Catalytic Static Mixers for the Continuous Flow Hydrogenation of a Key Intermediate of Linezolid (Zyvox)

    • James Gardiner a*
    • Xuan Nguyen a
    • Charlotte Genet a
    • Mike D. Horne b
    • Christian Hornung a
    • John Tsanaktsidis a
    • a CSIRO Manufacturing Flagship, Bayview Avenue, Clayton, Australia
    • b CSIRO Mineral Resources, Bayview Avenue, Clayton, VIC 3169, Australia

    Catalytic static mixers (CSMs) were used for the efficient preparation of a key intermediate of the antimicrobial drug linezolid (Zyvox). The approach combines 3D printing and additive manufacturing techniques with continuous flow processing to produce a general method for catalytic hydrogenations and the rapid production of the target molecule without the need for catalyst removal or recovery.

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