Development of fluorination methods using continuous-flow microreactors

• Marcus Baumann
• Ian R. Baxendale
• Laetitia J. Martin
• Steven V. Ley

• Innovative Technology Centre, Cambridge, UK

The safe and reliable use of various fluorination methods including nucleophilic fluorination (DAST), trifluoromethylation (Ruppert’s reagent) and electrophilic fluorination (Selectfluor®) in a continuous-flow microreactor is reported. Special attention was given to the use of in-line scavenging procedures in order to obtain clean products without the need for further purification.

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