Highly efficient and safe procedure for the synthesis of aryl 1,2,3-triazoles from aromatic amine in a continuous flow reactor
- Federica Stazi a
- Damiano Cancogni a
- Lucilla Turco b
- Pieter Westerduin a
- Sergio Bacchi a
- a GlaxoSmithKline Spa, Chemical Development Department, Synthetic Chemistry, Via Fleming 4, 37135 Verona, Italy
- b GlaxoSmithKline Spa, Analytical Chemistry, Via Fleming 4, 37135 Verona, ItalyRead the publication that featured this abstract
The Letter reports a safe and reliable synthesis of aryl 1,2,3-triazoles from the corresponding anilines via intermediate aryl azides, using a continuous process. The method was applied to a variety of substrates with good to excellent yields, without the need to isolate the reactive and possibly unstable intermediates which were constantly kept at low concentration in the matrix environment.
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