Cycloadditions are a type of chemical reaction in which two or more molecules combine to form a new molecule, with the formation of a new ring structure. In a cycloaddition reaction, the atoms in the reactant molecules rearrange to form the new ring structure, which often has unique physical and chemical properties. Cycloadditions are important in organic chemistry because they allow for the efficient synthesis of a wide range of complex molecules.

    Examples of published literature for Cycloaddition

    Dimeric cyclobutane formation under continuous flow conditions using organophotoredox catalysed [2+2]-cycloaddition

    Helena F. Granthama, Marc C. Kimbera

    • aSchool of Science, Department of Chemistry, Loughborough University, LE11 3TU, UK
    View abstract

    Development of a Continuous Photochemical Benzyne-Forming Process

    Cormac Brackena, Andrei S. Batsanovb, Marcus Baumanna

    • aSchool of Chemistry, University College Dublin, Science Centre South, D04 N2E2, Dublin, Ireland
    • bDepartment of Chemistry, University of Durham, South Road, DH1 3LE, Durham, UK
    View abstract

    Two Colour Photoflow Chemistry for Macromolecular Design

    Matthias Van De Walle, Kevin De Bruycker, James P. Blinco, Christopher Barner-Kowollik

    • Centre for Materials Science, School of Chemistry and Physics, Queensland University of Technology (QUT)2 George St., Brisbane, QLD 4000 (Australia)
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    A flow platform for degradation-free CuAAC bioconjugation

    Marine Z. C. Hatit1, Linus F. Reichenbach1, John M. Tobin2, Filipe Vilela2, Glenn A. Burley1, Allan J. B. Watson3

    • 1Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, UK
    • 2Chemical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK
    • 3School of Chemistry, University of St Andrews, North Haugh, St Andrews
    View abstract

    Rapid Photochemical Reaction Studies under Continuous-flow Conditions in the Vapourtec UV-150 Reactor-A Technical Note

    Richard Huntera, Sam Joslanda, Joseph Mooreb, Duncan Guthrieb, Mark J. Robertsona, Michael Oelgemöllera

    • a College of Science and Engineering, James Cook University, Townsville, QLD 4911, Australia
    • b Vapourtec Ltd, Park Farm Business Centre, Fornham St Genevieve, Bury St Edmunds, Suffolk, IP28 6TS, UK
    View abstract

    Integrating reactive distillation with continuous flow processing

    Marcus Baumann

    • School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland
    View abstract

    Studies toward the scaling of gas‐liquid photocycloadditions

    Dr. Emily B. Corcoran, Dr. François Lévesque, Dr. Jonathan P. McMullen, Dr. John R. Naber

    • Department of Process Research and Development, Merck Sharp & Dohme Corp., Rahway, USA
    View abstract

    In Situ Preparation and Consumption of O-Mesitylsulfonylhydroxylamine (MSH) in Continuous Flow for the Amination of Pyridines

    Cara E. Brocklehurst*, Guido Koch, Stephanie Rothe-Pöllet, Luigi La Vecchia

    • Synthesis and Technologies, Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Klybeckstrasse 141, 4057 Basel, Switzerland
    View abstract

    Flow Synthesis of Cyclobutanones via [2+2] Cycloaddition of Keteneiminium Salts and Ethylene Gas

    Claudio Battilocchioa, Grazia Iannuccia, Shiyi Wanga, Edouard Godineaub, Amandine Kriegerb, Alain De Mesmaekerb, Steven V Ley*a

    • a Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, UK
    • b Syngenta Crop Protection AG, Crop Protection Research, Schaffhauserstrasse 101, CH-4332, Switzerland
    View abstract

    The rapid generation of isothiocyanates in flow

    Marcus Baumann, Ian R. Baxendale

    • Department of Chemistry, University of Durham, U.K.
    View abstract

    Sustainable and efficient methodology for CLA synthesis and identification

    Andres Moreno, Maria Moreno, Maria Victoria Gómez, Cristina Cebrian, Pilar Prieto, Antonio de la Hoz

    • Departamento de Química Inorgánica, , Universidad de Castilla-La Mancha, Ciudad Real, Spain.
    View abstract

    Nitrile Oxide 1,3-Dipolar Cycloaddition by Dehydration of Nitromethane Derivatives Under Continuous Flow Conditions

    Malte Brasholz, Simon Saubern*, G. Paul Savage

    • CSIRO Materials Science and Engineering, Victoria, Australia.
    View abstract

    Continuous flow synthesis of fullerene derivatives

    Helga Seyler, Wallace Wing Ho Wong, Dave Jones, Andrew B. Holmes

    • University Of Melbourne, Australia
    View abstract

    A Gram-Scale Batch and Flow Total Synthesis of Perhydrohistrionicotoxin

    Dr. Malte Brasholz1, Dr. James M. Macdonald1, Dr. Simon Saubern1, Dr. John H. Ryan1, Prof. Dr. Andrew B. Holmes1,2

    • 1CSIRO Molecular and Health Technologies, Victoria, Australia
    • 2School of Chemistry, Bio 21 Institute, University of Melbourne, Victoria, Australia
    View abstract

    Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor

    Marcus Baumann, Ian R. Baxendale, Andreas Kirschning, Steven V. Ley*, Jens Wegner

    • Department of Chemistry, University of Cambridge
    View abstract

    Flow synthesis of tricyclic spiropiperidines as building blocks for the histrionicotoxin family of alkaloids

    Malte Brasholz1, Brian A. Johnson2, James M. Macdonald1, Anastasios Polyzos1, John Tsanaktsidis1, Simon Saubern1, Andrew B. Holmes1,2, John H. Ryan1

    • 1CSIRO Molecular and Health Technologies, Victoria, Australia
    • 2School of Chemistry, Bio 21 Institute, University of Melbourne, Victoria, Australia
    View abstract

    [3+2] Dipolar cycloadditions of an unstabilised azomethine ylide under continuous flow conditions

    Mark Grafton, Andrew C. Mansfield, M. Jonathan

    • Pfizer Global Research and Development, Sandwich, UK
    View abstract

    [3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor

    Christopher D. Smith1, Ian R. Baxendale1, Steve Lanners1, John J. Hayward1, Steven V. Ley1, Stephen C. Smith2

    • 1Innovative Technology Centre, University of Cambridge, UK
    • 2Syngenta, Jealots Hill International Research Centre, UK
    View abstract

    Application Notes regarding Cycloaddition

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