Delineating a green, catalyst free synthesis of a popular nutraceutical methylsulfonylmethane (MSM) in continuous flow
- Chinmay A. Shuklaa
- Bantu Udaykumara
- Y. Saisivanarayanaa
- Arsh Ismailia
- T Haripriyaa
- Manish M. Shindeb
- Srinivasan Netic
- Maheshkumar Uppadaa
- Vishnuvardhana Edac
- Saikat Senc
- Srinivas Orugantia,b,c
- a10X Chemical Process Automation Laboratory, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India
- bFlow Chemistry Technology Hub, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India
- cCentre for Process Research and Innovation, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, IndiaRead the publication that featured this abstract
A green and potentially scalable continuous flow synthesis of a popular sulfone containing nutraceutical, methylsulfonylmethane (MSM), has been demonstrated in a Vapourtec tubular reactor platform via metal catalyst-free hydrogen peroxide mediated oxidation of dimethyl sulfoxide. Under optimized conditions, MSM could be obtained in >85% isolated yield and purity >99% with a productivity of 23.6 g/h simply by cooling the reaction mixture collected at the output.
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