Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor

    Keiji Nakayama,a, Duncan L. Browne,b, Ian R. Baxendale,b,1, Steven V. Ley,*a

    • a Process Technology Research Laboratories, Pharmaceutical Technology Division, Daiichi Sankyo, Shinomiya, Hiratsuka, Kanagawa, 254-0014, Japan
    • b Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK

    The application of meso-scale flow chemistry in research laboratories continues to increase. Here, we report on the use of a modular cryo-flow device as applied to a diastereoselective fluorination process. The reactor can be incorporated into existing flow chemistry setups to permit continuous processing at low temperatures without recourse to cryogenic consumables.

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