, Philipsstrasse 8, 52068 Aachen, Germany

View abstract

Aryl amination using ligand-free Ni(II) salts and photoredox catalysis

Emily B. Corcoran¹, Michael T. Pirnot², Shishi Lin³, Spencer D. Dreher³, Daniel A. DiRocco³, Ian W. Davies³, Stephen L. Buchwald^2,*, David W. C. MacMillan^1,*

¹ Merck Center for Catalysis at Princeton University, Princeton, NJ 08544, USA

² Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

³ Department of Process Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA

View abstract

Catalytic Chan–Lam coupling using a ‘tube-in-tube’ reactor to deliver molecular oxygen as an oxidant

Carl J. Mallia¹, Paul M. Burton², Alexander M. R. Smith², Gary C. Walter², Ian R. Baxendale¹

¹ Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, United Kingdom

² Syngenta CP R&D Chemistry, Jealott’s Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, United Kingdom

View abstract

An approach to the synthesis of 4-aryl and 5-aryl substituted thiazole-2(3H)-thiones employing flow processing

Monaem Balti^a, Shelli A. Miller^b, Mohamed Lotfi Efrit^a, Nicholas E. Leadbeater^*b

^* Corresponding authors

^a Université Tunis El Manar, Laboratory of Organic Synthesis and Heterocyclic Chemistry, Faculty of Science of Tunis, Department of Chemistry, 1060 Tunis, Tunisia

^b Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, USA

View abstract

Flow carbonylation of sterically hindered ortho-subsituted iodoarenes

Carl J. Mallia¹, Gary C. Walter², Ian R. Baxendale¹

¹ Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, United Kingdom

² Syngenta CP R&D Chemistry, Jealott’s Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, United Kingdom

View abstract

Exploring flow procedures for diazonium formation

Te Hu, Ian R. Baxendale and Marcus Baumann

Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK

View abstract

Catalytic macrocyclization strategies using continuous flow: formal total synthesis of ivorenolide A

Mylène de Léséleuc, Eric Godin, Shawn Parisien-Collette, Alexandre Levesque, and Shawn K. Collins

University of Montréal, Department of Chemistry, Montréal, Canada

View abstract

Delivering enhanced efficiency in the synthesis of α-diazosulfoxides by exploiting the process control enabled in flow

Patrick G. McCaw¹, Benjamin J. Deadman¹, Anita R. Maguire^1,2, Stuart G. Collins¹

¹ Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork, Ireland

² Department of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork, Ireland

View abstract

The generation of a library of bromodomain-containing protein modulators expedited by continuous flow synthesis

Paolo Filipponi and Ian R. Baxendale^*

^* Department of Chemistry, University of Durham South Road, Durham, DH1 3LE, United Kingdom

View abstract

An efficient etherification of Ginkgol biloba extracts with fewer side effects in a micro-flow system

Yin-Lin Qin^a, Wei He^a, Mei Su^b, Zheng Fang^c, Ping-Kai Ouyang^a, Kai Guo^a,d

^a College of Biotechnology and Pharmaceutical Engineering, Nanjing Technology University, Nanjing 210009, China

^b Jiangsu Carephar Pharmaceutical Co., Ltd., Nanjing 210014, China

^c School of Pharmaceutical, Nanjing Technology University, Nanjing 210009, China

^d State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Technology University, Nanjing 211816, China

View abstract

Continuous-flow synthesis and derivatization of aziridines through palladium-catalyzed C(sp3)−H activation

Jacek Zakrzewski¹, Adam P. Smalley², Dr. Mikhail A. Kabeshov², Prof. Matthew J. Gaunt², Prof. Alexei A. Lapkin¹

¹ Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK

² Chemistry Department, University of Cambridge, Cambridge, UK

View abstract

Metal-free borylation of electron-rich aryl(pseudo)halides under continuous-flow photolytic conditions

Kai Chen^a, Man Sing Cheung^b, Zhenyang Lin^*b, Pengfei Li^*a

^a Center for Organic Chemistry, Frontier Institute of Science and Technology (FIST) and Frontier Institute of Chemistry, Xi'an Jiaotong University, 99 Yanxiang Road, Xi'an, China

^b Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, China

View abstract

Difluorocarbene addition to alkenes and alkynes in continuous flow

Pauline Rullière, Patrick Cyr, André B. Charette*

Université de Montréal, Centre in Green Chemistry and Catalysis, Department of Chemistry, Faculty of Arts and Science, P.O. Box 6128, Station Downtown, Québec, Canada H3C 3J7

View abstract

A simple setup for transfer hydrogenations in flow chemistry

Matthew Hutchings, Thomas Wirth*

School of Chemistry, Cardiff University, Cardiff CF10 3AT, UK

View abstract

A scalable and operationally simple radical trifluoromethylation

Joel W. Beatty¹, James J. Douglas^1,2, Kevin P. Cole², Corey R. J. Stephenson¹

¹ Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA

² Small Molecule Design and Development, Lilly Research Laboratoires, Eli Lilly and Company, Indianapolis, Indiana 46285, USA

View abstract

Photoactive and metal-free polyamide-based polymers for water and wastewater treatment under visible light irradiation

Junjie Shen^a, Roman Steinbach^a, John Tobin^a, Mayumi Mouro Nakata^a, Matthew Bower^b, Martin McCoustra^a, Helen Bridle^a, Valeria Arrighi^a, Filipe Vilela^a

^a School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, United Kingdom

^b Drinking Water Quality Regulator for Scotland, Edinburgh, EH6 6WW, United Kingdom

View abstract

Biodiesel synthesis using integrated acid and base catalysis in continuous flow

Mousa Asadi^a, Joel F. Hooper^a, David W. Lupton^a

^aSchool of Chemistry, Monash University, Clayton 3800, Victoria, Australia

View abstract

Fine chemical syntheses under flow using SiliaCat catalysts

Rosaria Ciriminna ^a, Valerica Pandarus ^b, François Béland ^*b, Mario Pagliaro ^*a

^* Corresponding authors ^a Istituto per lo Studio dei Materiali Nanostrutturati, CNR, via U. La Malfa 153, 90146 Palermo, Italy

^b SiliCycle, 2500, Parc-Technologique Blvd, Québec, G1P 4S6 Canada

View abstract

Continuous-flow synthesis of 2H-azirines and their diastereoselective transformation to aziridines

Marcus Baumann ^*, Ian R. Baxendale

Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK

View abstract

Continuous flow magnesiation or zincation of acrylonitriles, acrylates, and nitroolefins. Application to the synthesis of butenolides

Maximilian A. Ganiek, Matthias R. Becker, Marthe Ketels, Paul Knochel ^*

Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich, Germany

View abstract

Continuous flow photo-initiated RAFT polymerisation using a tubular photochemical reactor

James Gardiner ^a, Christian H. Hornung ^a, John Tsanaktsidis ^a, Duncan Guthrie ^b

^a CSIRO Manufacturing, Bag 10, Clayton South, Victoria 3169, Australia

^b Vapourtec Ltd, Park Farm Business Centre, Bury St Edmunds IP28 6TS, United Kingdom

View abstract

Continuous-flow photochemistry: a need for chemical engineering

Karine Loubière ^a,b, Michael Oelgemöller ^c, Tristan Aillet ^a,b, Odile Dechy-Cabaret ^a,d, Laurent Prat ^a,b

^a CNRS, Laboratoire de Génie Chimique (LGC UMR 5503), 4 allée Emile Monso, BP 84234, 31432 Toulouse, France

^b Université de Toulouse, INPT, ENSIACET, F-31432 Toulouse, France

^c James Cook University, College of Science, Technology and Engineering, Townsville, Queensland 4811, Australia

^d CNRS, Laboratoire de Chimie de Coordination (LCC UPR 8241), 205 route de Narbonne, BP 44099, F-31077 Toulouse, France

View abstract

Efficient metal-free photochemical borylation of aryl halides under batch and continuous-flow conditions

Kai Chen, Shuai Zhang, Pei He, Pengfei Li ^*

Center for Organic Chemistry, Frontier Institute of Science and Technology (FIST), Xi'an Jiaotong University, 99 Yanxiang Road, Xi'an, Shaanxi 710054, China

View abstract

Continuous flow photochemistry as an enabling synthetic technology: synthesis of substituted-6(5H)-phenanthridinones for use as poly(ADP-ribose) polymerase inhibitors

Y. Fang ^a, G. K. Tranmer ^*a,b

^* Corresponding authors ^a College of Pharmacy, Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada

^b Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, Canada

View abstract

Controlled generation and use of CO in flow

Steffen V. F. Hansen ^a,b, Zoe E. Wilson ^a, Trond Ulven ^*b, Steven V. Ley ^*a

^a Department of Chemistry, University of Cambridge Lensfield Road, Cambridge, CB2 1EW, UK

^b Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark

View abstract

The solid copper-mediated C-N cross-coupling of phenylboronic acids under continuous flow conditions

Jennifer Bao ^a, Geoffrey K. Tranmer ^a,b

^a College of Pharmacy, Faculty of Health Science, University of Manitoba, Winnipeg, MB R3E 0T5, Canada

^b Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada

View abstract

Visible-light photoredox catalysis using a macromolecular ruthenium complex: reactivity and recovery by size-exclusion nanofiltration in continuous flow

Javier Guerra ^ab, David Cantillo ^a, C. Oliver Kappe ^*a, Antonio Macchiarulo ^a, Antimo Gioiello ^*a

^a Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz, Austria

^b Crystal Pharma, Gadea Pharmaceutical Group, a division of AMRI, Parque Tecnológico de Boecillo, Valladolid, 47151, Spain

