A modular flow reactor for performing Curtius rearrangements as a continuous flow process

The use of a mesofluidic flow reactor is described for performing Curtius rearrangement reactions of carboxylic acids in the presence of diphenylphosphoryl azide and trapping of the intermediate isocyanates with various nucleophiles.

• Marcus Baumann¹
• Ian R. Baxendale¹
• Steven V. Ley¹
• Nikzad Nikbin¹
• Christopher D. Smith¹
• Jason P. Tierney²

• ¹Innovative Technology Centre, Department of Chemistry, University of Cambridge
• ²Neurology Lead Discovery Chemistry, GlaxoSmithKline R and D, Harlow, UK

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