Examples of published literature for Solid supported

Integrated plug flow synthesis and crystallisation of pyrazinamide

C. Daniel Scotta, Ricardo Labesb, Martin Depardieuc, Claudio Battilocchiob, Matthew G. Davidsona, Steven V. Leyb, Chick C. Wilsonad, and Karen Robertson*c

  • a Centre for Sustainable Chemical Technologies, Department of Chemistry, University of Bath, UK
  • b Department of Chemistry, University of Cambridge, UK
  • c Department of Chemistry, University of Bath, UK
  • d EPSRC Future Continuous Manufacturing and Advanced Crystallisation Research Hub, University of Bath, UK
View abstract

Transaminase‐catalyzed continuous synthesis of biogenic aldehydes

Martina L. Contente a, Francesca Paradisi *a,b

  • a School of Chemistry, University of Nottingham, University Park, Nottingham, NG7, 2RD, United Kingdom
  • b Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern
View abstract

Bioprocess Intensification Using Flow Reactors: Stereoselective Oxidation of Achiral 1,3-diols with Immobilized Acetobacter Aceti

Valerio De Vitis 1, Federica Dall’Oglio 2, Francesca Tentori 3, Martina Letizia Contente 4, Elisabetta Brenna 3, Lucia Tamborini 2, Francesco Molinari 1

  • 1 Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, Via Celoria 2, 20133 Milan, Italy
  • 2 Department of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy
  • 3 Dipartimento di Chimica, Materiali ed Ingegneria Chimica “Giulio Natta” Politecnico di Milano, Via Mancinelli 7, I-20131 Milan, Italy
  • 4 School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
View abstract

Rapid and Multigram Synthesis of Vinylogous Esters under Continuous Flow: An Access to Transetherification and Reverse Reaction of Vinylogous Esters

Nirmala Mohanta, Moreshwar B. Chaudhari, Naveen Kumar Digrawal, and Boopathy Gnanaprakasam

  • Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India
View abstract

A solid-supported arylboronic acid catalyst for direct amidation

Yihao Dua,, Thomas Barbera,, Sol Ee Lima,, Henry S. Rzepab,, Ian R. Baxendale*a,, Andrew Whiting*a,

  • a Centre for Sustainable Chemical Processes, Department of Chemistry, Durham University, Science Laboratories, South Road, Durham, UK
  • a Department of Chemistry, Imperial College, South Kensington Campus, London, UK
View abstract

Copper mediated, heterogeneous, enantioselective intramolecular Buchner reactions of α-diazoketones using continuous flow processing

DC Crowley, D Lynch, AR Maguire

  • School of Chemistry, Analytical and Biological Chemistry Research Facility, University College Cork, Cork T12 K8AF, Ireland
  • School of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork T12 K8AF, Ireland
View abstract

Novel Polystyrene-Immobilized Chiral Amino Alcohols as Heterogeneous Ligands for the Enantioselective Arylation of Aldehydes in Batch and Continuous Flow Regime

José AugustoForni, Luiz Fernando Toneto, Novaes, Renan Galaverna, Julio C.Pastre

  • Institute of Chemistry, University of Campinas – UNICAMP, PO Box 6154, 13083-970, Campinas, SP, Brazil
View abstract

Active Site-Mapping of Xylan-Deconstructing Enzymes with Arabinoxylan Oligosaccharides Produced by Automated Glycan Assembly

Deborah Senf, Colin Ruprecht, Goswinus de Kruijff, Sebastian Simonetti, Frank Schuhmacher, Peter Seeberger, Fabian Pfrengle

  • Max-Planck-Institute of Colloids and Interfaces, Biomolecular Systems, Potsdam, Germany
View abstract

BODIPY-based conjugated microporous polymers as reusable heterogeneous photosensitisers in a photochemical flow reactor

J. M. Tobina, J. Liub, H. Hayesa, M. Demleitnera, D. Ellisa, V. Arrighia, Z. Xu*b, F. Vilela*a

  • * Corresponding author
  • a School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK
  • b Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, China
View abstract