View abstract

Integrating multicomponent flow synthesis and computational approaches for the generation of a tetrahydroquinoline compound based library

Bruno Cerra ^a, Serena Mostarda ^a, Chiara Custodi ^a, Antonio Macchiarulo ^a, Antimo Gioiello ^*a

^a Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, I-06122 Perugia, Italy

View abstract

The expanding utility of continuous flow hydrogenation

Peter J. Cossar ^a, Lacey Hizartzidis ^a, Michela I. Simone ^a, Adam McCluskey ^*a, Christopher P. Gordon ^*b

^* Corresponding authors ^a Centre for Chemical Biology, Chemistry Building, School of Environmental and Life Science, The University of Newcastle, University Drive, Callaghan, Australia

^b Nanoscale Organisation and Dynamics Group, School of Science and Health, University of Western Sydney, Locked Bag, Penrith, Australia

View abstract

Highly efficient and safe procedure for the synthesis of aryl 1,2,3-triazoles from aromatic amine in a continuous flow reactor

Federica Stazi ^a, Damiano Cancogni ^a, Lucilla Turco ^b, Pieter Westerduin ^a, Sergio Bacchi ^a

^a GlaxoSmithKline Spa, Chemical Development Department, Synthetic Chemistry, Via Fleming 4, 37135 Verona, Italy

^b GlaxoSmithKline Spa, Analytical Chemistry, Via Fleming 4, 37135 Verona, Italy

View abstract

Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor

Keiji Nakayama,^a, Duncan L. Browne,^b, Ian R. Baxendale,^b,1, Steven V. Ley,^*a

^a Process Technology Research Laboratories, Pharmaceutical Technology Division, Daiichi Sankyo, Shinomiya, Hiratsuka, Kanagawa, 254-0014, Japan

^b Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK

View abstract

The Changing Face of Organic Synthesis

Ley, Steven V., Baxendale, Ian R.

CHIMIA International Journal for Chemistry, Volume 62, Number 3, March 2008, pp. 162-168(7)

View abstract

Continuous Heterogeneously Catalyzed Oxidation of Benzyl Alcohol in a Ceramic Membrane Packed- Bed Reactor

Achilleas Constantinou^†¶, Gaowei Wu^†, Albert Corredera^†, Peter Ellis^‡, Donald Bethell^§, Graham J. Hutchings^∥, Simon Kuhn^⊥, Asterios Gavriilidis^*†

^† Department of Chemical Engineering, University College London, Torrington Place, London, WC1E 7JE, United Kingdom

^¶ Division of Chemical and Petroleum Engineering, School of Engineering, London South Bank University, London, SE1 0AA, United Kingdom

^‡ Johnson Matthey, Blounts Court Road, Reading, RG4 9NH, United Kingdom

^§ Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, United Kingdom

^∥ School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, United Kingdom

^⊥ Department of Chemical Engineering, KU Leuven, W. de Croylaan 46, 3001 Leuven, Belgium

View abstract

Continuous flow Buchwald–Hartwig amination of a pharmaceutical intermediate

Polina Yaseneva ^a, Paul Hodgson ^a, Jacek Zakrzewski ^a, Sebastian Falß ^b, Rebecca E. Meadows ^c, Alexei A. Lapkin ^{* a}

^a Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK. E-mail: [email protected] Fax: +44 (0)1223 334796

^bINVITE GmbH, Chempark Leverkusen, 51373 Leverkusen, Germany

^cPharmaceutical Development, AstraZeneca, Silk Road Business Park, Macclesfield SK10 2NA, UK

View abstract

Thermolysis of 1,3-dioxin-4-ones: fast generation of kinetic data using in-line analysis under flow

Thomas Durand^a, Cyril Henry^a, David Bolien^a, David C. Harrowven^a, Sally Bloodworth^a, Xavier Franck^b, Richard J. Whitby^{* a}

^a Chemistry, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, UK

^b Normandie Université, COBRA, UMR 6014 & FR 3038, Université de Rouen, INSA Rouen, CNRS, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex, France

View abstract

Continuous photochemistry: the flow synthesis of ibuprofen via a photo-Favorskii rearrangement

M. Baumann^a, Ian R. Baxendale^{* a}

^a Department of Chemistry, University of Durham, South Road, Durham, UK

View abstract

Automated glycan assembly of xyloglucan oligosaccharides

Pietro Dallabernardina^{a b}, Frank Schuhmacher^{a b}, Peter H. Seeberger^{a b}, Fabian Pfrengle^{* a b}

^a Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany

^b Freie Universität Berlin, Institute of Chemistry and Biochemistry, Arnimallee 22, 14195 Berlin, Germany

View abstract

Dynamic flow synthesis of porous organic cages

Michael E. Briggs^a, Anna G. Slater^a, Neil Lunt^a, Shan Jiang^a, Marc A. Little^a, Rebecca L. Greenaway^a, Tom Hasell^a, Claudio Battilocchio^b, Steven V. Ley^b, Andrew I. Cooper^{* a}

^a Department of Chemistry and Centre for Materials Discovery, University of Liverpool, Crown Street, Liverpool, UK

^b Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK

View abstract

An integrated flow and microwave approach to a broad spectrum protein kinase inhibitor

Cecilia Russell^a, Andrew J. S. Lin^a, Peter Hains^b, Michela I. Simone^a, Phillip J. Robinson^b, Adam McCluskey^{* a}

^A Centre for Chemical Biology, Chemistry, School of Environmental and Life Science, The University of Newcastle, University Drive, Callaghan, Australia

^B Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, Australia

View abstract

A Flow-based Synthesis of Telmisartan

Alex Martin, Ali Siamaki, Katherine Belecki, B. Gupton

Department of Chemistry and Department of Chemical and Life Science Engineering Virginia Commonwealth University 601 W. Main St. Richmond Virginia 23284 United States

View abstract

The Preparation of Ethyl Levulinate Facilitated by Flow Processing: The Catalyzed and Uncatalyzed Esterification of Levulinic Acid

Meghan P. Negus¹, Andrew C. Mansfield², Nicholas E. Leadbeater¹

¹ Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269, United States

² Vapourtec Ltd., Park Farm Business Centre, Bury St. Edmunds IP28 6TS, United Kingdom

³ Department of Community Medicine and Health Care, University of Connecticut Health Center, The Exchange, 263 Farmington Ave, Farmington, CT 06030, United States

View abstract

Photodecarboxylations in an advanced meso-scale continuous flow photoreactor

Sam Josland¹, Saira Mumtaz², Michael Oelgemöller^{2 *}

¹ University of Southampton, Department of Chemistry, University Road, Southampton, SO17 1BJ, United Kingdom

² James Cook University, College of Science, Technology and Engineering, Townsville, QLD 4811, Australia

View abstract

Efficient Continuous-Flow Synthesis of Macrocyclic Triazoles

Anne-Catherine Bédard, Jeffrey Santandrea, Shawn K. Collins

Department of Chemistry and Centre for Green Chemistry and Catalysis, University of Montreal

View abstract

Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing

Thomas M. Kohl ^*, Christian H. Hornung, John Tsanaktsidis

CSIRO Manufacturing Flagship, Bag 10, Clayton South, Victoria 3169, Australia

View abstract

A Short Multi-step Flow Synthesis of a Potential Spirocyclic Fragrance Component

Ian R. Baxendale*

Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK

View abstract

Flow Synthesis of 2-Methylpyridines via α-Methylation

Camille Manansala¹, Geoffrey K. Tranmer^{1 2 *}

¹ College of Pharmacy, Faculty of Health Science, University of Manitoba, Winnipeg, MB R3E 0T6, Canada

² Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada

View abstract

The development of a short route to the API ropinirole hydrochloride

Zeshan Yousuf^a, Andrew K. Richards^b, Andrew N. Dwyer^c, Bruno Linclau^a, David C. Harrowven^{* a}

^a Chemistry, University of Southampton, Highfield, Southampton, UK

^b GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, UK

^c Formally at GlaxoSmithKline Innovation and Sustainable Manufacturing COE, Worthing, UK

View abstract

Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform

Bimbisar Desai, Karen Dixon, Elizabeth Farrant, Qixing Feng, Karl R. Gibson, Willem P. van Hoorn, James Mills, Trevor Morgan, David M. Parry, Manoj K. Ramjee, Christopher Nicholas Selway, Gary J. Tarver, Gavin Whitlock, Adrian G. Wright

Cyclofluidic Ltd.

View abstract

Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

Ashley R. Longstreet¹, Suzanne M. Opalka¹, Brian S. Campbell¹, B. Frank Gupton², Tyler McQuade¹

¹ Department of Chemistry and Biochemistry, Florida State University, United States

¹ Department of Chemistry, Virginia Commonwealth University, United States

View abstract

Efficient synthesis of panaxadiol derivatives using continuous-flow microreactor and evaluation of anti-tumor activity

Yan Wu^a,1, Wei-Qi Chen^b,1, Yu-Qing Zhao^c, Hu-Ri Piao^a

^aKey Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy, China

^bDepartment of Chemistry, Fudan University, Shanghai, China

^cSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China

View abstract

Continuous Reductions and Reductive Aminations Using Solid Sodium borohydride

Kerry Gilmore^†, Stella Vukelic^‡, D. Tyler McQuade^†§, Beate Koksch^‡, Peter H. Seeberger^*†‡

^† Max Planck Institute of Colloids and Interfaces, Germany

^‡ Institute of Chemistry and Biochemistry, Freie Universität Berlin, Germany

^§ Department of Chemistry and Biochemistry, Florida State University, United States

View abstract

Photodecarboxylative Benzylations of N-Methoxyphthalimide under Batch and Continuous-Flow Conditions

Hossein Mohammadkhani Pordanjani ^A ^B, Christian Faderl ^A ^C, Jun Wang ^A, Cherie A. Motti ^D, Peter C. Junk ^A, Michael Oelgemöller ^A ^E

^A James Cook University, College of Science, Technology and Engineering, Townsville, Qld 4811, Australia.

