An efficient benzoxaborole one‐pot synthesis by SiliaCat DPP‐Pd heterogeneous catalysis using diboronic acid

• Kana kunihiro¹
• Laurence Dumais²
• Guillaume Lafitte²
• Emeric Varvier²
• Loïc Tomas²
• Craig Harris²

• ¹ Ecole Nationale Supérieure des Ingenieurs en Arts Chimiques et Technologiques, France
• ² Nestlé Skin Health, Galderma R&D, France

Organoboron compounds are valuable molecules of increasing interest in organic synthesis, catalysis, biology and medicine. Among them, benzoxaboroles emerged as promising building blocks for numerous research programs. In this letter, we communicate the development of new conditions for the one‐pot benzoxaborole synthesis by SiliaCat DPP‐Pd catalysis using diboronic acid as the boron source. This low cost and sustainable strategy permitted the preparation of a useful range of benzoxaborole building blocks. Finally, the transformation was extended to a continuous flow process using our Vapourtec system.

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