An approach to the synthesis of 4-aryl and 5-aryl substituted thiazole-2(3H)-thiones employing flow processing

    • Monaem Baltia
    • Shelli A. Millerb
    • Mohamed Lotfi Efrita
    • Nicholas E. Leadbeater*b
    • * Corresponding authors
    • a Université Tunis El Manar, Laboratory of Organic Synthesis and Heterocyclic Chemistry, Faculty of Science of Tunis, Department of Chemistry, 1060 Tunis, Tunisia
    • b Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, USA

    A method for the preparation of 4-aryl and 5-aryl substituted thiazole-2(3H)-thiones is described. Flow processing is employed as a tool, and supported acids and bases used to facilitate both the synthetic strategy and product isolation. The methodology is applicable to a range of substrates.

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