Examples of published literature for High temperature

Continuous flow aminolysis under high temperature and pressure

Bryan Li1, Scott Bader1, 2, Steve M. Guinness1, Sally Gut Ruggeri1, Cheryl M. Hayward1, Steve Hoagland1, John Lucas1, 3, Ruizhi Li1, David Limburg1, J. Christopher McWilliams1, Jeffrey Raggo1, John Van Alsten1, 4

  • 1Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT, 06340, USA
  • 2Celgene Corporation, 556 Morris Ave, Summit, NJ, USA
  • 3Rhodes Technologies, 498 Washington Street, Coventry, RI, USA
  • 4Nitto Denko Avecia Inc, 155 Fortune Blvd., Milford, MA, USA
View abstract

Selective N-monomethylation of primary anilines with dimethyl carbonate in continuous flow

Hyowon Seo, Anne-Catherine Bédard, Willie P. Chen, Robert W. Hicklin, Alexander Alabugin, Timothy F. Jamison

  • Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139, USA
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Auto-Tandem Catalysis: Pd(II)-Catalysed Dehydrogenation/Oxidative Heck of Cyclopentane-1,3-diones

Claire J C Lamb, Bryan G Nderitu, Gemma McMurdo, John MTobin, Filipe Vilela, and Ai-Lan Lee

  • Institute of Chemical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, United Kingdom
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Methanolysis of epoxidized soybean oil in continuous flow conditions

Vincenzo Pantonea, Amelita Grazia Laurensab, Cosimo Annesec, Francesco Fracassib, Caterina Fuscob, Angelo Naccib,c, Antonella Russoa, Lucia D’Accoltib,c

  • a Greenswitch s.r.l., Ferrandina MT, Italy
  • b Dipartimento di Chimica, Università di Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy
  • c ICCOM-CNR, SS Bari, Via E. Orabona 4, 70126 Bari, Italy
View abstract

Co-production of HMF and gluconic acid from sucrose by chemo-enzymatic method

Hongli Wu, Ting Huang, Fei Cao, Qiaogen Zou, Ping Wei, Pingkai Ouyang

  • College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816 PR China
View abstract

The Preparation of Ethyl Levulinate Facilitated by Flow Processing: The Catalyzed and Uncatalyzed Esterification of Levulinic Acid

Meghan P. Negus1, Andrew C. Mansfield2, Nicholas E. Leadbeater1

  • 1 Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269, United States
  • 2 Vapourtec Ltd., Park Farm Business Centre, Bury St. Edmunds IP28 6TS, United Kingdom
  • 3 Department of Community Medicine and Health Care, University of Connecticut Health Center, The Exchange, 263 Farmington Ave, Farmington, CT 06030, United States
View abstract

Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing

Thomas M. Kohl *, Christian H. Hornung, John Tsanaktsidis

  • CSIRO Manufacturing Flagship, Bag 10, Clayton South, Victoria 3169, Australia
View abstract

Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

Ashley R. Longstreet1, Suzanne M. Opalka1, Brian S. Campbell1, B. Frank Gupton2, Tyler McQuade1

  • 1 Department of Chemistry and Biochemistry, Florida State University, United States
  • 1 Department of Chemistry, Virginia Commonwealth University, United States
View abstract

Two-Stage Flow Synthesis of Coumarin via O-Acetylation of Salicylaldehyde

Xin Li1, Anbang Chen1, Yangzhi Zhou1, Lingling Huang2, Zheng Fang2, Haifeng Gan1, Kai Guo1

  • 1 College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
  • 2 School of Pharmaceutical Sciences, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
  • 3 State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
View abstract

Heterogenization of Pd–NHC complexes onto a silica support and their application in Suzuki–Miyaura coupling under batch and continuous flow conditions

Alberto Martíneza, Jamin L. Krinskya, Itziar Peñafiela, Sergio Castillónb, Konstantin Loponov, Alexei Lapkinc, Cyril Godard*a, Carmen Claver*a

  • aDepartment of Physical and Inorganic Chemistry, Universitat Rovira i Virgili, Tarragona, Spain
  • bDepartment of Analytical and Organic Chemistry, Universitat Rovira i Virgili, Tarragona, Spain
  • cDepartment of Chemical Engineering and Biotechnology, University of Cambridge, , Cambridge, UK
View abstract

Glycosylation with N-acetyl glycosamine donors using catalytic iron(III) triflate: from microwave batch chemistry to a scalable continuous-flow process

