Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles

    • Marcus Baumann
    • Ian R. Baxendale
    • Steven V. Ley
    • Christoper D. Smith
    • Geoffrey K. Tranmer
    • Innovative Technology Center, University of Cambridge

    A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured to provide the maximum flexibility for screening of reaction parameters that incorporate on-chip mixing and columns of solid supported reagents to expedite the chemical syntheses.

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