Catalytic Static Mixers for the Continuous Flow Hydrogenation of a Key Intermediate of Linezolid (Zyvox)
James Gardiner *, Xuan Nguyen †, Charlotte Genet †, Mike D. Horne ‡, Christian Hornung †, John Tsanaktsidis †
- a CSIRO Manufacturing Flagship, Bayview Avenue, Clayton, Australia
- b CSIRO Mineral Resources, Bayview Avenue, Clayton, VIC 3169, AustraliaRead the publication that featured this abstract
Catalytic static mixers (CSMs) were used for the efficient preparation of a key intermediate of the antimicrobial drug linezolid (Zyvox). The approach combines 3D printing and additive manufacturing techniques with continuous flow processing to produce a general method for catalytic hydrogenations and the rapid production of the target molecule without the need for catalyst removal or recovery.
The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
The R-Series is undoubtedly the most versatile, modular flow chemistry system available today.
The Vapourtec E-Series is the perfect introductory system for flow chemistry
- Robust :
- Easy to use :
The E-Series is a robust and affordable, entry level flow chemistry system designed for reliability and ease of use.