^B Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 6517838683, Iran.

^C Institut für Organische Chemie, Universität Regensburg, Universitätsstr. 31, D-93053 Regensburg, Germany.

^D Australian Institute of Marine Science (AIMS), Biomolecular Analysis Facility, Townsville, Qld 4810, Australia.

^E Corresponding author. Email: [email protected]

View abstract

Chemical Assembly Systems: Layered Control for Divergent, Continuous, Multistep Syntheses of Active Pharmaceutical Ingredients

Dr. Diego Ghislieri, Dr. Kerry Gilmore, Prof. Dr. Peter H. Seeberger^*

Department of Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Universität Berlin, Germany

View abstract

Light-Induced C-H Arylation of (Hetero)arenes by In Situ Generated Diazo Anhydrides

Dr. David Cantillo¹, Dr. Carlos Mateos², Dr. Juan A. Rincon², Dr. Oscar de Frutos^{2 *}, Prof. Dr. C. Oliver Kappe^{1 *}

¹ Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010 Graz (Austria)

² Centro de Investigación Lilly S. A. Avda. de la Industria 30, 28108 Alcobendas-Madrid (Spain)

View abstract

Continuous flow polymerisation process

Inventors:, John Chiefari, Christian Hornung, Simon Saubern

Assignee: Commonwealth Scientific and Industrial Research Organization CSIRO

View abstract

Two-Stage Flow Synthesis of Coumarin via O-Acetylation of Salicylaldehyde

Xin Li¹, Anbang Chen¹, Yangzhi Zhou¹, Lingling Huang², Zheng Fang², Haifeng Gan¹, Kai Guo¹

¹ College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China

² School of Pharmaceutical Sciences, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China

³ State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China

View abstract

Flow Alkylation of Thiols, Phenols, and Amines Using a Heterogenous Base in a Packed-Bed Reactor

Alastair Baker¹, Michael Graz², Robert Saunders², Gareth J. S. Evans², Ilaria Pitotti1 Thomas Wirth¹

¹ School of Chemistry, Cardiff University, Park Place, Main Building, Cardiff CF10 3AT, UK

² Neem Biotech, Willowbrook Technical Units, Llandogo Road, St. Mellons, Cardiff CF3 0EF, UK

View abstract

An efficient continuous flow process for the synthesis of a non-conventional mixture of fructooligosaccharides

Paolo Zambelli^a, Lucia Tamborini^b, Samuele Cazzamalli^b, Andrea Pinto^b, Stefania Arioli^a, Silvia Balzaretti^a, Francisco J. Plou^c, Lucia Fernandez-Arrojo^c, Francesco Molinari^a, Paola Conti^b, Diego Romano^a

^a Department of Food Environmental and Nutritional Science (DeFENS), University of Milan, Via Mangiagalli, 20133 Milan, Italy

^b Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy

^c Instituto de Catálisis y Petroleoquímica, CSIC, 28049 Madrid, Spain

View abstract

A practical deca-gram scale ring expansion of (R)-(−)-carvone to (R)-(+)-3-methyl-6-isopropenyl- cyclohept-3-enone-1

Leandro de C. Alves^a, André L. Desiderá^a, Kleber T. de Oliveira^a, Sean Newton^b, Steven V. Ley^{* b}, Timothy J. Brocksom^{* a}

^a Departamento de Química, Universidade Federal de São Carlos, P.O. Box 676, São Carlos – SP, Brazil

^b Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK

View abstract

Factors Influencing the Regioselectivity of the Oxidation of Asymmetric Secondary Amines with Singlet Oxygen

Dr. Dmitry B. Ushakov ^{1 †}, Matthew B. Plutschack ^{1 †}, Dr. Kerry Gilmore ^{1 *}, Prof. Dr. Peter H. Seeberger ¹

¹ Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany)

View abstract

Electroactive and Photoactive Poly[Isoindigo-alt-EDOT] Synthesized Using Direct (Hetero)Arylation Polymerization in Batch and in Continuous Flow

François Grenier ^†, Badrou Réda Aïch ^{† ‡}, Yu-Ying Lai ^§, Maxime Guérette ^†, Andrew B. Holmes ^§, Ye Tao ^‡, Wallace W. H. Wong ^{* §}, Mario Leclerc ^{* †}

^† Département de Chimie, Université Laval, Québec City, Qc G1V 0A6, Canada

^‡ Information and Communications Technologies Portfolio, National Research Council of Canada, Ottawa, ON K1A 0R6, Canada

^§ School of Chemistry, Bio21 Institute, the University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia

View abstract

A Concise Flow Synthesis of Efavirenz

Dr. Camille A. Correia¹, Dr. Kerry Gilmore¹, Prof. Dr. D. Tyler McQuade³, Prof. Dr. Peter H. Seeberger^{1 2 *}

¹ Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany)

² Institute for Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195 Berlin (Germany)

³ Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306 (USA)

View abstract

Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines

Marcus Baumann ¹, Antonio M. Rodriguez Garcia ^{1 2}, Ian R. Baxendale ^{* 1}

¹ Department of Chemistry, Durham University, South Road, Durham, UK

² Universidad de Castilla-La Mancha, Departamento de Química Orgánica, Facultad de Ciencias y Tecnologías Químicas, Avd. Camilo José Cela, 10, 13071 Ciudad Real, Spain

View abstract

Development of a flow method for the hydroboration/oxidation of olefins

José A. Souto^{* 1 2}, Robert A. Stockman³, Steven V. Ley¹

¹ Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK

² Departamento de Química Orgánica, Universidade de Vigo, Vigo, Spain

³ School of Chemistry, University of Nottingham, Nottingham, UK

View abstract

Making Ends Meet: Flow Synthesis as the Answer to Reproducible High-Performance Conjugated Polymers on the Scale that Roll-to-Roll Processing Demands

Martin Helgesen, Jon E. Carlé, Gisele A. dos Reis Benatto, Roar R. Søndergaard, Mikkel Jørgensen, Eva Bundgaard, Frederik C. Krebs

Department of Energy Conversion and Storage, Technical University of Denmark, Roskilde, Denmark

View abstract

Reevaluation of the 2-nitrobenzyl protecting group for nitrogen containing compounds: an application of flow photochemistry

Chloe I. Wendell, Michael J. Boyd

Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA, United States

View abstract

Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent

Catherine J. Smith, Christopher D. Smith, Nikzad Nikbin, Steven V. Ley, Ian R. Baxendale

Innovative Technology Centre, Cambridge, UK

View abstract

Generation and Trapping of Ketenes in Flow

Cyril Henry¹, David Bolien¹, Bogdan Ibanescu¹, Sally Bloodworth¹, David C. Harrowven¹, Xunli Zhang², Andy Craven³, Helen F. Sneddon³, Richard J. Whitby^{1 *}

¹ Chemistry, University of Southampton, Southampton, HANTS, SO17 1BJ, UK,

² Bioengineering Group, Faculty of Engineering and the Environment, University of Southampton, Southampton, HANTS, SO17 1BJ, UK

³ GlaxoSmithKline R&D Ltd., Medicines Research Centre, Gunnels Wood Road, Stevenage, HERTS, SG1 2NY, UK

View abstract

A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions

Maria Victoria Rojo^{* 1}, Lucie Guetzoyan¹, Ian. R. Baxendale^{1 2}

¹ Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK

² Department of Chemistry, University of Durham, South Road, Durham, UK

View abstract

C(sp³)–H functionalisation of N-aryl tetrahydroisoquinolines via an iron-catalysed aerobic nitro-Mannich reaction and continuous flow processing

Martin Brzozowski, Jose A. Forni, G. Paul Savage and Anastasios Polyzos^*

CSIRO Manufacturing Flagship, Bayview Avenue, Clayton, Australia

View abstract

Facilitating Biomimetic Syntheses of Borrerine Derived Alkaloids by Means of Flow-Chemical Methods

Sonja B. Kamptmann^A, Steven V. Ley

^A Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK

View abstract

The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

Steffen Glöckner, Duc N. Tran, Richard J. Ingham, Sabine Fenner, Zoe E. Wilson, Claudio Battilocchio, Steven V. Ley^*

Department of Chemistry, University of Cambridge, Cambridge, UK

View abstract

Development of a Grignard-Type Reaction for Manufacturing in a Continuous-Flow Reactor

Fabrice G. J. Odille^†§, Anna Stenemyr^†§, Fritiof Pontén^*‡

^† Pharmaceutical Development R&D, Chemical Science, AstraZeneca, SE-151 85 Södertälje, Sweden

^‡ Innovative Medicines, Cardiovascular and Metabolic Diseases, Medicinal Chemistry, AstraZeneca R&D, Sweden

^§ SP Process Development, Forskargatan, Sweden

View abstract

Regioselective Synthesis of 3-Aminoimidazo[1,2-a]-pyrimidines under Continuous Flow Conditions

Ashlie J. E. Butler, Mark J. Thompson, Patrick J. Maydom, James A. Newby, Kai Guo, Harry Adams, Beining Chen^*

Department of Chemistry, University of Sheffield, Sheffield, U.K.

