Using Carbon Dioxide as a Building Block in Continuous Flow Synthesis

• Hyowon Seo
• Long V. Nguyen
• Timothy F. Jamison

• Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts

Carbon dioxide (CO2) is an attractive building block for organic synthesis that is environmentally friendly. Continuous flow technologies have enabled C−O and C−C bond forming reactions with CO2 that previously were either low‐yielding or impossible in batch to afford value‐added chemicals. This review describes recent advances in continuous flow as an enabling strategy in utilizing CO2 as a C1 building block in chemical synthesis.

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