Continuous Flow Synthesis of Coumarin

Anbang Chen¹, Xin Li¹, Yangzhi Zhou¹, Lingling Huang², Zheng Fang², Haifeng Gan¹, Kai Guo¹

• ¹ College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology ² School of Pharmceutical Sciences, Nanjing University of Technology

Flow chemistry, as a rapidly emerging technology, is exploited to provide a safe and scalable route for the pharmaceutically interesting coumarin. Here, a continuous flow approach for the generation of coumarin is reported, which relies on the two connected coil reactors design. The synthesis of coumarin has been performed successfully in high conversion on small scale and can be scaled up substantially.

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