Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes

• Swapna S. Mohapatra^a,b
• Zoe E. Wilson^a
• Sujit Roy^b
• Steven V. Ley^a

• ^a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
• ^b Organometallics & Catalysis Laboratory, School of Basic Sciences, Indian Institute of Technology, Bhubaneswar 751013, India

Flow chemistry enables the preparation of bis(indolyl)methanes from various indoles and structurally divergent aldehydes using Sc(OTf)3 catalysis. The reaction is regioselective for C-3 functionalization of the indoles, occurring over short reaction times allowing for rapid investigation of scope with straightforward work up facilitating product isolation.

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