View abstract

Microwave irradiation and flow chemistry for a straightforward synthesis of piano-stool iron complexes

Anastassiya Pagnoux-Ozherelyeva^a, David Bolien^b, Sylvain Gaillard^a, Flavie Peudru^a, Jean-François Lohier^a, Richard J. Whitby^b, Jean-Luc Renaud^a

^aNormandie University, University of Caen Basse Normandie, Laboratoire de Chimie Moléculaire et Thioorganique, CNRS, Caen, France

^bChemistry, University of Southampton, Southampton, UK

View abstract

Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs–Knorr reaction optimization

Serena Mostarda^a, Paolo Filipponi^a, Roccaldo Sardella^a, Francesco Venturoni^a, Benedetto Natalini^a, Roberto Pellicciaria^b, Antimo Gioiello^*a

^aLaboratory of Medicinal and Advanced Synthetic Chemistry (Lab MASC), Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy

^bTES Pharma S.r.l., Corciano, Italy

View abstract

A General Continuous Flow Method for Palladium Catalysed Carbonylation Reactions Using Single and Multiple Tube-in-Tube Gas-Liquid Microreactors

Ulrike Gross¹, Peter Koos¹, Matthew O'Brien^1,2,*, Anastasios Polyzos^1,3, Steven V. Ley¹

¹Whiffen Laboratory, Department of Chemistry, University of Cambridge, Cambridge, UK

²School of Physical and Geographical Sciences, Keele University, Staffordshire, UK

³CSIRO, Materials Science and Engineering, Clayton South, Australia

View abstract

Consecutive Oxygen-based Oxidations Convert Amines to a-Cyanoepoxides

Dmitry B. Ushakov^a, Kerry Gilmore^*a, Peter H. Seeberger^*a,b

^aMax Planck Institute of Colloids and Interfaces, Potsdam, Germany

^bInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany

View abstract

Synthesis of a Carprofen Analogue Using a Continuous Flow UV-Reactor

Antoine Caron, Augusto C. Hernandez-Perez, Shawn K. Collins^*

Department of Chemistry and Centre for Green Chemistry and Catalysis, Université de Montréal, Québec, Canada.

View abstract

Flow Chemistry Meets Advanced Functional Materials

Dr. Rebecca M. Myers, Daniel E. Fitzpatrick, Dr. Richard M. Turner, Prof. Steven V. Ley^*

Department of Chemistry, University of Cambridge, Cambridge, UK

View abstract

Continuous Synthesis of Artemisinin-Derived Medicines

Kerry Gilmore^a, Daniel Kopetzki^a, Ju Weon Lee^b, Zoltan Horvath^b, D. Tyler McQuade^a, Andreas Seidel-Morgenstern^b,c, Peter H. Seeberger^a,d

^aMax-Planck-Institute of Colloids and Interfaces, Department of Biomolecular Systems, Germany

^bMax-Planck-Institute for Dynamics of Complex Technical Systems, Germany

^cOtto-von-Guericke-University, Chair for Chemical Process Technology, Germany

^dFreie Universität Berlin, Institute of Chemistry and Biochemistry, Berlin, Germany

View abstract

A Continuous-Flow Approach to 3,3,3-Trifluoromethylpropenes: Bringing Together Grignard Addition, Peterson Elimination, Inline Extraction, and Solvent Switching

Trevor A. Hamlin^†, Gillian M. L. Lazarus^†, Christopher B. Kelly^†, Nicholas E. Leadbeater^*†‡

^†Department of Chemistry, University of Connecticut, United States

^‡Department of Community Medicine & Health Care, University of Connecticut Health Center, United States

View abstract

Heterogenization of Pd–NHC complexes onto a silica support and their application in Suzuki–Miyaura coupling under batch and continuous flow conditions

Alberto Martínez^a, Jamin L. Krinsky^a, Itziar Peñafiel^a, Sergio Castillón^b, Konstantin Loponov^c, Alexei Lapkin^c, Cyril Godard^*a, Carmen Claver^*a

^aDepartment of Physical and Inorganic Chemistry, Universitat Rovira i Virgili, Tarragona, Spain

^bDepartment of Analytical and Organic Chemistry, Universitat Rovira i Virgili, Tarragona, Spain

^cDepartment of Chemical Engineering and Biotechnology, University of Cambridge, , Cambridge, UK

View abstract

Glycosylation with N-acetyl glycosamine donors using catalytic iron(III) triflate: from microwave batch chemistry to a scalable continuous-flow process

Amandine Xolin^a, Arnaud Stévenin^a, Mathieu Pucheault^b, Stéphanie Norsikian^a, François-Didier Boyer^*ac, Jean-Marie Beau^*ad

^aCentre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France

^bInstitut des Sciences Moléculaires, CNRS-Université de Bordeaux, Talence, France

^cInstitut Jean-Pierre Bourgin, UMR1318 INRA-AgroParisTech, Versailles, France

^dUniversité Paris-Sud and CNRS, Laboratoire de Synthèse de Biomolécules, Institut de Chimie Moléculaire et des Matériaux, Orsay, France

View abstract

Multistep Flow Synthesis of 5-Amino-2-aryl-2H-[1,2,3]-triazole-4-carbonitriles

YDr. Jérôme Jacq, Dr. Patrick Pasau^*

UCB Biopharma, Avenue de l'Industrie, 1420 Braine l'Alleud (Belgium)

View abstract

Versatile, High Quality and Scalable Continuous Flow Production of Metal-Organic Frameworks

Marta Rubio-Martinez, Michael P. Batten, Anastasios Polyzos, Keri-Constanti Carey, James I. Mardel, Kok-Seng Lim, Matthew R. Hill

CSIRO Materials Science and Engineering, Australia

View abstract

Continuous Flow Magnesiation of Functionalized Heterocycles and Acrylates with TMPMgCl·LiCl

Dr. Trine P. Petersen, Matthias R. Becker, Prof. Dr. Paul Knochel^*

Ludwig-Maximilians-Universität München, Department Chemie, München, Germany

View abstract

Continuous Synthesis of Organozinc Halides Coupled to Negishi Reactions

Nerea Alonso^2,3, L. Zane Miller¹, Juan de M. Muñoz2, Jesus Alcázar^2,*, D. Tyler McQuade^1,*

¹Department of Chemistry and Biochemistry, Florida State University, USA

²Janssen Research and Development, Janssen-Cilag, Toledo, Spain

³Facultad de Química, Universidad de Castilla-La Mancha, Spain

View abstract

Continuous Flow Synthesis of Thieno[2,3-c]isoquinolin-5(4H)-one Scaffold: A Valuable Source of PARP-1 Inhibitors

Paolo Filipponi^†, Carmine Ostacolo^‡, Ettore Novellino^‡, Roberto Pellicciari^†§, Antimo Gioiello^*†

^†Dipartimento di Scienze Farmaceutiche, Università di Perugia, Via del Liceo 1, I-06123 Perugia, Italy

^‡Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Napoli, Italy §TES Pharma S.r.l., Corciano (Perugia), Italy

View abstract

First Example of a Continuous-Flow Carbonylation Reaction Using Aryl Formates as CO Precursors

Nerea Alonso^1,3, Juan de Muñoz¹, Brecht Egle², Johannes L. Vrijdag², Wim M. De Borggraeve², Antonio de la Hoz³, Angel Díaz-Ortiz³, Jesús Alcázar¹

¹Janssen Research and Development, Janssen-Cilag Department of Medicinal Chemistry S.A., Toledo, Spain

²Molecular Design and Synthesis University of Leuven, Department of Chemistry, Heverlee Belgium

³Universidad de Castilla-La Mancha Facultad de Ciencias y Tecnologías Químicas Real, Spain

View abstract

Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Richard J. Ingham¹, Claudio Battilocchio¹, Joel M. Hawkins², Steven V. Ley¹

¹ Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK

² Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA

View abstract

Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure–Activity Relationship Data of ?-Secretase (BACE1) Inhibitors

Dr. Michael Werner^1,*, Christoph Kuratli¹, Dr. Rainer E. Martin^1,*, Dr. Remo Hochstrasser¹, David Wechsler¹, Dr. Thilo Enderle¹, Dr. Alexander I. Alanine¹, Prof. Dr. Horst Vogel²

¹ Medicinal Chemistry, Small Molecule Research, Pharma Research & Early Development (pRED), F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel (Switzerland)

² Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology of Lausanne (EPFL), Station 6, 1015 Lausanne (Switzerland)

View abstract

Sequential flow process for the controlled polymerisation and thermolysis of RAFT-synthesised polymers

CH Hornung, A Postma, S Saubern, J Chiefari

CSIRO Materials Science and Engineering, Victoria, Australia

View abstract

Robust and reusable supported palladium catalysts for cross-coupling reactions in flow

William R. Reynolds^ab, Pawel Plucinskib^c, Christopher G. Frost^*ab

^* Corresponding authors

^a Centre for Sustainable Chemical Technologies, University of Bath, Claverton Down, Bath, UK

^b Department of Chemistry, University of Bath, Claverton Down, Bath, UK

^c Department of Chemical Engineering, University of Bath, Claverton Down, Bath, UK

View abstract

Continuous-Flow Oxidative Cyanation of Primary and Secondary Amines Using Singlet Oxygen

Dmitry B. Ushakov, Kerry Gilmore, Daniel Kopetzki, D. Tyler McQuade, Peter H. Seeberger

