Catalytic Static Mixers for the Continuous Flow Hydrogenation of a Key Intermediate of Linezolid (Zyvox)

• James Gardiner ^a*
• Xuan Nguyen ^a
• Charlotte Genet ^a
• Mike D. Horne ^b
• Christian Hornung ^a
• John Tsanaktsidis ^a

• ^a CSIRO Manufacturing Flagship, Bayview Avenue, Clayton, Australia
• ^b CSIRO Mineral Resources, Bayview Avenue, Clayton, VIC 3169, Australia

Catalytic static mixers (CSMs) were used for the efficient preparation of a key intermediate of the antimicrobial drug linezolid (Zyvox). The approach combines 3D printing and additive manufacturing techniques with continuous flow processing to produce a general method for catalytic hydrogenations and the rapid production of the target molecule without the need for catalyst removal or recovery.

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