High temperature

Continuous flow aminolysis under high temperature and pressure

Bryan Li¹, Scott Bader^{1, 2}, Steve M. Guinness¹, Sally Gut Ruggeri¹, Cheryl M. Hayward¹, Steve Hoagland¹, John Lucas^{1, 3}, Ruizhi Li¹, David Limburg¹, J. Christopher McWilliams¹, Jeffrey Raggo¹, John Van Alsten^{1, 4}

• ¹Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT, 06340, USA
• ²Celgene Corporation, 556 Morris Ave, Summit, NJ, USA
• ³Rhodes Technologies, 498 Washington Street, Coventry, RI, USA
• ⁴Nitto Denko Avecia Inc, 155 Fortune Blvd., Milford, MA, USA

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Selective N-monomethylation of primary anilines with dimethyl carbonate in continuous flow

Hyowon Seo, Anne-Catherine Bédard, Willie P. Chen, Robert W. Hicklin, Alexander Alabugin, Timothy F. Jamison

• Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139, USA

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Auto-Tandem Catalysis: Pd(II)-Catalysed Dehydrogenation/Oxidative Heck of Cyclopentane-1,3-diones

Claire J C Lamb, Bryan G Nderitu, Gemma McMurdo, John MTobin, Filipe Vilela, and Ai-Lan Lee

• Institute of Chemical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, United Kingdom

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Methanolysis of epoxidized soybean oil in continuous flow conditions

Vincenzo Pantone^a, Amelita Grazia Laurensa^b, Cosimo Annese^c, Francesco Fracassi^b, Caterina Fusco^b, Angelo Nacci^b,c, Antonella Russo^a, Lucia D’Accolti^b,c

• ^a Greenswitch s.r.l., Ferrandina MT, Italy
• ^b Dipartimento di Chimica, Università di Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy
• ^c ICCOM-CNR, SS Bari, Via E. Orabona 4, 70126 Bari, Italy

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Co-production of HMF and gluconic acid from sucrose by chemo-enzymatic method

Hongli Wu, Ting Huang, Fei Cao, Qiaogen Zou, Ping Wei, Pingkai Ouyang

• College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816 PR China

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The Preparation of Ethyl Levulinate Facilitated by Flow Processing: The Catalyzed and Uncatalyzed Esterification of Levulinic Acid

Meghan P. Negus¹, Andrew C. Mansfield², Nicholas E. Leadbeater¹

• ¹ Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269, United States
• ² Vapourtec Ltd., Park Farm Business Centre, Bury St. Edmunds IP28 6TS, United Kingdom
• ³ Department of Community Medicine and Health Care, University of Connecticut Health Center, The Exchange, 263 Farmington Ave, Farmington, CT 06030, United States

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Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing

Thomas M. Kohl ^*, Christian H. Hornung, John Tsanaktsidis

• CSIRO Manufacturing Flagship, Bag 10, Clayton South, Victoria 3169, Australia

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Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

Ashley R. Longstreet¹, Suzanne M. Opalka¹, Brian S. Campbell¹, B. Frank Gupton², Tyler McQuade¹

• ¹ Department of Chemistry and Biochemistry, Florida State University, United States
• ¹ Department of Chemistry, Virginia Commonwealth University, United States

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Two-Stage Flow Synthesis of Coumarin via O-Acetylation of Salicylaldehyde

Xin Li¹, Anbang Chen¹, Yangzhi Zhou¹, Lingling Huang², Zheng Fang², Haifeng Gan¹, Kai Guo¹

• ¹ College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
• ² School of Pharmaceutical Sciences, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
• ³ State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China

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Heterogenization of Pd–NHC complexes onto a silica support and their application in Suzuki–Miyaura coupling under batch and continuous flow conditions

Alberto Martínez^a, Jamin L. Krinsky^a, Itziar Peñafiel^a, Sergio Castillón^b, Konstantin Loponov^c, Alexei Lapkinc, Cyril Godard^*a, Carmen Claver^*a