¹Department für Biomolekulare Systeme, Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Potsdam, Germany

²Institut für Chemie und Biochemie, Freie Universität Berlin, Berlin, Germany

³Department of Chemistry and Biochemistry, Florida State University, Tallahassee, USA

View abstract

Flow synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe

Matthew B. Plutschack^1,2, D. Tyler McQuade^1,2, Giulio Valenti², Peter H. Seeberger²

¹Department of Chemistry and Biochemistry, Florida State University, USA

²Max Planck Institute of Colloids and Interfaces, Germany

View abstract

The Fit For Purpose Development of S1P1 Receptor Agonist GSK2263167 Using a Robinson Annulation and Saegusa Oxidation to Access an Advanced Phenol Intermediate

Robert M. Harris, Benjamin I. Andrews, Stacy Clark, Jason W. B. Cooke, John C. S. Gray, Stephanie Q. Q. Ng

Chemical Development, GlaxoSmithKline Research and Development Ltd., UK

View abstract

Flow-Based, Cerium Oxide Enhanced, Low-Level Palladium Sonogashira and Heck Coupling Reactions by Perovskite Catalysts

Claudio Battilocchio¹, Benjamin N. Bhawal¹, Rajeev Chorghade¹, Benjamin J. Deadman¹, Joel M. Hawkins², Steven V. Ley¹

¹ Innovative Technology Centre, Department of Chemistry, University of Cambridge, UK

² Pfizer Worldwide Research & Development, Groton, USA

View abstract

Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions

Trevor A. Hamlin, Nicholas E. Leadbeater

Department of Chemistry, University of Connecticut, USA

View abstract

Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z)-Tamoxifen

Philip R D Murray, Duncan L Browne, Julio C Pastre, Chris Butters, Duncan Guthrie, Steven V Ley

Department of Chemistry, University of Cambridge, UK Instituto de Química, University of Campinas, Brazil Vapourtec Ltd, UK

View abstract

Biotransformation with whole microbial systems in a continuous flow reactor: resolution of (RS)-flurbiprofen using Aspergillus oryzae by direct esterification with ethanol in organic solvent

Lucia Tamborini^a, Diego Romano^b, Andrea Pinto^a, Martina Contente^a, Maria C. Iannuzzi^a, Paola Conti^a, Francesco Molinari^b

^a Dipartimento di Scienze Farmaceutiche, Universitá degli Studi di Milano, Italy

^b Dipartimento di Scienze per gli Alimenti, la Nutrizione e l'Ambiente (DEFENS), Universitá degli Studi di Milano, Italy

View abstract

Porous, functional, poly(styrene-co-divinylbenzene) monoliths by RAFT polymerization

Kristine J. Barlow (née Tan), Xiaojuan Hao, Timothy C. Hughes, Oliver E. Hutt, Anastasios Polyzos, Kathleen A. Turner, Graeme Moad

Commonwealth Scientific and Industrial Research Organisation (CSIRO), Materials Science & Engineering, Australia

View abstract

The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow

Kimberley A. Roper¹, Malcolm B. Berry², Steven V. Ley¹

¹ Innovative Technology Centre, Department of Chemistry, University of Cambridge, Cambridge, U.K.

² GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.

View abstract

Continuous Flow Synthesis of Coumarin

Anbang Chen¹, Xin Li¹, Yangzhi Zhou¹, Lingling Huang², Zheng Fang², Haifeng Gan¹, Kai Guo¹

¹ College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology ² School of Pharmceutical Sciences, Nanjing University of Technology

View abstract

Synthesis of All Four Stereoisomers of 3-(tert-Butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid

Bettina Bakonyi^†, Markus Furegati^*‡, Christian Kramer^§, Luigi La Vecchia^‡, Flavio Ossola^‡

^† Doetsch Grether AG, Falkensteinerstrasse 37, 4132 Muttenz, Switzerland

^‡ Preparations Laboratories, Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Klybeckstrasse 141, 4057 Basel,Switzerland

^§ Institute of General, Inorganic and Theoretical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria

View abstract

The rapid generation of isothiocyanates in flow

Marcus Baumann, Ian R. Baxendale

Department of Chemistry, University of Durham, U.K.

View abstract

Continuous synthesis of pyridocarbazoles and initial photophysical and bioprobe characterization

D. Tyler McQuade^*ab, Alexander G. O'Brien^a, Markus Dörr^c, Rajathees Rajaratnam^c, Ursula Eisold^d, Bopanna Monnanda^a, Tomoya Nobuta^a, Hans-Gerd Löhmannsröben^d, Eric Meggers^c, Peter H. Seebergera^e

^a Department for Biomolecular Systems, Max Planck Institute for Colloids and Interfaces

^b Department of bChemistry and Biochemistry, Florida State University

^c Fachbereich Chemie, Philipps-Universität Marburg

^d Potsdam Institut für Chemie

^e Freie Universität Berlin

View abstract

Microwave heating and conventionally-heated continuous-flow processing as tools for performing cleaner palladium-catalyzed decarboxylative couplings using oxygen as the oxidant – a proof of principle study

Nicholas E. Leadbeater¹, DiAndra M. Rudzinski¹

¹ Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269, USA

View abstract

Hypervalent iodine/TEMPO-mediated oxidation in flow systems: a fast and efficient protocol for alcohol oxidation

Nida Ambreen, Ravi Kumar, Thomas Wirth

Innovative Technology Centre, Cardiff University, School of Chemistry, Park Place, Cardiff, UK

View abstract

First Example of Alkyl-Aryl Negishi Cross-Coupling in Flow: Mild, Efficient and Clean Introduction of Functionalized Alkyl Groups

Brecht Egle², Juan de Muñoz¹, Nerea Alonso¹, Wim M. De Borggraeve², Antonio de la Hoz³, Angel Díaz-Ortiz³, Jesús Alcázar¹

¹Janssen Research and Development Department of Medicinal Chemistry Janssen-Cilag, Toledo Spain

²Department of Chemistry, Molecular Design and Synthesis University of Leuven, Heverlee Belgium

³Universidad de Castilla-La Mancha Facultad de Ciencias y Tecnologías Químicas, Spain

View abstract

Controlled synthesis of poly(3-hexylthiophene) in continuous flow

Helga Seyler, Jegadesan Subbiah, David J. Jones, Andrew B. Holmes, Wallace W. H. Wong^*

School of Chemistry, Bio21 Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia

*Corresponding author

View abstract

Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhibitors: Application to Drug Discovery

Werngard Czechtizky, Jurgen Dedio, Bimbisar Desai, Karen Dixon, Elizabeth Farrant, Qixing Feng Trevor Morgen, David M Parry, Manoj K. Ramjee, Christopher N. Selway, Thorsten Schmidt, Gary J. Tarver, Adrian G. Wright

Sanofi-Aventis, Frankfurt, Germany. Cyclofluidic Ltd., U.K.

View abstract

Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis

D. Tyler McQuade^{1 3}, Peter H. Seeberger^{1 2}

¹ Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces

² Institute for Chemistry and Biochemistry, Freie Universität Berlin,

³ Department of Chemistry and Biochemistry, Florida State University

View abstract

Continuous flow macrocyclization at high concentrations: synthesis of macrocyclic lipids

Anne-Catherine Bédard, Sophie Régnie, Shawn K. Collins

Département de Chimie, Centre for Green Chemistry, Catalysis, Université de Montréal, Montréal, Canada

View abstract

Continuous Synthesis and Use of N-Heterocyclic Carbene Copper(I) Complexes from Insoluble Cu2O

Suzanne M. Opalka¹, Jin Kyoon Park³, Ashley R. Longstreet², D. Tyler McQuade²

¹Department of Chemistry and Biochemistry, Florida State University, USA

²Department of Chemistry and Chemical Biology, Cornell University, USA

³Department of Chemistry and Chemical Institute for Functional Materials, Pusan National University, Korea

View abstract

Ozonolysis of some complex organic substrates in flow

M. D. Roydhouse¹, W. B. Motherwell¹, A. Constantinou², A. Gavriilidis², R. Wheeler³, K. Down³, I. Campbell³

¹Dept of Chemistry, University College London, UK

²Dept of Chemical Engineering, University College London, UK

³GSK, Stevenage, UK

View abstract

Synthesis of Carbohydrate-Functionalised Sequence-Defined Oligo(amidoamine)s by Photochemical ThiolEne Coupling in a Continuous Flow Reactor

Felix Wojcik^1,2, Alexander G. O'Brien^1,2, Sebastian Götze^1,2, Peter H. Seeberger^1,2, Laura Hartmann^1,2

¹Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam (Germany)

²Institute for Chemistry and Biochemistry, Freie Universität Berlin, Berlin (Germany)

View abstract

Continuous-flow generation of diazoesters and their direct use in S-H and P-H insertion reactions: synthesis of a-sulfanyl, a-sulfonyl and a-phosphono carboxylates

Hannah E. Bartrum¹, David C. Blakemore², Christopher J. Moody¹, Christopher J. Hayes¹

¹School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK

²Pfizer Neusentis, The Portway Building, Granta Park, Cambridge, CB21 6GS, UK

View abstract

Synthesis of RAFT Block Copolymers in a Multi-Stage Continuous Flow Process Inside a Tubular Reactor

Christian H. Hornung, Xuan Nguyen, Stella Kyi, John Chiefari, Simon Saubern

CSIRO Materials Science & Engineering, Victoria, Australia.

