Catalytic Static Mixers for the Continuous Flow Hydrogenation of a Key Intermediate of Linezolid (Zyvox)
- James Gardiner a*
- Xuan Nguyen a
- Charlotte Genet a
- Mike D. Horne b
- Christian Hornung a
- John Tsanaktsidis a
- a CSIRO Manufacturing Flagship, Bayview Avenue, Clayton, Australia
- b CSIRO Mineral Resources, Bayview Avenue, Clayton, VIC 3169, Australia
Read the publication that featured this abstractCatalytic static mixers (CSMs) were used for the efficient preparation of a key intermediate of the antimicrobial drug linezolid (Zyvox). The approach combines 3D printing and additive manufacturing techniques with continuous flow processing to produce a general method for catalytic hydrogenations and the rapid production of the target molecule without the need for catalyst removal or recovery.
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