Solid supported

    A solid supported catalyst is a type of catalyst that is immobilized or attached onto a solid support material. This can be beneficial because it allows the catalyst to be easily separated from the reaction mixture, and it also allows for the use of a higher catalyst loading, which can increase the reaction rate. Solid supported catalysts are commonly used in a variety of chemical reactions, including hydrogenation, oxidation, and dehydrogenation reactions.

    Examples of published literature for Solid supported

    Continuous Flow Synthesis of Methyl Oximino Acetoacetate: Accessing Greener Purification Methods with Inline Liquid-Liquid Extraction and Membrane Separation Technology

    René Lebl1, 2, Trevor Murray3, Andrea Adamo3, David Cantillo1, 2, C. Oliver Kappe1, 2

    • 1Center for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria
    • 2Institute of Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria
    • 3Zaiput Flow Technologies, 300 2nd Avenue, Waltham, Massachusetts 02451, United States
    View abstract

    Real-Time Monitoring of Solid-Phase Peptide Synthesis Using a Variable Bed Flow Reactor

    Eric T. Slettena, Manuel Nunob, Duncan Guthrieb, Peter Seebergera,c

    • aDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany
    • bVapourtec Ltd, Park Farm Business Centre, Fornham St Genevieve, Bury St Edmunds, Suffolk IP28 6TS, U.K
    • cDepartment of Chemistry and Biochemistry, Freie Universität Berlin, Arnimalle 22, 14195, Berlin, Germany
    View abstract

    Integrated plug flow synthesis and crystallisation of pyrazinamide

    C. Daniel Scotta, Ricardo Labesb, Martin Depardieuc, Claudio Battilocchiob, Matthew G. Davidsona, Steven V. Leyb, Chick C. Wilsonad, and Karen Robertson*c

    • a Centre for Sustainable Chemical Technologies, Department of Chemistry, University of Bath, UK
    • b Department of Chemistry, University of Cambridge, UK
    • c Department of Chemistry, University of Bath, UK
    • d EPSRC Future Continuous Manufacturing and Advanced Crystallisation Research Hub, University of Bath, UK
    View abstract

    Transaminase‐catalyzed continuous synthesis of biogenic aldehydes

    Martina L. Contente a, Francesca Paradisi *a,b

    • a School of Chemistry, University of Nottingham, University Park, Nottingham, NG7, 2RD, United Kingdom
    • b Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern
    View abstract

    Bioprocess Intensification Using Flow Reactors: Stereoselective Oxidation of Achiral 1,3-diols with Immobilized Acetobacter Aceti

    Valerio De Vitis 1, Federica Dall’Oglio 2, Francesca Tentori 3, Martina Letizia Contente 4, Elisabetta Brenna 3, Lucia Tamborini 2, Francesco Molinari 1

    • 1 Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, Via Celoria 2, 20133 Milan, Italy
    • 2 Department of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy
    • 3 Dipartimento di Chimica, Materiali ed Ingegneria Chimica “Giulio Natta” Politecnico di Milano, Via Mancinelli 7, I-20131 Milan, Italy
    • 4 School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
    View abstract

    A solid-supported arylboronic acid catalyst for direct amidation

    Yihao Dua,, Thomas Barbera,, Sol Ee Lima,, Henry S. Rzepab,, Ian R. Baxendale*a,, Andrew Whiting*a,

    • a Centre for Sustainable Chemical Processes, Department of Chemistry, Durham University, Science Laboratories, South Road, Durham, UK
    • a Department of Chemistry, Imperial College, South Kensington Campus, London, UK
    View abstract

    Copper mediated, heterogeneous, enantioselective intramolecular Buchner reactions of α-diazoketones using continuous flow processing

    DC Crowley†, D Lynch†, AR Maguire‡

    • † School of Chemistry, Analytical and Biological Chemistry Research Facility, University College Cork, Cork T12 K8AF, Ireland
    • ‡ School of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork T12 K8AF, Ireland
    View abstract

    Novel Polystyrene-Immobilized Chiral Amino Alcohols as Heterogeneous Ligands for the Enantioselective Arylation of Aldehydes in Batch and Continuous Flow Regime

    José AugustoForni, Luiz Fernando Toneto, Novaes, Renan Galaverna, Julio C.Pastre

    • Institute of Chemistry, University of Campinas – UNICAMP, PO Box 6154, 13083-970, Campinas, SP, Brazil
    View abstract

    Active Site-Mapping of Xylan-Deconstructing Enzymes with Arabinoxylan Oligosaccharides Produced by Automated Glycan Assembly