View abstract

An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

Mark D Hopkin, Ian Baxendale, Steven.V.Ley

Dept of Chemistry, University of Cambridge, UK

View abstract

A Multi-Step Continuous Flow Process for the N-Demethylation of Alkaloids

Yuji Nakano¹, G. Paul Savage¹, Simon Saubern¹, Peter J. Scammells², Anastasios Polyzos¹

¹ CSIRO Materials Science and Engineering, Victoria, Australia.

² Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria, Australia.

View abstract

A Two-Stage Continuous-Flow Synthesis of Spirooxazine Photochromic Dyes

Mark York¹²³, Adriana Edenharter¹

¹CSIRO Materials Science and Engineering, Clayton, Vic. 3169, Australia.

²Cooperative Research Centre for Polymers, Notting Hill, Vic. 3168, Australia.

³Advanced Polymerik Pty Ltd, Notting Hill, Vic. 3168, Australia.

View abstract

Continuous Flow Synthesis of Organic Electronic Materials : Case Studies in Methodology Translation and Scale-up

Helga Seyler¹, Stefan Haid², Tae-Hyuk Kwon¹, David J. Jones¹, Peter Bäuerle², Andrew B. Holmes¹, Wallace W. H. Wong^1*

¹Bio21 Institute, University of Melbourne, Australia.

²Institute of Organic Chemistry II and Advanced Materials, University of Ulm, Germany.

View abstract

Preparation of Arene Chromium Tricarbonyl Complexes Using Continuous-Flow Processing: (n6-C6H5CH3)Cr(CO)3 as an example

Christopher (Xiang) Lee¹, Elizabeth A. Pedrick¹, Nicholas E. Leadbeater¹

¹Department of Chemistry, University of Connecticut, USA

²Department of Community Medicine and Health Care, University of Connecticut Health Center, USA

View abstract

Visible Light-Initiated Preparation of Functionalized Polystyrene Monoliths for Flow Chemistry

Farhan R. Bou-Hamdan¹, Kathleen Krüger¹, Klaus Tauer¹, Tyler McQuade^1,3 , Peter H. Seeberger ^1,2

¹Max Planck Institute of Colloids and Interfaces Potsdam, Germany.

²Institute of Chemistry and Biochemistry, Freie Universität Berlin , Germany.

³Department of Chemistry and Biochemistry, Florida State University, USA.

View abstract

Integrated Continuous Processing and Flow Characterization of RAFT Polymerization in Tubular Flow Reactors

Christian H. Hornung, Xuan Nguyen, Geoff Dumsday, Simon Saubern^*

CSIRO Materials Science and Engineering, Victoria. Australia

View abstract

Synthesis of an H3 Antagonist via Sequential One-Pot Additions of a Magnesium Ate Complex and an Amine to a 1,4-Ketoester followed by Carbonyl-Directed Fluoride Addition

Joel M. Hawkins, Pascal Dubé, Mark T. Maloney, Lulin Wei. Marcus Ewing, Stephen M. Chesnut, Joshua R. Denette, Brett M. Lillie, Rajappa Vaidyanathan

Pharmaceutical Sciences, Pfizer Inc., Groton, USA

View abstract

A “Catch-React-Release” Method for the Flow Synthesis of 2-Aminopyrimidines and Preparation of the Imatinib Base

Richard J. Ingham, Elena Riva, Nikzad Nikbin, Ian R. Baxendale, Steven V. Ley^*

Innovative Technology Centre, University of Cambridge, U.K.

View abstract

Sustainable and efficient methodology for CLA synthesis and identification

Andres Moreno, Maria Moreno, Maria Victoria Gómez, Cristina Cebrian, Pilar Prieto, Antonio de la Hoz

Departamento de Química Inorgánica, , Universidad de Castilla-La Mancha, Ciudad Real, Spain.

View abstract

A Continuous Flow Process for the Radical Induced End Group Removal of RAFT Polymers

Christian H. Hornung, Almar Postma, Simon Saubern, John Chiefari

CSIRO Materials Science & Engineering, Victoria Australia

View abstract

Continuous Synthesis and Purification by Direct Coupling of a Flow Reactor with Simulated Moving-Bed Chromatography

Alexander G. O’Brien¹, Zoltán Horváth³, François Lévesque¹, Ju Weon Lee³, Andreas Seidel-Morgenstern³, Peter H. Seeberger^1,2

¹Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Potsdam, Germany

²Freie Universität Berlin, Germany

³Max-Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

View abstract

Asymmetric Homogeneous Hydrogenation in Flow using a Tube-in-Tube Reactor

Sean Newton¹, Steven V. Ley¹, Eva Casas Arcé², Damian M. Grainger²

¹Department of Chemistry, University of Cambridge, U.K.

²Johnson Matthey Catalysis and Chiral Technology, Cambridge, U.K.

View abstract

Continuous Flow Synthesis of Secondary Amides by Tandem Azidation- Amidation of Anilines

Christian Spiteri, John E. Moses^*

School of Chemistry, University of Nottingham, UK

View abstract

Continuous Flow Hydrogenation Using an On-Demand Gas Delivery Reactor

Michael A. Mercadante, Christopher B. Kelly, Christopher (Xiang) Lee, Nicholas E. Leadbeater^*

Department of Chemistry, University of Connecticut, USA

View abstract

Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts

Francesco Venturoni, Antimo Gioiello, Roccaldo Sardella, Benedetto Natalini, Roberto Pellicciari

Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy

View abstract

Phase-Transfer Catalysis under Continuous Flow Conditions: An Alternative Approach to the Biphasic Liquid/Liquid O-Alkylation of Phenols

Daniele De Zani², Matteo Colombo¹

¹NiKem Research 20021 via Zambeletti 25 Milan Baranzate Italy

²Erregierre, San Paolo D'Argon Bergamo Italy

View abstract

An efficient method for the lipase-catalysed resolution and in-line purification of racemic flurbiprofen in a continuous-flow reactor

Lucia Tamborini¹, Diego Romano², Andrea Pinto¹, Arianna Bertolani^1,2, Francesco Molinari², Paola Conti¹

¹Dipartimento di Scienze Farmaceutiche ‘Pietro Pratesi’, Universitá degli Studi di Milano, Italy

²Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, Universitá degli Studi di Milano, Italy

View abstract

Development of a Continuous Flow Scale-Up Approach of Reflux Inhibitor AZD6906

Tomas Gustafsson, Henrik Sörensen, Fritiof Pontén^*

Medicinal Chemistry, AstraZeneca R&D Mölndal, Sweden

View abstract

Soluble Polymer-Supported Flow Synthesis: A Green Process for the Preparation of Heterocycles

Nicolò Prosa, Raphaël Turgis, Riccardo Piccardi, Marie-Christine Scherrmann

Institut de Chimie Moléculaire et des Matériaux d'Orsay, Université Paris-Sud, France

View abstract

Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands

Claudio Battilocchio^1,3, Marcus Baumann¹, Ian R. Baxendale¹, Mariangela Biava³, Matthew O. Kitching¹, Steven V. Ley¹, Rainer E. Martin^*2, Stephan A. Ohnmacht², Nicholas D. C. Tappin¹

¹Department of Chemistry, University of Cambridge, UK

²F. Hoffmann-La Roche Ltd., Pharmaceuticals Division, Basel, Switzerland

³Department of Pharmaceutical Chemistry and Technology, Sapienza University of Rome, Italy

View abstract

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

François Lévesque¹, Peter H. Seeberger^1,2

¹Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Germany

²Institute for Chemistry and Biochemistry, Freie Universität Berlin, Germany

View abstract

The Continuous-Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas Permeable Membrane Reactor

Anastasios Polyzos, Matthew O’Brien, Trine P. Petersen, Ian R. Baxendale, Steven V. Ley

Innovative Technology Centre, Department of Chemistry, University of Cambridge

View abstract

Continuous proline catalysis via leaching of solid proline

Suzanne M. Opalka¹, Ashley R. Longstreet², D. Tyler McQuade²

¹Department of Chemistry and Chemical Biology, Cornell University, USA

²Department of Chemistry and Biochemistry, Florida State University,USA

View abstract

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

Kimberley A. Roper¹, Heiko Lange¹, Anastasios Polyzos¹, Malcolm B. Berry², Ian R. Baxendale¹, Steven V. Ley¹

¹Innovative Technology Centre, University of Cambridge

²GlaxoSmithKline, Stevenage, UK

View abstract

Application of Flow Chemistry to the Selective Reduction of Esters to Aldehydes

Juan de M. Muñoz¹, Jesús Alcázar¹, Antonio de la Hoz², Angel Díaz-Ortiz²

¹Janssen, Toledo, Spain

²Facultad de Ciencias Químicas, Universidad de Castilla-La Mancha, Spain

View abstract

Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels-Alder Reaction under Superheated Continuous Flow Conditions

Rainer E. Martin¹, Falk Morawitz¹, Christoph Kuratli¹, André M. Alker², Alexander I. Alanine¹

¹Chemistry Technology and Innovation, F. Hoffmann-La Roche Ltd, Basel, Switzerland

²Biostructure Section, F. Hoffmann-La Roche Ltd,Basel, Switzerland

View abstract

Continuous Preparation of Arylmagnesium Reagents in Flow with Inline IR Monitoring

Tobias Brodmann¹, Peter Koos¹, Albrecht Metzger¹, Paul Knochel^*2, Steven V. Ley^*1

¹Department of Chemistry, University of Cambridge, U.K.

