Continuous Flow Ligand-Free Heck Reactions Using Monolithic Pd [0] Nanoparticles

• Nikzad Nikbin
• Mark Ladlow
• Steven V. Ley

• Department of Chemistry, University of Cambridge, UK

An automated reactor has been developed for performing ligand-free Heck reactions in continuous flow mode. The reactor utilises a monolithic reactor cartridge derivatised with Pd(0) nanoparticles in-line with a scavenging cartridge containing Quadrapure-TU to efficiently capture palladium residues and thereby afford Heck products directly in high purity.

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