A continuous-flow synthesis of annulated and polysubstituted furans from the reaction of ketones and a-haloketones

• Mark York

• CSIRO Materials Science and Engineering, Australia
• Cooperative Research Centre for Polymers, Notting Hill, Australia

A synthesis of di-, tri- and tetra-substituted furans from reaction of the corresponding ketones and α-haloketones with LiHMDS is reported. Reaction under continuous-flow conditions gave increased yields and removed the need for external cooling when compared to the unoptimised batch conditions.

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