Application Note 57 – Automated library synthesis


    Equipping a Vapourtec R-Series with a liquid handler creates a powerful, automated synthesis platform that has been used to carry out reaction screening of nucleophilic aromatic substitution partners, including volatile amines.
    This application note describes:

    – Automated reaction screening using automated reagent loading and collection
    – Safe out-of-hours operation permitted by Flow Commander™
    – The use of highly volatile amines and ammonia at 160 °C through the use of high pressures difficult to achieve in batch

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