A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols
- Ian R. Baxendale
- Steven V. Ley
- Christopher D. Smith
- Geoffrey K. Tranmer
- Innovative Technology Centre, Cambridge, UKRead the publication that featured this abstract
A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of the method to enable the preparation of a tripeptide derivative.
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