Flow assisted synthesis: a key fragment of SR 142948A
Matthew Oliver Kitching, Olivia E Dixon, Marcus Baumann, Ian Richard Baxendale
- University of Durham, Chemistry, Durham, UKRead the publication that featured this abstract
We report a series of multi-step flow operations to deliver an advanced hydrazine intermediate used in the assembly of the Neurotensin modulator SR142948A. Several new reactor configurations have enabled chemical transformations that would be otherwise difficult or dangerous to perform at scale. Overall the flow approach has allowed the preparation of kilogram quantities of the required hydrazine via a short and efficient route.
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