First Example of a Continuous-Flow Carbonylation Reaction Using Aryl Formates as CO Precursors
- Nerea Alonso1,3
- Juan de Muñoz1
- Brecht Egle2
- Johannes L. Vrijdag2
- Wim M. De Borggraeve2
- Antonio de la Hoz3
- Angel Díaz-Ortiz3
- Jesús Alcázar1
- 1Janssen Research and Development, Janssen-Cilag Department of Medicinal Chemistry S.A., Toledo, Spain
- 2Molecular Design and Synthesis University of Leuven, Department of Chemistry, Heverlee Belgium
- 3Universidad de Castilla-La Mancha Facultad de Ciencias y Tecnologías Químicas Real, SpainRead the publication that featured this abstract
The first continuous flow carbonylation reaction using aryl formates as CO precursor is reported. The reaction is practical, scalable and high yielding. The use of a flow protocol safely allows expanding the scope to activated chlorides, nitrogen heterocycles and to the selective introduction of an ester group in dihalo-derivatives. Further selective reduction of the ester formed to an aldehyde in flow is also described.
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