Development of fluorination methods using continuous-flow microreactors

    • Marcus Baumann
    • Ian R. Baxendale
    • Laetitia J. Martin
    • Steven V. Ley
    • Innovative Technology Centre, Cambridge, UK

    The safe and reliable use of various fluorination methods including nucleophilic fluorination (DAST), trifluoromethylation (Ruppert’s reagent) and electrophilic fluorination (Selectfluor®) in a continuous-flow microreactor is reported. Special attention was given to the use of in-line scavenging procedures in order to obtain clean products without the need for further purification.

    Read the publication that featured this abstract

    Get in touch

    For more information on flow chemistry systems and services please use the contact methods below.

    Call us on +44 (0)1284 728659 or Email us