Amandine Xolina, Arnaud Stévenina, Mathieu Pucheaultb, Stéphanie Norsikiana, François-Didier Boyer*ac, Jean-Marie Beau*ad

  • aCentre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France
  • bInstitut des Sciences Moléculaires, CNRS-Université de Bordeaux, Talence, France
  • cInstitut Jean-Pierre Bourgin, UMR1318 INRA-AgroParisTech, Versailles, France
  • dUniversité Paris-Sud and CNRS, Laboratoire de Synthèse de Biomolécules, Institut de Chimie Moléculaire et des Matériaux, Orsay, France
View abstract

Continuous Flow Synthesis of Thieno[2,3-c]isoquinolin-5(4H)-one Scaffold: A Valuable Source of PARP-1 Inhibitors

Paolo Filipponi, Carmine Ostacolo, Ettore Novellino, Roberto Pellicciari†§, Antimo Gioiello*†

  • Dipartimento di Scienze Farmaceutiche, Università di Perugia, Via del Liceo 1, I-06123 Perugia, Italy
  • Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Napoli, Italy §TES Pharma S.r.l., Corciano (Perugia), Italy
View abstract

First Example of a Continuous-Flow Carbonylation Reaction Using Aryl Formates as CO Precursors

Nerea Alonso1,3, Juan de Muñoz1, Brecht Egle2, Johannes L. Vrijdag2, Wim M. De Borggraeve2, Antonio de la Hoz3, Angel Díaz-Ortiz3, Jesús Alcázar1

  • 1Janssen Research and Development, Janssen-Cilag Department of Medicinal Chemistry S.A., Toledo, Spain
  • 2Molecular Design and Synthesis University of Leuven, Department of Chemistry, Heverlee Belgium
  • 3Universidad de Castilla-La Mancha Facultad de Ciencias y Tecnologías Químicas Real, Spain
View abstract

Sequential flow process for the controlled polymerisation and thermolysis of RAFT-synthesised polymers

CH Hornung, A Postma, S Saubern, J Chiefari

  • CSIRO Materials Science and Engineering, Victoria, Australia
View abstract

Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels-Alder Reaction under Superheated Continuous Flow Conditions

Rainer E. Martin1, Falk Morawitz1, Christoph Kuratli1, André M. Alker2, Alexander I. Alanine1

  • 1Chemistry Technology and Innovation, F. Hoffmann-La Roche Ltd, Basel, Switzerland
  • 2Biostructure Section, F. Hoffmann-La Roche Ltd,Basel, Switzerland
View abstract

Controlled RAFT Polymerization in a Continuous Flow Microreactor

Christian H. Hornung, Carlos Guerrero-Sanchez, Malte Brasholz, Simon Saubern, John Chiefari, Graeme Moad, Ezio Rizzardo, San H. Thang

  • CSIRO Materials Science & Engineering, Victoria, Australia
View abstract

Decarboxylative biaryl synthesis in a continuous flow reactor

1Paul P. Lange, 1Lukas J. Gooßen, 2Philip Podmore, 2Toby Underwood, 2Nunzio Sciammetta

  • 1Technische Universität Kaiserslautern, Germany
  • 2Pfizer Global R&D, Sandwich, UK
View abstract

A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT1B> Antagonist

Zizheng Qian, Ian R. Baxendale, Steven V. Ley

  • Innovative Technology Centre, Department of Chemistry, University of Cambridge
View abstract

Application Notes regarding High temperature

Application Note 57 – Automated library synthesis


Equipping a Vapourtec R-Series with a liquid handler creates a powerful, automated synthesis platform that has been used to carry out reaction screening of nucleophilic aromatic substitution partners, including volatile amines.
This application note describes:

– Automated reaction screening using automated reagent loading and collection
– Safe out-of-hours operation permitted by Flow Commander™
– The use of highly volatile amines and ammonia at 160 °C through the use of high pressures difficult to achieve in batch

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Application Note 33 : Chromium Arene Synthesis


This application note demonstrates the preparation of arene chromium tricarbonyl complexes using continuous-flow processing: (η6C6H5CH3)Cr(CO)3 as an example.

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Application Note 32: High Pressure and Temperature Process Scale S N Ar Reaction under Solvent Free Conditions using Liquefied Dimethylamine.


This application note illustrates the use of the Vapourtec R-Series system to run reactions under solvent free (neat) conditions and it’s ability to pump liquefied gases at high temperatures and pressures. This expands on work carried out in Application note 29 (where a game changing throughput of material from a bench top system was demonstrated).

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