Exploring flow procedures for diazonium formation

Te Hu, Ian R. Baxendale and Marcus Baumann

  • Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK
View abstract

Delivering enhanced efficiency in the synthesis of α-diazosulfoxides by exploiting the process control enabled in flow

Patrick G. McCaw1, Benjamin J. Deadman1, Anita R. Maguire1,2, Stuart G. Collins1

  • 1 Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork, Ireland
  • 2 Department of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork, Ireland
View abstract

Biodiesel synthesis using integrated acid and base catalysis in continuous flow

Mousa Asadi, Joel F. Hooper, David W. Lupton

  • School of Chemistry, Monash University, Clayton 3800, Victoria, Australia
View abstract

Fine chemical syntheses under flow using SiliaCat catalysts

Rosaria Ciriminna a, Valerica Pandarus b, François Béland *b, Mario Pagliaro *a

  • * Corresponding authors a Istituto per lo Studio dei Materiali Nanostrutturati, CNR, via U. La Malfa 153, 90146 Palermo, Italy
  • b SiliCycle, 2500, Parc-Technologique Blvd, Québec, G1P 4S6 Canada
View abstract

A Flow-based Synthesis of Telmisartan

Alex Martin, Ali Siamaki, Katherine Belecki, B. Gupton

  • Department of Chemistry and Department of Chemical and Life Science Engineering Virginia Commonwealth University 601 W. Main St. Richmond Virginia 23284 United States
View abstract

Flow Synthesis of 2-Methylpyridines via α-Methylation

Camille Manansala1, Geoffrey K. Tranmer1 2 *

  • 1 College of Pharmacy, Faculty of Health Science, University of Manitoba, Winnipeg, MB R3E 0T6, Canada
  • 2 Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
View abstract

Flow Alkylation of Thiols, Phenols, and Amines Using a Heterogenous Base in a Packed-Bed Reactor

Alastair Baker1, Michael Graz2, Robert Saunders2, Gareth J. S. Evans2, Ilaria Pitotti1 Thomas Wirth1

  • 1 School of Chemistry, Cardiff University, Park Place, Main Building, Cardiff CF10 3AT, UK
  • 2 Neem Biotech, Willowbrook Technical Units, Llandogo Road, St. Mellons, Cardiff CF3 0EF, UK
View abstract

Generation and Trapping of Ketenes in Flow

Cyril Henry1, David Bolien1, Bogdan Ibanescu1, Sally Bloodworth1, David C. Harrowven1, Xunli Zhang2, Andy Craven3, Helen F. Sneddon3, Richard J. Whitby1 *

  • 1 Chemistry, University of Southampton, Southampton, HANTS, SO17 1BJ, UK,
  • 2 Bioengineering Group, Faculty of Engineering and the Environment, University of Southampton, Southampton, HANTS, SO17 1BJ, UK
  • 3 GlaxoSmithKline R&D Ltd., Medicines Research Centre, Gunnels Wood Road, Stevenage, HERTS, SG1 2NY, UK
View abstract

A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions

Maria Victoria Rojo* 1, Lucie Guetzoyan1, Ian. R. Baxendale1 2

  • 1 Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
  • 2 Department of Chemistry, University of Durham, South Road, Durham, UK
View abstract

Facilitating Biomimetic Syntheses of Borrerine Derived Alkaloids by Means of Flow-Chemical Methods

Sonja B. KamptmannA, Steven V. Ley

  • A Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
View abstract

Continuous Synthesis of Organozinc Halides Coupled to Negishi Reactions

Nerea Alonso2,3, L. Zane Miller1, Juan de M. Muñoz2, Jesus Alcázar2,*, D. Tyler McQuade1,*

  • 1Department of Chemistry and Biochemistry, Florida State University, USA
  • 2Janssen Research and Development, Janssen-Cilag, Toledo, Spain
  • 3Facultad de Química, Universidad de Castilla-La Mancha, Spain
View abstract

The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow

Kimberley A. Roper1, Malcolm B. Berry2, Steven V. Ley1

  • 1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, Cambridge, U.K.
  • 2 GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
View abstract

First Example of Alkyl-Aryl Negishi Cross-Coupling in Flow: Mild, Efficient and Clean Introduction of Functionalized Alkyl Groups

