Nano particle synthesis

    A Nanoparticle is defined as a particle between 1 and 100 nanometres in size. Nanoparticle synthesis research is currently an area of intense scientific interest due to a wide variety of potential applications in biomedical, optical and electronic fields.

    In the biomedical field two classes of nano particle synthesis are having increased applications in in-vivo and vitro biological applications, these are Quantum dots and metal colloids.  In recent years chemists have been  moving away from traditional batch based processes towards flow processing.  For both quantum dots and metal colloid formation, microfluidic synthesis has been shown to be superior to traditional batch methods for producing high quality, monodisperse particles due to the ability to maintain fine control of all reaction variables including reactant concentration, mixing, timing of reagent addition, and temperature.

    Examples of published literature for Nano particle synthesis

    An efficient and green pathway for continuous Friedel-Crafts acylation over α-Fe2O3 and CaCO3 nanoparticles prepared in the microreactors

    Zheng Fanga1, Wei Heb1, Tao Tub, Niuniu Lva, Chuanhong Qiua, Xin Lia, Ning Zhua, Li Wana, Kai Guoac

    • a College of Biotechnology and Pharmaceutical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China
    • b Department of Chemistry, Fudan University, No. 220 Handan Road, Shanghai, 200433, PR China
    • c State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Technology University, No. 30 Puzhu South Road, Nanjing, 211816, PR China
    View abstract

    Flow Chemistry Meets Advanced Functional Materials

    Dr. Rebecca M. Myers, Daniel E. Fitzpatrick, Dr. Richard M. Turner, Prof. Steven V. Ley*

    • Department of Chemistry, University of Cambridge, Cambridge, UK
    View abstract

    Continuous Flow Ligand-Free Heck Reactions Using Monolithic Pd [0] Nanoparticles

    Nikzad Nikbin, Mark Ladlow, Steven V. Ley

    • Department of Chemistry, University of Cambridge, UK
    View abstract

    Application Notes regarding Nano particle synthesis

    Application Note 40 – Preparation of Silver Nanoparticles under Continuous Flow Conditions

    This application note illustrates the use of the Vapourtec E-Series to synthesise nanoparticles under continuous flow conditions. Two classes of silver nanoparticles are reported. The properties of metal nanoparticles are highly dependent on size and morphology, so ensuring consistency is paramount. Flow chemistry brings the advantages of precise control over experimental conditions (temperature, pressure, and residence time) and essentially limitless scale. As such, it is often the method of choice for production of nanoparticles.

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