Continuous Flow Synthesis of Organic Electronic Materials : Case Studies in Methodology Translation and Scale-up

• Helga Seyler¹
• Stefan Haid²
• Tae-Hyuk Kwon¹
• David J. Jones¹
• Peter Bäuerle²
• Andrew B. Holmes¹
• Wallace W. H. Wong^1*

• ¹Bio21 Institute, University of Melbourne, Australia.
• ²Institute of Organic Chemistry II and Advanced Materials, University of Ulm, Germany.

The continuous flow synthesis of functional thiophene derivatives was examined. Methodology for the lithiation of thiophene building blocks was developed using a commercial bench-top flow reactor. In addition, the advantages of flow processing were demonstrated in the synthesis of a high performance organic dye in gram scale.

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