Effect of phase transfer chemistry, segmented fluid flow, and sonication on the synthesis of cinnamic esters

• Mauro Riccaboni
• Elena La Porta
• Andrea Martorana
• Roberta Attanasio

• Department of Medicinal Chemistry, NiKem Research Srl, Milan, Italy

Wittig reaction under Phase Transfer conditions was performed in a flow reaction system. Different bases, aldehydes, phosphonium salts, and flow reaction parameters were investigated, in absence of a phase transfert catalyst. An improvement of the reaction outcome (yield and reaction time) was achieved through the immersion of the reactor into an ultrasound bath

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