An efficient etherification of Ginkgol biloba extracts with fewer side effects in a micro-flow system

    • Yin-Lin Qina
    • Wei Hea
    • Mei Sub
    • Zheng Fangc
    • Ping-Kai Ouyanga
    • Kai Guoa,d
    • a College of Biotechnology and Pharmaceutical Engineering, Nanjing Technology University, Nanjing 210009, China
    • b Jiangsu Carephar Pharmaceutical Co., Ltd., Nanjing 210014, China
    • c School of Pharmaceutical, Nanjing Technology University, Nanjing 210009, China
    • d State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Technology University, Nanjing 211816, China

    In this study, etherification of ginkgolide B and dimethylaminoethyl chloride hydrochloride was investigated as a model reaction in a micro-flow system (MFS), providing the resulting ethers in high yield with fewer side effects. Meanwhile, this novel process in MFS worked well for other ginkgolides from Ginkgol biloba and halides, giving moderate yields.

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