A convenient, mild and green synthesis of NH-sulfoximines in flow reactors

• Leonardo Degennaro¹
• Arianna Tota¹
• Sonia De Angelis¹
• Michael Andresini¹
• Cosimo Cardellicchio²
• Maria Annunziata Capozzi¹
• Giuseppe Romanazzi³
• Renzo Luisi¹

• ¹ University of Bari, Department of Pharmacy - Drug Sciences, Bari, Italy
• ² CNR ICCOM, Department of Chemistry, Bari, Italy
• ³ Politecnico di Bari, DICATECh, Bari, Italy

NH-Sulfoximines are emerging as useful and important targets in drug discovery and synthetic organic chemistry. We report herein the development of an efficient, convenient, and sustainable continuous flow strategy, for the direct straightforward preparation of NH-sulfoximines using sulfides or sulfoxides as suitable starting material. The flow process uses PhI(OAc)2 as the oxidant and aqueous solutions of ammonia as the N-source. The scope of the reaction has been demonstrated by using several substituted sulfides and sulfoxides including enantioenriched and biologically relevant starting materials. The flow strategy was found more convenient with respect to conventional batch processing.

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