Continuous flow processing as a tool for the generation of terpene-derived monomer libraries

    Renan Galavernaa, Lucas P. Fernandesa, Duncan L. Browneb, Julio C. Pastrea

    • a Institute of Chemistry, University of Campinas – UNICAMP, Campinas, Brazil
    • b School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK

    We report the development of a continuous flow approach for the preparation of two bio-derived monomer libraries. A small range of terpenes (ocimene, myrcene, α-terpinene, α-phellandrene, isoprene, and farnesene) have been used as the base set for the library, with the first library derived from a Diels–Alder reaction with the platform chemical maleic anhydride. The second library requires the derivatization of the first through a hydrogenation reaction. The potential for scale-up of both libraries has been demonstrated, with the Diels–Alder process delivering 10.5 grams of the product in 3 hours and the hydrogenation process delivering 10 grams of the material in 16 hours.

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