²Department of Chemistry, Ludwig Maximilians-Universität München, Germany

View abstract

Lead Diversification 2: Application to P38, gMTP and lead compounds

M. Abid Masood¹, Marc Bazin², Mark E. Bunnage¹, Andrew Calabrese³, Mark Cox¹, Sally-Ann Fancy¹, Elizabeth Farrant¹, David W. Pearce¹, Manuel Perez¹, Laure Hitzel¹, Torren Peakman¹

¹Worldwide Medicinal Chemistry, Pfizer, UK

²Hepatochem, Cambridge, MA, USA

³Celgene San Diego, USA

View abstract

New Insights into Cyclobutenone Rearrangements: A Total Synthesis of the Natural ROS-Generating Anti-Cancer Agent Cribrostatin 6

Mubina Mohamed¹, Théo P. Gonçalves¹, Prof. Richard J. Whitby¹, Dr. Helen F. Sneddon², Prof. David C. Harrowven¹

¹ Chemistry, University of Southampton, UK

² GlaxoSmithKline Medicines Research Centre, UK

View abstract

New Insights into Cyclobutenone Rearrangements: A Total Synthesis of the Natural ROS-Generating Anti-Cancer Agent Cribrostatin (ROS=reactive-oxygen species)

Mubina Mohamed¹, Théo P. Gonçalves¹, Richard J. Whitby¹, Helen F. Sneddon², David C. Harrowven¹

¹Dept of Chemistry, University of Southampton, UK

²GSK Medicines Research Centre, Stevenage, UK

View abstract

A continuous-flow synthesis of annulated and polysubstituted furans from the reaction of ketones and a-haloketones

Mark York

CSIRO Materials Science and Engineering, Australia

Cooperative Research Centre for Polymers, Notting Hill, Australia

View abstract

The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact

Trine P. Petersen^1,2,3, Anastasios Polyzos^1,4, Matthew O’Brien¹, Trond Ulven², Ian R. Baxendale¹, Steven V. Ley¹

¹Whiffen Laboratory, University of Cambridge, UK

²Department of Physics and Chemistry, University of Southern Denmark

³Discovery Chemistry and DMPK, H. Lundbeck A/S,Denmark

⁴CSIRO, Materials Science and Engineering, Australia

View abstract

Continuous flow synthesis of conjugated polymers

Helga Seyler, David J. Jones, Andrew B. Holmes, Wallace W. H. Wong

Bio21 Institute, University of Melbourne, Australia

View abstract

Suzuki-Miyaura Cross-Coupling of Heteroaryl Halides and Arylboronic Acids in Continuous Flow

Timothy Noël, Andrew J. Musacchio

Department of Chemistry, MIT, USA

View abstract

Nitrile Oxide 1,3-Dipolar Cycloaddition by Dehydration of Nitromethane Derivatives Under Continuous Flow Conditions

Malte Brasholz, Simon Saubern^*, G. Paul Savage

CSIRO Materials Science and Engineering, Victoria, Australia.

View abstract

Continuous-flow, palladium-catalysed alkoxycarbonylation reactions using a prototype reactor in which it is possible to load gas and heat simultaneously

Michael A. Mercadante, Nicholas E. Leadbeater

Department of Chemistry, University of Connecticut, USA

View abstract

Continuous flow photolysis of aryl azides: Preparation of 3H-azepinones

Farhan R. Bou-Hamdan, François Lévesque, Alexander G. O'Brien, Peter H. Seeberger

Max Planck Institute of Colloids and Interfaces, Berlin, Germany

View abstract

Teflon AF-2400 mediated gas–liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

Peter Koos, Ulrike Gross, Anastasios Polyzos, Matthew O'Brien, Ian Baxendale, Steven V. Ley

Innovative Technology Centre, University of Cambridge, UK

View abstract

Rapid Access to α-Alkoxy and α-Amino Acid Derivatives through Safe Continuous-Flow Generation of Diazoesters

Hannah E. Bartrum¹, David C. Blakemore², Christopher J. Moody¹, Christopher J. Hayes¹, ¹School of Chemistry, University of Nottingham, UK, ²Pfizer Global Research and Development, Sandwich, UK
View abstract

Ozonolysis in Flow Using Capillary Reactors

M. D. Roydhouse¹, A. Ghaini², A. Constantinou, A. Cantu-Perez², W. B. Motherwell¹, A. Gavriilidis²

¹ Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ

² Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE

View abstract

An Integrated Flow and Batch-Based Approach for the Synthesis of O-Methyl Siphonazole

Marcus Baumann, Ian R. Baxendale, Malte Brasholz, John J. Hayward, Steven V. Ley, Nikzad Nikbin

Innovative Technology Centre, Cambridge, UK

View abstract

Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods

Marcus Baumann¹, Ian R. Baxendale¹, Steven V. Ley¹, Christoph Kuratli², Rainer E. Martin², Josef Schneider²

¹Innovative Technology Centre, University of Cambridge, U.K.

²F. Hoffmann-La Roche Ltd., Basel, Switzerland

View abstract

Nitration Chemistry in Continuous Flow using Fuming Nitric Acid in a Commercially Available Flow Reactor

Cara E. Brocklehurst, Hansjoerg Lehmann, Luigi La Vecchia

Global Discovery Chemistry, Novartis, Basel, Switzerland

View abstract

Synthesis of (+)-Dumetorine and Congeners by Using Flow Chemistry Technologies

Elena Riva², Anna Rencurosi¹, Stefania Gagliardi¹, Daniele Passarella², Marisa Martinelli^1*

¹NiKem Research S.r.l., Milan, Italy

²Università degli Studi di Milano,Milan, Italy

View abstract

Continuous flow synthesis of fullerene derivatives

Helga Seyler, Wallace Wing Ho Wong, Dave Jones, Andrew B. Holmes

University Of Melbourne, Australia

View abstract

Preparation of fluoxetine by multiple flow processing steps

Batoul Ahmed-Omer, Adam J. Sanderson

Eli Lilly and Co. Ltd.

Lilly Research Centre, UK.

View abstract

Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith

Heiko Lange, Matthew J. Capener, Alexander X. Jones, Catherine J. Smith, Nikzad Nikbin, Ian R. Baxendale, Steven V. Ley^*

Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK

View abstract

Highly efficient dehydration of carbohydrates to 5-(chloromethyl)furfural (CMF), 5-(hydroxymethyl)furfural (HMF) and levulinic acid by biphasic continuous flow processing

Malte Brasholz, Karin von Känel, Christian H. Hornung, Simon Saubern, John Tsanaktsidis

CSIRO Materials Science & Engineering, Victoria , Australia

View abstract

A General, One-Step Synthesis of Substituted Indazoles using a Flow Reactor

Rob C. Wheeler, Emma Baxter, Ian B. Campbell, Simon J. F. Macdonald

GlaxoSmithKline, Stevenage, UK

View abstract

Controlled RAFT Polymerization in a Continuous Flow Microreactor

Christian H. Hornung, Carlos Guerrero-Sanchez, Malte Brasholz, Simon Saubern, John Chiefari, Graeme Moad, Ezio Rizzardo, San H. Thang

CSIRO Materials Science & Engineering, Victoria, Australia

View abstract

Diastereoselective Chain-Elongation Reactions Using Microreactors for Applications in Complex Molecule Assembly

Catherine F. Carter¹, Heiko Lange¹, Daiki Sakai², Ian R. Baxendale¹, Steven V. Ley¹

¹Innovative Technology Centre, University of Cambridge, UK, CB2 1EW, UK

²Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan

View abstract

Decarboxylative biaryl synthesis in a continuous flow reactor

¹Paul P. Lange, ¹Lukas J. Gooßen, ²Philip Podmore, ²Toby Underwood, ²Nunzio Sciammetta

¹Technische Universität Kaiserslautern, Germany

²Pfizer Global R&D, Sandwich, UK

View abstract

A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

Catherine J. Smith, Nikzad Nikbin, Steven V. Ley, Heiko Lange, Ian R. Baxendale

Innovative Technology Centre, Cambridge, UK

View abstract

A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing

Heiko Lange¹, Catherine F. Carter¹, Mark D. Hopkin¹, Adrian Burke², Jon G. Goode², Ian R. Baxendale¹, Steven V. Ley¹

¹Innovative Technology Centre, University of Cambridge, UK

²Mettler-Toledo AutoChem UK

View abstract

One-Flow, Multistep Synthesis of Nucleosides by Brønsted Acid-Catalyzed Glycosylation

Adam Sniady, Matthew W. Bedore, Timothy F. Jamison

Novartis Institutes for Biomedical Research Inc., Cambridge, USA MIT, Cambridge, USA

View abstract

Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates

Alexander G. O'Brien, François Lévesque, Peter H. Seeberger

Max Planck Institute of Colloids and Interfaces, Potsdam, Germany

View abstract

Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor

Laetitia J. Martin¹, Andreas L. Marzinzik¹, Steven V. Ley², Ian R. Baxendale²

¹Novartis Institute for BioMedical Research, Basel, Switzerland

²Innovative Technology Centre, Department of Chemistry, University of Cambridge

View abstract

Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing

Yun Zhang¹, Timothy F. Jamison², Sejal Patel¹, Nello Mainolfi¹, ¹Novartis Institutes for Biomedical Research Inc., Cambridge, USA, ²MIT, Cambridge, USA
View abstract

Synthesis of β-Keto Esters In-Flow and Rapid Access to Substituted Pyrimidines

Hannah E. Bartrum¹, David C. Blakemore², Christopher J. Moody1, Christopher J. Hayes¹

