A modular flow reactor for performing Curtius rearrangements as a continuous flow process
- Marcus Baumann1
- Ian R. Baxendale1
- Steven V. Ley1
- Nikzad Nikbin1
- Christopher D. Smith1
- Jason P. Tierney2
- 1Innovative Technology Centre, Department of Chemistry, University of Cambridge
- 2Neurology Lead Discovery Chemistry, GlaxoSmithKline R and D, Harlow, UK
Read the publication that featured this abstractThe use of a mesofluidic flow reactor is described for performing Curtius rearrangement reactions of carboxylic acids in the presence of diphenylphosphoryl azide and trapping of the intermediate isocyanates with various nucleophiles.
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