A practical flow synthesis of 1,2,3-triazoles

• Dawid Drelinkiewicz^a
• Richard J. Whitby^a

• ^aSchool of Chemistry, Faculty of Engineering and Physical Sciences, The University of Southampton, Southampton, UK

A robust and versatile protocol for synthesis of 1-monosubstituted and 1,4-disubstituted 1H-1,2,3-triazoles was established under continuous flow conditions using copper-on-charcoal as a heterogeneous catalyst. This methodology allowed for the synthesis of a diverse set of substituted 1,2,3-triazoles with good functional group tolerance and high yields. 2-Ynoic acids were also used as small-chain alkyne donors in a decarboxylation/cycloaddition cascade, allowing gaseous reagents to be bypassed, delivering desired triazoles in high yields. The developed methodology was used to synthesize an antiepileptic agent, rufinamide, which was obtained in 96% isolated yield.

Read the publication that featured this abstract