A modular flow reactor for performing Curtius rearrangements as a continuous flow process

    • Marcus Baumann1
    • Ian R. Baxendale1
    • Steven V. Ley1
    • Nikzad Nikbin1
    • Christopher D. Smith1
    • Jason P. Tierney2
    • 1Innovative Technology Centre, Department of Chemistry, University of Cambridge
    • 2Neurology Lead Discovery Chemistry, GlaxoSmithKline R and D, Harlow, UK

    The use of a mesofluidic flow reactor is described for performing Curtius rearrangement reactions of carboxylic acids in the presence of diphenylphosphoryl azide and trapping of the intermediate isocyanates with various nucleophiles.

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