Cycloaddition

A flow platform for degradation-free CuAAC bioconjugation

Marine Z. C. Hatit¹, Linus F. Reichenbach¹, John M. Tobin², Filipe Vilela², Glenn A. Burley¹, Allan J. B. Watson³

• ¹Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, UK
• ²Chemical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK
• ³School of Chemistry, University of St Andrews, North Haugh, St Andrews

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Rapid Photochemical Reaction Studies under Continuous-flow Conditions in the Vapourtec UV-150 Reactor-A Technical Note

Richard Hunter^a, Sam Josland^a, Joseph Moore^b, Duncan Guthrie^b, Mark J. Robertson^a, Michael Oelgemöller^a

• ^a College of Science and Engineering, James Cook University, Townsville, QLD 4911, Australia
• ^b Vapourtec Ltd, Park Farm Business Centre, Fornham St Genevieve, Bury St Edmunds, Suffolk, IP28 6TS, UK

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Integrating reactive distillation with continuous flow processing

Marcus Baumann

• School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland

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Studies toward the scaling of gas‐liquid photocycloadditions

Dr. Emily B. Corcoran, Dr. François Lévesque, Dr. Jonathan P. McMullen, Dr. John R. Naber

• Department of Process Research and Development, Merck Sharp & Dohme Corp., Rahway, USA

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In Situ Preparation and Consumption of O-Mesitylsulfonylhydroxylamine (MSH) in Continuous Flow for the Amination of Pyridines

Cara E. Brocklehurst*, Guido Koch, Stephanie Rothe-Pöllet, Luigi La Vecchia

• Synthesis and Technologies, Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Klybeckstrasse 141, 4057 Basel, Switzerland

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Flow Synthesis of Cyclobutanones via [2+2] Cycloaddition of Keteneiminium Salts and Ethylene Gas

Claudio Battilocchio^a, Grazia Iannucci^a, Shiyi Wang^a, Edouard Godineau^b, Amandine Krieger^b, Alain De Mesmaeker^b, Steven V Ley^*a

• ^a Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, UK
• ^b Syngenta Crop Protection AG, Crop Protection Research, Schaffhauserstrasse 101, CH-4332, Switzerland

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The rapid generation of isothiocyanates in flow

Marcus Baumann, Ian R. Baxendale

• Department of Chemistry, University of Durham, U.K.

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Sustainable and efficient methodology for CLA synthesis and identification

Andres Moreno, Maria Moreno, Maria Victoria Gómez, Cristina Cebrian, Pilar Prieto, Antonio de la Hoz

• Departamento de Química Inorgánica, , Universidad de Castilla-La Mancha, Ciudad Real, Spain.

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Nitrile Oxide 1,3-Dipolar Cycloaddition by Dehydration of Nitromethane Derivatives Under Continuous Flow Conditions

Malte Brasholz, Simon Saubern^*, G. Paul Savage

• CSIRO Materials Science and Engineering, Victoria, Australia.

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Continuous flow synthesis of fullerene derivatives

Helga Seyler, Wallace Wing Ho Wong, Dave Jones, Andrew B. Holmes

• University Of Melbourne, Australia

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A Gram-Scale Batch and Flow Total Synthesis of Perhydrohistrionicotoxin

Dr. Malte Brasholz¹, Dr. James M. Macdonald¹, Dr. Simon Saubern¹, Dr. John H. Ryan¹, Prof. Dr. Andrew B. Holmes^1,2

• ¹CSIRO Molecular and Health Technologies, Victoria, Australia
• ²School of Chemistry, Bio 21 Institute, University of Melbourne, Victoria, Australia

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Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor

Marcus Baumann, Ian R. Baxendale, Andreas Kirschning, Steven V. Ley^*, Jens Wegner

• Department of Chemistry, University of Cambridge

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Flow synthesis of tricyclic spiropiperidines as building blocks for the histrionicotoxin family of alkaloids

Malte Brasholz¹, Brian A. Johnson², James M. Macdonald¹, Anastasios Polyzos¹, John Tsanaktsidis¹, Simon Saubern¹, Andrew B. Holmes^1,2, John H. Ryan¹

• ¹CSIRO Molecular and Health Technologies, Victoria, Australia
• ²School of Chemistry, Bio 21 Institute, University of Melbourne, Victoria, Australia

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[3+2] Dipolar cycloadditions of an unstabilised azomethine ylide under continuous flow conditions

Mark Grafton, Andrew C. Mansfield, M. Jonathan

• Pfizer Global Research and Development, Sandwich, UK

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[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor

Christopher D. Smith¹, Ian R. Baxendale¹, Steve Lanners¹, John J. Hayward¹, Steven V. Ley¹, Stephen C. Smith²

• ¹Innovative Technology Centre, University of Cambridge, UK
• ²Syngenta, Jealots Hill International Research Centre, UK

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