Microfluidic Asymmetrical Synthesis and Chiral Analysis

• Konstantin A.Kochetkov^a
• Nataliya A.Bystrova^a
• Pavel A.Pavlov^b
• Maxim S.Oshchepkov^b
• Aleksandr S.Oshchepkov^c

• ^aNesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Moscow 119991, Russia
• ^bMendeleev University of Chemical Technology of Russia, Miusskaya pl. 9, Moscow 125047, Russia
• ^cMax Planck Institute for the Science of Light, Department of Physics, D-91058 Erlangen, Germany

In recent years, more attention has been paid to efficient, cost-effective and energy-saving technologies. In particular, there is a lot of recent information on the advantages of microfluidic technologies, combining economy, safety and environmental friendliness with reproducibility, high yields and high stereoselectivity of chemical reactions. Therefore, an important task is to generalize the available material on microfluidic technologies in order to identify new horizons of application in the field of a chiral synthesis. The difficulties of implementation microfluidic a chiral synthesis, its capabilities and prospects for further development are discussed in detail in this review. Various types of microfluidic reactors, synthetic schemes for carrying out chemical reactions are considered, and their comparison with traditional methods of synthesis is also given. Finally, a description is given of enantioselective analysis using microfluidic technologies and the possibilities for further improvement of microfluidics are discussed.

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