• ^aDepartment of Physical and Inorganic Chemistry, Universitat Rovira i Virgili, Tarragona, Spain
• ^bDepartment of Analytical and Organic Chemistry, Universitat Rovira i Virgili, Tarragona, Spain
• ^cDepartment of Chemical Engineering and Biotechnology, University of Cambridge, , Cambridge, UK

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Glycosylation with N-acetyl glycosamine donors using catalytic iron(III) triflate: from microwave batch chemistry to a scalable continuous-flow process

Amandine Xolin^a, Arnaud Stévenin^a, Mathieu Pucheault^b, Stéphanie Norsikian^a, François-Didier Boyer^*ac, Jean-Marie Beau^*ad

• ^aCentre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France
• ^bInstitut des Sciences Moléculaires, CNRS-Université de Bordeaux, Talence, France
• ^cInstitut Jean-Pierre Bourgin, UMR1318 INRA-AgroParisTech, Versailles, France
• ^dUniversité Paris-Sud and CNRS, Laboratoire de Synthèse de Biomolécules, Institut de Chimie Moléculaire et des Matériaux, Orsay, France

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Continuous Flow Synthesis of Thieno[2,3-c]isoquinolin-5(4H)-one Scaffold: A Valuable Source of PARP-1 Inhibitors

Paolo Filipponi^†, Carmine Ostacolo^‡, Ettore Novellino^‡, Roberto Pellicciari^†§, Antimo Gioiello^*†

• ^†Dipartimento di Scienze Farmaceutiche, Università di Perugia, Via del Liceo 1, I-06123 Perugia, Italy
• ^‡Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Napoli, Italy §TES Pharma S.r.l., Corciano (Perugia), Italy

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First Example of a Continuous-Flow Carbonylation Reaction Using Aryl Formates as CO Precursors

Nerea Alonso^1,3, Juan de Muñoz¹, Brecht Egle², Johannes L. Vrijdag², Wim M. De Borggraeve², Antonio de la Hoz³, Angel Díaz-Ortiz³, Jesús Alcázar¹

• ¹Janssen Research and Development, Janssen-Cilag Department of Medicinal Chemistry S.A., Toledo, Spain
• ²Molecular Design and Synthesis University of Leuven, Department of Chemistry, Heverlee Belgium
• ³Universidad de Castilla-La Mancha Facultad de Ciencias y Tecnologías Químicas Real, Spain

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Sequential flow process for the controlled polymerisation and thermolysis of RAFT-synthesised polymers

CH Hornung, A Postma, S Saubern, J Chiefari

• CSIRO Materials Science and Engineering, Victoria, Australia

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Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels-Alder Reaction under Superheated Continuous Flow Conditions

Rainer E. Martin¹, Falk Morawitz¹, Christoph Kuratli¹, André M. Alker², Alexander I. Alanine¹

• ¹Chemistry Technology and Innovation, F. Hoffmann-La Roche Ltd, Basel, Switzerland
• ²Biostructure Section, F. Hoffmann-La Roche Ltd,Basel, Switzerland

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Controlled RAFT Polymerization in a Continuous Flow Microreactor

Christian H. Hornung, Carlos Guerrero-Sanchez, Malte Brasholz, Simon Saubern, John Chiefari, Graeme Moad, Ezio Rizzardo, San H. Thang

• CSIRO Materials Science & Engineering, Victoria, Australia

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Decarboxylative biaryl synthesis in a continuous flow reactor

¹Paul P. Lange, ¹Lukas J. Gooßen, ²Philip Podmore, ²Toby Underwood, ²Nunzio Sciammetta

• ¹Technische Universität Kaiserslautern, Germany
• ²Pfizer Global R&D, Sandwich, UK

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A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT1B> Antagonist

Zizheng Qian, Ian R. Baxendale, Steven V. Ley

• Innovative Technology Centre, Department of Chemistry, University of Cambridge

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