Highly efficient and safe procedure for the synthesis of aryl 1,2,3-triazoles from aromatic amine in a continuous flow reactor
- Federica Stazi a
- Damiano Cancogni a
- Lucilla Turco b
- Pieter Westerduin a
- Sergio Bacchi a
- a GlaxoSmithKline Spa, Chemical Development Department, Synthetic Chemistry, Via Fleming 4, 37135 Verona, Italy
- b GlaxoSmithKline Spa, Analytical Chemistry, Via Fleming 4, 37135 Verona, ItalyRead the publication that featured this abstract
The Letter reports a safe and reliable synthesis of aryl 1,2,3-triazoles from the corresponding anilines via intermediate aryl azides, using a continuous process. The method was applied to a variety of substrates with good to excellent yields, without the need to isolate the reactive and possibly unstable intermediates which were constantly kept at low concentration in the matrix environment.
The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
The R-Series is undoubtedly the most versatile, modular flow chemistry system available today.
The Vapourtec E-Series is the perfect introductory system for flow chemistry
- Robust :
- Easy to use :
The E-Series is a robust and affordable, entry level flow chemistry system designed for reliability and ease of use.