    Deborah Senf, Colin Ruprecht, Goswinus de Kruijff, Sebastian Simonetti, Frank Schuhmacher, Peter Seeberger, Fabian Pfrengle

    • Max-Planck-Institute of Colloids and Interfaces, Biomolecular Systems, Potsdam, Germany
    View abstract

    BODIPY-based conjugated microporous polymers as reusable heterogeneous photosensitisers in a photochemical flow reactor

    J. M. Tobina, J. Liub, H. Hayesa, M. Demleitnera, D. Ellisa, V. Arrighia, Z. Xu*b, F. Vilela*a

    • * Corresponding author
    • a School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK
    • b Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, China
    View abstract

    Exploring flow procedures for diazonium formation

    Te Hu, Ian R. Baxendale and Marcus Baumann

    • Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK
    View abstract

    Delivering enhanced efficiency in the synthesis of α-diazosulfoxides by exploiting the process control enabled in flow

    Patrick G. McCaw1, Benjamin J. Deadman1, Anita R. Maguire1,2, Stuart G. Collins1

    • 1 Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork, Ireland
    • 2 Department of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork, Ireland
    View abstract

    Biodiesel synthesis using integrated acid and base catalysis in continuous flow

    Mousa Asadia, Joel F. Hoopera, David W. Luptona

    • aSchool of Chemistry, Monash University, Clayton 3800, Victoria, Australia
    View abstract

    Fine chemical syntheses under flow using SiliaCat catalysts

    Rosaria Ciriminna a, Valerica Pandarus b, François Béland *b, Mario Pagliaro *a

    • * Corresponding authors a Istituto per lo Studio dei Materiali Nanostrutturati, CNR, via U. La Malfa 153, 90146 Palermo, Italy
    • b SiliCycle, 2500, Parc-Technologique Blvd, Québec, G1P 4S6 Canada
    View abstract

    A Flow-based Synthesis of Telmisartan

    Alex Martin, Ali Siamaki, Katherine Belecki, B. Gupton

    • Department of Chemistry and Department of Chemical and Life Science Engineering Virginia Commonwealth University 601 W. Main St. Richmond Virginia 23284 United States
    View abstract

    Flow Synthesis of 2-Methylpyridines via α-Methylation

    Camille Manansala1, Geoffrey K. Tranmer1 2 *

    • 1 College of Pharmacy, Faculty of Health Science, University of Manitoba, Winnipeg, MB R3E 0T6, Canada
    • 2 Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
    View abstract

    Flow Alkylation of Thiols, Phenols, and Amines Using a Heterogenous Base in a Packed-Bed Reactor

    Alastair Baker1, Michael Graz2, Robert Saunders2, Gareth J. S. Evans2, Ilaria Pitotti1 Thomas Wirth1

    • 1 School of Chemistry, Cardiff University, Park Place, Main Building, Cardiff CF10 3AT, UK
    • 2 Neem Biotech, Willowbrook Technical Units, Llandogo Road, St. Mellons, Cardiff CF3 0EF, UK
    View abstract

    Generation and Trapping of Ketenes in Flow

    Cyril Henry1, David Bolien1, Bogdan Ibanescu1, Sally Bloodworth1, David C. Harrowven1, Xunli Zhang2, Andy Craven3, Helen F. Sneddon3, Richard J. Whitby1 *

    • 1 Chemistry, University of Southampton, Southampton, HANTS, SO17 1BJ, UK,
    • 2 Bioengineering Group, Faculty of Engineering and the Environment, University of Southampton, Southampton, HANTS, SO17 1BJ, UK
    • 3 GlaxoSmithKline R&D Ltd., Medicines Research Centre, Gunnels Wood Road, Stevenage, HERTS, SG1 2NY, UK
    View abstract

    A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions

    Maria Victoria Rojo* 1, Lucie Guetzoyan1, Ian. R. Baxendale1 2

    • 1 Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
    • 2 Department of Chemistry, University of Durham, South Road, Durham, UK
    View abstract

    Facilitating Biomimetic Syntheses of Borrerine Derived Alkaloids by Means of Flow-Chemical Methods

    Sonja B. KamptmannA, Steven V. Ley

    • A Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    View abstract

    Continuous Synthesis of Organozinc Halides Coupled to Negishi Reactions

    Nerea Alonso2,3, L. Zane Miller1, Juan de M. Muñoz2, Jesus Alcázar2,*, D. Tyler McQuade1,*

    • 1Department of Chemistry and Biochemistry, Florida State University, USA
    • 2Janssen Research and Development, Janssen-Cilag, Toledo, Spain
    • 3Facultad de Química, Universidad de Castilla-La Mancha, Spain
    View abstract

