Development of a flow method for the hydroboration/oxidation of olefins

    • José A. Souto* 1 2
    • Robert A. Stockman3
    • Steven V. Ley1
    • 1 Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    • 2 Departamento de Química Orgánica, Universidade de Vigo, Vigo, Spain
    • 3 School of Chemistry, University of Nottingham, Nottingham, UK
    Development of a flow method for the hydroboration/oxidation of olefins

    A method for the continuous preparation of alcohols by hydroboration/oxidation of olefins using flow techniques is described. The process allows the isolation of up to 120 mmol h−1 of the desired alcohol in a very rapid manner with good functional group tolerance. The flow setup can be modified to perform a continuous extraction of the desired alcohol from the biphasic mixture produced by the reaction.

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