Synthesis of 3-Aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole Derivatives: A Comparison between Conventional, Microwave-Assisted and Flow-Based Methodologies
Sabrina Castellano1, Lucia Tamborini2, Monica Viviano1, Andrea Pinto2, Gianluca Sbardella1, Paola Conti2
- 1Dipartimento di Scienze Farmaceutiche, Universit degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Italy
- 2Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universit degli Studi di Milano , ItalyRead the publication that featured this abstract
Two modern synthetic technologies to perform 1,3-dipolar cycloaddition reactions were compared. This study puts in evidence the power of microwave-assisted and flow-based methodologies compared to the conventional one in terms of reaction time and yield, and demonstrates the potential of flow chemistry in terms of time, automation, and scaling up opportunities.
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