Catalytic Static Mixers for the Continuous Flow Hydrogenation of a Key Intermediate of Linezolid (Zyvox)
James Gardiner a*, Xuan Nguyen a, Charlotte Genet a, Mike D. Horne b, Christian Hornung a, John Tsanaktsidis a
- a CSIRO Manufacturing Flagship, Bayview Avenue, Clayton, Australia
- b CSIRO Mineral Resources, Bayview Avenue, Clayton, VIC 3169, AustraliaRead the publication that featured this abstract
Catalytic static mixers (CSMs) were used for the efficient preparation of a key intermediate of the antimicrobial drug linezolid (Zyvox). The approach combines 3D printing and additive manufacturing techniques with continuous flow processing to produce a general method for catalytic hydrogenations and the rapid production of the target molecule without the need for catalyst removal or recovery.
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