    The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow

    Kimberley A. Roper1, Malcolm B. Berry2, Steven V. Ley1

    • 1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, Cambridge, U.K.
    • 2 GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
    View abstract

    First Example of Alkyl-Aryl Negishi Cross-Coupling in Flow: Mild, Efficient and Clean Introduction of Functionalized Alkyl Groups

    Brecht Egle2, Juan de Muñoz1, Nerea Alonso1, Wim M. De Borggraeve2, Antonio de la Hoz3, Angel Díaz-Ortiz3, Jesús Alcázar1

    • 1Janssen Research and Development Department of Medicinal Chemistry Janssen-Cilag, Toledo Spain
    • 2Department of Chemistry, Molecular Design and Synthesis University of Leuven, Heverlee Belgium
    • 3Universidad de Castilla-La Mancha Facultad de Ciencias y Tecnologías Químicas, Spain
    View abstract

    Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands

    Claudio Battilocchio1,3, Marcus Baumann1, Ian R. Baxendale1, Mariangela Biava3, Matthew O. Kitching1, Steven V. Ley1, Rainer E. Martin*2, Stephan A. Ohnmacht2, Nicholas D. C. Tappin1

    • 1Department of Chemistry, University of Cambridge, UK
    • 2F. Hoffmann-La Roche Ltd., Pharmaceuticals Division, Basel, Switzerland
    • 3Department of Pharmaceutical Chemistry and Technology, Sapienza University of Rome, Italy
    View abstract

    The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

    Kimberley A. Roper1, Heiko Lange1, Anastasios Polyzos1, Malcolm B. Berry2, Ian R. Baxendale1, Steven V. Ley1

    • 1Innovative Technology Centre, University of Cambridge
    • 2GlaxoSmithKline, Stevenage, UK
    View abstract

    An Integrated Flow and Batch-Based Approach for the Synthesis of O-Methyl Siphonazole

    Marcus Baumann, Ian R. Baxendale, Malte Brasholz, John J. Hayward, Steven V. Ley, Nikzad Nikbin

    • Innovative Technology Centre, Cambridge, UK
    View abstract

    Synthesis of (+)-Dumetorine and Congeners by Using Flow Chemistry Technologies

    Elena Riva2, Anna Rencurosi1, Stefania Gagliardi1, Daniele Passarella2, Marisa Martinelli1*

    • 1NiKem Research S.r.l., Milan, Italy
    • 2Università degli Studi di Milano,Milan, Italy
    View abstract

    Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith

    Heiko Lange, Matthew J. Capener, Alexander X. Jones, Catherine J. Smith, Nikzad Nikbin, Ian R. Baxendale, Steven V. Ley*

    • Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
    View abstract

    The application of flow microreactors to the preparation of a family of casein kinase I inhibitors

    Francesco Venturoni, Nikzad Nikbin, Steven V. Ley, Ian R. Baxendale

    • Innovative Technology Centre, Department of Chemistry, University of Cambridge
    View abstract

    Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of YneOnes and Their Use in Heterocycle Synthesis

    Ian R. Baxendale1, Søren C. Schou2, Jörg Sedelmeier1, Steven V. Ley1

    • 1ITC, Department of Chemistry, University of Cambridge
    • 2LEO Pharma, Medicinal Chemistry Research, Denmark
    View abstract

    Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles

    Ian R. Baxendale1, Steven V. Ley1, Andrew C. Mansfield2, Christopher D. Smith1

    • 1ITC, Department of Chemistry, University of Cambridge,
    • 2Pfizer Global R&D Research Centre, Sandwich, (UK)
    View abstract

    Application Notes regarding Solid supported

    Application Note 58 – Visible light singlet oxygen

    App-note-58-scheme

    In this application, the conversion of α-terpinene to ascaridole was used to indirectly detect the formation of singlet oxygen in continuous flow. The production of singlet oxygen in continuous flow was optimised using the two methods, and the heterogeneous photocatalyst stability was investigated. Once optimised, the singlet oxygen was used for the aerobic oxidation of boronic acids to phenols, and to degrade two environmental pollutants: bis-phenol A and cimetidine.

    This application note describes:

    • Production of singlet oxygen in continuous flow
    • The use of the UV-150 photochemical reactor for heterogeneous dispersions
    • Use of heterogeneous photocatalysts as slurries and packed beds in continuous flow
    • Easy handling of a complex flow stream of solid, liquid and gas
    Read more

    Get in touch

    For more information on flow chemistry systems and services please use the contact methods below.

    Call us on +44 (0)1284 728659 or Email us