A flow-based synthesis of Imatinib: the API of Gleevec
- Mark D. Hopkin
- Ian R. Baxendale
- Steven V. Ley
- Innovative Technology Centre, Department of Chemistry, University of Cambridge
Read the publication that featured this abstractA concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or cartridges packed with reagents or scavengers to effect clean product formation. An in-line solvent switching procedure was developed enabling the procedure to be performed with limited manual handling of intermediates.
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R-Series
The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
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