A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

• Ian R. Baxendale
• Steven V. Ley
• Christopher D. Smith
• Geoffrey K. Tranmer

• Innovative Technology Centre, Cambridge, UK

A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of the method to enable the preparation of a tripeptide derivative.

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