KMnO4-Mediated Oxidation as a Continuous Flow Process

An efficient and easily scalable transformation of alcohols and aldehydes to carboxylic acids and nitroalkane derivatives to the corresponding carbonyls and carboxylic acids using permanganate as the oxidant within a continuous flow reactor is reported. Notably, the generation and downstream processing of MnO₂ slurries was not found to cause any blocking of the reactor when ultrasound pulses were applied to the flow system.

• Jorg Sedelmeier
• Steven V. Ley
• Ian R. Baxendale
• Marcus Baumann

• Innovative Technology Centre, University of Cambridge

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