Nano particle synthesis and applications

    A Nano particle is defined as a particle between 1 and 100 nanometres in size. Nano particle synthesis research is currently an area of intense scientific interest. There are a wide variety of potential applications in biomedical, optical and electronic fields.

    Applications for Nano particles

    In the biomedical field two classes of nano particle synthesis are having increased applications.  Uses include in-vivo and vitro biological applications. The Nano particle used in these cases are Quantum dots and metal colloids. In recent years chemists have been moving away from traditional batch based processes towards flow chemistry.  For both quantum dots and metal colloid formation, micro-fluidic synthesis has been shown to be superior to traditional batch methods.

    Benefits of flow Nano particle synthesis

    High quality, monodisperse particles can be produced by flow processes due to the ability to maintain fine control of all reaction variables. These variables include reactant concentration, mixing, timing of reagent addition, and temperature.

    SEM image of Nano particles

    The image below shows Nano particles produced in a tubular rector fitted with Kenics static mixers.

    Nano particles synthesis - Vapourtec

    Examples of published literature for Nano particle synthesis and applications

    In-Flow Flash Nanoprecipitation of Size-Controlled D-Leucine Nanoparticles for Spray-Drying Formulations

    Bruno Cerraa, Gabriele Moscaa, Maurizio Riccia, Aurélie Schoubbena, Antimo Gioielloa

    • aDepartment of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, I-06122 Perugia, Italy.
    View abstract

    Continuous Flow Chemo-Enzymatic Baeyer–Villiger Oxidation with Superactive and Extra-Stable Enzyme/Carbon Nanotube Catalyst: An Efficient Upgrade from Batch to Flow

    Anna Szelwickaa, Przemysław Zawadzkib, Magdalena Sitkoa, Sławomir Boncelc, Wojciech Czardybonb, Anna Chrobok*a

    • aDepartment of Chemical Organic Technology and Petrochemistry, Silesian University of Technology, Krzywoustego 4, 44-100 Gliwice, Poland
    • bSelvita S.A., Bobrzynskiego 14, 30-348 Cracow, Poland
    • cDepartment of Organic Chemistry, Bioorganic Chemistry, and Biotechnology, Silesian University of Technology, Krzywoustego 4, 44-100 Gliwice, Poland
    View abstract

    Investigation of a Weak Temperature–Rate Relationship in the Carbamoylation of a Barbituric Acid Pharmaceutical Intermediate

    Alexander G. O’Brien *†, Yangmu Chloe Liu *†, Mark J. Hughes , John Jin Lim , Neil S. Hodnett , Nicholas Falco

    • GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States
    • GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom
    View abstract

    P‐121: Successive and scalable synthesis of highly stable Cs4PbBr6 perovskite microcrystal by microfluidic system and their application in backlight display

    Hung-Chia Wang1, Zhen Bao1, Ru-Shi Liu1,2

    • 1 Department of Chemistry, National Taiwan University, Taipei, Taiwan
    • 2 Department of Mechanical Engineering and Graduate Institute of Manufacturing Technology, National Taipei University of Technology, Taipei, Taiwan
    View abstract

    An efficient and green pathway for continuous Friedel-Crafts acylation over α-Fe2O3 and CaCO3 nanoparticles prepared in the microreactors

    Zheng Fanga1, Wei Heb1, Tao Tub, Niuniu Lva, Chuanhong Qiua, Xin Lia, Ning Zhua, Li Wana, Kai Guoac

    • a College of Biotechnology and Pharmaceutical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China
    • b Department of Chemistry, Fudan University, No. 220 Handan Road, Shanghai, 200433, PR China
    • c State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China
    View abstract

    A novel micro-flow system under microwave irradiation for continuous synthesis of 1, 4-dihydropyridines in the absence of solvents via Hantzsch reaction

    Wei Hea,b, Zheng Fangb, Kai Zhangb, Tao Tua, Niuniu Lvb, Chuanhong Qiub, Kai Guob,c

    • a Department of Chemistry, Fudan University, No. 220 Handan Road, Shanghai, 200433, PR China
    • b College of Biotechnology and Pharmaceutical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China
    • c State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China
    View abstract

    Flow Chemistry Meets Advanced Functional Materials

    Dr. Rebecca M. Myers, Daniel E. Fitzpatrick, Dr. Richard M. Turner, Prof. Steven V. Ley*

    • Department of Chemistry, University of Cambridge, Cambridge, UK
    View abstract

    Continuous Flow Ligand-Free Heck Reactions Using Monolithic Pd [0] Nanoparticles

    Nikzad Nikbin, Mark Ladlow, Steven V. Ley

    • Department of Chemistry, University of Cambridge, UK
    View abstract

    Application Notes regarding Nano particle synthesis and applications

    Application Note 40 – Preparation of Silver Nanoparticles under Continuous Flow Conditions

    This application note illustrates the use of the Vapourtec E-Series to synthesise nanoparticles under continuous flow conditions. Two classes of silver nanoparticles are reported. The properties of metal nanoparticles are highly dependent on size and morphology, so ensuring consistency is paramount. Flow chemistry brings the advantages of precise control over experimental conditions (temperature, pressure, and residence time) and essentially limitless scale. As such, it is often the method of choice for production of nanoparticles.

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