Synthesis of CTA and DNAN using flow chemistry
- Ankit Kumar Mittala
- Gaurav Prakasha
- Pramod Pathaka
- Debabrata Maitia
- aIndian Institute of Technology Bombay, Department of Chemistry, Mumbai, INDIA
Read the publication that featured this abstractThis paper describes a flow chemistry approach for synthesising two high-energy molecules, cyanuric triazide (CTA) and 2,4-dinitroanisole (DNAN), and scaling them up to multi-gram scale using an automated flow reactor system. The flow chemistry approach offers high degree of safety and easy to scale compared to conventional syntheses. The development of two processes: a. CTA via azidation of cyanuric chloride; b. DNAN via methoxylation of 2,4-dinitrichlorobenzene (2,4-DNCB) on an automated commercially available flow reactor system is described. High yield (> 95%) was achieved in both the processes. Very short reaction times (30 seconds) were applied. The process parameters were optimized using the automated flow chemistry system. The optimized process was scaled to multi gram scale (> 30 g/hr). The method can be considered fit for the safe production of CTA and DNAN at multi gram scale in laboratory.
Get in touch
For more information on flow chemistry systems and services please use the contact methods below.
Call us on +44 (0)1284 728659 or Email us
Resource Centre
R-Series

The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
- Flexible |
- Precise |
- Automatable
The R-Series is undoubtedly the most versatile, modular flow chemistry system available today.
E-Series

The Vapourtec E-Series is the perfect introductory system for flow chemistry
- Robust |
- Easy to use |
- Affordable
The E-Series is a robust and affordable, entry level flow chemistry system designed for reliability and ease of use.