Examples of published literature for Packed bed reactions

Enhanced mixing of biphasic liquid-liquid systems for the synthesis of gem-dihalocyclopropanes using packed bed reactors

T von Keutz1,2, D Cantillo1,2, CO Kappe1,2

  • 1 Center for Continuous Flow Synthesis and Processing (CCFLOW) Research Center Pharmaceutical Engineering GmbH (RCPE) Graz, Austria
  • 2 Institute of Chemistry, NAWI Graz, University of Graz, Graz, Austria
View abstract

Copper mediated, heterogeneous, enantioselective intramolecular Buchner reactions of α-diazoketones using continuous flow processing

DC Crowley, D Lynch, AR Maguire

  • School of Chemistry, Analytical and Biological Chemistry Research Facility, University College Cork, Cork T12 K8AF, Ireland
  • School of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork T12 K8AF, Ireland
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Continuous flow biocatalysis: production and in-line purification of amines by immobilised transaminase from Halomonas elongata

Matteo Planchestainera, Martina Letizia Contenteab, Jennifer Cassidya, Francesco Molinarib, Lucia Tamborini*c, Francesca Paradisi*ad

  • * Corresponding authors
  • a UCD School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland
  • b Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli studi di Milano, Via Mangiagalli 25, Milan, Italy
  • c Department of Pharmaceutical Sciences (DISFARM), Università degli studi di Milano, Via Mangiagalli 25, Milan, Italy
  • d School of Chemistry, University of Nottingham, University Park, Nottingham, UK
View abstract

Continuous Reductions and Reductive Aminations Using Solid Sodium borohydride

Kerry Gilmore, Stella Vukelic, D. Tyler McQuade†§, Beate Koksch, Peter H. Seeberger*†‡

  • Max Planck Institute of Colloids and Interfaces, Germany
  • Institute of Chemistry and Biochemistry, Freie Universität Berlin, Germany
  • § Department of Chemistry and Biochemistry, Florida State University, United States
View abstract

Flow Alkylation of Thiols, Phenols, and Amines Using a Heterogenous Base in a Packed-Bed Reactor

Alastair Baker1, Michael Graz2, Robert Saunders2, Gareth J. S. Evans2, Ilaria Pitotti1 Thomas Wirth1

  • 1 School of Chemistry, Cardiff University, Park Place, Main Building, Cardiff CF10 3AT, UK
  • 2 Neem Biotech, Willowbrook Technical Units, Llandogo Road, St. Mellons, Cardiff CF3 0EF, UK
View abstract

An efficient continuous flow process for the synthesis of a non-conventional mixture of fructooligosaccharides

Paolo Zambellia, Lucia Tamborinib, Samuele Cazzamallib, Andrea Pintob, Stefania Ariolia, Silvia Balzarettia, Francisco J. Plouc, Lucia Fernandez-Arrojoc, Francesco Molinaria, Paola Contib, Diego Romanoa

  • a Department of Food Environmental and Nutritional Science (DeFENS), University of Milan, Via Mangiagalli, 20133 Milan, Italy
  • b Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
  • c Instituto de Catálisis y Petroleoquímica, CSIC, 28049 Madrid, Spain
View abstract

Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent

Catherine J. Smith, Christopher D. Smith, Nikzad Nikbin, Steven V. Ley, Ian R. Baxendale

  • Innovative Technology Centre, Cambridge, UK
View abstract

The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

Steffen Glöckner, Duc N. Tran, Richard J. Ingham, Sabine Fenner, Zoe E. Wilson, Claudio Battilocchio, Steven V. Ley*

  • Department of Chemistry, University of Cambridge, Cambridge, UK
View abstract

Continuous Synthesis of Organozinc Halides Coupled to Negishi Reactions

Nerea Alonso2,3, L. Zane Miller1, Juan de M. Muñoz2, Jesus Alcázar2,*, D. Tyler McQuade1,*

  • 1Department of Chemistry and Biochemistry, Florida State University, USA
  • 2Janssen Research and Development, Janssen-Cilag, Toledo, Spain
  • 3Facultad de Química, Universidad de Castilla-La Mancha, Spain
View abstract

Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Richard J. Ingham1, Claudio Battilocchio1, Joel M. Hawkins2, Steven V. Ley1

  • 1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK
  • 2 Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA
View abstract

Robust and reusable supported palladium catalysts for cross-coupling reactions in flow

William R. Reynoldsab, Pawel Plucinskibc, Christopher G. Frost*ab

  •   * Corresponding authors
  • a Centre for Sustainable Chemical Technologies, University of Bath, Claverton Down, Bath, UK
  • b Department of Chemistry, University of Bath, Claverton Down, Bath, UK
  • c Department of Chemical Engineering, University of Bath, Claverton Down, Bath, UK
View abstract

Flow-Based, Cerium Oxide Enhanced, Low-Level Palladium Sonogashira and Heck Coupling Reactions by Perovskite Catalysts

Claudio Battilocchio1, Benjamin N. Bhawal1, Rajeev Chorghade1, Benjamin J. Deadman1, Joel M. Hawkins2, Steven V. Ley1

  • 1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, UK
  • 2 Pfizer Worldwide Research & Development, Groton, USA
View abstract

The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow

Kimberley A. Roper1, Malcolm B. Berry2, Steven V. Ley1

  • 1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, Cambridge, U.K.
  • 2 GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
View abstract

The rapid generation of isothiocyanates in flow

Marcus Baumann, Ian R. Baxendale

  • Department of Chemistry, University of Durham, U.K.
View abstract

Continuous Synthesis and Use of N-Heterocyclic Carbene Copper(I) Complexes from Insoluble Cu2O

