Self-Optimisation and Model-Based Design of Experiments for Developing a C–H Activation Flow Process
Alexander Echtermeyer1,2, Yehia Amar2, Jacek Zakrzewski2, Alexei Lapkin2
- 1 Aachener Verfahrenstechnik – Process Systems Engineering, RWTH Aachen University, Aachen, Germany
- 2 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United KingdomRead the publication that featured this abstract
A recently described C(sp3)–H activation reaction to synthesise aziridines was used as a model reaction to demonstrate the methodology of developing a process model using model-based design of experiments (MBDoE) and self-optimisation approaches in flow. The two approaches are compared in terms of experimental efficiency. The self-optimisation approach required the least number of experiments to reach the specified objectives of cost and product yield, whereas the MBDoE approach enabled a rapid generation of a process model.
Get in touch
For more information on flow chemistry systems and services please use the contact methods below.
Call us on +44 (0)1284 728659 or Email us
The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
- Flexible |
- Precise |
The R-Series is undoubtedly the most versatile, modular flow chemistry system available today.
The Vapourtec E-Series is the perfect introductory system for flow chemistry
- Robust |
- Easy to use |
The E-Series is a robust and affordable, entry level flow chemistry system designed for reliability and ease of use.