Continuous Flow Synthesis of Secondary Amides by Tandem Azidation- Amidation of Anilines

    • Christian Spiteri
    • John E. Moses*
    • School of Chemistry, University of Nottingham, UK

    The continuous flow synthesis of a variety of secondary amides by tandem azidation–amidation of anilines is described. This new procedure benefits from the improved safety feature of generating aromatic azides in flow, thus ensuring low concentrations of any potentially hazardous intermediates. The protocol was amenable to the production of multi-gram quantities of the amide product.

    Read the publication that featured this abstract

    Get in touch

    For more information on flow chemistry systems and services please use the contact methods below.

    Call us on +44 (0)1284 728659 or Email us

    Request a quote