Development of a flow method for the hydroboration/oxidation of olefins
- José A. Souto* 1 2
- Robert A. Stockman3
- Steven V. Ley1
- 1 Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
- 2 Departamento de Química Orgánica, Universidade de Vigo, Vigo, Spain
- 3 School of Chemistry, University of Nottingham, Nottingham, UKRead the publication that featured this abstract
A method for the continuous preparation of alcohols by hydroboration/oxidation of olefins using flow techniques is described. The process allows the isolation of up to 120 mmol h−1 of the desired alcohol in a very rapid manner with good functional group tolerance. The flow setup can be modified to perform a continuous extraction of the desired alcohol from the biphasic mixture produced by the reaction.
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