Flow Chemistry as a Drug Discovery Tool: A Medicinal Chemistry Perspective

Andrew R. Bogdan¹, Michael G. Organ²

• ¹ Discovery Chemistry and Technology, AbbVie Inc., North Chicago, USA
• ² Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada

The applications of flow chemistry in a drug discovery environment are discussed within. The development of integrated synthesis–bioassay platforms is discussed in the context of enabling medicinal chemistry programs, as is the use of flow chemistry to facilitate intermediate scale-up in a lead optimization setting. Emerging chemical technologies are also discussed, highlighting the use of high temperatures, hazardous gases, and photochemistry in flow to support medicinal chemistry efforts.

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