Continuous preparation and use of dibromoformaldoxime as a reactive intermediate for the synthesis of 3- bromoisoxazolines
- Claudio Battilocchioa*
- Francesco Bosicaa
- Sam M. Rowea
- Bruna L. Abreua
- Edouard Godineaub*
- Matthias Lehmannb
- Steven V. Leya
- a Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
- b Syngenta Crop Protection AG, Crop Protection Research, Schaffhauserstrasse 101, CH-4332 Stein, SwitzerlandRead the publication that featured this abstract
We report the multistep continuous process for the preparation of dibromoformaldoxime (DBFO) as a precursor to generate bromoisoxazolines. We also report process improvements that afford a productivity of over 620 mmol h-1 of DBFO.
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