A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

    • Ian R. Baxendale
    • Steven V. Ley
    • Christopher D. Smith
    • Geoffrey K. Tranmer
    • Innovative Technology Centre, Cambridge, UK

    A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of the method to enable the preparation of a tripeptide derivative.

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