Total Synthesis of Neomarchantin A: Key Bond Constructions Performed Using Continuous Flow Methods

• Émilie Morin, Michaël Raymond, Amaury Dubart, and Shawn K. Collins

• Department of Chemistry and Centre for Green Chemistry and Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, Canada H3C 3J7

A synthesis of neomarchantin A has been achieved wherein key bond constructions involving C–O or C–C bond formations were augmented via continuous flow techniques. Of note, the synthesis of neomarchantin A represents the first demonstration of catalytic macrocyclic olefin metathesis as a key step for the synthesis of a macrocyclic bisbibenzyl natural product.

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