Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles

• Marcus Baumann
• Ian R. Baxendale
• Steven V. Ley
• Christoper D. Smith
• Geoffrey K. Tranmer

• Innovative Technology Center, University of Cambridge

A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured to provide the maximum flexibility for screening of reaction parameters that incorporate on-chip mixing and columns of solid supported reagents to expedite the chemical syntheses.

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