A modular flow reactor for performing Curtius rearrangements as a continuous flow process

    • Marcus Baumann1
    • Ian R. Baxendale1
    • Steven V. Ley1
    • Nikzad Nikbin1
    • Christopher D. Smith1
    • Jason P. Tierney2
    • 1Innovative Technology Centre, Department of Chemistry, University of Cambridge
    • 2Neurology Lead Discovery Chemistry, GlaxoSmithKline R and D, Harlow, UK

    The use of a mesofluidic flow reactor is described for performing Curtius rearrangement reactions of carboxylic acids in the presence of diphenylphosphoryl azide and trapping of the intermediate isocyanates with various nucleophiles.

    Read the publication that featured this abstract

    Get in touch

    For more information on flow chemistry systems and services please use the contact methods below.

    Call us on +44 (0)1284 728659 or Email us

    Request a quote