Flow Hydrodediazoniation of Aromatic Heterocycles
- Liesa Röder1
- Alexander J. Nicholls2
- Ian R. Baxendale2
- 1 Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany
- 2 Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UKRead the publication that featured this abstract
Continuous flow processing was applied for the rapid replacement of an aromatic amino group with a hydride. The approach was applied to a range of aromatic heterocycles, confirming the wide scope and substituent-tolerance of the processes. Flow equipment was utilized and the process optimised to overcome the problematically-unstable intermediates that have restricted yields in previous studies relying on batch procedures. Various common organic solvents were investigated as potential hydride sources. The approach has allowed key structures, such as amino-pyrazoles and aminopyridines, to be deaminated in good yield using a purely organic-soluble system.
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