Continuous flow processing as a tool for the generation of terpene-derived monomer libraries

    • Renan Galavernaa
    • Lucas P. Fernandesa
    • Duncan L. Browneb
    • Julio C. Pastrea
    • a Institute of Chemistry, University of Campinas – UNICAMP, Campinas, Brazil
    • b School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK

    We report the development of a continuous flow approach for the preparation of two bio-derived monomer libraries. A small range of terpenes (ocimene, myrcene, α-terpinene, α-phellandrene, isoprene, and farnesene) have been used as the base set for the library, with the first library derived from a Diels–Alder reaction with the platform chemical maleic anhydride. The second library requires the derivatization of the first through a hydrogenation reaction. The potential for scale-up of both libraries has been demonstrated, with the Diels–Alder process delivering 10.5 grams of the product in 3 hours and the hydrogenation process delivering 10 grams of the material in 16 hours.

    Read the publication that featured this abstract

    Get in touch

    For more information on flow chemistry systems and services please use the contact methods below.

    Call us on +44 (0)1284 728659 or Email us