Delineating a green, catalyst free synthesis of a popular nutraceutical methylsulfonylmethane (MSM) in continuous flow
- Chinmay A. Shuklaa
- Bantu Udaykumara
- Y. Saisivanarayanaa
- Arsh Ismailia
- T Haripriyaa
- Manish M. Shindeb
- Srinivasan Netic
- Maheshkumar Uppadaa
- Vishnuvardhana Edac
- Saikat Senc
- Srinivas Orugantia,b,c
- a10X Chemical Process Automation Laboratory, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India
- bFlow Chemistry Technology Hub, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India
- cCentre for Process Research and Innovation, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India
Read the publication that featured this abstractA green and potentially scalable continuous flow synthesis of a popular sulfone containing nutraceutical, methylsulfonylmethane (MSM), has been demonstrated in a Vapourtec tubular reactor platform via metal catalyst-free hydrogen peroxide mediated oxidation of dimethyl sulfoxide. Under optimized conditions, MSM could be obtained in >85% isolated yield and purity >99% with a productivity of 23.6 g/h simply by cooling the reaction mixture collected at the output.
Get in touch
For more information on flow chemistry systems and services please use the contact methods below.
Call us on +44 (0)1284 728659 or Email us
Resource Centre
R-Series

The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
- Flexible |
- Precise |
- Automatable
The R-Series is undoubtedly the most versatile, modular flow chemistry system available today.
E-Series

The Vapourtec E-Series is the perfect introductory system for flow chemistry
- Robust |
- Easy to use |
- Affordable
The E-Series is a robust and affordable, entry level flow chemistry system designed for reliability and ease of use.