Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes

Flow chemistry enables the preparation of bis(indolyl)methanes from various indoles and structurally divergent aldehydes using Sc(OTf)3 catalysis. The reaction is regioselective for C-3 functionalization of the indoles, occurring over short reaction times allowing for rapid investigation of scope with straightforward work up facilitating product isolation.

• Swapna S. Mohapatra^a,b
• Zoe E. Wilson^a
• Sujit Roy^b
• Steven V. Ley^a

• ^a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
• ^b Organometallics & Catalysis Laboratory, School of Basic Sciences, Indian Institute of Technology, Bhubaneswar 751013, India

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