Continuous Flow Synthesis of Coumarin

    Anbang Chen1, Xin Li1, Yangzhi Zhou1, Lingling Huang2, Zheng Fang2, Haifeng Gan1, Kai Guo1

    • 1 College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology 2 School of Pharmceutical Sciences, Nanjing University of Technology

    Flow chemistry, as a rapidly emerging technology, is exploited to provide a safe and scalable route for the pharmaceutically interesting coumarin. Here, a continuous flow approach for the generation of coumarin is reported, which relies on the two connected coil reactors design. The synthesis of coumarin has been performed successfully in high conversion on small scale and can be scaled up substantially.

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