Brecht Egle2, Juan de Muñoz1, Nerea Alonso1, Wim M. De Borggraeve2, Antonio de la Hoz3, Angel Díaz-Ortiz3, Jesús Alcázar1

  • 1Janssen Research and Development Department of Medicinal Chemistry Janssen-Cilag, Toledo Spain
  • 2Department of Chemistry, Molecular Design and Synthesis University of Leuven, Heverlee Belgium
  • 3Universidad de Castilla-La Mancha Facultad de Ciencias y Tecnologías Químicas, Spain
View abstract

Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands

Claudio Battilocchio1,3, Marcus Baumann1, Ian R. Baxendale1, Mariangela Biava3, Matthew O. Kitching1, Steven V. Ley1, Rainer E. Martin*2, Stephan A. Ohnmacht2, Nicholas D. C. Tappin1

  • 1Department of Chemistry, University of Cambridge, UK
  • 2F. Hoffmann-La Roche Ltd., Pharmaceuticals Division, Basel, Switzerland
  • 3Department of Pharmaceutical Chemistry and Technology, Sapienza University of Rome, Italy
View abstract

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

Kimberley A. Roper1, Heiko Lange1, Anastasios Polyzos1, Malcolm B. Berry2, Ian R. Baxendale1, Steven V. Ley1

  • 1Innovative Technology Centre, University of Cambridge
  • 2GlaxoSmithKline, Stevenage, UK
View abstract

An Integrated Flow and Batch-Based Approach for the Synthesis of O-Methyl Siphonazole

Marcus Baumann, Ian R. Baxendale, Malte Brasholz, John J. Hayward, Steven V. Ley, Nikzad Nikbin

  • Innovative Technology Centre, Cambridge, UK
View abstract

Synthesis of (+)-Dumetorine and Congeners by Using Flow Chemistry Technologies

Elena Riva2, Anna Rencurosi1, Stefania Gagliardi1, Daniele Passarella2, Marisa Martinelli1*

  • 1NiKem Research S.r.l., Milan, Italy
  • 2Università degli Studi di Milano,Milan, Italy
View abstract

Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith

Heiko Lange, Matthew J. Capener, Alexander X. Jones, Catherine J. Smith, Nikzad Nikbin, Ian R. Baxendale, Steven V. Ley*

  • Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
View abstract

The application of flow microreactors to the preparation of a family of casein kinase I inhibitors

Francesco Venturoni, Nikzad Nikbin, Steven V. Ley, Ian R. Baxendale

  • Innovative Technology Centre, Department of Chemistry, University of Cambridge
View abstract

Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of YneOnes and Their Use in Heterocycle Synthesis

Ian R. Baxendale1, Søren C. Schou2, Jörg Sedelmeier1, Steven V. Ley1

  • 1ITC, Department of Chemistry, University of Cambridge
  • 2LEO Pharma, Medicinal Chemistry Research, Denmark
View abstract

Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles

Ian R. Baxendale1, Steven V. Ley1, Andrew C. Mansfield2, Christopher D. Smith1

  • 1ITC, Department of Chemistry, University of Cambridge,
  • 2Pfizer Global R&D Research Centre, Sandwich, (UK)
View abstract

Application Notes regarding Solid supported

Application Note 58 – Visible light singlet oxygen

Application note 58 Singlet Oxygen

In this application, the conversion of α-terpinene to ascaridole was used to indirectly detect the formation of singlet oxygen in continuous flow. The production of singlet oxygen in continuous flow was optimised using the two methods, and the heterogeneous photocatalyst stability was investigated. Once optimised, the singlet oxygen was used for the aerobic oxidation of boronic acids to phenols, and to degrade two environmental pollutants: bis-phenol A and cimetidine.

This application note describes:

  • Production of singlet oxygen in continuous flow
  • The use of the UV-150 photochemical reactor for heterogeneous dispersions
  • Use of heterogeneous photocatalysts as slurries and packed beds in continuous flow
  • Easy handling of a complex flow stream of solid, liquid and gas
Read more

Get in touch

For more information on flow chemistry systems and services please use the contact methods below.

Call us on +44 (0)1284 728659 or Email us

Request a quote