¹School of Chemistry, University of Nottingham, UK

²Pfizer Global Research and Development, Sandwich, UK

View abstract

Synthesis of 3-Aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole Derivatives: A Comparison between Conventional, Microwave-Assisted and Flow-Based Methodologies

Sabrina Castellano¹, Lucia Tamborini², Monica Viviano¹, Andrea Pinto², Gianluca Sbardella¹, Paola Conti²

¹Dipartimento di Scienze Farmaceutiche, Universit degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Italy

²Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universit degli Studi di Milano , Italy

View abstract

Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor

Laia Malet-Sanz, Julia Madrzak, Steven V.Ley, Ian R.Baxendale

Innovative Technology Centre, University of Cambridge

View abstract

A Gram-Scale Batch and Flow Total Synthesis of Perhydrohistrionicotoxin

Dr. Malte Brasholz¹, Dr. James M. Macdonald¹, Dr. Simon Saubern¹, Dr. John H. Ryan¹, Prof. Dr. Andrew B. Holmes^1,2

¹CSIRO Molecular and Health Technologies, Victoria, Australia

²School of Chemistry, Bio 21 Institute, University of Melbourne, Victoria, Australia

View abstract

A Continuous Flow Process Using a Sequence of Microreactors with In-line IR Analysis for the Preparation of N,N-Diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a Potent and Highly Selective δ-Opioid Receptor Agonist

Zizheng Qian, Ian R. Baxendale, Steven V. Ley

Innovative Technology Centre, University of Cambridge

View abstract

Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor

Marcus Baumann, Ian R. Baxendale, Andreas Kirschning, Steven V. Ley^*, Jens Wegner

Department of Chemistry, University of Cambridge

View abstract

KMnO4-Mediated Oxidation as a Continuous Flow Process

Jorg Sedelmeier, Steven V. Ley, Ian R. Baxendale, Marcus Baumann

Innovative Technology Centre, University of Cambridge

View abstract

Flow synthesis of tricyclic spiropiperidines as building blocks for the histrionicotoxin family of alkaloids

Malte Brasholz¹, Brian A. Johnson², James M. Macdonald¹, Anastasios Polyzos¹, John Tsanaktsidis¹, Simon Saubern¹, Andrew B. Holmes^1,2, John H. Ryan¹

¹CSIRO Molecular and Health Technologies, Victoria, Australia

²School of Chemistry, Bio 21 Institute, University of Melbourne, Victoria, Australia

View abstract

Effect of phase transfer chemistry, segmented fluid flow, and sonication on the synthesis of cinnamic esters

Mauro Riccaboni, Elena La Porta, Andrea Martorana, Roberta Attanasio

Department of Medicinal Chemistry, NiKem Research Srl, Milan, Italy

View abstract

Continuous Flow Palladium(II)-Catalyzed Oxidative Heck Reactions with Arylboronic Acids

Luke R. Odell¹, Jonas Lindh¹, Tomas Gustafsson², Mats Larhed^1*

¹Organic Pharmaceutical Chemistry, Department of MedChem, Uppsala University, Sweden

²AstraZeneca R&D Mölndal, Sweden

View abstract

A flow-based synthesis of Imatinib: the API of Gleevec

Mark D. Hopkin, Ian R. Baxendale, Steven V. Ley

Innovative Technology Centre, Department of Chemistry, University of Cambridge

View abstract

Reaction of Grignard reagents with carbonyl compounds under continuous flow conditions

E. Riva¹, S. Gagliardi², M. Martinelli², D. Passarella¹, D. Vigo², A. Rencurosi²

¹Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Milano, Italy

²NiKem Research S.r.l., , Milan, Italy

View abstract

The application of flow microreactors to the preparation of a family of casein kinase I inhibitors

Francesco Venturoni, Nikzad Nikbin, Steven V. Ley, Ian R. Baxendale

Innovative Technology Centre, Department of Chemistry, University of Cambridge

View abstract

A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT1B> Antagonist

Zizheng Qian, Ian R. Baxendale, Steven V. Ley

Innovative Technology Centre, Department of Chemistry, University of Cambridge

View abstract

ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

Catherine F. Carter¹, Heiko Lange¹, Steven V. Ley¹, Ian R. Baxendale¹, Brian Wittkamp², Jon G. Goode³, Nigel L. Gaunt³

¹Innovative Technology Centre, Department of Chemistry, University of Cambridge

²Mettler-Toledo AutoChem, USA

³Mettler-Toledo AutoChem, UK

View abstract

A highly efficient flow reactor process for the synthesis of N-Boc-3,4-dehydro-l-proline methyl ester

Lucia Tamborini, Paola Conti, Andrea Pinto, Carlo De Micheli

Dipartimento di Scienze Farmaceutiche ‘Pietro Pratesi’,

Università degli Studi di Milano, Italy

View abstract

[3+2] Dipolar cycloadditions of an unstabilised azomethine ylide under continuous flow conditions

Mark Grafton, Andrew C. Mansfield, M. Jonathan

Pfizer Global Research and Development, Sandwich, UK

View abstract

Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of YneOnes and Their Use in Heterocycle Synthesis

Ian R. Baxendale¹, Søren C. Schou², Jörg Sedelmeier¹, Steven V. Ley¹

¹ITC, Department of Chemistry, University of Cambridge

²LEO Pharma, Medicinal Chemistry Research, Denmark

View abstract

A safe and reliable procedure for the iododeamination of aromatic and heteroaromatic amines in a continuous flow reactor

Laia Malet-Sanz, Julia Madrzak, Rhian S. Holvey, Toby Underwood

Research Chemistry, Pfizer Global Research and Development, Sandwich, UK

View abstract

Development of fluorination methods using continuous-flow microreactors

Marcus Baumann, Ian R. Baxendale, Laetitia J. Martin, Steven V. Ley

Innovative Technology Centre, Cambridge, UK

View abstract

Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles

Ian R. Baxendale¹, Steven V. Ley¹, Andrew C. Mansfield², Christopher D. Smith¹

¹ITC, Department of Chemistry, University of Cambridge,

²Pfizer Global R&D Research Centre, Sandwich, (UK)

View abstract

Efficient Continuous Flow Synthesis of Hydroxamic Acids and Suberoylanilide Hydroxamic Acid Preparation

E. Riva¹, S. Gagliardi², Caterina Mazzoni², M. Martinelli², D. Passarella¹, D. Vigo², A. Rencurosi²

¹Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Italy

²NiKem Research S.r.l., Milan, Italy

View abstract

A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor

Ian R. Baxendale, Steven V. Ley, Christopher D. Smith, Lucia Tamborini, Ana-Florina Voica

Innovative Technology Centre, Cambridge, UK

View abstract

The Use of Diethylaminosulfur Trifluoride (DAST) for Fluorination in a Continuous-Flow Microreactor

Baumann, Marcus, Baxendale, Ian R., Ley, Steven V.

Innovative Technology Centre, Cambridge, UK

View abstract

A modular flow reactor for performing Curtius rearrangements as a continuous flow process

Marcus Baumann¹, Ian R. Baxendale¹, Steven V. Ley¹, Nikzad Nikbin¹, Christopher D. Smith¹, Jason P. Tierney²

¹Innovative Technology Centre, Department of Chemistry, University of Cambridge

²Neurology Lead Discovery Chemistry, GlaxoSmithKline R and D, Harlow, UK

View abstract

Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions

Marcus Baumann, Ian R. Baxendale, Steven V. Ley, Nikzad Nikbin, Christopher D. Smith

Innovative Technology Centre, Cambridge, UK

View abstract

A Microcapillary Flow Disc Reactor for Organic Synthesis

Christian H. Hornung¹, Malcolm R. Mackley², Ian R. Baxendale¹, Steven V. Ley¹

¹Department of Chemistry, University of Cambridge

²Department of Chemical Engineering, University of Cambridge

View abstract

Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

Christopher D. Smith, Ian Baxendale, Geoffrey Tranmer, Marcus Baumann, Stephen Smith, Russell Lewthwaite, Steven V. Ley

Department of Chemistry, University of Cambridge, UK

View abstract

[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor

Christopher D. Smith¹, Ian R. Baxendale¹, Steve Lanners¹, John J. Hayward¹, Steven V. Ley¹, Stephen C. Smith²

¹Innovative Technology Centre, University of Cambridge, UK

²Syngenta, Jealots Hill International Research Centre, UK

View abstract

Continuous Flow Ligand-Free Heck Reactions Using Monolithic Pd [0] Nanoparticles

Nikzad Nikbin, Mark Ladlow, Steven V. Ley

Department of Chemistry, University of Cambridge, UK

View abstract

Fully Automated Flow-Through Synthesis of Secondary Sulfonamides in a Binary Reactor System

Charlotte M. Griffiths-Jones, Mark D. Hopkin, Daniel Jönsson, Steven V. Ley, David J. Tapolczay, Emma Vickerstaffe, Mark Ladlow

GlaxoSmithKline Cambridge Technology Centre, Cambridge

View abstract

Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles

Marcus Baumann, Ian R. Baxendale, Steven V. Ley, Christoper D. Smith, Geoffrey K. Tranmer

Innovative Technology Center, University of Cambridge

View abstract

A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

Ian R. Baxendale, Steven V. Ley, Christopher D. Smith, Geoffrey K. Tranmer

Innovative Technology Centre, Cambridge, UK

View abstract

A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly

Ian R. Baxendale, Jon Deeley, Charlotte M. Griffiths-Jones, Steven V. Ley, Steen Saaby, Geoffrey K. Tranmer

Innovative Technology Centre, University of Cambridge

View abstract

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