Application Note 57 – Automated library synthesis

Equipping a Vapourtec R-Series with a liquid handler creates a powerful, automated synthesis platform that has been used to carry out reaction screening of nucleophilic aromatic substitution partners, including volatile amines.
This application note describes:

– Automated reaction screening using automated reagent loading and collection
– Safe out-of-hours operation permitted by Flow Commander™
– The use of highly volatile amines and ammonia at 160 °C through the use of high pressures difficult to achieve in batch