Numbering-Up Flow Electroreduction of α,β-Unsaturated Carbonyls from Gram to Pilot-Relevant Scale

A scalable flow electrochemical platform achieves up to 9.2 g/h productivity at a 100 g scale using an innovative three-electrode reactor design. Dual-sided cathodes enable 16 parallel channels across eight modules, maintaining 1 min residence time without reoptimization. The methodology processes diverse α,β-unsaturated carbonyl substrates (chalcones, heterocyclic enones, esters, ketones, carboxylic acids), explored 18 examples with broad functional group tolerance. The average productivity improvement across the substrates is 75-fold than the batch method with consistent performance from gram to pilot scale, establishing a cost-effective pathway for the electrochemical reduction reaction.

• Boruah T^1,2
• Arepally S¹
• Melen R²
• Wirth T¹

•   ¹School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, Cymru/Wales, U.K.
• ²Cardiff Catalysis Institute, School of Chemistry, Cardiff University, Translational Research Hub, Maindy Road, Cardiff CF24 4HQ, Cymru/Wales, U.K.

• Request a Brochure
• Request more Info
• Request a Quote