Regioselective Chlorination of Quinoline Derivatives via Fluorine Mediation in a Microfluidic Reactor
- Hao Qi
- Xin Li
- Zhuang Liu
- Shan‐Shan Miao
- Prof. Zheng Fang, Lin Chen, Zheng Fang, Prof. Kai Guo
- College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, China
Read the publication that featured this abstractA novel green and efficient reaction route for the synthesis of 2‐chloroquinoline via N‐fluoride fluorinated by 1‐Chloromethyl‐4‐fluoro‐1,4‐diazoniabicyclo [2.2.2] octane bis(tetrafluoroborate) (Selectfluor) with 1,3‐Dichloro‐5,5‐dimethylhydantoin (DCDMH) in Vapourtec reactor has been developed. In addition, a series of C2 heterocyclic derivative products are obtained in moderate to good yields under no metal conditions.
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The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
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