Suzanne M. Opalka1, Jin Kyoon Park3, Ashley R. Longstreet2, D. Tyler McQuade2

  • 1Department of Chemistry and Biochemistry, Florida State University, USA
  • 2Department of Chemistry and Chemical Biology, Cornell University, USA
  • 3Department of Chemistry and Chemical Institute for Functional Materials, Pusan National University, Korea
View abstract

An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

Mark D Hopkin, Ian Baxendale, Steven.V.Ley

  • Dept of Chemistry, University of Cambridge, UK
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A “Catch-React-Release” Method for the Flow Synthesis of 2-Aminopyrimidines and Preparation of the Imatinib Base

Richard J. Ingham, Elena Riva, Nikzad Nikbin, Ian R. Baxendale, Steven V. Ley*

  • Innovative Technology Centre, University of Cambridge, U.K.
View abstract

Continuous proline catalysis via leaching of solid proline

Suzanne M. Opalka1, Ashley R. Longstreet2, D. Tyler McQuade2

  • 1Department of Chemistry and Chemical Biology, Cornell University, USA
  • 2Department of Chemistry and Biochemistry, Florida State University,USA
View abstract

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

Kimberley A. Roper1, Heiko Lange1, Anastasios Polyzos1, Malcolm B. Berry2, Ian R. Baxendale1, Steven V. Ley1

  • 1Innovative Technology Centre, University of Cambridge
  • 2GlaxoSmithKline, Stevenage, UK
View abstract

Suzuki-Miyaura Cross-Coupling of Heteroaryl Halides and Arylboronic Acids in Continuous Flow

Timothy Noël, Andrew J. Musacchio

  • Department of Chemistry, MIT, USA
View abstract

An Integrated Flow and Batch-Based Approach for the Synthesis of O-Methyl Siphonazole

Marcus Baumann, Ian R. Baxendale, Malte Brasholz, John J. Hayward, Steven V. Ley, Nikzad Nikbin

  • Innovative Technology Centre, Cambridge, UK
View abstract

Synthesis of (+)-Dumetorine and Congeners by Using Flow Chemistry Technologies

Elena Riva2, Anna Rencurosi1, Stefania Gagliardi1, Daniele Passarella2, Marisa Martinelli1*

  • 1NiKem Research S.r.l., Milan, Italy
  • 2Università degli Studi di Milano,Milan, Italy
View abstract

Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith

Heiko Lange, Matthew J. Capener, Alexander X. Jones, Catherine J. Smith, Nikzad Nikbin, Ian R. Baxendale, Steven V. Ley*

  • Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
View abstract

A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

Catherine J. Smith, Nikzad Nikbin, Steven V. Ley, Heiko Lange, Ian R. Baxendale

  • Innovative Technology Centre, Cambridge, UK
View abstract

A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing

Heiko Lange1, Catherine F. Carter1, Mark D. Hopkin1, Adrian Burke2, Jon G. Goode2, Ian R. Baxendale1, Steven V. Ley1

  • 1Innovative Technology Centre, University of Cambridge, UK
  • 2Mettler-Toledo AutoChem UK
View abstract

Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor

Laetitia J. Martin1, Andreas L. Marzinzik1, Steven V. Ley2, Ian R. Baxendale2

  • 1Novartis Institute for BioMedical Research, Basel, Switzerland
  • 2Innovative Technology Centre, Department of Chemistry, University of Cambridge
View abstract

A Continuous Flow Process Using a Sequence of Microreactors with In-line IR Analysis for the Preparation of N,N-Diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a Potent and Highly Selective δ-Opioid Receptor Agonist

Zizheng Qian, Ian R. Baxendale, Steven V. Ley

  • Innovative Technology Centre, University of Cambridge
View abstract

Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor

Marcus Baumann, Ian R. Baxendale, Andreas Kirschning, Steven V. Ley*, Jens Wegner

  • Department of Chemistry, University of Cambridge
View abstract

A highly efficient flow reactor process for the synthesis of N-Boc-3,4-dehydro-l-proline methyl ester

Lucia Tamborini, Paola Conti, Andrea Pinto, Carlo De Micheli

  • Dipartimento di Scienze Farmaceutiche ‘Pietro Pratesi’,
  • Università degli Studi di Milano, Italy
View abstract

Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles

Ian R. Baxendale1, Steven V. Ley1, Andrew C. Mansfield2, Christopher D. Smith1

  • 1ITC, Department of Chemistry, University of Cambridge,
  • 2Pfizer Global R&D Research Centre, Sandwich, (UK)
View abstract

A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor

Ian R. Baxendale, Steven V. Ley, Christopher D. Smith, Lucia Tamborini, Ana-Florina Voica

  • Innovative Technology Centre, Cambridge, UK
View abstract

The Use of Diethylaminosulfur Trifluoride (DAST) for Fluorination in a Continuous-Flow Microreactor

Baumann, Marcus, Baxendale, Ian R., Ley, Steven V.

  • Innovative Technology Centre, Cambridge, UK
View abstract

Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

Christopher D. Smith, Ian Baxendale, Geoffrey Tranmer, Marcus Baumann, Stephen Smith, Russell Lewthwaite, Steven V. Ley

  • Department of Chemistry, University of Cambridge, UK
View abstract

Fully Automated Flow-Through Synthesis of Secondary Sulfonamides in a Binary Reactor System

Charlotte M. Griffiths-Jones, Mark D. Hopkin, Daniel Jönsson, Steven V. Ley, David J. Tapolczay, Emma Vickerstaffe, Mark Ladlow

  • GlaxoSmithKline Cambridge Technology Centre, Cambridge
View abstract

A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

Ian R. Baxendale, Steven V. Ley, Christopher D. Smith, Geoffrey K. Tranmer

  • Innovative Technology Centre, Cambridge, UK
View abstract

Application Notes regarding Packed bed reactions

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