Phase-Transfer Catalysis under Continuous Flow Conditions: An Alternative Approach to the Biphasic Liquid/Liquid O-Alkylation of Phenols

    • Daniele De Zani2
    • Matteo Colombo1
    • 1NiKem Research 20021 via Zambeletti 25 Milan Baranzate Italy
    • 2Erregierre, San Paolo D'Argon Bergamo Italy

    O-Alkylation of phenol compounds was performed in a continuous flow apparatus under biphasic liquid/liquid conditions and promoted by tetrabutylammonium bromide (TBAB) as a phase-transfer catalyst. The segmented flow that is generated within the flow system is able to afford the desired ethers in high yield and in very short times.

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