An approach to the synthesis of 4-aryl and 5-aryl substituted thiazole-2(3H)-thiones employing flow processing

• Monaem Balti^a
• Shelli A. Miller^b
• Mohamed Lotfi Efrit^a
• Nicholas E. Leadbeater^*b

• ^* Corresponding authors
• ^a Université Tunis El Manar, Laboratory of Organic Synthesis and Heterocyclic Chemistry, Faculty of Science of Tunis, Department of Chemistry, 1060 Tunis, Tunisia
• ^b Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, USA

A method for the preparation of 4-aryl and 5-aryl substituted thiazole-2(3H)-thiones is described. Flow processing is employed as a tool, and supported acids and bases used to facilitate both the synthetic strategy and product isolation. The methodology is applicable to a range of substrates.

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