A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic

Added on:
18 Dec, 2017

An assembled suite of flow-based transformations have been used to rapidly scale-up the production of a novel auxin mimic-based herbicide which was required for preliminary field trials. The overall synthetic approach and optimisation studies are described along with a full description of the final reactor configurations employed for the synthesis as well as the downstream processing of the reaction streams.

  • Marcus Baumann, Ian R. Baxendale and Fabien Deplante
  • Department of Chemistry, University of Durham, South Road, Durham, Durham, DH1 3LE, UK
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