Development of fluorination methods using continuous-flow microreactors
- Marcus Baumann
- Ian R. Baxendale
- Laetitia J. Martin
- Steven V. Ley
- Innovative Technology Centre, Cambridge, UKRead the publication that featured this abstract
The safe and reliable use of various fluorination methods including nucleophilic fluorination (DAST), trifluoromethylation (Ruppert’s reagent) and electrophilic fluorination (Selectfluor®) in a continuous-flow microreactor is reported. Special attention was given to the use of in-line scavenging procedures in order to obtain clean products without the need for further purification.
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